Abstract:
:Vitamin D deficiency, common in the population with irritable bowel syndrome (IBS), can induce the main factors that lead to IBS clinical symptoms, such as depression, anxiety, and inflammation. Serotonin (5-HT) plays an important role in the pathophysiology of IBS, and its production and secretion are increased from the lumen due to stress and inflammation. The aim of this study was to evaluate the effect of vitamin D3 supplementation on the pathogenesis of diarrhea-predominant IBS (IBS-D). Seventy-four IBS-D patients (age: 18-65 y) participated in a randomized, double-blind, placebo-controlled trial study from February 2017 to May 2018, at Rasoul-e-Akram Hospital, Tehran, Iran. Subjects were allocated into two groups receiving 50,000 IU/week of vitamin D3 or placebo for 9 weeks. IBS severity score system (IBS-SSS), IBS-quality of life questionnaire (QoL), hospital anxiety and depression Scale (HADs), visceral sensitivity index (VSI) and serum 25(OH) vitamin D3, serotonin, 5-hydroxy-indole acetic acid and ratio of 5-HIAA/5-HT were evaluated before and after the interventions. Symptoms severity, QoL, HADs-depression, and VSI score improved significantly in the vitamin D group as compared to the placebo group (P-values: <0.001, 0.049, 0.023, and 0.008; respectively). There were no significant differences in abdominal bloating, HADs-anxiety, serum 5-HT, 5-HIAA, and 5-HIAA/5-HT between the two groups at the end of the study. Based on our results, we recommend serum vitamin D be evaluated in the process of treatment of these patients to ameliorate symptoms and quality life of IBS-D patients with vitamin D deficiency and/or insufficiency.
journal_name
EXCLI Jjournal_title
EXCLI journalauthors
Khalighi Sikaroudi M,Mokhtare M,Shidfar F,Janani L,Faghihi Kashani A,Masoodi M,Agah S,Dehnad A,Shidfar Sdoi
10.17179/excli2020-2247subject
Has Abstractpub_date
2020-05-19 00:00:00pages
652-667issn
1611-2156pii
2020-2247journal_volume
19pub_type
杂志文章相关文献
EXCLI Journal文献大全abstract::Pharmaceutical effluents contain toxic xenobiotics capable of contaminating aquatic environments. Untreated effluents are illegally discharged into aquatic environment in most developing countries. Pharmaceutical effluent induced alterations in biomarkers of genetic and systemic damage on rodents. However, information...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2019-02-06 00:00:00
abstract::Objective: Although osteoarthritis (OA) is widely accepted as a degenerative disease, autoimmune processes are believed to be involved in the pathogenesis. There are limited studies in this area and most of them focused on antibodies against chondrocyte membrane. In an attempt to address the paucity of evidence in thi...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2012-09-07 00:00:00
abstract::[This retracts the article DOI: 10.17179/excli2015-642.]. ...
journal_title:EXCLI journal
pub_type: 杂志文章,撤回出版物
doi:10.17179/excli2016-570
更新日期:2016-09-19 00:00:00
abstract::Aromatase is a rate-limiting enzyme for estrogen biosynthesis that is overproduced in breast cancer tissue. To block the growth of breast tumors, aromatase inhibitors (AIs) are employed to bind and inhibit aromatase in order to lower the amount of estrogen produced in the body. Although a number of synthetic aromatase...
journal_title:EXCLI journal
pub_type: 杂志文章,评审
doi:10.17179/excli2018-1417
更新日期:2018-07-20 00:00:00
abstract::The aim of this study was the design and evaluation of a novel plasma stable, pH-sensitive niosomal formulation of Mitoxantrone by a modified ethanol injection method. Cholesterol hemisuccinate was added instead of cholesterol in order to produce pH-sensitivity property and using PEG-Poly (monomethyl itaconate)-CholC6...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2013-609
更新日期:2015-01-06 00:00:00
abstract::Nephropathy associated with type 2 diabetes is the single most common cause of end-stage renal disease. The aim of the present study was to evaluate the preventive effect of ethanolic extract of Embelia ribes fruit (EER) against high fat diet (HFD) and low dose streptozotocin (STZ)-induced diabetic nephrotoxicity in W...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2013-09-24 00:00:00
abstract::Hematopoietic stem cells (HSCs) form a rare population of multipotent stem cells, which give rise to all hematopoietic lineages. HSCs home to bone marrow niches and circulate between blood and bone marrow. Many factors, especially SDF1a, affect the circulation of HSCs, but these have not been fully recognized. SDF1a h...
journal_title:EXCLI journal
pub_type: 杂志文章,评审
doi:10.17179/excli2014-585
更新日期:2016-02-15 00:00:00
abstract::Unlike conventional materials that covalent bonds connecting atoms as the major force to hold the materials together, supramolecular biomaterials rely on noncovalent intermolecular interactions to assemble. The reversibility and biocompatibility of supramolecular biomaterials render them with diverse range of function...
journal_title:EXCLI journal
pub_type: 杂志文章,评审
doi:10.17179/excli2020-2656
更新日期:2020-08-05 00:00:00
abstract::An enzyme-coupled colorimetric assay for quantification of urinary sarcosine was developed. The proposed method is a specific reaction based on hydrogen peroxide (H2O2) formation via sarcosine oxidase (SOX). The liberated H2O2 reacts with Amplex Red in the presence of horseradish peroxidase (HRP) to produce the red-fl...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2018-145
更新日期:2018-05-17 00:00:00
abstract::Lack of data on safety of herbal medicines have endangered human health and life. The present study evaluated the genotoxic and mutagenic effect of Kalanchoe laciniata to access the safety and usefulness of the medicinal plant. Aqua-methanolic and n-hexane extracts of K. laciniata were evaluated for the genotoxic pote...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2016-748
更新日期:2017-04-24 00:00:00
abstract::The aim of this study is to investigate the mechanism of electro-acupuncture (EA) on the recovery of injured spinal cord. Rats were randomly divided into normal control, sham-operated, SCI, SCI+EA group and T10 segment spinal cord injury (SCI) rat model was established by the modified Allen's method. After 7 days, the...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2017-123
更新日期:2017-03-23 00:00:00
abstract::The liver is famous for its strong regenerative capacity, employing different modes of regeneration according to type and extent of injury. Mature liver cells are able to proliferate in order to replace the damaged tissue allowing the recovery of the parenchymal function. In more severe scenarios hepatocytes are belie...
journal_title:EXCLI journal
pub_type: 杂志文章,评审
doi:10.17179/excli2014-576
更新日期:2015-01-06 00:00:00
abstract::This review will concentrate on the clinical pharmacology, in particular pharmacodynamic data, related to atypical antipsychotics, clozapine, risperidone, paliperidone, olanzapine, que¬tiapine, amisulpride, ziprasidone, aripiprazole, asenapine, iloperidone, lurasidone and cariprazine. A summary of their acute pharmaco...
journal_title:EXCLI journal
pub_type: 杂志文章,评审
doi:
更新日期:2014-10-13 00:00:00
abstract::Fibroblast growth factor 21 (FGF21) is a major metabolic regulator that has been shown to be elevated in a number of metabolic disturbances including type 2 diabetes mellitus (T2DM) and the metabolic syndrome, but few studies about the relationship between serum FGF21 and the complications of diabetes have been done. ...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2017-672
更新日期:2017-11-22 00:00:00
abstract::A series of phenyl-3-(thiophen-2-yl)-4, 5-dihydro-1H-pyrazole-1-carbothioamides (TTa-TTg) were synthesized by the ring closure reaction of phenyl-1-(thiophen-2-yl) prop-2-en-1-ones with thiosemicarbazide in alcoholic basic medium. All the final derivatives were evaluated for their antidepressant and neurotoxicity scre...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2014-04-29 00:00:00
abstract::Our experimental work was aimed at evaluating the safety and protective effects of dietary spirulina supplementation on the kidney of newborn rats, the offspring of lead contaminated lactating mothers. Female rats were randomly divided into four groups: group I (control) was given a normal diet, group II (positive con...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2017-1016
更新日期:2018-03-02 00:00:00
abstract::Everolimus (EVR), as a rapamycin analog, is a selective inhibitor of the mammalian target of rapamycin (mTOR) kinase and its associated signaling pathway. mTOR is a serine/threonine protein kinase and its hyperactivity is involved in the pathophysiology of Alzheimer's disease (AD) and associated cognitive deficits. Th...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2018-1626
更新日期:2018-10-29 00:00:00
abstract::The purpose of the present study was to investigate whether the markers of oxidative stress could be altered in workers exposed to asbestos. A comparative cross-sectional research was conducted in a group of 50 subjects exposed to asbestos and another group of 50 with the same age and sex unexposed to asbestos. Malond...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2015-469
更新日期:2015-09-28 00:00:00
abstract::Endometriosis is defined by presence of endometrial-like-tissue outside the uterus. Recently, ectopic endometriotic lesions have been suggested to originate by abnormal differentiation of endometrial mesenchymal stem cells (eMSCs). MicroRNAs (miRNAs) play an important role in the pathophysiology of endometriosis. Thro...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2017-101
更新日期:2017-06-14 00:00:00
abstract::Hepatocellular carcinoma or Liver cancer (LC) is the sixth most common cancer and the fourth cause of death worldwide in 2018. There has not been a comprehensive study on the survival rate of patients with LC in Asia yet. Therefore, the present study was conducted to evaluate the survival rate of patients with LC in A...
journal_title:EXCLI journal
pub_type: 杂志文章,评审
doi:10.17179/excli2019-1842
更新日期:2020-01-13 00:00:00
abstract::Corn cob is a major component of agricultural and domestic waste in many parts of the world. It is composed mainly of cellulose which can be converted to energy in form of bioethanol as an efficient and effective means of waste management. Production of cellulolytic enzymes were induced in the fungi Aspergillus niger ...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2012-08-15 00:00:00
abstract::Ursolic acid (UA) is a pentacyclic triterpenoid carboxylic acid that is found in plants and herbal products. It is one of the chemopreventive agents, which can suppress cancer cell proliferation and induce apoptosis. UA possesses various biological activities including anticancer, anti-inflammatory, anti-oxidative and...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2013-02-08 00:00:00
abstract::Considering the therapeutic values of bioflavonoids in colon cancer treatment, six 2'-hydroxy chalcones (C1-C6) were synthesized, characterized and screened for in vitro cytotoxicity on human colon carcinoma (HCT116) and African green monkey kidney epithelial cells (Vero). Only C5 showed selective cytotoxicity against...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2016-643
更新日期:2017-04-03 00:00:00
abstract::The traditional uses of Portulaca oleracea L. (PO) with anti-inflammatory and anti-cancer activity as well as antioxidants properties were expressed previously. Glioma is considered the most common primary brain tumor and its malignant form is the most lethal adult brain tumor, that glioblastoma covers about 50 % of g...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2019-1063
更新日期:2019-03-20 00:00:00
abstract::The present study deals with the isolation and partial purification of bioactive compounds from the crude methanol extracts of the leaves of Ageratum houstonianum (Asteraceae). The quantification and the identification of compounds in the crude extract and active bands isolated by preparative TLC were accomplished usi...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2012-02-28 00:00:00
abstract::To date, a number of significant herbal drug interactions have their origins in the alteration of cytochrome P450 (CYP) activity by various phytochemicals. Among the most noteworthy are those involving St. John's wort and drugs metabolized by human CYP3A4 enzyme. This review article is the continued work from our prev...
journal_title:EXCLI journal
pub_type: 杂志文章,评审
doi:
更新日期:2014-08-20 00:00:00
abstract::DNA methylation, an epigenetic modification, is mediated by DNA methyltransferases (DNMTs), a family of enzymes. Inhibitions of these enzymes are considered a promising strategy for the treatment of several diseases. In this study, a quantitative structure-activity relationship (QSAR) modeling was employed to understa...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2020-1096
更新日期:2020-04-02 00:00:00
abstract::Dibutyltin dichloride (DBTC) is an organotin compound used as model for acute and chronic pancreatitis. Oxidative stress is one of the mechanisms of propagation of acinar cell injury in acute pancreatitis. Selenium is an essential cofactor in the antioxidant glutathione peroxidase pathway. Selenium levels are describe...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2016-466
更新日期:2017-02-16 00:00:00
abstract::Achillea eriophora (Asteraceae) is a medicinal plant commonly used in Iran. This study was performed to determine the cardiovascular effects of hydroethanolic extract of A. eriophora (HEAE) and the underlying mechanisms in anaesthetized rats. The acute effects of intravenous (i.v.) administration of different doses of...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2016-529
更新日期:2016-12-07 00:00:00
abstract::Morphological identification is a widespread procedure to assess the presence of apoptosis by visual inspection of the morphological characteristics or the fluorescence images. The procedure is lengthy and results are observer dependent. A quantitative automatic analysis is objective and would greatly help the routine...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2014-01-29 00:00:00