Albuterol multidose dry powder inhaler and albuterol hydrofluoroalkane versus placebo in children with persistent asthma.

Abstract:

BACKGROUND:Many children struggle with albuterol hydrofluoroalkane (HFA) inhalers. Albuterol multidose dry powder inhaler (MDPI) may simplify rescue bronchodilator use in children. OBJECTIVE:To demonstrate the comparability of albuterol MDPI and albuterol HFA in children with asthma. METHODS:This phase II, multicenter, double-blind, double-dummy, single-dose, five-period, crossover study randomized patients (ages 4-11 years) with persistent asthma and prestudy forced expiratory volume in 1 second (FEV1) of 60-90% of predicted to 1 of 10 treatment sequences that contained albuterol MDPI (90 and 180 μg), albuterol HFA (90 and 180 μg), and placebo MDPI and placebo HFA. Efficacy was evaluated by measuring the area under the baseline-adjusted percent-predicted FEV1-time curve over 6 hours (PPFEV1 AUC0-6) after dosing. Safety was evaluated by adverse events. RESULTS:The full analysis set included 61 patients. Albuterol MDPI and albuterol HFA significantly improved PPFEV1 AUC0-6 versus placebo (p ≤ 0.0107). Mean improvement (± standard error [SE]) in PPFEV1 AUC0-6 versus placebo with albuterol MDPI at 90 and 180 μg was similar (21.2 ± 4.87 [95% confidence interval {CI}, 11.60-30.81], and 22.6 ± 4.87 [95% CI, 13.00-32.20], %·hour, respectively). Mean improvement (± SE) with albuterol HFA 180 μg was significantly (p = 0.0226) greater versus albuterol HFA 90 μg (23.7 ± 4.85 [95% CI, 14.13-33.23], and 12.5 ± 4.85 [95% CI, 2.93-22.05], %·hour, respectively). All doses of albuterol were well tolerated. CONCLUSION:Albuterol MDPI 90 and 180 μg and albuterol HFA 180 μg provided similar and significant FEV1 improvements versus placebo; albuterol HFA 90 μg was significant versus placebo but seemed less effective based on absolute improvements in FEV1. ClinicalTrials.gov identifier: NCT01899144.

journal_name

Allergy Asthma Proc

authors

Qaqundah PY,Taveras H,Iverson H,Shore P

doi

10.2500/aap.2016.37.3986

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

350-8

issue

5

eissn

1088-5412

issn

1539-6304

journal_volume

37

pub_type

杂志文章,多中心研究,随机对照试验
  • New insights into the pathophysiology of allergic rhinitis.

    abstract::The immune response to an allergen is dependent on an initial sensitization process, with future exposures triggering a two-part allergic response including an early and a late phase. The process by which an allergen is recognized as such, including which cell types and cytokines are involved in the sensitization proc...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2007.28.2977

    authors: Rosenwasser L

    更新日期:2007-01-01 00:00:00

  • Natural history of hay fever: a 23-year follow-up of college students.

    abstract::The purpose of this study is to examine the natural history of hay fever among former college students who were diagnosed with this disease either before or after their freshman year. The diagnosis of hay fever or seasonal allergic rhinitis was based on a history of watery, itchy eyes, rhinorrhea, and sneezing occurri...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/108854198778557728

    authors: Greisner WA 3rd,Settipane RJ,Settipane GA

    更新日期:1998-09-01 00:00:00

  • Emergency department treatment of adults with acute asthma exacerbations: effect on exhaled nitric oxide levels.

    abstract::Measurement of exhaled nitric oxide levels (eNO) from asthmatic patients is a noninvasive marker of airway inflammation in both adults and children and has been used as an outpatient measure of asthma control. We examined eNO in acute asthma exacerbations and how it is affected by treatment in the emergency departmen...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,随机对照试验

    doi:10.2500/aap.2012.33.3613

    authors: Silverberg JI,Rodenas M,Sinert R,Joks R

    更新日期:2012-11-01 00:00:00

  • Properties of the ideal corticosteroid therapy.

    abstract::Currently, inhaled corticosteroids (ICSs) are the most effective long-term control therapy for persistent asthma. However, patients show a variable response to ICSs and some exhibit glucocorticoid resistance. At recommended doses, there is little evidence to suggest that ICSs can either prevent or reverse the chronic ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:

    authors: Zitt MJ

    更新日期:2005-05-01 00:00:00

  • Asthma persistence versus progression: does airway smooth muscle function predict irreversible airflow obstruction?

    abstract::Asthma, a disease characterized by airway inflammation and reversible bronchoconstriction, manifests a variety of phenotypes, and in some, but not all, asthma leads to a persistent and/or progressive loss of lung function. Conceptually, asthma persistence is identified by a stable decrement in lung function over time,...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2009.30.3202

    authors: Panettieri RA Jr

    更新日期:2009-03-01 00:00:00

  • Atopy patch testing for foods: a review of the literature.

    abstract::The atopy patch test (APT) was first reported in 1895 by the German dermatologist, Jadassohn and was used for evaluation of contact dermatitis. The first documented epicutaneous application of aeroallergens was by Rostenberg and Sulzbergen in 1937. Although others including Mitchell and Platts-Mills, further described...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2014.35.3797

    authors: Edwards KP,Martinez BA

    更新日期:2014-11-01 00:00:00

  • Association of maternal depression and allergic diseases in Korean children.

    abstract:PURPOSE:An association between childhood allergic disease and parental psychological disorders has been reported. However, little is known about the relationship between childhood allergic disease and maternal depression. This study was performed to determine if there is an association between childhood allergic diseas...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2017.38.4059

    authors: Kim CH,Kim SH,Lee JS

    更新日期:2017-07-01 00:00:00

  • The role of outcome studies in allergy and clinical immunology.

    abstract::Outcomes research is becoming an integral part of the sweeping changes occurring in the U.S. health care system. By developing outcomes monitoring systems in allergic disorders, allergists will be able to collect information showing their commitment to excellent clinical care, which improves the patient's quality of l...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/108854196778606455

    authors: Blaiss MS

    更新日期:1996-11-01 00:00:00

  • Cross-sectional study on Asthma Insights and Management in the Gulf and Russia.

    abstract::Background: Asthma is a chronic and complex lung disease that is not completely understood. It involves airway inflammation, reversible airflow obstruction, and bronchial hyperresponsiveness. The most common symptoms are recurrent wheezing, chest tightness, shortness of breath, and coughing. Objective: The Asthma Insi...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,多中心研究

    doi:10.2500/aap.2018.39.4180

    authors: Alzaabi A,Idrees M,Behbehani N,Khaitov MR,Tunceli K,Urdaneta E,Awad N,Safwat M

    更新日期:2018-11-16 00:00:00

  • Community-acquired pneumonia: an approach to antimicrobial therapy.

    abstract::Community-acquired pneumonia (CAP), the sixth leading cause of death in the United States, has undergone significant changes in the past 30 years. In addition to the fact that it increasingly is a disease affecting the elderly and those patients with underlying comorbidities, the spectrum of microbiological agents cau...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/108854100778248980

    authors: Lange M

    更新日期:2000-01-01 00:00:00

  • ECP level in nasopharyngeal secretions and serum from children with respiratory virus infections and asthmatic children.

    abstract::Infection with respiratory virus has been shown to exacerbate asthma in humans. However, the role of a respiratory virus in the pathogenesis of chronic asthma and/or wheezing in young children has not been clearly defined. It has also been debated whether virus-induced wheezing in young children is one entity and alle...

    journal_title:Allergy and asthma proceedings

    pub_type: 临床试验,杂志文章

    doi:10.2500/108854100778250888

    authors: Oh JW,Lee HB,Yum MK,Kim CR,Kang JO,Park IK

    更新日期:2000-03-01 00:00:00

  • Oxidative stress markers in patients with hymenoptera venom allergy.

    abstract::Oxidative stress occurs in many allergic and immunologic disorders as a result of the imbalance between the endogenous production of free reactive oxygen species (ROS) and/or the reduction of antioxidant defense mechanisms. Advanced glycation end products (AGEs), advanced oxidation protein products (AOPPs), and nitros...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2015.36.3814

    authors: Patella V,Incorvaia C,Minciullo PL,Oricchio C,Saitta S,Florio G,Saija A,Gangemi S

    更新日期:2015-01-01 00:00:00

  • The status of asthma control in the U.S. adult population.

    abstract::Treatment guidelines recognize the importance of achieving and maintaining asthma control. This study was designed to assess the prevalence of asthma control in a representative U.S. population. A survey regarding asthma and associated symptoms was sent to a representative national sample of 134,401 households managed...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2009.30.3276

    authors: Fuhlbrigge A,Reed ML,Stempel DA,Ortega HO,Fanning K,Stanford RH

    更新日期:2009-09-01 00:00:00

  • Chapter 7: Nasal polyps.

    abstract::Nasal polyps are inflammatory outgrowths of paranasal sinus mucosa caused by chronic mucosal inflammation that typically arise from the middle meatus and ethmoid region. The main symptoms of nasal polyps are perennial nasal congestion, nasal obstruction, and anosmia or hyposmia. Unlike patients with chronic rhinosinu...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2012.33.3537

    authors: Georgy MS,Peters AT

    更新日期:2012-05-01 00:00:00

  • The "Peter Pan" syndrome and allergy practice: facilitating adherence through the use of social support.

    abstract::The complexity of care of some patients in an allergy-immunology practice may be increased by behavioral abnormalities of the patients. Facilitating adherence through the use of social support may be the most effective treatment strategy for some of the most difficult of these patients. We report three patients whose ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/108854100778248845

    authors: Patterson R,McGrath KG

    更新日期:2000-07-01 00:00:00

  • Chapter 17: Occupational immunologic lung disease.

    abstract::Occupational immunologic lung disease is characterized by an immunologic response in the lung to an airborne agent inhaled in the work environment and can be subdivided into immunologically mediated occupational asthma (OA) and hypersensitivity pneumonitis (HP). Irritant-induced OA, a separate nonimmunologic entity, ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2012.33.3550

    authors: Sabin BR,Grammer LC

    更新日期:2012-05-01 00:00:00

  • Effect of omalizumab on outcomes in patients with aspirin-exacerbated respiratory disease.

    abstract::Background: The current treatment for patients with aspirin-exacerbated respiratory disease (AERD) who have uncontrolled asthma or chronic rhinosinusitis is aspirin desensitization. For patients who are unable to undergo or do not benefit from aspirin desensitization, treatment with biologics is an option, although ef...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2019.40.4241

    authors: Jean T,Eng V,Sheikh J,Kaplan MS,Goldberg B,Jau Yang S,Samant S

    更新日期:2019-09-01 00:00:00

  • Rhinorrhea not responding to nasal corticosteroids.

    abstract::A woman with multiple illnesses including allergic rhinitis presented for a follow-up visit at our clinic with constant rhinorrhea for 2 weeks despite regular use of nasal corticosteroids. Two weeks earlier, after alcohol drinking and doubling some of her medications for missed doses, she fell on her face. The Emergen...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2007.28.3061

    authors: Patel PN,Oyefara B,Aarstad R,Bahna SL

    更新日期:2007-11-01 00:00:00

  • Airway responsiveness in asthma: bronchial challenge with histamine and 4.5% sodium chloride before and after budesonide.

    abstract::Inhalation of histamine is commonly used to assess the severity of and to monitor treatment of asthma. Histamine causes airways to narrow by acting directly on specific receptors. Hyperosmolar saline causes airways of asthmatics to narrow indirectly by endogenously mediated events that are potentially modified by drug...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/108854197778612817

    authors: du Toit JI,Anderson SD,Jenkins CR,Woolcock AJ,Rodwell LT

    更新日期:1997-01-01 00:00:00

  • Efficacy and safety of beclomethasone dipropionate breath-actuated or metered-dose inhaler in pediatric patients with asthma.

    abstract:BACKGROUND:Breath-actuated inhalers (BAI) eliminate the need for hand-breath coordination and, therefore, simplify the delivery of inhaled medication. OBJECTIVE:To evaluate the efficacy and safety of beclomethasone dipropionate BAI and metered-dose inhaler (MDI) versus placebo in pediatric patients ages 4-11 years wit...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,随机对照试验

    doi:10.2500/aap.2017.38.4078

    authors: Vandewalker M,Hickey L,Small CJ

    更新日期:2017-09-14 00:00:00

  • Anaphylaxis and epinephrine prescribing patterns in a military hospital: underutilization of the intramuscular route.

    abstract::Epinephrine is the only definitive treatment of anaphylaxis, and recent evidence suggests that the intramuscular route has superior pharmacokinetics to subcutaneous administration. There is little data regarding what route is commonly used in clinical practice. The objective of this article is to determine the rate of...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:

    authors: Haymore BR,Carr WW,Frank WT

    更新日期:2005-09-01 00:00:00

  • Fifty-five-year-old man with chronic yeast infections.

    abstract::As immunologists, we are frequently asked to evaluate patients with recurrent infections. These infections can provide us with clues regarding what pathways might be aberrant in a given patient, e.g., specific pyogenic bacteria with Toll-like receptor problems, atypical mycobacteria with interferon gamma receptor auto...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2014.35.3776

    authors: Kennedy JL,Schroeder N,Palacios T,Rosen LB,Martinez B,Browne S,Borish L

    更新日期:2014-09-01 00:00:00

  • Are primary care physicians following National Institute of Allergy and Infectious Disease guidelines for the prevention of peanut allergy? A survey-based study.

    abstract::Background: The 2017 addendum to the National Institute of Allergy and Infectious Diseases (NIAID) guidelines on peanut allergy prevention significantly altered recommendations for patients at risk of developing peanut allergies. It is unknown if primary care physicians are aware of or are following these guidelines. ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2020.41.200019

    authors: Alvarez A,Gupta M,Poowuttikul P,Baptist AP

    更新日期:2020-05-01 00:00:00

  • Novel cytokines and cytokine-producing T cells in allergic disorders.

    abstract::Allergic diseases reflect various pathways of T lymphocyte inflammation and largely comprise T helper (Th) 2-associated processes. Recent investigations have identified pathways involved in promoting Th2 responses. Additionally, novel T-cell subtypes, each with its own distinct cytokine profile, contribute to the hete...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2011.32.3428

    authors: Wisniewski JA,Borish L

    更新日期:2011-03-01 00:00:00

  • An overview of allergens.

    abstract::Most allergens are proteins or glycoproteins that range in molecular weight from 5000 to 100,000 Da, although polysaccharides and low-molecular-weight substances may also be allergenic. Common allergens include pollens, fungal spores, house-dust mites, and animal epithelial materials but can also include drugs, biolog...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2019.40.4247

    authors: Lei DK,Grammer LC

    更新日期:2019-11-01 00:00:00

  • Mast cells in allergy and host defense.

    abstract::Mast cells have been implicated in the pathogenesis of allergic diseases and in inflammatory responses associated with pathological immune and disease-related processes including fibrosis, autoimmune pathology, and neoplasia. Recent findings in animal models of bacterial infection also suggest that mast cells may have...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/108854101778148764

    authors: Taylor ML,Metcalfe DD

    更新日期:2001-05-01 00:00:00

  • The burden of hospitalizations and emergency department visits with hereditary angioedema and angioedema in the United States, 2007.

    abstract::Hereditary angioedema (HAE) is a rare inherited disorder of complement factor C1 inhibitor. HAE is frequently confused with angioedema (AE), and little is known about emergency department (ED) or hospital utilization by patients with attacks in the United States. We examined hospitalizations and ED utilization for HAE...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2010.31.3403

    authors: Zilberberg MD,Jacobsen T,Tillotson G

    更新日期:2010-11-01 00:00:00

  • Airway hyperreactivity: managing outcomes and new directions.

    abstract::Bronchial hyperreactivity is defined as an increased sensitivity to bronchoconstrictor stimuli. It is regarded as the physiological hallmark of bronchial asthma. It is usually associated with a positive family history of asthma, atopy, and evaluated total serum immunoglobulin E. Its prevalence in the normal population...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:

    authors: Bardana EJ Jr

    更新日期:2002-11-01 00:00:00

  • Clinical efficacy, mechanisms of action, and adverse effects of complementary and alternative medicine therapies for asthma.

    abstract::Complementary and Alternative Medicine (CAM) therapies such as herbal therapy, acupuncture, yoga, homeopathy, chiropractic medicine, and massage therapy, continue to gain popularity as modalities for the treatment of asthma. In the Chinese, Japanese, Korean, Indian, and Western cultures, herbal therapies appear to be ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:

    authors: Bielory L,Russin J,Zuckerman GB

    更新日期:2004-09-01 00:00:00

  • The role of montelukast on perennial allergic rhinitis and associated sleep disturbances and daytime somnolence.

    abstract::Perennial allergic rhinitis (PAR) often causes sleep disturbances and associated daytime somnolence, thus resulting in a poor quality of life. Various clinical interventions in patients suffering from the disorder seek to improve symptoms and quality of life. Additional studies are needed to establish whether the alle...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2008.29.3097

    authors: Santos CB,Hanks C,McCann J,Lehman EB,Pratt E,Craig TJ

    更新日期:2008-03-01 00:00:00