Abstract:
:Unlike conventional materials that covalent bonds connecting atoms as the major force to hold the materials together, supramolecular biomaterials rely on noncovalent intermolecular interactions to assemble. The reversibility and biocompatibility of supramolecular biomaterials render them with diverse range of functions and lead to rapid development in the past two decades. This review focuses on the noncovalent and enzymatic control of supramolecular biomaterials, with the introduction to various triggering mechanism to initiate self-assembly. Representative applications of supramolecular biomaterials are highlighted in four categories: tissue engineering, cancer therapy, drug delivery, and molecular imaging. By introducing various applications, we intend to show enzymatic control and noncovalent interactions as a powerful tool for achieving spatiotemporal control of biomaterials both invitro and in vivo for biomedicine.
journal_name
EXCLI Jjournal_title
EXCLI journalauthors
Guo J,Tian C,Xu Bdoi
10.17179/excli2020-2656subject
Has Abstractpub_date
2020-08-05 00:00:00pages
1124-1140issn
1611-2156pii
2020-2656journal_volume
19pub_type
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