Abstract:
:Rhinitis symptom complex consists of rhinorrhea, congestion, itchy mucosa, itchy eyes, and sneezing. Available medications vary in their benefit for each of these symptoms. It was the purpose of this article to compare symptom reduction with three different classes of medications. Montelukast, azelastine, and budesonide were compared to determine the effect on individual, as well as total, symptom scores using the Rhinitis Severity Score (RSS). All three medications were compared with placebo and showed efficacy in prior studies using Balaam's crossover design. The inclusion and exclusion criteria and all procedures were identical for all three studies. In analyzing the data from the RSS questionnaire, we used the procedure PROC MIXED in SAS specific for Balaam's crossover design (SAS Institute, Inc., Cary, NC). Although all three medications were effective compared with placebo, montelukast had the greatest effect of the three medications on reduction of ocular itching and throat and palate itching. Azelastine's effect was greater than budesonide and montelukast for reduction of rhinorrhea. Systemic medication, montelukast, as expected, provided better relief for symptoms distant from the nasal cavity, and the antihistamine, azelastine, reduced rhinorrhea, more than either montelukast or budesonide.
journal_name
Allergy Asthma Procjournal_title
Allergy and asthma proceedingsauthors
Sardana N,Santos C,Lehman E,Craig Tdoi
10.2500/aap.2010.31.3308subject
Has Abstractpub_date
2010-01-01 00:00:00pages
5-9issue
1eissn
1088-5412issn
1539-6304journal_volume
31pub_type
杂志文章,评审abstract::Background: Peanut allergy is a major health burden in the United States. Treatment is limited to avoidance and acute reaction management. No drug or medical product is approved for use as a peanut oral immunotherapy (POIT) agent. Objective: To examine peanut allergy diagnosis and treatment, peanut challenge protocols...
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
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journal_title:Allergy and asthma proceedings
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pub_type: 杂志文章
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pub_type: 指南,杂志文章,实务指引,评审
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更新日期:2003-03-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章
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