Blocking of rat hippocampal Cx36 by quinine accelerates kindling epileptogenesis.

abstract：:Presently, functional foods and nutraceuticals are gaining immense importance in the prevention of various maladies through dietary regimen module. Consumption of fruits and vegetables based diet has pursuit a range of bioactive components, especially phytochemicals targeting life threatening ailments. In this context...

journal_title：EXCLI journal

authors： Naz A,Butt MS,Sultan MT,Qayyum MM,Niaz RS

更新日期：2014-06-03 00:00:00

abstract：:Lack of data on safety of herbal medicines have endangered human health and life. The present study evaluated the genotoxic and mutagenic effect of Kalanchoe laciniata to access the safety and usefulness of the medicinal plant. Aqua-methanolic and n-hexane extracts of K. laciniata were evaluated for the genotoxic pote...

journal_title：EXCLI journal

authors： Sharif A,Akhtar MF,Akhtar B,Saleem A,Manan M,Shabbir M,Ashraf M,Peerzada S,Ahmed S,Raza M

更新日期：2017-04-24 00:00:00

abstract：:L-asparaginase and L-glutaminase can be effectively used for the treatment of patients who suffer from accute lymphoblastic leukemia and tumor cells. Microbial sources are the best source for the bulk production of these enzymes. However, their long-term administration may cause immunological responses, so screening f...

journal_title：EXCLI journal

authors： Shirazian P,Asad S,Amoozegar MA

更新日期：2016-04-18 00:00:00

abstract：:The traditional uses of Portulaca oleracea L. (PO) with anti-inflammatory and anti-cancer activity as well as antioxidants properties were expressed previously. Glioma is considered the most common primary brain tumor and its malignant form is the most lethal adult brain tumor, that glioblastoma covers about 50 % of g...

journal_title：EXCLI journal

authors： Baradaran Rahimi V,Mousavi SH,Haghighi S,Soheili-Far S,Askari VR

更新日期：2019-03-20 00:00:00

abstract：:The aim of this study was to evaluate the effect of acute and chronic physical and psychological stressors on the induction of oxidative stress in male rat liver. Male Wistar rats were randomly divided into 3 groups as following: control, physical and psychological stress groups. Stress was induced by communication bo...

journal_title：EXCLI journal

authors： Jafari M,Salehi M,Zardooz H,Rostamkhani F

更新日期：2014-02-24 00:00:00

abstract：:This study was undertaken to determine whether exposure of operating room personnel to inhalation anesthetics, including nitrous oxide, isoflurane, and sevoflurane was associated with any hepatotoxic or nephrotoxic changes. Fifty-two operating room personnel and 52 non-exposed subjects were studied. A questionnaire pe...

journal_title：EXCLI journal

authors： Neghab M,Amiri F,Soleimani E,Yousefinejad S,Hassanzadeh J

更新日期：2020-03-25 00:00:00

abstract：:Fibroblast growth factor 21 (FGF21) is a major metabolic regulator that has been shown to be elevated in a number of metabolic disturbances including type 2 diabetes mellitus (T2DM) and the metabolic syndrome, but few studies about the relationship between serum FGF21 and the complications of diabetes have been done. ...

journal_title：EXCLI journal

authors： Mousavi Z,Bonakdaran S,Sahebkar A,Yaghoubi G,Yaghoubi MA,Davoudian N,Mohebbi M

更新日期：2017-11-22 00:00:00

abstract：:Objective: Although osteoarthritis (OA) is widely accepted as a degenerative disease, autoimmune processes are believed to be involved in the pathogenesis. There are limited studies in this area and most of them focused on antibodies against chondrocyte membrane. In an attempt to address the paucity of evidence in thi...

journal_title：EXCLI journal

authors： Sakthiswary R,Rajalingam S,Norazman MR,Hussein H

更新日期：2012-09-07 00:00:00

abstract：:Serum concentration of lipids and lipoproteins changes during the course of acute coronary syndrome as a consequence of the inflammatory response. The objective of this study was to evaluate the effect of acute myocardial infarction (AMI) on the levels of lipid profile and inflammatory markers. We investigated 400 pat...

journal_title：EXCLI journal

authors： Shrivastava AK,Singh HV,Raizada A,Singh SK

更新日期：2015-04-10 00:00:00

abstract：:The effect of leaf essential oil of Hoslundia opposita (Vahl) on the haematological parameters of alloxan-induced diabetic rats was investigated. Forty-eight albino rats (Rattus norvegicus), of average weight 132.5 g, were randomly selected into normal and diabetic groups, each with four sub-groups. The rats were trea...

journal_title：EXCLI journal

authors： Muhammad NO,Akolade JO,Usman LA,Oloyede OB

更新日期：2012-09-25 00:00:00

abstract：:Endometriosis is defined by presence of endometrial-like-tissue outside the uterus. Recently, ectopic endometriotic lesions have been suggested to originate by abnormal differentiation of endometrial mesenchymal stem cells (eMSCs). MicroRNAs (miRNAs) play an important role in the pathophysiology of endometriosis. Thro...

journal_title：EXCLI journal

authors： Abdel-Rasheed M,Nour Eldeen G,Mahmoud M,ElHefnawi M,Abu-Shahba N,Reda M,Elsetohy K,Nabil M,Elnoury A,Taha T,Azmy O

更新日期：2017-06-14 00:00:00

abstract：:The aim of this study was the design and evaluation of a novel plasma stable, pH-sensitive niosomal formulation of Mitoxantrone by a modified ethanol injection method. Cholesterol hemisuccinate was added instead of cholesterol in order to produce pH-sensitivity property and using PEG-Poly (monomethyl itaconate)-CholC6...

journal_title：EXCLI journal

authors： Tila D,Yazdani-Arazi SN,Ghanbarzadeh S,Arami S,Pourmoazzen Z

更新日期：2015-01-06 00:00:00

abstract：:Exposure to microgravity leads to orthostatic intolerance in astronauts and differential vascular structural and functional adaptations have been implicated in its occurrence. The present study tended to clarify the characteristics of vascular inflammation and oxidative stress in hindlimb unweighting (HU) rat vasculat...

journal_title：EXCLI journal

authors： Zhang R,Ran HH,Gao YL,Ma J,Huang Y,Bai YG,Lin LJ

更新日期：2010-12-23 00:00:00

abstract：:From both the structural and functional points of view, β-turns play important biological roles in proteins. In the present study, a novel two-stage hybrid procedure has been developed to identify β-turns in proteins. Binary logistic regression was initially used for the first time to select significant sequence param...

journal_title：EXCLI journal

authors： Asghari MP,Hayatshahi SH,Abdolmaleki P

更新日期：2012-07-05 00:00:00

abstract：:Corn cob is a major component of agricultural and domestic waste in many parts of the world. It is composed mainly of cellulose which can be converted to energy in form of bioethanol as an efficient and effective means of waste management. Production of cellulolytic enzymes were induced in the fungi Aspergillus niger ...

journal_title：EXCLI journal

authors： Saliu BK,Sani A

更新日期：2012-08-15 00:00:00

abstract：:Dynamin 2 is a GTPase protein that has been implicated in cancer progression through its various roles such as endocytosis, morphogenesis, epithelial-mesenchymal transition (EMT), cellular contractions, and focal adhesion maturation. The increased expression levels of this molecule have been demonstrated with the deve...

journal_title：EXCLI journal

authors： Sajed R,Saeednejad Zanjani L,Rahimi M,Mansoori M,Zarnani AH,Madjd Z,Ghods R

更新日期：2020-10-29 00:00:00

abstract：:Octyl gallate (OG) is an antioxidant commonly used in food, although there is no definition of its acceptable daily intake. There are reports in vitro and in vivo showing that food additives and drugs can alter lipid metabolism. Lipid droplet accumulation in hepatic cells is one of the main findings in the unregulated...

journal_title：EXCLI journal

authors： Lima KG,Schneider Levorse VG,Rosa Garcia MC,de Souza Basso B,Pasqualotto Costa B,Antunes GL,Luft C,Haute GV,Leal Xavier L,Donadio MVF,Rodrigues de Oliveira J

更新日期：2020-07-06 00:00:00

abstract：:Genome editing technologies include techniques used for desired genetic modifications and allow the insertion, modification or deletion of specific DNA fragments. Recent advances in genome biology offer unprecedented promise for interdisciplinary collaboration and applications in gene editing. New genome editing techn...

journal_title：EXCLI journal

authors： Görücü Yilmaz S

更新日期：2021-01-04 00:00:00

abstract：:Nephropathy associated with type 2 diabetes is the single most common cause of end-stage renal disease. The aim of the present study was to evaluate the preventive effect of ethanolic extract of Embelia ribes fruit (EER) against high fat diet (HFD) and low dose streptozotocin (STZ)-induced diabetic nephrotoxicity in W...

journal_title：EXCLI journal

authors： Chaudhari HS,Bhandari U,Khanna G

更新日期：2013-09-24 00:00:00

abstract：:Activation of the hypoxia-inducible factor (HIF)-pathway in hepatocellular carcinoma (HCC) induces therapy resistant tumours, characterized by increased liver progenitor cell (LPCs) characteristics and poor prognosis. We previously reported corresponding results in mice with HCC in which hypoxia was mimicked by prolyl...

journal_title：EXCLI journal

authors： Bogaerts E,Paridaens A,Verhelst X,Carmeliet P,Geerts A,Van Vlierberghe H,Devisscher L

更新日期：2016-11-11 00:00:00

abstract：:The liver is famous for its strong regenerative capacity, employing different modes of regeneration according to type and extent of injury. Mature liver cells are able to proliferate in order to replace the damaged tissue allowing the recovery of the parenchymal function. In more severe scenarios hepatocytes are belie...

journal_title：EXCLI journal

authors： Verhulst S,Best J,van Grunsven LA,Dollé L

更新日期：2015-01-06 00:00:00

abstract：:One of the most fundamental operations in biological sequence analysis is multiple sequence alignment (MSA). The basic of multiple sequence alignment problems is to determine the most biologically plausible alignments of protein or DNA sequences. In this paper, an alignment method using genetic algorithm for multiple ...

journal_title：EXCLI journal

authors： Kumar M

更新日期：2015-12-15 00:00:00

abstract：:Hepatocellular carcinoma or Liver cancer (LC) is the sixth most common cancer and the fourth cause of death worldwide in 2018. There has not been a comprehensive study on the survival rate of patients with LC in Asia yet. Therefore, the present study was conducted to evaluate the survival rate of patients with LC in A...

journal_title：EXCLI journal

authors： Hassanipour S,Vali M,Gaffari-Fam S,Nikbakht HA,Abdzadeh E,Joukar F,Pourshams A,Shafaghi A,Malakoutikhah M,Arab-Zozani M,Salehiniya H,Mansour-Ghanaei F

更新日期：2020-01-13 00:00:00

abstract：:Hepatitis C is a major global health burden and Egypt has the highest prevalence of hepatitis C virus (HCV) worldwide. The current study was designed to evaluate the beneficial therapeutic effects of ethanolic extracts of Nigella sativa, Zingiber officinale and their mixture in Egyptian HCV patients. Sixty volunteer p...

journal_title：EXCLI journal

authors： Abdel-Moneim A,Morsy BM,Mahmoud AM,Abo-Seif MA,Zanaty MI

更新日期：2013-11-11 00:00:00

abstract：:Stevens-Johnson syndrome (SJS) is an immune mediated hypersensitivity reaction. Significant involvement of oral, nasal, eye, vaginal, urethral, GI and lower respiratory tract mucous membrane may develop. It is usually a reaction due to a medication or due to an infection. In 95 % of case reports, drugs were found to b...

journal_title：EXCLI journal

authors： Zaidi M,Zaidi SK,Bhutto M,Umer MY

更新日期：2017-05-18 00:00:00

abstract：:The purpose of the present study was to investigate whether the markers of oxidative stress could be altered in workers exposed to asbestos. A comparative cross-sectional research was conducted in a group of 50 subjects exposed to asbestos and another group of 50 with the same age and sex unexposed to asbestos. Malond...

journal_title：EXCLI journal

authors： Afaghi A,Oryan S,Rahzani K,Abdollahi M

更新日期：2015-09-28 00:00:00

abstract：:Previous research has shown the beneficial effects of aqueous extract of Piper sarmentosum (P.s) on atherosclerosis. The first stage in atherosclerosis is the formation of foam cell. The aim of this study was to investigate the effect of the methanol extract of P.s on fatty streaks by calculating neointimal foam cell ...

journal_title：EXCLI journal

authors： Amran AA,Zakaria Z,Othman F,Das S,Al-Mekhlafi HM,Raj S,Nordin NA

更新日期：2012-06-15 00:00:00

abstract：:DNA methylation, an epigenetic modification, is mediated by DNA methyltransferases (DNMTs), a family of enzymes. Inhibitions of these enzymes are considered a promising strategy for the treatment of several diseases. In this study, a quantitative structure-activity relationship (QSAR) modeling was employed to understa...

journal_title：EXCLI journal

authors： Phanus-Umporn C,Prachayasittikul V,Nantasenamat C,Prachayasittikul S,Prachayasittikul V

更新日期：2020-04-02 00:00:00

abstract：:Patients with diabetes tend to have an increased risk of osteoporosis that may be related to hyperglycemia. In vitro evidence has shown that high glucose can affect the proliferation and osteogenic differentiation of mesenchymal stem cells (MSCs). Tissue regeneration depends mainly on MSCs. However, the exact mechanis...

journal_title：EXCLI journal

authors： Wang J,Wang B,Li Y,Wang D,Lingling E,Bai Y,Liu H

更新日期：2013-06-27 00:00:00

abstract：:The aim of this study was to determine the effects of caffeine and chlorogenic acid supplementation on gut microbiota, and metabolic disturbances in patients with NAFLD and diabetes. In this randomized, placebo-controlled, clinical trial, 26 patients with diabetes and NAFLD were randomly assigned to four groups to rec...

journal_title：EXCLI journal

authors： Mansour A,Mohajeri-Tehrani MR,Karimi S,Sanginabadi M,Poustchi H,Enayati S,Asgarbeik S,Nasrollahzadeh J,Hekmatdoost A

更新日期：2020-03-02 00:00:00