Albuterol multidose dry powder inhaler and albuterol hydrofluoroalkane versus placebo in children with persistent asthma.


BACKGROUND:Many children struggle with albuterol hydrofluoroalkane (HFA) inhalers. Albuterol multidose dry powder inhaler (MDPI) may simplify rescue bronchodilator use in children. OBJECTIVE:To demonstrate the comparability of albuterol MDPI and albuterol HFA in children with asthma. METHODS:This phase II, multicenter, double-blind, double-dummy, single-dose, five-period, crossover study randomized patients (ages 4-11 years) with persistent asthma and prestudy forced expiratory volume in 1 second (FEV1) of 60-90% of predicted to 1 of 10 treatment sequences that contained albuterol MDPI (90 and 180 μg), albuterol HFA (90 and 180 μg), and placebo MDPI and placebo HFA. Efficacy was evaluated by measuring the area under the baseline-adjusted percent-predicted FEV1-time curve over 6 hours (PPFEV1 AUC0-6) after dosing. Safety was evaluated by adverse events. RESULTS:The full analysis set included 61 patients. Albuterol MDPI and albuterol HFA significantly improved PPFEV1 AUC0-6 versus placebo (p ≤ 0.0107). Mean improvement (± standard error [SE]) in PPFEV1 AUC0-6 versus placebo with albuterol MDPI at 90 and 180 μg was similar (21.2 ± 4.87 [95% confidence interval {CI}, 11.60-30.81], and 22.6 ± 4.87 [95% CI, 13.00-32.20], %·hour, respectively). Mean improvement (± SE) with albuterol HFA 180 μg was significantly (p = 0.0226) greater versus albuterol HFA 90 μg (23.7 ± 4.85 [95% CI, 14.13-33.23], and 12.5 ± 4.85 [95% CI, 2.93-22.05], %·hour, respectively). All doses of albuterol were well tolerated. CONCLUSION:Albuterol MDPI 90 and 180 μg and albuterol HFA 180 μg provided similar and significant FEV1 improvements versus placebo; albuterol HFA 90 μg was significant versus placebo but seemed less effective based on absolute improvements in FEV1. identifier: NCT01899144.


Allergy Asthma Proc


Qaqundah PY,Taveras H,Iverson H,Shore P




Has Abstract


2016-09-01 00:00:00












  • The emotional needs of allergic and asthmatic patients and their families.

    abstract::This article describes the emotional needs of allergic and asthmatic patients and their families that must addressed if optimal management and well-being is to be achieved. Health care professionals need to recognize the psychosocial issues of patients and parents, which include the effect of stressors, illness percep...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Wallerstedt DB,Bellanti JA

    更新日期:1998-07-01 00:00:00

  • Delayed food-dependent, exercise-induced anaphylaxis.

    abstract::Food-dependent, exercise-induced anaphylaxis (FDEIA) is a clinically distinct form of anaphylaxis in which symptoms occur only when the patient exercises within a few hours of eating the food. Its precise mechanism remains unclear and has been reported to have a wide spectrum of presentations. The objective of this re...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Oyefara BI,Bahna SL

    更新日期:2007-01-01 00:00:00

  • Pharmaceutical care for asthma patients: a community pharmacy-based pilot project.

    abstract::Asthma is a clinical problem with social, psychological, and economic burdens. To improve patient disease management and quality of life (QOL), different education programs have been developed. The purpose of this study is to adapt and implement a community-based educational program for patients with asthma. A prospec...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,随机对照试验


    authors: Petkova VB

    更新日期:2008-01-01 00:00:00

  • Are fish oil supplements safe in finned fish-allergic patients?

    abstract::Fish oil supplements are popular alternative medicines. Many manufacturers label their products with the warning "avoid this product if you are allergic to fish." The objective of this study was to determine if finned fish (FF)-allergic patients could safely tolerate fish oil supplements. Six FF-sensitive subjects as ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Mark BJ,Beaty AD,Slavin RG

    更新日期:2008-09-01 00:00:00

  • Oral allergy syndrome (pollen-food allergy syndrome).

    abstract::A case of Oral Allergy syndrome or Pollen-Food Allergy Syndrome is briefly discussed. The clinical characteristics, diagnosis, pathogenesis, and management of this syndrome are discussed followed by clinical pearls and pitfalls for the practicing allergist. Symptoms generally occur with the ingestion of raw fruits/veg...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Purohit-Sheth TS,Carr WW

    更新日期:2005-05-01 00:00:00

  • Nasal lavage cytometry in the diagnosis of nonallergic rhinitis with eosinophilia syndrome (NARES).

    abstract::The nonallergic rhinitis with eosinophilia syndrome (NARES) is a type of chronic rhinitis, characterized by intense (> 20%) eosinophilia of the nasal secretions. In this study, screening for NARES in 81 patients with nonallergic chronic rhinitis was performed using a modified nasal lavage cytometric method. Twenty-one...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Schiavino D,Nucera E,Milani A,Della Corte AM,D'Ambrosio C,Pagliari G,Patriarca G

    更新日期:1997-11-01 00:00:00

  • Potentially (near) fatal asthma.

    abstract::Potentially (near) fatal asthma (PFA) defines a subset of patients with asthma who are at increased risk for death from their disease. The diagnosis of PFA should motivate treating physicians, health professionals, and patients to be more aggressive in the monitoring, treatment, and control of this high-risk type of a...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Greenberger PA

    更新日期:2019-11-01 00:00:00

  • Physician prescribing practices: the role of patient preference in the selection of nasal steroids.

    abstract::A telephone survey of 100 primary care physicians was performed to assess the awareness of the influence patient preference, patient satisfaction, and other factors have on the selection of nasal steroids for the treatment of allergic rhinitis. Results indicated that physicians believe drug efficacy is the primary rea...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Kaliner MA

    更新日期:2001-11-01 00:00:00

  • Reducing asthma attacks in patients with severe asthma: The role of bronchial thermoplasty.

    abstract::Asthma remains one of the most common diseases worldwide and results in significant societal health care costs and in morbidity and mortality to those afflicted. Despite currently available medications, 5-10% of patients with asthma have severe disease with debilitating symptoms and/or life-threatening exacerbations. ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审


    authors: Dunn R,Wechsler ME

    更新日期:2015-07-01 00:00:00

  • Solar urticaria.

    abstract::A case of solar urticaria is presented, followed by a discussion of the clinical characteristics, pathophysiology, diagnosis, and management of this disease. Special emphasis is given to clinical pearls and pitfalls for the practicing allergist. Solar urticaria is a physical urticaria that can be difficult to diagnose...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Webb LM,Mikita CP

    更新日期:2009-09-01 00:00:00

  • Asthma in the female: hormonal effect and pregnancy.

    abstract::Data support an increase in adverse outcomes in the pregnant woman with asthma, particularly those who are poorly controlled. Additionally, pregnancy is recognized to influence the course of asthma. Hormonal and physiologic changes are felt to direct the eventual course and outcome, but their roles are incompletely un...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审


    authors: Beck SA

    更新日期:2001-01-01 00:00:00

  • Quality of life in respiratory allergy.

    abstract::The HRQL (Health Related Quality of Life) is considered a relevant aspect of pharmacological treatment, since it evaluates the outcomes from the patient's viewpoint. This article reviews the currently available information about HRQL as an outcome measure in Respiratory Allergy. Pertinent abstracts and articles were c...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审


    authors: Baiardini I,Pasquali M,Giardini A,Majani G,Canonica GW

    更新日期:2001-05-01 00:00:00

  • Hygiene factors associated with childhood food allergy and asthma.

    abstract:BACKGROUND:Childhood food allergy and asthma rates are increasing. The hygiene hypothesis has been proposed as an explanation for the increased incidence of allergic disease. OBJECTIVE:To describe the association of childhood food allergy and asthma with hygiene factors, such as the number of siblings, antibiotic use,...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Gupta RS,Singh AM,Walkner M,Caruso D,Bryce PJ,Wang X,Pongracic JA,Smith BM

    更新日期:2016-11-01 00:00:00

  • The role of antioxidants and 25-hydroxyvitamin D during pregnancy in the development of allergic diseases in early school-age children - Polish Mother and Child Cohort Study.

    abstract::Purpose: Based on the available data, alterations of the antioxidant defense as well as the vitamin status in mothers may affect the prenatal process of lung and immune system development as a pathophysiological background of increased prevalence of allergic diseases. The primary aim of the current study was to assess...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Bobrowska-Korzeniowska M,Jerzyńska J,Polańska K,Gromadzińska J,Hanke W,Wasowicz W,Stelmach I

    更新日期:2020-01-01 00:00:00

  • The autoimmune nature of chronic urticaria.

    abstract::The association between chronic urticaria (CU) and autoimmune disease has been recognized for some time, especially with autoimmune thyroid disease. More recently, functional IgG autoantibodies against FcepsilonRIalpha and less commonly against IgE have been reported in a subset of patients with CU. These patients hav...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审


    authors: Boguniewicz M

    更新日期:2008-09-01 00:00:00

  • Treatment of allergic rhinitis: effects of allergic rhinitis and antihistamines on performance.

    abstract::Antihistamines are the most commonly used drugs for allergic rhinitis, and many antihistamines may cause subclinical side effects which are not noticeable by the patient. These include impaired driving performance, impaired work performance, reduced coordination, reduced motor skills, sleepiness and impaired informati...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Storms WW

    更新日期:1997-03-01 00:00:00

  • Atopy patch testing for foods: a review of the literature.

    abstract::The atopy patch test (APT) was first reported in 1895 by the German dermatologist, Jadassohn and was used for evaluation of contact dermatitis. The first documented epicutaneous application of aeroallergens was by Rostenberg and Sulzbergen in 1937. Although others including Mitchell and Platts-Mills, further described...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审


    authors: Edwards KP,Martinez BA

    更新日期:2014-11-01 00:00:00

  • Serum interleukin 17, interleukin 23, and interleukin 10 values in children with atopic eczema/dermatitis syndrome (AEDS): association with clinical severity and phenotype.

    abstract::To date cytokines profile in AEDS is poorly described in children. We evaluated the interleukin (IL)-17, IL-23, and IL-10 levels in atopic eczema/dermatitis syndrome (AEDS) children and healthy controls, in atopic AEDS (aAEDS) and nonatopic (naAEDS) subtypes and their relationship with disease severity. A total of 181...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Leonardi S,Cuppari C,Manti S,Filippelli M,Parisi GF,Borgia F,Briuglia S,Cannavò P,Salpietro A,Arrigo T,Salpietro C

    更新日期:2015-01-01 00:00:00

  • Are primary care physicians following National Institute of Allergy and Infectious Disease guidelines for the prevention of peanut allergy? A survey-based study.

    abstract::Background: The 2017 addendum to the National Institute of Allergy and Infectious Diseases (NIAID) guidelines on peanut allergy prevention significantly altered recommendations for patients at risk of developing peanut allergies. It is unknown if primary care physicians are aware of or are following these guidelines. ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Alvarez A,Gupta M,Poowuttikul P,Baptist AP

    更新日期:2020-05-01 00:00:00

  • Fever of unknown origin and isolated noncaseating granuloma of the marrow: could this be sarcoidosis?

    abstract::Fever of unknown origin (FUO) is both a clinical and a diagnostic challenge. Furthermore, an FUO case with isolated marrow noncaseating granuloma can further confound diagnosis. However, these two findings together may help narrow down the pathological possibilities. This article presents a case report of FUO and lymp...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审


    authors: Miller AC,Chacko T,Rashid RM,Ledford DK

    更新日期:2007-03-01 00:00:00

  • The role of nonsedating antihistamines in asthma therapy.

    abstract::There is well-established evidence that histamine plays a significant role as a chemical mediator in asthma. However, although antihistamines are commonly used for the treatment of allergic rhinitis, their use in asthma has been somewhat controversial. Mechanistically, their application for asthma appears logical. In ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审


    authors: Zitt MJ

    更新日期:2003-07-01 00:00:00

  • Purified natural rubber latex antigens show variable reactivity with IgE in the sera of latex allergic patients.

    abstract::Immediate-hypersensitivity reactions related to latex products have increased rapidly in recent years. However, a reliable diagnosis is hampered by lack of purified and well characterized latex allergens. We have purified allergens in natural rubber latex (NRL) after SDS-PAGE by electroelution, and tested specific IgE...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Lu L,Kurup VP,Kelly KJ,Fink JN

    更新日期:1996-07-01 00:00:00

  • Airway hyperreactivity: managing outcomes and new directions.

    abstract::Bronchial hyperreactivity is defined as an increased sensitivity to bronchoconstrictor stimuli. It is regarded as the physiological hallmark of bronchial asthma. It is usually associated with a positive family history of asthma, atopy, and evaluated total serum immunoglobulin E. Its prevalence in the normal population...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审


    authors: Bardana EJ Jr

    更新日期:2002-11-01 00:00:00

  • The tale of the allergist's life: a series of interesting case reports.

    abstract::The practicing allergist has the unique opportunity to see an extraordinary variety of fascinating patients. Identifying the precise cause of the patient's complaints makes for a satisfying intellectual endeavor. This is exemplified by the description of nine cases seen in a university allergy clinic. The cases includ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Slavin RG

    更新日期:2008-07-01 00:00:00

  • Hypodense eosinophils: characterization of surface molecule expression.

    abstract::Distinct eosinophil populations have been characterized on the basis of discontinuous Percoll density gradients. In peripheral blood, normal individuals show a low number of normodense and hypodense eosinophils, contrasting with the high amount of hypodense cells in patients who have allergies. To characterize these t...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Conesa A,Tassinari P,Rivera H,De Sanctis JB,Bianco N,Aldrey O

    更新日期:2002-03-01 00:00:00

  • Flunisolide hydrofluoroalkane with integrated spacer for treating asthma: an updated review.

    abstract::Flunisolide hydrofluoroalkane (HFA) with integrated spacer is the most recent reformulated inhaled corticosteroid (ICS) for asthma available in the United States. It is the only product that combines a corticosteroid extrafine aerosol with a built-in spacer. The potential clinical benefit of the flunisolide HFA formul...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审


    authors: Berger WE,Tashkin DP

    更新日期:2015-03-01 00:00:00

  • Increased expression of CD30 and CD57 molecules on CD4(+) T cells from children with atopic asthma: a preliminary report.

    abstract::T helper type 2 (Th2) cells play an important role in the onset and persistence of allergic airway inflammation. Consequently, many authors have attempted to identify cell surface markers associated with a Th2 phenotype. This work was aimed at correlating CD30 and CD57 expression on CD4(+) T cells with interleukin (IL...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Rojas-Ramos E,Garfias Y,Jiménez-Martínez Mdel C,Martínez-Jiménez N,Zenteno E,Gorocica P,Lascurain R

    更新日期:2007-11-01 00:00:00

  • Successful treatment of coronavirus disease 2019 in a patient with asthma.

    abstract::Underlying lung disease, especially asthma, has recently been found to be associated with a higher risk of hospitalization with coronavirus disease 2019 (COVID-19) infection. Inhaled corticosteroids (ICS) are the most commonly used controller medications in patients with asthma. It is unclear whether ICS use increases...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Joshi AY,Mullakary RM,Iyer VN

    更新日期:2020-07-01 00:00:00

  • Immunobiologic treatments for severe asthma, atopic dermatitis, and chronic urticaria.

    abstract::Immunobiologic agents are an important therapeutic alternative for severe asthma, atopic dermatitis, and chronic urticaria. In this article, we reviewed the most relevant studies that addressed the use of anti-immunoglobulin E (omalizumab), anti-IL-5 (mepolizumab, reslizumab, and benralizumab), and anti-IL-4/IL-13 (du...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审


    authors: Chiarella SE

    更新日期:2019-11-01 00:00:00

  • Nasal reactivity evaluation in children with allergic rhinitis receiving grass pollen sublingual immunotherapy.

    abstract::Background: The European Academy of Allergy and Clinical Immunology guidelines, strongly recommended allergen immunotherapy (AIT) as an effective treatment to achieve long-term clinical benefits and to modify the natural history of allergic diseases. Sublingual immunotherapy (SLIT) offers the possibility of home admin...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Schiavi L,Brindisi G,De Castro G,De Vittori V,Loffredo L,Spalice A,Duse M,Zicari AM

    更新日期:2020-09-01 00:00:00