Everolimus, a mammalian target of rapamycin inhibitor, ameliorated streptozotocin-induced learning and memory deficits via neurochemical alterations in male rats.


:Everolimus (EVR), as a rapamycin analog, is a selective inhibitor of the mammalian target of rapamycin (mTOR) kinase and its associated signaling pathway. mTOR is a serine/threonine protein kinase and its hyperactivity is involved in the pathophysiology of Alzheimer's disease (AD) and associated cognitive deficits. The present study evaluated the impact of EVR, on cognitive functions, hippocampal cell loss, and neurochemical parameters in the intracerebroventricular streptozotocin (icv-STZ) model of AD rats. EVR (1 and 5 mg/kg) was administered for 21 days following the single administration of STZ (3 mg/kg, icv) or for 7 days on days 21-28 post-STZ injection after establishment of cognitive dysfunction. Cognitive deficits (passive avoidance and spatial memory), oxidative stress parameters, acetylcholinesterase (AChE) activity, and percentage of cell loss were evaluated in the hippocampus. Chronic administration (1 and 5 mg/kg for 21 days from the day of surgery and icv-STZ infusion) or acute injection (5 mg/kg for 7 days after establishment of cognitive impairment) of EVR significantly attenuated cognitive dysfunction, neuronal loss, oxidative stress and AChE activity in the hippocampus of STZ-AD rats. In conclusion, our study showed that EVR could prevent or improve deteriorations in behavioral, biochemical and histopathological features of the icv-STZ rat model of AD. Therefore, inhibition of the hyperactivated mTOR may be an important therapeutic target for AD.




EXCLI journal


Fanoudi S,Hosseini M,Alavi MS,Boroushaki MT,Hosseini A,Sadeghnia HR




Has Abstract


2018-10-29 00:00:00










  • Octyl gallate induces hepatic steatosis in HepG2 cells through the regulation of SREBP-1c and PPAR-gamma gene expression.

    abstract::Octyl gallate (OG) is an antioxidant commonly used in food, although there is no definition of its acceptable daily intake. There are reports in vitro and in vivo showing that food additives and drugs can alter lipid metabolism. Lipid droplet accumulation in hepatic cells is one of the main findings in the unregulated...

    journal_title:EXCLI journal

    pub_type: 杂志文章


    authors: Lima KG,Schneider Levorse VG,Rosa Garcia MC,de Souza Basso B,Pasqualotto Costa B,Antunes GL,Luft C,Haute GV,Leal Xavier L,Donadio MVF,Rodrigues de Oliveira J

    更新日期:2020-07-06 00:00:00

  • Effect of methanolic extract of Piper sarmentosum leaves on neointimal foam cell infiltration in rabbits fed with high cholesterol diet.

    abstract::Previous research has shown the beneficial effects of aqueous extract of Piper sarmentosum (P.s) on atherosclerosis. The first stage in atherosclerosis is the formation of foam cell. The aim of this study was to investigate the effect of the methanol extract of P.s on fatty streaks by calculating neointimal foam cell ...

    journal_title:EXCLI journal

    pub_type: 杂志文章


    authors: Amran AA,Zakaria Z,Othman F,Das S,Al-Mekhlafi HM,Raj S,Nordin NA

    更新日期:2012-06-15 00:00:00

  • Human-based dynamics of mental workload in complicated systems.

    abstract::As a dynamic system in which different factors affect human performance via dynamic interactions, mental workload needs a dynamic measure to monitor its factors and evidence in a complicated system, an approach that is lacking in the literature. The present study introduces a system dynamics-based model for designing ...

    journal_title:EXCLI journal

    pub_type: 杂志文章


    authors: Jafari MJ,Zaeri F,Jafari AH,Payandeh Najafabadi AT,Hassanzadeh-Rangi N

    更新日期:2019-07-11 00:00:00

  • Electro-acupuncture promotes the proliferation of neural stem cells and the survival of neurons by downregulating miR-449a in rat with spinal cord injury.

    abstract::The aim of this study is to investigate the mechanism of electro-acupuncture (EA) on the recovery of injured spinal cord. Rats were randomly divided into normal control, sham-operated, SCI, SCI+EA group and T10 segment spinal cord injury (SCI) rat model was established by the modified Allen's method. After 7 days, the...

    journal_title:EXCLI journal

    pub_type: 杂志文章


    authors: Zhu Y,Wu Y,Zhang R

    更新日期:2017-03-23 00:00:00

  • Overexpression and translocation of dynamin 2 promotes tumor aggressiveness in breast carcinomas.

    abstract::Dynamin 2 is a GTPase protein that has been implicated in cancer progression through its various roles such as endocytosis, morphogenesis, epithelial-mesenchymal transition (EMT), cellular contractions, and focal adhesion maturation. The increased expression levels of this molecule have been demonstrated with the deve...

    journal_title:EXCLI journal

    pub_type: 杂志文章


    authors: Sajed R,Saeednejad Zanjani L,Rahimi M,Mansoori M,Zarnani AH,Madjd Z,Ghods R

    更新日期:2020-10-29 00:00:00

  • Evaluating the relationship of blood pressure, plasma angiotensin peptides and aldosterone with cognitive functions in patients with hypertension.

    abstract::Renin Angiotensin Aldosterone System (RAAS) plays an important role in the development of hypertension. On the other hand, hypertension is a well-known and independent risk factor for cognitive impairment. The aim of the present study was to evaluate the relationship of blood pressure control, plasma angiotensin pepti...

    journal_title:EXCLI journal

    pub_type: 杂志文章


    authors: Sen S,Gürel N,Ufuktepe B,Özünal ZG,Büyüklü Ç,Üresin Y

    更新日期:2017-03-10 00:00:00

  • Serum leptin changes with metformin treatment in polycystic ovarian syndrome: correlation with ovulation, insulin and testosterone levels.

    abstract::The relationship between leptin, insulin resistance and other hormonal parameters in polycystic ovarian syndrome (PCOS) is controversial. We investigated the effect of metformin on leptin levels in women with PCOS. Thirty women with PCOS received metformin 500 mg thrice a day. After two months of metformin treatment t...

    journal_title:EXCLI journal

    pub_type: 杂志文章


    authors: Upadhyaya P,Rehan HS,Seth V

    更新日期:2011-02-24 00:00:00

  • In vitro and in vivo anticancer studies of 2'-hydroxy chalcone derivatives exhibit apoptosis in colon cancer cells by HDAC inhibition and cell cycle arrest.

    abstract::Considering the therapeutic values of bioflavonoids in colon cancer treatment, six 2'-hydroxy chalcones (C1-C6) were synthesized, characterized and screened for in vitro cytotoxicity on human colon carcinoma (HCT116) and African green monkey kidney epithelial cells (Vero). Only C5 showed selective cytotoxicity against...

    journal_title:EXCLI journal

    pub_type: 杂志文章


    authors: Pande AN,Biswas S,Reddy ND,Jayashree BS,Kumar N,Rao CM

    更新日期:2017-04-03 00:00:00

  • The effect of different antidepressant drugs on oxidative stress after lipopolysaccharide administration in mice.

    abstract::This study investigated the effect of the serotonin selective reuptake inhibitors (SSRIs) fluoxetine, sertraline, fluvoxamine and the tricyclic antidepressant (TCA) impiramine on oxidative stress in brain and liver induced by lipopolysaccharide administration in mice. Each drug was administered subcutaneously at doses...

    journal_title:EXCLI journal

    pub_type: 杂志文章


    authors: Abdel-Salam OME,Morsy SMY,Sleem AA

    更新日期:2011-12-08 00:00:00

  • Genotoxic and cytotoxic potential of whole plant extracts of Kalanchoe laciniata by Ames and MTT assay.

    abstract::Lack of data on safety of herbal medicines have endangered human health and life. The present study evaluated the genotoxic and mutagenic effect of Kalanchoe laciniata to access the safety and usefulness of the medicinal plant. Aqua-methanolic and n-hexane extracts of K. laciniata were evaluated for the genotoxic pote...

    journal_title:EXCLI journal

    pub_type: 杂志文章


    authors: Sharif A,Akhtar MF,Akhtar B,Saleem A,Manan M,Shabbir M,Ashraf M,Peerzada S,Ahmed S,Raza M

    更新日期:2017-04-24 00:00:00

  • Exposure to effluent from pharmaceutical industry induced cytogenotoxicity, hematological and histopathological alterations in Clarias gariepinus (Burchell, 1822).

    abstract::Pharmaceutical effluents contain toxic xenobiotics capable of contaminating aquatic environments. Untreated effluents are illegally discharged into aquatic environment in most developing countries. Pharmaceutical effluent induced alterations in biomarkers of genetic and systemic damage on rodents. However, information...

    journal_title:EXCLI journal

    pub_type: 杂志文章


    authors: Alimba CG,Adekoya KO,Soyinka OO

    更新日期:2019-02-06 00:00:00

  • Influence of daily oral prophylactic selenium treatment on the dibutyltin dichloride (DBTC)-induced pancreatitis in rats.

    abstract::Dibutyltin dichloride (DBTC) is an organotin compound used as model for acute and chronic pancreatitis. Oxidative stress is one of the mechanisms of propagation of acinar cell injury in acute pancreatitis. Selenium is an essential cofactor in the antioxidant glutathione peroxidase pathway. Selenium levels are describe...

    journal_title:EXCLI journal

    pub_type: 杂志文章


    authors: Merkord J,Görl N,Lemke M,Berg A,Weber H,Ramer R,Hennighausen G

    更新日期:2017-02-16 00:00:00

  • Ameliorative effects of Spirulina platensis against lead-induced nephrotoxicity in newborn rats: Modulation of oxidative stress and histopathological changes.

    abstract::Our experimental work was aimed at evaluating the safety and protective effects of dietary spirulina supplementation on the kidney of newborn rats, the offspring of lead contaminated lactating mothers. Female rats were randomly divided into four groups: group I (control) was given a normal diet, group II (positive con...

    journal_title:EXCLI journal

    pub_type: 杂志文章


    authors: Gargouri M,Soussi A,Akrouti A,Magné C,El Feki A

    更新日期:2018-03-02 00:00:00

  • Serial measurement of lipid profile and inflammatory markers in patients with acute myocardial infarction.

    abstract::Serum concentration of lipids and lipoproteins changes during the course of acute coronary syndrome as a consequence of the inflammatory response. The objective of this study was to evaluate the effect of acute myocardial infarction (AMI) on the levels of lipid profile and inflammatory markers. We investigated 400 pat...

    journal_title:EXCLI journal

    pub_type: 杂志文章


    authors: Shrivastava AK,Singh HV,Raizada A,Singh SK

    更新日期:2015-04-10 00:00:00

  • Curcumin as an indirect methylation inhibitor modulates the effects of Toxoplasma gondii on genes involved in male fertility.

    abstract::Toxoplasma gondii is a common protozoan parasite, which infects warm-blooded mammals, including mice and humans, throughout the world. The negative effects of T. gondii infection on the human reproductive system have been documented, especially in females. However, only few studies have examined the effects of T. gond...

    journal_title:EXCLI journal

    pub_type: 杂志文章


    authors: Saki J,Sabaghan M,Arjmand R,Teimoori A,Rashno M,Saki G,Shojaee S

    更新日期:2020-08-24 00:00:00

  • A novel hybrid method of beta-turn identification in protein using binary logistic regression and neural network.

    abstract::From both the structural and functional points of view, β-turns play important biological roles in proteins. In the present study, a novel two-stage hybrid procedure has been developed to identify β-turns in proteins. Binary logistic regression was initially used for the first time to select significant sequence param...

    journal_title:EXCLI journal

    pub_type: 杂志文章


    authors: Asghari MP,Hayatshahi SH,Abdolmaleki P

    更新日期:2012-07-05 00:00:00

  • High glucose inhibits osteogenic differentiation through the BMP signaling pathway in bone mesenchymal stem cells in mice.

    abstract::Patients with diabetes tend to have an increased risk of osteoporosis that may be related to hyperglycemia. In vitro evidence has shown that high glucose can affect the proliferation and osteogenic differentiation of mesenchymal stem cells (MSCs). Tissue regeneration depends mainly on MSCs. However, the exact mechanis...

    journal_title:EXCLI journal

    pub_type: 杂志文章


    authors: Wang J,Wang B,Li Y,Wang D,Lingling E,Bai Y,Liu H

    更新日期:2013-06-27 00:00:00

  • Polyhydroxylated fullerene nanoparticles attenuate brain infarction and oxidative stress in rat model of ischemic stroke.

    abstract::Oxidative stress is the common underlying mechanism of damage in ischemic stroke. Therefore, we aimed to evaluate the possible protective effects of polyhydroxylated fullerene derivatives on brain infarction and oxidative/nitrosative stress in a rat model of ischemic stroke. The experiment was performed by four groups...

    journal_title:EXCLI journal

    pub_type: 杂志文章


    authors: Vani JR,Mohammadi MT,Foroshani MS,Jafari M

    更新日期:2016-06-20 00:00:00

  • Genome editing technologies: CRISPR, LEAPER, RESTORE, ARCUT, SATI, and RESCUE.

    abstract::Genome editing technologies include techniques used for desired genetic modifications and allow the insertion, modification or deletion of specific DNA fragments. Recent advances in genome biology offer unprecedented promise for interdisciplinary collaboration and applications in gene editing. New genome editing techn...

    journal_title:EXCLI journal

    pub_type: 杂志文章,评审


    authors: Görücü Yilmaz S

    更新日期:2021-01-04 00:00:00

  • QSAR-driven rational design of novel DNA methyltransferase 1 inhibitors.

    abstract::DNA methylation, an epigenetic modification, is mediated by DNA methyltransferases (DNMTs), a family of enzymes. Inhibitions of these enzymes are considered a promising strategy for the treatment of several diseases. In this study, a quantitative structure-activity relationship (QSAR) modeling was employed to understa...

    journal_title:EXCLI journal

    pub_type: 杂志文章


    authors: Phanus-Umporn C,Prachayasittikul V,Nantasenamat C,Prachayasittikul S,Prachayasittikul V

    更新日期:2020-04-02 00:00:00

  • [Not Available].

    abstract::Experimentally-induced total sleep deprivation (TSD) and chronic partial sleep restriction (CPSR) leads to the emergence of cognitive impairments. This is hypothesized to result from a consequent neuroinflammation which may also hasten the neurodegenerative processes. Neuroinflammatory markers such as tumor necrosis f...

    journal_title:EXCLI journal

    pub_type: 杂志文章


    authors: Torabi-Nami M,Nasehi M,Zarrindast MR

    更新日期:2013-04-14 00:00:00

  • Beneficial therapeutic effects of Nigella sativa and/or Zingiber officinale in HCV patients in Egypt.

    abstract::Hepatitis C is a major global health burden and Egypt has the highest prevalence of hepatitis C virus (HCV) worldwide. The current study was designed to evaluate the beneficial therapeutic effects of ethanolic extracts of Nigella sativa, Zingiber officinale and their mixture in Egyptian HCV patients. Sixty volunteer p...

    journal_title:EXCLI journal

    pub_type: 杂志文章


    authors: Abdel-Moneim A,Morsy BM,Mahmoud AM,Abo-Seif MA,Zanaty MI

    更新日期:2013-11-11 00:00:00

  • The potential of halophilic and halotolerant bacteria for the production of antineoplastic enzymes: L-asparaginase and L-glutaminase.

    abstract::L-asparaginase and L-glutaminase can be effectively used for the treatment of patients who suffer from accute lymphoblastic leukemia and tumor cells. Microbial sources are the best source for the bulk production of these enzymes. However, their long-term administration may cause immunological responses, so screening f...

    journal_title:EXCLI journal

    pub_type: 杂志文章


    authors: Shirazian P,Asad S,Amoozegar MA

    更新日期:2016-04-18 00:00:00

  • Towards understanding aromatase inhibitory activity via QSAR modeling.

    abstract::Aromatase is a rate-limiting enzyme for estrogen biosynthesis that is overproduced in breast cancer tissue. To block the growth of breast tumors, aromatase inhibitors (AIs) are employed to bind and inhibit aromatase in order to lower the amount of estrogen produced in the body. Although a number of synthetic aromatase...

    journal_title:EXCLI journal

    pub_type: 杂志文章,评审


    authors: Shoombuatong W,Schaduangrat N,Nantasenamat C

    更新日期:2018-07-20 00:00:00

  • Effects of vitamin D3 supplementation on clinical symptoms, quality of life, serum serotonin (5-hydroxytryptamine), 5-hydroxy-indole acetic acid, and ratio of 5-HIAA/5-HT in patients with diarrhea-predominant irritable bowel syndrome: A randomized clinica

    abstract::Vitamin D deficiency, common in the population with irritable bowel syndrome (IBS), can induce the main factors that lead to IBS clinical symptoms, such as depression, anxiety, and inflammation. Serotonin (5-HT) plays an important role in the pathophysiology of IBS, and its production and secretion are increased from ...

    journal_title:EXCLI journal

    pub_type: 杂志文章


    authors: Khalighi Sikaroudi M,Mokhtare M,Shidfar F,Janani L,Faghihi Kashani A,Masoodi M,Agah S,Dehnad A,Shidfar S

    更新日期:2020-05-19 00:00:00

  • An in silico approach in predicting the possible mechanism involving restoration of wild-type p53 functions by small molecular weight compounds in tumor cells expressing R273H mutant p53.

    abstract::R273H mutant p53 is a DNA-contact mutant that renders p53 dysfunctional due to a single substitution of Arg273 for His273. Rescuing R273 mutant p53 implies that a competent molecule would have to bind to the site of DNA-contact hot spots to complement the loss of contact with the DNA-binding domain. Here, curcumin, fl...

    journal_title:EXCLI journal

    pub_type: 杂志文章


    authors: Malami I,Muhammad A,Etti IC,Waziri PM,Alhassan AM

    更新日期:2017-12-08 00:00:00

  • MicroRNA expression analysis in endometriotic serum treated mesenchymal stem cells.

    abstract::Endometriosis is defined by presence of endometrial-like-tissue outside the uterus. Recently, ectopic endometriotic lesions have been suggested to originate by abnormal differentiation of endometrial mesenchymal stem cells (eMSCs). MicroRNAs (miRNAs) play an important role in the pathophysiology of endometriosis. Thro...

    journal_title:EXCLI journal

    pub_type: 杂志文章


    authors: Abdel-Rasheed M,Nour Eldeen G,Mahmoud M,ElHefnawi M,Abu-Shahba N,Reda M,Elsetohy K,Nabil M,Elnoury A,Taha T,Azmy O

    更新日期:2017-06-14 00:00:00

  • Data mining for the identification of metabolic syndrome status.

    abstract::Metabolic syndrome (MS) is a condition associated with metabolic abnormalities that are characterized by central obesity (e.g. waist circumference or body mass index), hypertension (e.g. systolic or diastolic blood pressure), hyperglycemia (e.g. fasting plasma glucose) and dyslipidemia (e.g. triglyceride and high-dens...

    journal_title:EXCLI journal

    pub_type: 杂志文章,评审


    authors: Worachartcheewan A,Schaduangrat N,Prachayasittikul V,Nantasenamat C

    更新日期:2018-01-10 00:00:00

  • An enhanced algorithm for multiple sequence alignment of protein sequences using genetic algorithm.

    abstract::One of the most fundamental operations in biological sequence analysis is multiple sequence alignment (MSA). The basic of multiple sequence alignment problems is to determine the most biologically plausible alignments of protein or DNA sequences. In this paper, an alignment method using genetic algorithm for multiple ...

    journal_title:EXCLI journal

    pub_type: 杂志文章


    authors: Kumar M

    更新日期:2015-12-15 00:00:00

  • Short term effects of coffee components consumption on gut microbiota in patients with non-alcoholic fatty liver and diabetes: A pilot randomized placebo-controlled, clinical trial.

    abstract::The aim of this study was to determine the effects of caffeine and chlorogenic acid supplementation on gut microbiota, and metabolic disturbances in patients with NAFLD and diabetes. In this randomized, placebo-controlled, clinical trial, 26 patients with diabetes and NAFLD were randomly assigned to four groups to rec...

    journal_title:EXCLI journal

    pub_type: 杂志文章


    authors: Mansour A,Mohajeri-Tehrani MR,Karimi S,Sanginabadi M,Poustchi H,Enayati S,Asgarbeik S,Nasrollahzadeh J,Hekmatdoost A

    更新日期:2020-03-02 00:00:00