解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Genome editing technologies include techniques used for desired genetic modifications and allow the insertion, modification or deletion of specific DNA fragments. Recent advances in genome biology offer unprecedented promise for interdisciplinary collaboration and applications in gene editing. New genome editing techn...
journal_title:EXCLI journal
pub_type: 杂志文章,评审
doi:10.17179/excli2020-3070
更新日期:2021-01-04 00:00:00
abstract::Some debates exist regarding the association of diabetes mellitus (DM) with COVID-19 infection severity and mortality. In this study, we aimed to describe and compare the clinical characteristics and outcomes of hospitalized COVID-19 patients with and without DM. In this single-centered, retrospective, observational s...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2020-2988
更新日期:2020-11-16 00:00:00
abstract::Dynamin 2 is a GTPase protein that has been implicated in cancer progression through its various roles such as endocytosis, morphogenesis, epithelial-mesenchymal transition (EMT), cellular contractions, and focal adhesion maturation. The increased expression levels of this molecule have been demonstrated with the deve...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2020-2762
更新日期:2020-10-29 00:00:00
abstract::Toxoplasma gondii is a common protozoan parasite, which infects warm-blooded mammals, including mice and humans, throughout the world. The negative effects of T. gondii infection on the human reproductive system have been documented, especially in females. However, only few studies have examined the effects of T. gond...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2020-2052
更新日期:2020-08-24 00:00:00
abstract::Unlike conventional materials that covalent bonds connecting atoms as the major force to hold the materials together, supramolecular biomaterials rely on noncovalent intermolecular interactions to assemble. The reversibility and biocompatibility of supramolecular biomaterials render them with diverse range of function...
journal_title:EXCLI journal
pub_type: 杂志文章,评审
doi:10.17179/excli2020-2656
更新日期:2020-08-05 00:00:00
abstract::Octyl gallate (OG) is an antioxidant commonly used in food, although there is no definition of its acceptable daily intake. There are reports in vitro and in vivo showing that food additives and drugs can alter lipid metabolism. Lipid droplet accumulation in hepatic cells is one of the main findings in the unregulated...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2020-2214
更新日期:2020-07-06 00:00:00
abstract::Vitamin D deficiency, common in the population with irritable bowel syndrome (IBS), can induce the main factors that lead to IBS clinical symptoms, such as depression, anxiety, and inflammation. Serotonin (5-HT) plays an important role in the pathophysiology of IBS, and its production and secretion are increased from ...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2020-2247
更新日期:2020-05-19 00:00:00
abstract::DNA methylation, an epigenetic modification, is mediated by DNA methyltransferases (DNMTs), a family of enzymes. Inhibitions of these enzymes are considered a promising strategy for the treatment of several diseases. In this study, a quantitative structure-activity relationship (QSAR) modeling was employed to understa...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2020-1096
更新日期:2020-04-02 00:00:00
abstract::This study was undertaken to determine whether exposure of operating room personnel to inhalation anesthetics, including nitrous oxide, isoflurane, and sevoflurane was associated with any hepatotoxic or nephrotoxic changes. Fifty-two operating room personnel and 52 non-exposed subjects were studied. A questionnaire pe...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2019-1911
更新日期:2020-03-25 00:00:00
abstract::Bladder cancer (BC) is the sixth most common malignancy in men and 17th in women. Exosomal long non-coding RNAs (lncRNAs) have been defined as a novel biomarker for BC. The aim of this study is to evaluate the clinical significance of urine exosomal PVT-1, ANRIL and PCAT-1 as a biomarker in BC patients with tumors cla...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2019-1683
更新日期:2020-03-04 00:00:00
abstract::The aim of this study was to determine the effects of caffeine and chlorogenic acid supplementation on gut microbiota, and metabolic disturbances in patients with NAFLD and diabetes. In this randomized, placebo-controlled, clinical trial, 26 patients with diabetes and NAFLD were randomly assigned to four groups to rec...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2019-2021
更新日期:2020-03-02 00:00:00
abstract::Hepatocellular carcinoma or Liver cancer (LC) is the sixth most common cancer and the fourth cause of death worldwide in 2018. There has not been a comprehensive study on the survival rate of patients with LC in Asia yet. Therefore, the present study was conducted to evaluate the survival rate of patients with LC in A...
journal_title:EXCLI journal
pub_type: 杂志文章,评审
doi:10.17179/excli2019-1842
更新日期:2020-01-13 00:00:00
abstract::Previous studies proved the pro-angiogenic effect of Crocetin, a natural carotenoid dicarboxylic acid, in both in vivo and in vitro models. However, the exact mechanism of Crocetin action has not completely been elucidated yet. The current experiment was designed to find the activity of PI3K-Akt-eNOS axis after the tr...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2019-1175
更新日期:2019-10-21 00:00:00
abstract::To our knowledge, in spite of several trials exploring the beneficial effect of n-3 polyunsaturated fatty acids (PUFA) on polycystic ovary syndrome (PCOS), no comprehensive evidence has investigated the effects of n-3 PUFA consumption on PCOS complications. Therefore, our aim was to conduct a review to investigate the...
journal_title:EXCLI journal
pub_type: 杂志文章,评审
doi:10.17179/excli2019-1534
更新日期:2019-07-25 00:00:00
abstract::As a dynamic system in which different factors affect human performance via dynamic interactions, mental workload needs a dynamic measure to monitor its factors and evidence in a complicated system, an approach that is lacking in the literature. The present study introduces a system dynamics-based model for designing ...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2019-1372
更新日期:2019-07-11 00:00:00
abstract::Curcuminoids are dietary complexes extracted from the seeds of Curcuma longa L. that contain curcumin, bisdemethoxycurcumin and desmethoxycurcumin. Curcuminoids are popular for their pleiotropic therapeutic functions, such as their anti-inflammatory and anti-oxidant effects. Nonetheless, their clinical use is associat...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2019-1366
更新日期:2019-06-17 00:00:00
abstract::We present the case of a 77 year old male patient with metastatic pancreatic neuroendocrine tumor (NET). The patient was initially treated by extensive surgical resection that however, led to severe complications with delayed recovery. During follow-up, a number of new liver metastases were detected, one of which was ...
journal_title:EXCLI journal
pub_type:
doi:10.17179/excli2019-1220
更新日期:2019-05-21 00:00:00
abstract::The traditional uses of Portulaca oleracea L. (PO) with anti-inflammatory and anti-cancer activity as well as antioxidants properties were expressed previously. Glioma is considered the most common primary brain tumor and its malignant form is the most lethal adult brain tumor, that glioblastoma covers about 50 % of g...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2019-1063
更新日期:2019-03-20 00:00:00
abstract::Pharmaceutical effluents contain toxic xenobiotics capable of contaminating aquatic environments. Untreated effluents are illegally discharged into aquatic environment in most developing countries. Pharmaceutical effluent induced alterations in biomarkers of genetic and systemic damage on rodents. However, information...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:
更新日期:2019-02-06 00:00:00
abstract::Everolimus (EVR), as a rapamycin analog, is a selective inhibitor of the mammalian target of rapamycin (mTOR) kinase and its associated signaling pathway. mTOR is a serine/threonine protein kinase and its hyperactivity is involved in the pathophysiology of Alzheimer's disease (AD) and associated cognitive deficits. Th...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2018-1626
更新日期:2018-10-29 00:00:00
abstract::Healthcare professionals, especially nurses and pre-hospital emergency (PHE) staff, are influenced by many stressors due to their responsibility to provide comfort as well as care and treatment of patients. The aim of the present study was to identify and rank the occupational stressors in nurses and PHE staff using F...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2018-1505
更新日期:2018-08-20 00:00:00
abstract::Aromatase is a rate-limiting enzyme for estrogen biosynthesis that is overproduced in breast cancer tissue. To block the growth of breast tumors, aromatase inhibitors (AIs) are employed to bind and inhibit aromatase in order to lower the amount of estrogen produced in the body. Although a number of synthetic aromatase...
journal_title:EXCLI journal
pub_type: 杂志文章,评审
doi:10.17179/excli2018-1417
更新日期:2018-07-20 00:00:00
abstract::Little is known about biogenically synthesized Zinc oxide nanoparticles (ZnONPs) from Isodon rugosus. Synthesis of metal oxide NPs from essential oil producing medicinal plants results in less harmful side effects to the human population as compared to chemically synthesized NPs. In this article, we report biogenic sy...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2018-1327
更新日期:2018-07-16 00:00:00
abstract::An enzyme-coupled colorimetric assay for quantification of urinary sarcosine was developed. The proposed method is a specific reaction based on hydrogen peroxide (H2O2) formation via sarcosine oxidase (SOX). The liberated H2O2 reacts with Amplex Red in the presence of horseradish peroxidase (HRP) to produce the red-fl...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2018-145
更新日期:2018-05-17 00:00:00
abstract::Our experimental work was aimed at evaluating the safety and protective effects of dietary spirulina supplementation on the kidney of newborn rats, the offspring of lead contaminated lactating mothers. Female rats were randomly divided into four groups: group I (control) was given a normal diet, group II (positive con...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2017-1016
更新日期:2018-03-02 00:00:00
abstract::Metabolic syndrome (MS) is a condition associated with metabolic abnormalities that are characterized by central obesity (e.g. waist circumference or body mass index), hypertension (e.g. systolic or diastolic blood pressure), hyperglycemia (e.g. fasting plasma glucose) and dyslipidemia (e.g. triglyceride and high-dens...
journal_title:EXCLI journal
pub_type: 杂志文章,评审
doi:10.17179/excli2017-911
更新日期:2018-01-10 00:00:00
abstract::R273H mutant p53 is a DNA-contact mutant that renders p53 dysfunctional due to a single substitution of Arg273 for His273. Rescuing R273 mutant p53 implies that a competent molecule would have to bind to the site of DNA-contact hot spots to complement the loss of contact with the DNA-binding domain. Here, curcumin, fl...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2017-299
更新日期:2017-12-08 00:00:00
abstract::Fibroblast growth factor 21 (FGF21) is a major metabolic regulator that has been shown to be elevated in a number of metabolic disturbances including type 2 diabetes mellitus (T2DM) and the metabolic syndrome, but few studies about the relationship between serum FGF21 and the complications of diabetes have been done. ...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2017-672
更新日期:2017-11-22 00:00:00
abstract::A reliable biomarker has not been identified to predict the outcome of traumatic brain injury (TBI) in children. Therefore, the present systematic review and meta-analysis aimed to assess the association between neuron specific enolase (NSE) and traumatic brain injury (TBI) in children. Two independent reviewers searc...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2017-405
更新日期:2017-07-03 00:00:00
abstract::Endometriosis is defined by presence of endometrial-like-tissue outside the uterus. Recently, ectopic endometriotic lesions have been suggested to originate by abnormal differentiation of endometrial mesenchymal stem cells (eMSCs). MicroRNAs (miRNAs) play an important role in the pathophysiology of endometriosis. Thro...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2017-101
更新日期:2017-06-14 00:00:00
abstract::Stevens-Johnson syndrome (SJS) is an immune mediated hypersensitivity reaction. Significant involvement of oral, nasal, eye, vaginal, urethral, GI and lower respiratory tract mucous membrane may develop. It is usually a reaction due to a medication or due to an infection. In 95 % of case reports, drugs were found to b...
journal_title:EXCLI journal
pub_type:
doi:10.17179/excli2017-345
更新日期:2017-05-18 00:00:00
abstract::Lack of data on safety of herbal medicines have endangered human health and life. The present study evaluated the genotoxic and mutagenic effect of Kalanchoe laciniata to access the safety and usefulness of the medicinal plant. Aqua-methanolic and n-hexane extracts of K. laciniata were evaluated for the genotoxic pote...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2016-748
更新日期:2017-04-24 00:00:00
abstract::Considering the therapeutic values of bioflavonoids in colon cancer treatment, six 2'-hydroxy chalcones (C1-C6) were synthesized, characterized and screened for in vitro cytotoxicity on human colon carcinoma (HCT116) and African green monkey kidney epithelial cells (Vero). Only C5 showed selective cytotoxicity against...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2016-643
更新日期:2017-04-03 00:00:00
abstract::The aim of this study is to investigate the mechanism of electro-acupuncture (EA) on the recovery of injured spinal cord. Rats were randomly divided into normal control, sham-operated, SCI, SCI+EA group and T10 segment spinal cord injury (SCI) rat model was established by the modified Allen's method. After 7 days, the...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2017-123
更新日期:2017-03-23 00:00:00
abstract::Renin Angiotensin Aldosterone System (RAAS) plays an important role in the development of hypertension. On the other hand, hypertension is a well-known and independent risk factor for cognitive impairment. The aim of the present study was to evaluate the relationship of blood pressure control, plasma angiotensin pepti...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2016-725
更新日期:2017-03-10 00:00:00
abstract::Dibutyltin dichloride (DBTC) is an organotin compound used as model for acute and chronic pancreatitis. Oxidative stress is one of the mechanisms of propagation of acinar cell injury in acute pancreatitis. Selenium is an essential cofactor in the antioxidant glutathione peroxidase pathway. Selenium levels are describe...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2016-466
更新日期:2017-02-16 00:00:00
abstract::The aim was to establish a cell culture of adult primary bovine hepatocytes obtained from liver following slaughter and to cultivate the cells in a sandwich culture. Cells and medium samples were taken after separation of cells (day 0), during monolayer (days 1, 2 and 3) and during sandwich culture (days 1, 2, 3, 4, 7...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2016-794
更新日期:2016-12-22 00:00:00
abstract::Achillea eriophora (Asteraceae) is a medicinal plant commonly used in Iran. This study was performed to determine the cardiovascular effects of hydroethanolic extract of A. eriophora (HEAE) and the underlying mechanisms in anaesthetized rats. The acute effects of intravenous (i.v.) administration of different doses of...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2016-529
更新日期:2016-12-07 00:00:00
abstract::Activation of the hypoxia-inducible factor (HIF)-pathway in hepatocellular carcinoma (HCC) induces therapy resistant tumours, characterized by increased liver progenitor cell (LPCs) characteristics and poor prognosis. We previously reported corresponding results in mice with HCC in which hypoxia was mimicked by prolyl...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2016-607
更新日期:2016-11-11 00:00:00
abstract::Prosopis cineraria (L.) Druce (Leguminosae) (syn. Prosopis spicigera L.) has antidiabetic and antioxidant potential. Earlier we reported its hypolipidemic activity obtained from ethanol extract (ET-PCF). Object of this work was to isolate ferulic acid (FA) from ET-PCF and evaluate hypolipidemic activity against high-f...
journal_title:EXCLI journal
pub_type: 杂志文章
doi:10.17179/excli2016-394
更新日期:2016-10-25 00:00:00