Beneficial therapeutic effects of Nigella sativa and/or Zingiber officinale in HCV patients in Egypt.

abstract：:Lack of data on safety of herbal medicines have endangered human health and life. The present study evaluated the genotoxic and mutagenic effect of Kalanchoe laciniata to access the safety and usefulness of the medicinal plant. Aqua-methanolic and n-hexane extracts of K. laciniata were evaluated for the genotoxic pote...

journal_title：EXCLI journal

authors： Sharif A,Akhtar MF,Akhtar B,Saleem A,Manan M,Shabbir M,Ashraf M,Peerzada S,Ahmed S,Raza M

更新日期：2017-04-24 00:00:00

abstract：:Genome editing technologies include techniques used for desired genetic modifications and allow the insertion, modification or deletion of specific DNA fragments. Recent advances in genome biology offer unprecedented promise for interdisciplinary collaboration and applications in gene editing. New genome editing techn...

journal_title：EXCLI journal

authors： Görücü Yilmaz S

更新日期：2021-01-04 00:00:00

abstract：:Prosopis cineraria (L.) Druce (Leguminosae) (syn. Prosopis spicigera L.) has antidiabetic and antioxidant potential. Earlier we reported its hypolipidemic activity obtained from ethanol extract (ET-PCF). Object of this work was to isolate ferulic acid (FA) from ET-PCF and evaluate hypolipidemic activity against high-f...

journal_title：EXCLI journal

authors： Jain PG,Surana SJ

更新日期：2016-10-25 00:00:00

abstract：:The aim of this study was the design and evaluation of a novel plasma stable, pH-sensitive niosomal formulation of Mitoxantrone by a modified ethanol injection method. Cholesterol hemisuccinate was added instead of cholesterol in order to produce pH-sensitivity property and using PEG-Poly (monomethyl itaconate)-CholC6...

journal_title：EXCLI journal

authors： Tila D,Yazdani-Arazi SN,Ghanbarzadeh S,Arami S,Pourmoazzen Z

更新日期：2015-01-06 00:00:00

abstract：INTRODUCTION:Hypovitaminosis D is reported to be associated with several medical complications. Recent studies have reported a high worldwide prevalence of Vitamin D deficiency in the general population (up to 80 %). This is even higher in patients with chronic kidney disease (CKD) and increases with advancing stages o...

journal_title：EXCLI journal

authors： Rozita M,Noorul Afidza M,Ruslinda M,Cader R,Halim AG,Kong CT,Nor Azmi K,Shah SA

更新日期：2013-06-11 00:00:00

abstract：:Phoenix sylvestris (Arecaceae family) known as Indian Date Palm has been identified as a component of traditional medicine against various ailments. The present study was focused on phytochemical screening of crude hexane, dichloromethane and methanol leaf extracts. The crude extracts showed the presence of alkaloids,...

journal_title：EXCLI journal

authors： Sharma DC,Shukla R,Ali J,Sharma S,Bajpai P,Pathak N

更新日期：2016-02-05 00:00:00

abstract：:The aim of this study is to investigate the mechanism of electro-acupuncture (EA) on the recovery of injured spinal cord. Rats were randomly divided into normal control, sham-operated, SCI, SCI+EA group and T10 segment spinal cord injury (SCI) rat model was established by the modified Allen's method. After 7 days, the...

journal_title：EXCLI journal

authors： Zhu Y,Wu Y,Zhang R

更新日期：2017-03-23 00:00:00

abstract：:Metabolic syndrome (MS) is a condition associated with metabolic abnormalities that are characterized by central obesity (e.g. waist circumference or body mass index), hypertension (e.g. systolic or diastolic blood pressure), hyperglycemia (e.g. fasting plasma glucose) and dyslipidemia (e.g. triglyceride and high-dens...

journal_title：EXCLI journal

authors： Worachartcheewan A,Schaduangrat N,Prachayasittikul V,Nantasenamat C

更新日期：2018-01-10 00:00:00

abstract：:Pharmaceutical effluents contain toxic xenobiotics capable of contaminating aquatic environments. Untreated effluents are illegally discharged into aquatic environment in most developing countries. Pharmaceutical effluent induced alterations in biomarkers of genetic and systemic damage on rodents. However, information...

journal_title：EXCLI journal

authors： Alimba CG,Adekoya KO,Soyinka OO

更新日期：2019-02-06 00:00:00

abstract：:Sleep deprivation affects all aspects of health. Adverse health effects by sleep deviation are still underestimated and undervalued in clinical practice and, to a much greater extent in monitoring human health. We hypothesized that sleep deprivation-induced mild organ injuries; oxidative stress and inflammation might ...

journal_title：EXCLI journal

authors： Periasamy S,Hsu DZ,Fu YH,Liu MY

更新日期：2015-05-18 00:00:00

abstract：:To date, a number of significant herbal drug interactions have their origins in the alteration of cytochrome P450 (CYP) activity by various phytochemicals. Among the most noteworthy are those involving St. John's wort and drugs metabolized by human CYP3A4 enzyme. This review article is the continued work from our prev...

journal_title：EXCLI journal

authors： Wanwimolruk S,Phopin K,Prachayasittikul V

更新日期：2014-08-20 00:00:00

abstract：:[This retracts the article DOI: 10.17179/excli2015-642.]. ...

journal_title：EXCLI journal

authors： Finelli C,Crispino P,Gioia S,La Sala N,D'amico L,La Grotta M,Miro O,Colarusso D

更新日期：2016-09-19 00:00:00

abstract：:Everolimus (EVR), as a rapamycin analog, is a selective inhibitor of the mammalian target of rapamycin (mTOR) kinase and its associated signaling pathway. mTOR is a serine/threonine protein kinase and its hyperactivity is involved in the pathophysiology of Alzheimer's disease (AD) and associated cognitive deficits. Th...

journal_title：EXCLI journal

authors： Fanoudi S,Hosseini M,Alavi MS,Boroushaki MT,Hosseini A,Sadeghnia HR

更新日期：2018-10-29 00:00:00

abstract：:Objective: Although osteoarthritis (OA) is widely accepted as a degenerative disease, autoimmune processes are believed to be involved in the pathogenesis. There are limited studies in this area and most of them focused on antibodies against chondrocyte membrane. In an attempt to address the paucity of evidence in thi...

journal_title：EXCLI journal

authors： Sakthiswary R,Rajalingam S,Norazman MR,Hussein H

更新日期：2012-09-07 00:00:00

abstract：:Spontaneous eye-blinks occur much more often than it would be necessary to maintain the tear film on the eyes. Various factors like cognitive demand, task engagement, or fatigue are influencing spontaneous blink rate. During cognitive information processing there is evidence that blinks occur preferably at moments tha...

journal_title：EXCLI journal

authors： Wascher E,Heppner H,Möckel T,Kobald SO,Getzmann S

更新日期：2015-11-27 00:00:00

abstract：:The purpose of the present study was to investigate whether the markers of oxidative stress could be altered in workers exposed to asbestos. A comparative cross-sectional research was conducted in a group of 50 subjects exposed to asbestos and another group of 50 with the same age and sex unexposed to asbestos. Malond...

journal_title：EXCLI journal

authors： Afaghi A,Oryan S,Rahzani K,Abdollahi M

更新日期：2015-09-28 00:00:00

abstract：:Salmonella enterica serovar Typhi (S. Typhi) is a human restricted pathogen. It biosynthesizes a virulence capsular polysaccharide named as Vi antigen. S. Typhi regulates expression of genes involved in the biosynthesis of Vi antigen in response to osmolarity. Beside Vi-positive isolates, Vi-negative (acapsulated) iso...

journal_title：EXCLI journal

authors： Liaquat S,Sarwar Y,Ali A,Haque A

更新日期：2015-02-09 00:00:00

abstract：:Renin Angiotensin Aldosterone System (RAAS) plays an important role in the development of hypertension. On the other hand, hypertension is a well-known and independent risk factor for cognitive impairment. The aim of the present study was to evaluate the relationship of blood pressure control, plasma angiotensin pepti...

journal_title：EXCLI journal

authors： Sen S,Gürel N,Ufuktepe B,Özünal ZG,Büyüklü Ç,Üresin Y

更新日期：2017-03-10 00:00:00

abstract：:An enzyme-coupled colorimetric assay for quantification of urinary sarcosine was developed. The proposed method is a specific reaction based on hydrogen peroxide (H2O2) formation via sarcosine oxidase (SOX). The liberated H2O2 reacts with Amplex Red in the presence of horseradish peroxidase (HRP) to produce the red-fl...

journal_title：EXCLI journal

authors： Yamkamon V,Phakdee B,Yainoy S,Suksrichawalit T,Tatanandana T,Sangkum P,Eiamphungporn W

更新日期：2018-05-17 00:00:00

abstract：:Oxidative stress is the common underlying mechanism of damage in ischemic stroke. Therefore, we aimed to evaluate the possible protective effects of polyhydroxylated fullerene derivatives on brain infarction and oxidative/nitrosative stress in a rat model of ischemic stroke. The experiment was performed by four groups...

journal_title：EXCLI journal

authors： Vani JR,Mohammadi MT,Foroshani MS,Jafari M

更新日期：2016-06-20 00:00:00

abstract：:A series of phenyl-3-(thiophen-2-yl)-4, 5-dihydro-1H-pyrazole-1-carbothioamides (TTa-TTg) were synthesized by the ring closure reaction of phenyl-1-(thiophen-2-yl) prop-2-en-1-ones with thiosemicarbazide in alcoholic basic medium. All the final derivatives were evaluated for their antidepressant and neurotoxicity scre...

journal_title：EXCLI journal

authors： Mathew B,Suresh J,Anbazhagan S

更新日期：2014-04-29 00:00:00

abstract：:DNA methylation, an epigenetic modification, is mediated by DNA methyltransferases (DNMTs), a family of enzymes. Inhibitions of these enzymes are considered a promising strategy for the treatment of several diseases. In this study, a quantitative structure-activity relationship (QSAR) modeling was employed to understa...

journal_title：EXCLI journal

authors： Phanus-Umporn C,Prachayasittikul V,Nantasenamat C,Prachayasittikul S,Prachayasittikul V

更新日期：2020-04-02 00:00:00

abstract：:Little is known about biogenically synthesized Zinc oxide nanoparticles (ZnONPs) from Isodon rugosus. Synthesis of metal oxide NPs from essential oil producing medicinal plants results in less harmful side effects to the human population as compared to chemically synthesized NPs. In this article, we report biogenic sy...

journal_title：EXCLI journal

authors： Siddiquah A,Hashmi SS,Mushtaq S,Renouard S,Blondeau JP,Abbasi R,Hano C,Abbasi BH

更新日期：2018-07-16 00:00:00

abstract：:Numerous studies have demonstrated the robustness of the framing effect in a variety of contexts, especially in medical decision making. Unfortunately, research is still inconsistent as to how so many variables impact framing effects in medical decision making. Additionally, much attention should be paid to the framin...

journal_title：EXCLI journal

authors： Gong J,Zhang Y,Feng J,Huang Y,Wei Y,Zhang W

更新日期：2013-01-18 00:00:00

abstract：:We present the case of a 77 year old male patient with metastatic pancreatic neuroendocrine tumor (NET). The patient was initially treated by extensive surgical resection that however, led to severe complications with delayed recovery. During follow-up, a number of new liver metastases were detected, one of which was ...

journal_title：EXCLI journal

authors： Ataeinia B,Loberg C,Kravets H,Beheshti M,von Mallek D,Mottaghy FM,Heinzel A

更新日期：2019-05-21 00:00:00

abstract：:The essential oil obtained from leaves of Melissa officinalis L. (Family of Lamiaceae) growing in Algeria, was investigated for its chemical composition and in vitro antimicrobial activity. The chemical composition was determined by hydrodistillation and analyzed by GC/MS and GC-FID. Sixty-three compounds were identif...

journal_title：EXCLI journal

authors： Abdellatif F,Boudjella H,Zitouni A,Hassani A

更新日期：2014-07-17 00:00:00

abstract：:Serum concentration of lipids and lipoproteins changes during the course of acute coronary syndrome as a consequence of the inflammatory response. The objective of this study was to evaluate the effect of acute myocardial infarction (AMI) on the levels of lipid profile and inflammatory markers. We investigated 400 pat...

journal_title：EXCLI journal

authors： Shrivastava AK,Singh HV,Raizada A,Singh SK

更新日期：2015-04-10 00:00:00

abstract：:Our experimental work was aimed at evaluating the safety and protective effects of dietary spirulina supplementation on the kidney of newborn rats, the offspring of lead contaminated lactating mothers. Female rats were randomly divided into four groups: group I (control) was given a normal diet, group II (positive con...

journal_title：EXCLI journal

authors： Gargouri M,Soussi A,Akrouti A,Magné C,El Feki A

更新日期：2018-03-02 00:00:00

abstract：:Presently, functional foods and nutraceuticals are gaining immense importance in the prevention of various maladies through dietary regimen module. Consumption of fruits and vegetables based diet has pursuit a range of bioactive components, especially phytochemicals targeting life threatening ailments. In this context...

journal_title：EXCLI journal

authors： Naz A,Butt MS,Sultan MT,Qayyum MM,Niaz RS

更新日期：2014-06-03 00:00:00

abstract：:Toxoplasma gondii is a common protozoan parasite, which infects warm-blooded mammals, including mice and humans, throughout the world. The negative effects of T. gondii infection on the human reproductive system have been documented, especially in females. However, only few studies have examined the effects of T. gond...

journal_title：EXCLI journal

authors： Saki J,Sabaghan M,Arjmand R,Teimoori A,Rashno M,Saki G,Shojaee S

更新日期：2020-08-24 00:00:00