Toxic responses of the liver and kidneys following occupational exposure to anesthetic gases.

abstract：:Renin Angiotensin Aldosterone System (RAAS) plays an important role in the development of hypertension. On the other hand, hypertension is a well-known and independent risk factor for cognitive impairment. The aim of the present study was to evaluate the relationship of blood pressure control, plasma angiotensin pepti...

journal_title：EXCLI journal

authors： Sen S,Gürel N,Ufuktepe B,Özünal ZG,Büyüklü Ç,Üresin Y

更新日期：2017-03-10 00:00:00

abstract：:As a dynamic system in which different factors affect human performance via dynamic interactions, mental workload needs a dynamic measure to monitor its factors and evidence in a complicated system, an approach that is lacking in the literature. The present study introduces a system dynamics-based model for designing ...

journal_title：EXCLI journal

authors： Jafari MJ,Zaeri F,Jafari AH,Payandeh Najafabadi AT,Hassanzadeh-Rangi N

更新日期：2019-07-11 00:00:00

abstract：:Salmonella enterica serovar Typhi (S. Typhi) is a human restricted pathogen. It biosynthesizes a virulence capsular polysaccharide named as Vi antigen. S. Typhi regulates expression of genes involved in the biosynthesis of Vi antigen in response to osmolarity. Beside Vi-positive isolates, Vi-negative (acapsulated) iso...

journal_title：EXCLI journal

authors： Liaquat S,Sarwar Y,Ali A,Haque A

更新日期：2015-02-09 00:00:00

abstract：:Previous research has shown the beneficial effects of aqueous extract of Piper sarmentosum (P.s) on atherosclerosis. The first stage in atherosclerosis is the formation of foam cell. The aim of this study was to investigate the effect of the methanol extract of P.s on fatty streaks by calculating neointimal foam cell ...

journal_title：EXCLI journal

authors： Amran AA,Zakaria Z,Othman F,Das S,Al-Mekhlafi HM,Raj S,Nordin NA

更新日期：2012-06-15 00:00:00

abstract：:Phoenix sylvestris (Arecaceae family) known as Indian Date Palm has been identified as a component of traditional medicine against various ailments. The present study was focused on phytochemical screening of crude hexane, dichloromethane and methanol leaf extracts. The crude extracts showed the presence of alkaloids,...

journal_title：EXCLI journal

authors： Sharma DC,Shukla R,Ali J,Sharma S,Bajpai P,Pathak N

更新日期：2016-02-05 00:00:00

abstract：:This review will concentrate on the clinical pharmacology, in particular pharmacodynamic data, related to atypical antipsychotics, clozapine, risperidone, paliperidone, olanzapine, que¬tiapine, amisulpride, ziprasidone, aripiprazole, asenapine, iloperidone, lurasidone and cariprazine. A summary of their acute pharmaco...

journal_title：EXCLI journal

authors： Mauri MC,Paletta S,Maffini M,Colasanti A,Dragogna F,Di Pace C,Altamura AC

更新日期：2014-10-13 00:00:00

abstract：:We present the case of a 77 year old male patient with metastatic pancreatic neuroendocrine tumor (NET). The patient was initially treated by extensive surgical resection that however, led to severe complications with delayed recovery. During follow-up, a number of new liver metastases were detected, one of which was ...

journal_title：EXCLI journal

authors： Ataeinia B,Loberg C,Kravets H,Beheshti M,von Mallek D,Mottaghy FM,Heinzel A

更新日期：2019-05-21 00:00:00

abstract：:To our knowledge, in spite of several trials exploring the beneficial effect of n-3 polyunsaturated fatty acids (PUFA) on polycystic ovary syndrome (PCOS), no comprehensive evidence has investigated the effects of n-3 PUFA consumption on PCOS complications. Therefore, our aim was to conduct a review to investigate the...

journal_title：EXCLI journal

authors： Salek M,Clark CCT,Taghizadeh M,Jafarnejad S

更新日期：2019-07-25 00:00:00

abstract：:DNA methylation, an epigenetic modification, is mediated by DNA methyltransferases (DNMTs), a family of enzymes. Inhibitions of these enzymes are considered a promising strategy for the treatment of several diseases. In this study, a quantitative structure-activity relationship (QSAR) modeling was employed to understa...

journal_title：EXCLI journal

authors： Phanus-Umporn C,Prachayasittikul V,Nantasenamat C,Prachayasittikul S,Prachayasittikul V

更新日期：2020-04-02 00:00:00

abstract：:A series of phenyl-3-(thiophen-2-yl)-4, 5-dihydro-1H-pyrazole-1-carbothioamides (TTa-TTg) were synthesized by the ring closure reaction of phenyl-1-(thiophen-2-yl) prop-2-en-1-ones with thiosemicarbazide in alcoholic basic medium. All the final derivatives were evaluated for their antidepressant and neurotoxicity scre...

journal_title：EXCLI journal

authors： Mathew B,Suresh J,Anbazhagan S

更新日期：2014-04-29 00:00:00

abstract：:Activation of the hypoxia-inducible factor (HIF)-pathway in hepatocellular carcinoma (HCC) induces therapy resistant tumours, characterized by increased liver progenitor cell (LPCs) characteristics and poor prognosis. We previously reported corresponding results in mice with HCC in which hypoxia was mimicked by prolyl...

journal_title：EXCLI journal

authors： Bogaerts E,Paridaens A,Verhelst X,Carmeliet P,Geerts A,Van Vlierberghe H,Devisscher L

更新日期：2016-11-11 00:00:00

abstract：:Everolimus (EVR), as a rapamycin analog, is a selective inhibitor of the mammalian target of rapamycin (mTOR) kinase and its associated signaling pathway. mTOR is a serine/threonine protein kinase and its hyperactivity is involved in the pathophysiology of Alzheimer's disease (AD) and associated cognitive deficits. Th...

journal_title：EXCLI journal

authors： Fanoudi S,Hosseini M,Alavi MS,Boroushaki MT,Hosseini A,Sadeghnia HR

更新日期：2018-10-29 00:00:00

abstract：:Some debates exist regarding the association of diabetes mellitus (DM) with COVID-19 infection severity and mortality. In this study, we aimed to describe and compare the clinical characteristics and outcomes of hospitalized COVID-19 patients with and without DM. In this single-centered, retrospective, observational s...

journal_title：EXCLI journal

authors： Mansour A,Sajjadi-Jazi SM,Kasaeian A,Khosravi B,Sorouri M,Azizi F,Rajabi Z,Motamedi F,Sirusbakht A,Eslahi M,Mojtabbavi H,Sima AR,Radmard AR,Mohajeri-Tehrani MR,Abdollahi M

更新日期：2020-11-16 00:00:00

abstract：:Recently, bioinformatics has advanced to the level that it allows almost accurate prediction of molecular interactions that hold together a protein and a ligand in the bound state. For instance, the program AutoDock has been developed to provide a procedure for predicting the interaction of small molecules with macrom...

journal_title：EXCLI journal

authors： Rizvi SM,Shakil S,Haneef M

更新日期：2013-09-23 00:00:00

abstract：:Recently, many articles have reported different levels and distribution of amphetamine hitherto detected in biological fluids now appreciably found in aquatic environment at ng/L levels. Identification and measurement of amphetamine and its metabolites in surface and sewage waters using higher performance liquid chrom...

journal_title：EXCLI journal

authors： Mustapha AO,Ajao UL

更新日期：2011-08-19 00:00:00

abstract：:Previous studies proved the pro-angiogenic effect of Crocetin, a natural carotenoid dicarboxylic acid, in both in vivo and in vitro models. However, the exact mechanism of Crocetin action has not completely been elucidated yet. The current experiment was designed to find the activity of PI3K-Akt-eNOS axis after the tr...

journal_title：EXCLI journal

authors： Nasirzadeh M,Rasmi Y,Rahbarghazi R,Kheradmand F,Karimipour M,Aramwit P,Astinfeshan M,Gholinejad Z,Daeihasani B,Saboory E,Shirpoor A,Rezabakhsh A,Zolali E,Khalaji N

更新日期：2019-10-21 00:00:00

abstract：:Patients with diabetes tend to have an increased risk of osteoporosis that may be related to hyperglycemia. In vitro evidence has shown that high glucose can affect the proliferation and osteogenic differentiation of mesenchymal stem cells (MSCs). Tissue regeneration depends mainly on MSCs. However, the exact mechanis...

journal_title：EXCLI journal

authors： Wang J,Wang B,Li Y,Wang D,Lingling E,Bai Y,Liu H

更新日期：2013-06-27 00:00:00

abstract：:Fibroblast growth factor 21 (FGF21) is a major metabolic regulator that has been shown to be elevated in a number of metabolic disturbances including type 2 diabetes mellitus (T2DM) and the metabolic syndrome, but few studies about the relationship between serum FGF21 and the complications of diabetes have been done. ...

journal_title：EXCLI journal

authors： Mousavi Z,Bonakdaran S,Sahebkar A,Yaghoubi G,Yaghoubi MA,Davoudian N,Mohebbi M

更新日期：2017-11-22 00:00:00

abstract：:Exposure to microgravity leads to orthostatic intolerance in astronauts and differential vascular structural and functional adaptations have been implicated in its occurrence. The present study tended to clarify the characteristics of vascular inflammation and oxidative stress in hindlimb unweighting (HU) rat vasculat...

journal_title：EXCLI journal

authors： Zhang R,Ran HH,Gao YL,Ma J,Huang Y,Bai YG,Lin LJ

更新日期：2010-12-23 00:00:00

abstract：:Nanoencapsulation of drug/small molecules in nanocarriers (NCs) is a very promising approach for development of nanomedicine. Modern drug encapsulation methods allow efficient loading of drug molecules inside the NCs thereby reducing systemic toxicity associated with drugs. Targeting of NCs can enhance the accumulatio...

journal_title：EXCLI journal

authors： Kumari A,Singla R,Guliani A,Yadav SK

更新日期：2014-03-20 00:00:00

abstract：:To date, a number of significant herbal drug interactions have their origins in the alteration of cytochrome P450 (CYP) activity by various phytochemicals. Among the most noteworthy are those involving St. John's wort and drugs metabolized by human CYP3A4 enzyme. This review article is the continued work from our prev...

journal_title：EXCLI journal

authors： Wanwimolruk S,Phopin K,Prachayasittikul V

更新日期：2014-08-20 00:00:00

abstract：:Vitamin D deficiency, common in the population with irritable bowel syndrome (IBS), can induce the main factors that lead to IBS clinical symptoms, such as depression, anxiety, and inflammation. Serotonin (5-HT) plays an important role in the pathophysiology of IBS, and its production and secretion are increased from ...

journal_title：EXCLI journal

authors： Khalighi Sikaroudi M,Mokhtare M,Shidfar F,Janani L,Faghihi Kashani A,Masoodi M,Agah S,Dehnad A,Shidfar S

更新日期：2020-05-19 00:00:00

abstract：:R273H mutant p53 is a DNA-contact mutant that renders p53 dysfunctional due to a single substitution of Arg273 for His273. Rescuing R273 mutant p53 implies that a competent molecule would have to bind to the site of DNA-contact hot spots to complement the loss of contact with the DNA-binding domain. Here, curcumin, fl...

journal_title：EXCLI journal

authors： Malami I,Muhammad A,Etti IC,Waziri PM,Alhassan AM

更新日期：2017-12-08 00:00:00

abstract：:Bladder cancer (BC) is the sixth most common malignancy in men and 17th in women. Exosomal long non-coding RNAs (lncRNAs) have been defined as a novel biomarker for BC. The aim of this study is to evaluate the clinical significance of urine exosomal PVT-1, ANRIL and PCAT-1 as a biomarker in BC patients with tumors cla...

journal_title：EXCLI journal

authors： Abbastabar M,Sarfi M,Golestani A,Karimi A,Pourmand G,Khalili E

更新日期：2020-03-04 00:00:00

abstract：:The purpose of the present study was to investigate whether the markers of oxidative stress could be altered in workers exposed to asbestos. A comparative cross-sectional research was conducted in a group of 50 subjects exposed to asbestos and another group of 50 with the same age and sex unexposed to asbestos. Malond...

journal_title：EXCLI journal

authors： Afaghi A,Oryan S,Rahzani K,Abdollahi M

更新日期：2015-09-28 00:00:00

abstract：:The effect of leaf essential oil of Hoslundia opposita (Vahl) on the haematological parameters of alloxan-induced diabetic rats was investigated. Forty-eight albino rats (Rattus norvegicus), of average weight 132.5 g, were randomly selected into normal and diabetic groups, each with four sub-groups. The rats were trea...

journal_title：EXCLI journal

authors： Muhammad NO,Akolade JO,Usman LA,Oloyede OB

更新日期：2012-09-25 00:00:00

abstract：:Little is known about biogenically synthesized Zinc oxide nanoparticles (ZnONPs) from Isodon rugosus. Synthesis of metal oxide NPs from essential oil producing medicinal plants results in less harmful side effects to the human population as compared to chemically synthesized NPs. In this article, we report biogenic sy...

journal_title：EXCLI journal

authors： Siddiquah A,Hashmi SS,Mushtaq S,Renouard S,Blondeau JP,Abbasi R,Hano C,Abbasi BH

更新日期：2018-07-16 00:00:00

abstract：:L-asparaginase and L-glutaminase can be effectively used for the treatment of patients who suffer from accute lymphoblastic leukemia and tumor cells. Microbial sources are the best source for the bulk production of these enzymes. However, their long-term administration may cause immunological responses, so screening f...

journal_title：EXCLI journal

authors： Shirazian P,Asad S,Amoozegar MA

更新日期：2016-04-18 00:00:00

abstract：:This study investigated the effect of the serotonin selective reuptake inhibitors (SSRIs) fluoxetine, sertraline, fluvoxamine and the tricyclic antidepressant (TCA) impiramine on oxidative stress in brain and liver induced by lipopolysaccharide administration in mice. Each drug was administered subcutaneously at doses...

journal_title：EXCLI journal

authors： Abdel-Salam OME,Morsy SMY,Sleem AA

更新日期：2011-12-08 00:00:00

abstract：:The present study deals with the isolation and partial purification of bioactive compounds from the crude methanol extracts of the leaves of Ageratum houstonianum (Asteraceae). The quantification and the identification of compounds in the crude extract and active bands isolated by preparative TLC were accomplished usi...

journal_title：EXCLI journal

authors： Zeeshan M,Rizvi SM,Khan MS,Kumar A

更新日期：2012-02-28 00:00:00