Isolation, partial purification and evaluation of bioactive compounds from leaves of Ageratum houstonianum.

abstract：:Hepatitis C is a major global health burden and Egypt has the highest prevalence of hepatitis C virus (HCV) worldwide. The current study was designed to evaluate the beneficial therapeutic effects of ethanolic extracts of Nigella sativa, Zingiber officinale and their mixture in Egyptian HCV patients. Sixty volunteer p...

journal_title：EXCLI journal

authors： Abdel-Moneim A,Morsy BM,Mahmoud AM,Abo-Seif MA,Zanaty MI

更新日期：2013-11-11 00:00:00

abstract：:DNA methylation, an epigenetic modification, is mediated by DNA methyltransferases (DNMTs), a family of enzymes. Inhibitions of these enzymes are considered a promising strategy for the treatment of several diseases. In this study, a quantitative structure-activity relationship (QSAR) modeling was employed to understa...

journal_title：EXCLI journal

authors： Phanus-Umporn C,Prachayasittikul V,Nantasenamat C,Prachayasittikul S,Prachayasittikul V

更新日期：2020-04-02 00:00:00

abstract：:Nanoencapsulation of drug/small molecules in nanocarriers (NCs) is a very promising approach for development of nanomedicine. Modern drug encapsulation methods allow efficient loading of drug molecules inside the NCs thereby reducing systemic toxicity associated with drugs. Targeting of NCs can enhance the accumulatio...

journal_title：EXCLI journal

authors： Kumari A,Singla R,Guliani A,Yadav SK

更新日期：2014-03-20 00:00:00

abstract：:Phoenix sylvestris (Arecaceae family) known as Indian Date Palm has been identified as a component of traditional medicine against various ailments. The present study was focused on phytochemical screening of crude hexane, dichloromethane and methanol leaf extracts. The crude extracts showed the presence of alkaloids,...

journal_title：EXCLI journal

authors： Sharma DC,Shukla R,Ali J,Sharma S,Bajpai P,Pathak N

更新日期：2016-02-05 00:00:00

abstract：:The essential oil obtained from leaves of Melissa officinalis L. (Family of Lamiaceae) growing in Algeria, was investigated for its chemical composition and in vitro antimicrobial activity. The chemical composition was determined by hydrodistillation and analyzed by GC/MS and GC-FID. Sixty-three compounds were identif...

journal_title：EXCLI journal

authors： Abdellatif F,Boudjella H,Zitouni A,Hassani A

更新日期：2014-07-17 00:00:00

abstract：:Some debates exist regarding the association of diabetes mellitus (DM) with COVID-19 infection severity and mortality. In this study, we aimed to describe and compare the clinical characteristics and outcomes of hospitalized COVID-19 patients with and without DM. In this single-centered, retrospective, observational s...

journal_title：EXCLI journal

authors： Mansour A,Sajjadi-Jazi SM,Kasaeian A,Khosravi B,Sorouri M,Azizi F,Rajabi Z,Motamedi F,Sirusbakht A,Eslahi M,Mojtabbavi H,Sima AR,Radmard AR,Mohajeri-Tehrani MR,Abdollahi M

更新日期：2020-11-16 00:00:00

abstract：:This review will concentrate on the clinical pharmacology, in particular pharmacodynamic data, related to atypical antipsychotics, clozapine, risperidone, paliperidone, olanzapine, que¬tiapine, amisulpride, ziprasidone, aripiprazole, asenapine, iloperidone, lurasidone and cariprazine. A summary of their acute pharmaco...

journal_title：EXCLI journal

authors： Mauri MC,Paletta S,Maffini M,Colasanti A,Dragogna F,Di Pace C,Altamura AC

更新日期：2014-10-13 00:00:00

abstract：:Previous studies proved the pro-angiogenic effect of Crocetin, a natural carotenoid dicarboxylic acid, in both in vivo and in vitro models. However, the exact mechanism of Crocetin action has not completely been elucidated yet. The current experiment was designed to find the activity of PI3K-Akt-eNOS axis after the tr...

journal_title：EXCLI journal

authors： Nasirzadeh M,Rasmi Y,Rahbarghazi R,Kheradmand F,Karimipour M,Aramwit P,Astinfeshan M,Gholinejad Z,Daeihasani B,Saboory E,Shirpoor A,Rezabakhsh A,Zolali E,Khalaji N

更新日期：2019-10-21 00:00:00

abstract：:Sleep deprivation affects all aspects of health. Adverse health effects by sleep deviation are still underestimated and undervalued in clinical practice and, to a much greater extent in monitoring human health. We hypothesized that sleep deprivation-induced mild organ injuries; oxidative stress and inflammation might ...

journal_title：EXCLI journal

authors： Periasamy S,Hsu DZ,Fu YH,Liu MY

更新日期：2015-05-18 00:00:00

abstract：:This study was undertaken to determine whether exposure of operating room personnel to inhalation anesthetics, including nitrous oxide, isoflurane, and sevoflurane was associated with any hepatotoxic or nephrotoxic changes. Fifty-two operating room personnel and 52 non-exposed subjects were studied. A questionnaire pe...

journal_title：EXCLI journal

authors： Neghab M,Amiri F,Soleimani E,Yousefinejad S,Hassanzadeh J

更新日期：2020-03-25 00:00:00

abstract：:Vitamin D deficiency, common in the population with irritable bowel syndrome (IBS), can induce the main factors that lead to IBS clinical symptoms, such as depression, anxiety, and inflammation. Serotonin (5-HT) plays an important role in the pathophysiology of IBS, and its production and secretion are increased from ...

journal_title：EXCLI journal

authors： Khalighi Sikaroudi M,Mokhtare M,Shidfar F,Janani L,Faghihi Kashani A,Masoodi M,Agah S,Dehnad A,Shidfar S

更新日期：2020-05-19 00:00:00

abstract：:One of the most fundamental operations in biological sequence analysis is multiple sequence alignment (MSA). The basic of multiple sequence alignment problems is to determine the most biologically plausible alignments of protein or DNA sequences. In this paper, an alignment method using genetic algorithm for multiple ...

journal_title：EXCLI journal

authors： Kumar M

更新日期：2015-12-15 00:00:00

abstract：:To investigate whether offspring sex ratio at birth (SRB) was associated with maternal breast cancer risk, the present case-control study and a meta-analysis of literature were done. A total of 389 female breast cancer patients who had at least one offspring participated in the study. From general population 356 healt...

journal_title：EXCLI journal

authors： Saadat M

更新日期：2010-07-26 00:00:00

abstract：:Morphological identification is a widespread procedure to assess the presence of apoptosis by visual inspection of the morphological characteristics or the fluorescence images. The procedure is lengthy and results are observer dependent. A quantitative automatic analysis is objective and would greatly help the routine...

journal_title：EXCLI journal

authors： Liu Y,Lin W,Yang X,Liang W,Zhang J,Meng M,Rice JR,Sa Y,Feng Y

更新日期：2014-01-29 00:00:00

abstract：:The liver is famous for its strong regenerative capacity, employing different modes of regeneration according to type and extent of injury. Mature liver cells are able to proliferate in order to replace the damaged tissue allowing the recovery of the parenchymal function. In more severe scenarios hepatocytes are belie...

journal_title：EXCLI journal

authors： Verhulst S,Best J,van Grunsven LA,Dollé L

更新日期：2015-01-06 00:00:00

abstract：:Recently, many articles have reported different levels and distribution of amphetamine hitherto detected in biological fluids now appreciably found in aquatic environment at ng/L levels. Identification and measurement of amphetamine and its metabolites in surface and sewage waters using higher performance liquid chrom...

journal_title：EXCLI journal

authors： Mustapha AO,Ajao UL

更新日期：2011-08-19 00:00:00

abstract：:The chemical composition of the essential oils of different Allium nigrum L. organs and the antibacterial activity were evaluated. The study is particularly interesting because hitherto there are no reports on the antibacterial screening of this species with specific chemical composition. Therefore, essential oils fro...

journal_title：EXCLI journal

authors： Rouis-Soussi LS,Ayeb-Zakhama AE,Mahjoub A,Flamini G,Jannet HB,Harzallah-Skhiri F

更新日期：2014-05-13 00:00:00

abstract：:Five Calligonum species endemic to the Tarim Basin - C. roborowskii, C. kuerlese, C. juoqiangense,C. yengisaricum, and C. taklimakanense - were compared using 14 morphological characteristics and nrDNA ITS and cpDNA trnL-F molecular data. Intraspecific and interspecific morphological variation was uncovered, with vari...

journal_title：EXCLI journal

authors： Abdurahman M,Sabirhazi G,Liu B,Yin L,Pan B

更新日期：2012-12-20 00:00:00

abstract：:The present study is conducted to determine the potential mechanisms of Boron compounds, boric acid (BA) and borax (BX), on genotoxicity of zebrafish Danio rerio for 24, 48, 72 and 96-hours acute exposure (level:1, 4, 16, 64 mg/l BA and BX) in semi-static bioassay experiment. For that purpose, peripheral erythrocytes ...

journal_title：EXCLI journal

authors： Gülsoy N,Yavas C,Mutlu Ö

更新日期：2015-07-30 00:00:00

abstract：:Oxidative stress is the common underlying mechanism of damage in ischemic stroke. Therefore, we aimed to evaluate the possible protective effects of polyhydroxylated fullerene derivatives on brain infarction and oxidative/nitrosative stress in a rat model of ischemic stroke. The experiment was performed by four groups...

journal_title：EXCLI journal

authors： Vani JR,Mohammadi MT,Foroshani MS,Jafari M

更新日期：2016-06-20 00:00:00

abstract：:This study aims to develop two alternate forms for Malay version of Auditory Verbal Learning Test (MAVLT) and to determine their equivalency and practice effect. Ninety healthy volunteers were subjected to the following neuropsychological tests at baseline, and at one month interval according to their assigned group; ...

journal_title：EXCLI journal

authors： Munjir N,Othman Z,Zakaria R,Shafin N,Hussain NA,Desa AM,Ahmad AH

更新日期：2015-07-07 00:00:00

abstract：:Bladder cancer (BC) is the sixth most common malignancy in men and 17th in women. Exosomal long non-coding RNAs (lncRNAs) have been defined as a novel biomarker for BC. The aim of this study is to evaluate the clinical significance of urine exosomal PVT-1, ANRIL and PCAT-1 as a biomarker in BC patients with tumors cla...

journal_title：EXCLI journal

authors： Abbastabar M,Sarfi M,Golestani A,Karimi A,Pourmand G,Khalili E

更新日期：2020-03-04 00:00:00

abstract：:Achillea eriophora (Asteraceae) is a medicinal plant commonly used in Iran. This study was performed to determine the cardiovascular effects of hydroethanolic extract of A. eriophora (HEAE) and the underlying mechanisms in anaesthetized rats. The acute effects of intravenous (i.v.) administration of different doses of...

journal_title：EXCLI journal

authors： Anvari S,Bahaoddini A,Moein M,Khosravi AR

更新日期：2016-12-07 00:00:00

abstract：:Hematopoietic stem cells (HSCs) form a rare population of multipotent stem cells, which give rise to all hematopoietic lineages. HSCs home to bone marrow niches and circulate between blood and bone marrow. Many factors, especially SDF1a, affect the circulation of HSCs, but these have not been fully recognized. SDF1a h...

journal_title：EXCLI journal

authors： Asri A,Sabour J,Atashi A,Soleimani M

更新日期：2016-02-15 00:00:00

abstract：:The aim of this study was the design and evaluation of a novel plasma stable, pH-sensitive niosomal formulation of Mitoxantrone by a modified ethanol injection method. Cholesterol hemisuccinate was added instead of cholesterol in order to produce pH-sensitivity property and using PEG-Poly (monomethyl itaconate)-CholC6...

journal_title：EXCLI journal

authors： Tila D,Yazdani-Arazi SN,Ghanbarzadeh S,Arami S,Pourmoazzen Z

更新日期：2015-01-06 00:00:00

abstract：:As a dynamic system in which different factors affect human performance via dynamic interactions, mental workload needs a dynamic measure to monitor its factors and evidence in a complicated system, an approach that is lacking in the literature. The present study introduces a system dynamics-based model for designing ...

journal_title：EXCLI journal

authors： Jafari MJ,Zaeri F,Jafari AH,Payandeh Najafabadi AT,Hassanzadeh-Rangi N

更新日期：2019-07-11 00:00:00

abstract：:Our experimental work was aimed at evaluating the safety and protective effects of dietary spirulina supplementation on the kidney of newborn rats, the offspring of lead contaminated lactating mothers. Female rats were randomly divided into four groups: group I (control) was given a normal diet, group II (positive con...

journal_title：EXCLI journal

authors： Gargouri M,Soussi A,Akrouti A,Magné C,El Feki A

更新日期：2018-03-02 00:00:00

abstract：:Serum concentration of lipids and lipoproteins changes during the course of acute coronary syndrome as a consequence of the inflammatory response. The objective of this study was to evaluate the effect of acute myocardial infarction (AMI) on the levels of lipid profile and inflammatory markers. We investigated 400 pat...

journal_title：EXCLI journal

authors： Shrivastava AK,Singh HV,Raizada A,Singh SK

更新日期：2015-04-10 00:00:00

abstract：:Activation of the hypoxia-inducible factor (HIF)-pathway in hepatocellular carcinoma (HCC) induces therapy resistant tumours, characterized by increased liver progenitor cell (LPCs) characteristics and poor prognosis. We previously reported corresponding results in mice with HCC in which hypoxia was mimicked by prolyl...

journal_title：EXCLI journal

authors： Bogaerts E,Paridaens A,Verhelst X,Carmeliet P,Geerts A,Van Vlierberghe H,Devisscher L

更新日期：2016-11-11 00:00:00

abstract：:Lack of data on safety of herbal medicines have endangered human health and life. The present study evaluated the genotoxic and mutagenic effect of Kalanchoe laciniata to access the safety and usefulness of the medicinal plant. Aqua-methanolic and n-hexane extracts of K. laciniata were evaluated for the genotoxic pote...

journal_title：EXCLI journal

authors： Sharif A,Akhtar MF,Akhtar B,Saleem A,Manan M,Shabbir M,Ashraf M,Peerzada S,Ahmed S,Raza M

更新日期：2017-04-24 00:00:00