Comparison of vasoactive intestinal peptide-mediated protein phosphorylation in human lymphoblasts and colonic epithelial cells.

abstract：:The insect gut participates in initial local immune responses by producing reactive oxygen and nitrogen species as well as anti-microbial peptides to resist pathogenic invasions. Nitric oxide (NO), a signaling and an immune effector molecule synthesized by the enzyme NO synthase (NOS), mediates an early step of the si...

journal_title：Molecular immunology

authors： Liu W,Wang Y,Leng Z,Wang Q,Duan X,Luo Y,Jiang Y,Qin L

更新日期：2020-10-01 00:00:00

abstract：:2-Aminopurine (2-AP) is widely used as an inhibitor for double stranded RNA-dependent protein kinase (PKR). Previously, we reported that 2-AP inhibits Toll-like receptor (TLR) ligand-induced nitric oxide production through the prevention of interferon (IFN)-β production. In this study, we investigated the mechanisms f...

journal_title：Molecular immunology

authors： Sugiyama T,Gotou T,Moriyama K,Kajiura N,Hasegawa T,Tomida J,Takahashi K,Komatsu T,Ueda H,Sato K,Tokoro S,Neri P,Mori H

更新日期：2012-10-01 00:00:00

abstract：:Evidence suggests that immune dysregulation is associated with autism spectrum disorder (ASD). T cell immunoglobulin and mucin domain-3 (TIM-3) has a critical role in several inflammatory disorders; however, the role of TIM-3 signaling has not been demonstrated in ASD. In the present study, we assessed the role of TIM...

journal_title：Molecular immunology

authors： Ahmad SF,Ansari MA,Nadeem A,Bakheet SA,Al-Ayadhi LY,Alotaibi MR,Alhoshani AR,Alshammari MA,Attia SM

更新日期：2019-02-01 00:00:00

abstract：:To investigate the interaction of DNA and anti-DNA antibodies in the immune complex disease of systemic lupus erythematosus, the fine specificity of binding of a monoclonal anti-DNA antibody was determined. This antibody, termed Cll, was derived from the fusion of spleen cells from an autoimmune MRL-lpr/lpr mouse with...

journal_title：Molecular immunology

authors： Pisetsky DS,Caster SA

更新日期：1982-05-01 00:00:00

abstract：:GK-1 is an immunomodulatory, 18-aa-long peptide that has been proved to promote the activation of mouse peritoneal macrophages and LPS-pulsed mouse bone marrow-derived dendritic cells (BM-DCs). This study is aimed to explore the mechanisms underlying the activation of these antigen-presenting cells (APCs) by GK-1. In ...

journal_title：Molecular immunology

authors： Montero L,Cervantes-Torres J,Sciutto E,Fragoso G

更新日期：2020-12-01 00:00:00

abstract：:The development of nanoparticles (NPs) for commercial products is undergoing a dramatic expansion. Many sunscreens and cosmetics now use zinc oxide (ZnO) or titania (TiO2) NPs, which are effective ultraviolet (UV) filters. Zinc oxide topical creams are also used in mild anti-inflammatory treatments. In this study we e...

journal_title：Molecular immunology

authors： Feltis BN,Elbaz A,Wright PF,Mackay GA,Turney TW,Lopata AL

更新日期：2015-08-01 00:00:00

abstract：:Recognition of pathogen-associated molecular patterns (PAMPs) by pattern-recognition receptors (PRRs) is important in innate immune signaling. Toll-like receptors (TLRs) are well-characterized PRRs and are pivotal in antiviral and antitumor host defense. TIR domain-containing adaptor molecule 1 (TICAM-1, also called T...

journal_title：Molecular immunology

authors： Funami K,Matsumoto M,Obuse C,Seya T

更新日期：2016-05-01 00:00:00

abstract：:Monoclonal antibodies were prepared against synthetic peptides synthetized on the basis of nucleotide sequence from cDNA and genomic clones encoding a class I antigen expressed by the rabbit RL-5 cell line. Using a peptide corresponding to positions 61-73 of the N domain, we were able to obtain an hybridoma producing ...

journal_title：Molecular immunology

authors： Le Guern A,Wetterskog D,Marche PN,Kindt TJ

更新日期：1987-05-01 00:00:00

abstract：:The SARS-CoV-2 virus responsible for coronavirus 2019 (COVID-19) poses a significant challenge to healthcare systems worldwide. According to the World Health Organization (WHO), the outbreak of COVID-19 has been a pandemic that infected more than 25.32 million people and caused more than 848.25 thousand deaths worldwi...

journal_title：Molecular immunology

authors： Liu D,Wu F,Cen Y,Ye L,Shi X,Huang Y,Fang S,Ma L

更新日期：2021-01-09 00:00:00

abstract：:Mannose-binding lectin (MBL) is a recognition molecule of the complement (C) system and binds to carbohydrate ligands present on a wide range of pathogenic bacteria, viruses, fungi, and parasites. MBL has been detected in the cervico-vaginal cavity where it can provide a first-line defence against infectious agents co...

journal_title：Molecular immunology

authors： Bulla R,De Seta F,Radillo O,Agostinis C,Durigutto P,Pellis V,De Santo D,Crovella S,Tedesco F

更新日期：2010-11-01 00:00:00

abstract：:Infection of ruminants and humans with Fasciola gigantica is attracting increasing attention due to its economic impact and public health significance. However, little is known of innate immune responses during F. gigantica infection. Here, we investigated the expression profiles of genes involved in Toll-like recepto...

journal_title：Molecular immunology

authors： Zhang FK,Hou JL,Guo AJ,Tian AL,Sheng ZA,Zheng WB,Huang WY,Elsheikha HM,Zhu XQ

更新日期：2018-02-01 00:00:00

abstract：:In addition to classic Smad signaling pathways, the pleiotropic immunoregulatory cytokine TGF-beta1 can activate MAP kinases, but a role for TGF-beta1-MAP kinase pathways in T cells has not been defined heretofore. We have shown previously that TGF-beta1 inhibits Th1 development by inhibiting IFN-gamma's induction of ...

journal_title：Molecular immunology

authors： Park IK,Letterio JJ,Gorham JD

更新日期：2007-07-01 00:00:00

abstract：:Glycosylation is an important protein post-translational modification. In this process, the intermediate product, Tn antigen, arises from somatic mutations in core1β3-galactosyltransferase-specific molecular chaperone (Cosmc), which is required for the formation of active core1β3-galactosyltransferase (T-synthase). As...

journal_title：Molecular immunology

authors： Shi C,Xu X,Yu X,Du Z,Luan X,Liu D,Hu T

更新日期：2017-10-01 00:00:00

abstract：:T-cell-replacing factor (TRF)/IL-5 is a T-cell-derived glycoprotein which has pleiotropic activity on lymphoid and myeloid cells. IL-5 polypeptide translated into Xenopus oocytes are heterogeneous in molecular size (40,000 to 60,000 under nonreducing conditions) and yields a monomeric form (Mr of 25,000 to 30,000) und...

journal_title：Molecular immunology

authors： Takahashi T,Yamaguchi N,Mita S,Yamaguchi Y,Suda T,Tominaga A,Kikuchi Y,Miura Y,Takatsu K

更新日期：1990-09-01 00:00:00

abstract：:Evidence has been accumulating for a role of inflammation in the development of Alzheimer's disease (AD), a progressive neurodegenerative disorder causing a common form of dementia in the elderly. C1q, part of the initiation component of the classical complement pathway (CCP), is associated with beta-sheet, fibrillar ...

journal_title：Molecular immunology

authors： Li M,Ager RR,Fraser DA,Tjokro NO,Tenner AJ

更新日期：2008-06-01 00:00:00

abstract：:We have developed a method for use in investigating factors controlling the binding and cross-linking by bivalent haptens of immunoglobulin E (IgE) bound to receptors on rat basophilic leukemia (RBL) cells. This method employs monoclonal anti-2,4-dinitrophenyl (DNP) IgE that is labeled with fluorescein-5-isothiocyanat...

journal_title：Molecular immunology

authors： Erickson J,Kane P,Goldstein B,Holowka D,Baird B

更新日期：1986-07-01 00:00:00

abstract：:This report demonstrates that a marker of human embryonic endoderm and embryonal carcinoma cells recognized by a hybridoma antibody FC 10.2, involves Type 1 blood group chains with the sequence Gal beta 1 leads to 3G1cNAc beta 1 leads to 3Gal beta 1 leads to 4G1c. This conclusion has been reached from antigenic analys...

journal_title：Molecular immunology

authors： Gooi HC,Williams LK,Uemura K,Hounsell EF,McIlhinney RA,Feizi T

更新日期：1983-06-01 00:00:00

abstract：:An antigen-coated plate radioimmunoassay was used to detect antibodies against homologous glutaraldehyde-modified albumin (in monomeric or polymeric form) in normal mouse sera. Mouse antibodies reacted also with heterologous glutaraldehyde-treated albumin; for instance human albumin. Immunoelectrophoresis of purified ...

journal_title：Molecular immunology

authors： Onică D,Mărgineanu I,Medeşan C,Călugăru A,Manciulea M

更新日期：1982-08-01 00:00:00

abstract：:The purpose of this study was to evaluate the effects of GATA-6 on airway inflammation and remodeling and the underlying mechanisms in a murine model of chronic asthma. Female BALB/c mice were randomly divided into four groups: phosphate-buffered saline control (PBS), ovalbumin (OVA)-induced asthma group (OVA), OVA+ s...

journal_title：Molecular immunology

authors： Fang P,Shi HY,Wu XM,Zhang YH,Zhong YJ,Deng WJ,Zhang YP,Xie M

更新日期：2016-07-01 00:00:00

abstract：:A set of 58 overlapping rod-bound peptides was used to map the antigenic reactivity pattern of a 64-residue neurotoxin (AaH II) from the venom of the scorpion Androctonus australis hector. Five anti-toxin rabbit antisera were assayed serially for their capacity to bind to each peptide in the set. Six regions of antige...

journal_title：Molecular immunology

authors： Devaux C,Juin M,Mansuelle P,Granier C

更新日期：1993-08-01 00:00:00

abstract：:A cDNA clone, designated sbIL-6 (seabream interleukin-6), was obtained from a cDNA library of enriched immune-stimulated sequences from gilthead seabream. The deduced sbIL-6 protein corresponds to a 225-amino acid protein with a putative 24-amino acid signal peptide, four conserved alpha helices and one N-linked glyco...

journal_title：Molecular immunology

authors： Castellana B,Iliev DB,Sepulcre MP,MacKenzie S,Goetz FW,Mulero V,Planas JV

更新日期：2008-07-01 00:00:00

abstract：:Bombyx mori nucleopolyhedrovirus (BmNPV) is one of the main pathogens that seriously affect the sustainable development of sericulture industry. Inhibition of Hsp90 by Hsp90 inhibitor, geldanamycin (GA) significantly suppresses BmNPV proliferation in Bombyx mori, while the functional mechanism is not clear. LncRNA has...

journal_title：Molecular immunology

authors： Yin H,Shang Q,Zhang S,Shen M,Huang H,Zhao W,Xijie G,Wu P

更新日期：2020-11-01 00:00:00

abstract：:Covalent Superose microspheres-bound C3b was used as a model system to simplify the analysis of antigen-bound C3b modifications during antigen processing. The model was set up using purified C3 and Superose-bound trypsin. C3b was covalently bound to Superose through an ester link, as indicated by lability to hydroxyla...

journal_title：Molecular immunology

authors： Rey-Millet CA,Chesne S,Colomb MG

更新日期：1993-07-01 00:00:00

abstract：:Egr-1 is an immediate early gene that is rapidly upregulated in response to mitogenic signals induced by antigen receptor crosslinking on murine B lymphocytes. It has been shown that levels of Egr-1 expression are closely correlated with B cell proliferation in several models of B cell activation and tolerance. We com...

journal_title：Molecular immunology

authors： Klaus SJ,Phillips NE,Parker DC

更新日期：1993-11-01 00:00:00

abstract：:The complement system is very tightly regulated by fluid-phase and membrane-bound factors that prevent injury to self-tissues. The study of genetically engineered animals with targeted deletion or gain of function mutations has highlighted the important role that many of the complement inhibitors play in vivo. The adv...

journal_title：Molecular immunology

authors： Turnberg D,Botto M

更新日期：2003-09-01 00:00:00

abstract：:Peach non-specific lipid transfer protein (Pru p 3; nsLTP) has been characterized as the major food allergen in the adult Mediterranean population. Its wheat homologous protein, Tri a 14 has a relevant inhalant allergen in occupational baker's asthma. Different sensitization patterns to these allergens have been found...

journal_title：Molecular immunology

authors： Tordesillas L,Pacios LF,Palacin A,Quirce S,Armentia A,Barber D,Salcedo G,Diaz-Perales A

更新日期：2009-12-01 00:00:00

abstract：:Autoimmunity is fundamentally a continuously evolving process. The autoimmune responses shift, drift and diversify with time not only to other epitopes in the original antigen but also to other related and sometimes to unrelated antigens. We have described a form of immune diversification--reciprocal T-B epitope sprea...

journal_title：Molecular immunology

authors： Singh RR

更新日期：2004-02-01 00:00:00

abstract：:Affinity-purified major histocompatibility complex (MHC) class II molecules are known to bind antigenic peptides in vitro. The percentage of MHC class II molecules occupied with such peptides is usually very low and varies significantly depending upon the sequence and size of a given antigenic peptide. The present stu...

journal_title：Molecular immunology

authors： Nag B,Mukku PV,Arimilli S,Phan D,Deshpande SV,Winkelhake JL

更新日期：1994-10-01 00:00:00

abstract：:T-cell activation requires interaction of T-cell receptors (TCR) with peptide epitopes bound by major histocompatibility complex (MHC) proteins. This interaction occurs at a special cell-cell junction known as the immune or immunological synapse. Fluorescence microscopy has shown that the interplay among one agonist p...

journal_title：Molecular immunology

authors： Wan S,Flower DR,Coveney PV

更新日期：2008-03-01 00:00:00

abstract：:Purified human C5 was converted non-enzymically to an activated form as defined by its ability to participate in reactive lysis. This conversion occurred following exposure to systems that generate oxygen radicals, namely addition of H2O2 in the presence of ascorbic acid and iron or the addition of xanthine oxidase, a...

journal_title：Molecular immunology

authors： Vogt W,Damerau B,von Zabern I,Nolte R,Brunahl D

更新日期：1989-12-01 00:00:00