Nanoencapsulation for drug delivery.

abstract：:Lack of data on safety of herbal medicines have endangered human health and life. The present study evaluated the genotoxic and mutagenic effect of Kalanchoe laciniata to access the safety and usefulness of the medicinal plant. Aqua-methanolic and n-hexane extracts of K. laciniata were evaluated for the genotoxic pote...

journal_title：EXCLI journal

authors： Sharif A,Akhtar MF,Akhtar B,Saleem A,Manan M,Shabbir M,Ashraf M,Peerzada S,Ahmed S,Raza M

更新日期：2017-04-24 00:00:00

abstract：:An enzyme-coupled colorimetric assay for quantification of urinary sarcosine was developed. The proposed method is a specific reaction based on hydrogen peroxide (H2O2) formation via sarcosine oxidase (SOX). The liberated H2O2 reacts with Amplex Red in the presence of horseradish peroxidase (HRP) to produce the red-fl...

journal_title：EXCLI journal

authors： Yamkamon V,Phakdee B,Yainoy S,Suksrichawalit T,Tatanandana T,Sangkum P,Eiamphungporn W

更新日期：2018-05-17 00:00:00

abstract：:Prosopis cineraria (L.) Druce (Leguminosae) (syn. Prosopis spicigera L.) has antidiabetic and antioxidant potential. Earlier we reported its hypolipidemic activity obtained from ethanol extract (ET-PCF). Object of this work was to isolate ferulic acid (FA) from ET-PCF and evaluate hypolipidemic activity against high-f...

journal_title：EXCLI journal

authors： Jain PG,Surana SJ

更新日期：2016-10-25 00:00:00

abstract：:The aim of this study was to evaluate the effect of acute and chronic physical and psychological stressors on the induction of oxidative stress in male rat liver. Male Wistar rats were randomly divided into 3 groups as following: control, physical and psychological stress groups. Stress was induced by communication bo...

journal_title：EXCLI journal

authors： Jafari M,Salehi M,Zardooz H,Rostamkhani F

更新日期：2014-02-24 00:00:00

abstract：:[This retracts the article DOI: 10.17179/excli2015-642.]. ...

journal_title：EXCLI journal

authors： Finelli C,Crispino P,Gioia S,La Sala N,D'amico L,La Grotta M,Miro O,Colarusso D

更新日期：2016-09-19 00:00:00

abstract：:Everolimus (EVR), as a rapamycin analog, is a selective inhibitor of the mammalian target of rapamycin (mTOR) kinase and its associated signaling pathway. mTOR is a serine/threonine protein kinase and its hyperactivity is involved in the pathophysiology of Alzheimer's disease (AD) and associated cognitive deficits. Th...

journal_title：EXCLI journal

authors： Fanoudi S,Hosseini M,Alavi MS,Boroushaki MT,Hosseini A,Sadeghnia HR

更新日期：2018-10-29 00:00:00

abstract：:Pharmaceutical effluents contain toxic xenobiotics capable of contaminating aquatic environments. Untreated effluents are illegally discharged into aquatic environment in most developing countries. Pharmaceutical effluent induced alterations in biomarkers of genetic and systemic damage on rodents. However, information...

journal_title：EXCLI journal

authors： Alimba CG,Adekoya KO,Soyinka OO

更新日期：2019-02-06 00:00:00

abstract：:To date, a number of significant herbal drug interactions have their origins in the alteration of cytochrome P450 (CYP) activity by various phytochemicals. Among the most noteworthy are those involving St. John's wort and drugs metabolized by human CYP3A4 enzyme. This review article is the continued work from our prev...

journal_title：EXCLI journal

authors： Wanwimolruk S,Phopin K,Prachayasittikul V

更新日期：2014-08-20 00:00:00

abstract：:There are abundant studies indicating that blocking gap junctions (GJs) containing connexin 36 (Cx36) inhibit seizures. However, recent evidences demonstrate proconvulsant effect of such intervention. Electrical coupling between GABAergic interneurons in CA1 region of hippocampus is mediated through Cx36 GJs. We inves...

journal_title：EXCLI journal

authors： Ghanbarabadi JK,Sayyah M

更新日期：2013-03-14 00:00:00

abstract：:Vitamin D deficiency, common in the population with irritable bowel syndrome (IBS), can induce the main factors that lead to IBS clinical symptoms, such as depression, anxiety, and inflammation. Serotonin (5-HT) plays an important role in the pathophysiology of IBS, and its production and secretion are increased from ...

journal_title：EXCLI journal

authors： Khalighi Sikaroudi M,Mokhtare M,Shidfar F,Janani L,Faghihi Kashani A,Masoodi M,Agah S,Dehnad A,Shidfar S

更新日期：2020-05-19 00:00:00

abstract：:Hematopoietic stem cells (HSCs) form a rare population of multipotent stem cells, which give rise to all hematopoietic lineages. HSCs home to bone marrow niches and circulate between blood and bone marrow. Many factors, especially SDF1a, affect the circulation of HSCs, but these have not been fully recognized. SDF1a h...

journal_title：EXCLI journal

authors： Asri A,Sabour J,Atashi A,Soleimani M

更新日期：2016-02-15 00:00:00

abstract：:Our experimental work was aimed at evaluating the safety and protective effects of dietary spirulina supplementation on the kidney of newborn rats, the offspring of lead contaminated lactating mothers. Female rats were randomly divided into four groups: group I (control) was given a normal diet, group II (positive con...

journal_title：EXCLI journal

authors： Gargouri M,Soussi A,Akrouti A,Magné C,El Feki A

更新日期：2018-03-02 00:00:00

abstract：:Healthcare professionals, especially nurses and pre-hospital emergency (PHE) staff, are influenced by many stressors due to their responsibility to provide comfort as well as care and treatment of patients. The aim of the present study was to identify and rank the occupational stressors in nurses and PHE staff using F...

journal_title：EXCLI journal

authors： Rajabi F,Jahangiri M,Molaeifar H,Honarbakhsh M,Farhadi P

更新日期：2018-08-20 00:00:00

abstract：:Salmonella enterica serovar Typhi (S. Typhi) is a human restricted pathogen. It biosynthesizes a virulence capsular polysaccharide named as Vi antigen. S. Typhi regulates expression of genes involved in the biosynthesis of Vi antigen in response to osmolarity. Beside Vi-positive isolates, Vi-negative (acapsulated) iso...

journal_title：EXCLI journal

authors： Liaquat S,Sarwar Y,Ali A,Haque A

更新日期：2015-02-09 00:00:00

abstract：:Recently, many articles have reported different levels and distribution of amphetamine hitherto detected in biological fluids now appreciably found in aquatic environment at ng/L levels. Identification and measurement of amphetamine and its metabolites in surface and sewage waters using higher performance liquid chrom...

journal_title：EXCLI journal

authors： Mustapha AO,Ajao UL

更新日期：2011-08-19 00:00:00

abstract：:From both the structural and functional points of view, β-turns play important biological roles in proteins. In the present study, a novel two-stage hybrid procedure has been developed to identify β-turns in proteins. Binary logistic regression was initially used for the first time to select significant sequence param...

journal_title：EXCLI journal

authors： Asghari MP,Hayatshahi SH,Abdolmaleki P

更新日期：2012-07-05 00:00:00

abstract：:The purpose of the present study was to investigate whether the markers of oxidative stress could be altered in workers exposed to asbestos. A comparative cross-sectional research was conducted in a group of 50 subjects exposed to asbestos and another group of 50 with the same age and sex unexposed to asbestos. Malond...

journal_title：EXCLI journal

authors： Afaghi A,Oryan S,Rahzani K,Abdollahi M

更新日期：2015-09-28 00:00:00

abstract：:The present study is conducted to determine the potential mechanisms of Boron compounds, boric acid (BA) and borax (BX), on genotoxicity of zebrafish Danio rerio for 24, 48, 72 and 96-hours acute exposure (level:1, 4, 16, 64 mg/l BA and BX) in semi-static bioassay experiment. For that purpose, peripheral erythrocytes ...

journal_title：EXCLI journal

authors： Gülsoy N,Yavas C,Mutlu Ö

更新日期：2015-07-30 00:00:00

abstract：:The chemical composition of the essential oils of different Allium nigrum L. organs and the antibacterial activity were evaluated. The study is particularly interesting because hitherto there are no reports on the antibacterial screening of this species with specific chemical composition. Therefore, essential oils fro...

journal_title：EXCLI journal

authors： Rouis-Soussi LS,Ayeb-Zakhama AE,Mahjoub A,Flamini G,Jannet HB,Harzallah-Skhiri F

更新日期：2014-05-13 00:00:00

abstract：:Ursolic acid (UA) is a pentacyclic triterpenoid carboxylic acid that is found in plants and herbal products. It is one of the chemopreventive agents, which can suppress cancer cell proliferation and induce apoptosis. UA possesses various biological activities including anticancer, anti-inflammatory, anti-oxidative and...

journal_title：EXCLI journal

authors： Kaewthawee N,Brimson S

更新日期：2013-02-08 00:00:00

abstract：:Doxorubicin (DOX) is an excellent antineoplastic agent used for the treatment of hematological and solid malignancies. The aqueous extract of Bombyx mori (BMAE) contains amino acids and some flavonoids with obvious cardioprotective effect. The aim of this study was to investigate the possible protective effect of BMAE...

journal_title：EXCLI journal

authors： Khan MS,Singh M,Khan MA,Arya DS,Ahmad S

更新日期：2014-09-05 00:00:00

abstract：:Bladder cancer (BC) is the sixth most common malignancy in men and 17th in women. Exosomal long non-coding RNAs (lncRNAs) have been defined as a novel biomarker for BC. The aim of this study is to evaluate the clinical significance of urine exosomal PVT-1, ANRIL and PCAT-1 as a biomarker in BC patients with tumors cla...

journal_title：EXCLI journal

authors： Abbastabar M,Sarfi M,Golestani A,Karimi A,Pourmand G,Khalili E

更新日期：2020-03-04 00:00:00

abstract：:Hepatitis C is a major global health burden and Egypt has the highest prevalence of hepatitis C virus (HCV) worldwide. The current study was designed to evaluate the beneficial therapeutic effects of ethanolic extracts of Nigella sativa, Zingiber officinale and their mixture in Egyptian HCV patients. Sixty volunteer p...

journal_title：EXCLI journal

authors： Abdel-Moneim A,Morsy BM,Mahmoud AM,Abo-Seif MA,Zanaty MI

更新日期：2013-11-11 00:00:00

abstract：:We present the case of a 77 year old male patient with metastatic pancreatic neuroendocrine tumor (NET). The patient was initially treated by extensive surgical resection that however, led to severe complications with delayed recovery. During follow-up, a number of new liver metastases were detected, one of which was ...

journal_title：EXCLI journal

authors： Ataeinia B,Loberg C,Kravets H,Beheshti M,von Mallek D,Mottaghy FM,Heinzel A

更新日期：2019-05-21 00:00:00

abstract：:Objective: Although osteoarthritis (OA) is widely accepted as a degenerative disease, autoimmune processes are believed to be involved in the pathogenesis. There are limited studies in this area and most of them focused on antibodies against chondrocyte membrane. In an attempt to address the paucity of evidence in thi...

journal_title：EXCLI journal

authors： Sakthiswary R,Rajalingam S,Norazman MR,Hussein H

更新日期：2012-09-07 00:00:00

abstract：:Activation of the hypoxia-inducible factor (HIF)-pathway in hepatocellular carcinoma (HCC) induces therapy resistant tumours, characterized by increased liver progenitor cell (LPCs) characteristics and poor prognosis. We previously reported corresponding results in mice with HCC in which hypoxia was mimicked by prolyl...

journal_title：EXCLI journal

authors： Bogaerts E,Paridaens A,Verhelst X,Carmeliet P,Geerts A,Van Vlierberghe H,Devisscher L

更新日期：2016-11-11 00:00:00

abstract：:Nephropathy associated with type 2 diabetes is the single most common cause of end-stage renal disease. The aim of the present study was to evaluate the preventive effect of ethanolic extract of Embelia ribes fruit (EER) against high fat diet (HFD) and low dose streptozotocin (STZ)-induced diabetic nephrotoxicity in W...

journal_title：EXCLI journal

authors： Chaudhari HS,Bhandari U,Khanna G

更新日期：2013-09-24 00:00:00

abstract：:Five Calligonum species endemic to the Tarim Basin - C. roborowskii, C. kuerlese, C. juoqiangense,C. yengisaricum, and C. taklimakanense - were compared using 14 morphological characteristics and nrDNA ITS and cpDNA trnL-F molecular data. Intraspecific and interspecific morphological variation was uncovered, with vari...

journal_title：EXCLI journal

authors： Abdurahman M,Sabirhazi G,Liu B,Yin L,Pan B

更新日期：2012-12-20 00:00:00

abstract：:To our knowledge, in spite of several trials exploring the beneficial effect of n-3 polyunsaturated fatty acids (PUFA) on polycystic ovary syndrome (PCOS), no comprehensive evidence has investigated the effects of n-3 PUFA consumption on PCOS complications. Therefore, our aim was to conduct a review to investigate the...

journal_title：EXCLI journal

authors： Salek M,Clark CCT,Taghizadeh M,Jafarnejad S

更新日期：2019-07-25 00:00:00

abstract：:Recently, bioinformatics has advanced to the level that it allows almost accurate prediction of molecular interactions that hold together a protein and a ligand in the bound state. For instance, the program AutoDock has been developed to provide a procedure for predicting the interaction of small molecules with macrom...

journal_title：EXCLI journal

authors： Rizvi SM,Shakil S,Haneef M

更新日期：2013-09-23 00:00:00