Immunomodulation in dermatology: lessons learned in the treatment of psoriasis.

Abstract:

:With the widespread recognition that T-cells are the key mediators of psoriasis, current treatment strategies have focused on reducing the population of these cells or modulating their activity through the use of immunosuppressive treatments such as methotrexate, cyclosporine, and psoralens plus ultraviolet A radiation. Now, a greater understanding of the immunologic basis of psoriasis based on scientific advances are enabling the development of rationally designed, biologic agents that selectively target specific elements in the immune system that are directly involved in the pathophysiology of psoriasis. This review discusses several basic strategies for biologic therapies for psoriasis and concludes that the allergist/immunologist is eminently qualified to treat this immune skin disorder.

journal_name

Allergy Asthma Proc

authors

Charlesworth EN

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

123-5

issue

2

eissn

1088-5412

issn

1539-6304

journal_volume

27

pub_type

杂志文章,评审
  • Effect of desloratadine on the control of morning symptoms in patients with seasonal and perennial allergic rhinitis.

    abstract::The symptoms of allergic rhinitis vary in severity over the course of the day and often are worse in the morning. This review focuses on data from clinical studies of the antihistamine desloratadine to establish whether it effectively controls the morning symptoms of allergic rhinitis. Studies of desloratadine in pati...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2006.27.2936

    authors: Schenkel EJ

    更新日期:2006-11-01 00:00:00

  • Clinical benefits of aspirin desensitization in patients with nonsteroidal anti-inflammatory drug exacerbated respiratory disease are not related to urinary eicosanoid release and are accompanied with decreased urine creatinine.

    abstract:BACKGROUND:Treatment with acetylsalicylic acid (ASA) after desensitization may be a therapeutic option in patients with nonsteroidal anti-inflammatory drug exacerbated respiratory disease (NERD). The mechanisms that lead to improvement in rhinosinusitis and asthma symptoms remain unknown. AIM:To attribute the document...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2016.37.3935

    authors: Makowska JS,Olszewska-Ziąber A,Bieńkiewicz B,Lewandowska-Polak A,Kurowski M,Woźniakowski B,Rotkiewicz A,Kowalski ML

    更新日期:2016-05-01 00:00:00

  • Relation of indoor and outdoor airborne fungal spore levels in the Kansas City metropolitan area.

    abstract:BACKGROUND:Environmental control is an important component of asthma management for persons with asthma. A damp indoor environment and elevated airborne spore levels are factors in housing environmental control. OBJECTIVES:We investigated if indoor airborne fungal spore levels correlated with outdoor ground-level airb...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2017.38.4030

    authors: Jara D,Portnoy J,Dhar M,Barnes C

    更新日期:2017-03-01 00:00:00

  • Management of asthma in adults: do the patients get what they need--and want?

    abstract::Suboptimal asthma control may be caused by a combination of factors, such as nonadherence to guidelines, lack of compliance, and poor asthma education. The aim was to assess patients' knowledge of asthma and different management strategies, including patients' attitudes toward involvement in treatment decisions. The p...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2007.28.3001

    authors: Backer V,Ulrik CS,Harving H,Lange P,Søes-Petersen U,Plaschke PP

    更新日期:2007-05-01 00:00:00

  • Pharmaceutical care for asthma patients: a community pharmacy-based pilot project.

    abstract::Asthma is a clinical problem with social, psychological, and economic burdens. To improve patient disease management and quality of life (QOL), different education programs have been developed. The purpose of this study is to adapt and implement a community-based educational program for patients with asthma. A prospec...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,随机对照试验

    doi:10.2500/aap2008.29.3083

    authors: Petkova VB

    更新日期:2008-01-01 00:00:00

  • Atopic eczema and the allergist.

    abstract::Several decades ago, the skin was considered to be little more than a simple barrier to dehydration, environmental toxins, and extrinsic bacteria; however, we now recognize that the skin is a complex immune organ that is fully integrated with the immune functions of the bone marrow, lymph nodes, liver, and spleen. Lym...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/108854199778251933

    authors: Charlesworth EN

    更新日期:1999-09-01 00:00:00

  • Association of maternal depression and allergic diseases in Korean children.

    abstract:PURPOSE:An association between childhood allergic disease and parental psychological disorders has been reported. However, little is known about the relationship between childhood allergic disease and maternal depression. This study was performed to determine if there is an association between childhood allergic diseas...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2017.38.4059

    authors: Kim CH,Kim SH,Lee JS

    更新日期:2017-07-01 00:00:00

  • Emergency department treatment of adults with acute asthma exacerbations: effect on exhaled nitric oxide levels.

    abstract::Measurement of exhaled nitric oxide levels (eNO) from asthmatic patients is a noninvasive marker of airway inflammation in both adults and children and has been used as an outpatient measure of asthma control. We examined eNO in acute asthma exacerbations and how it is affected by treatment in the emergency departmen...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,随机对照试验

    doi:10.2500/aap.2012.33.3613

    authors: Silverberg JI,Rodenas M,Sinert R,Joks R

    更新日期:2012-11-01 00:00:00

  • A 64-year-old man with chronic obstructive pulmonary disease and an atypical rash.

    abstract::A 64-year-old male patient with a 15-year history of chronic obstructive pulmonary disease presented with an atypical rash that was refractory to standard therapy. Pulmonary function tests confirmed an obstructive lung disease. Basic laboratory workup revealed conflicting information, leading to a diagnostic challenge...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2011.32.3430

    authors: Craig ET,Banta E,Craig TJ

    更新日期:2011-07-01 00:00:00

  • Difficulties encountered in the emergency department by patients with hereditary angioedema experiencing acute attacks.

    abstract:BACKGROUND:Hereditary angioedema (HAE) is a rare, potentially life-threatening disease characterized by recurrent angioedema attacks. Abdominal symptoms of HAE typically mimic numerous abdominal emergencies, which may result in a delay of correct diagnosis and inappropriate treatments. OBJECTIVE:We aimed to evaluate t...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2016.37.3905

    authors: Ucar R,Arslan S,Baran M,Caliskaner AZ

    更新日期:2016-01-01 00:00:00

  • When asthma and rhinitis coexist, could rhinitis reduce asthma control in children?

    abstract:Background:Bronchial asthma and rhinitis are among the most common diseases in children and frequently coexist in the patient. The primary aim of anti-asthmatic therapy is disease control. Several questionnaires can be used in pediatrics to assess asthma control and the Children Asthma Control Test (C-ACT) is one of th...

    journal_title:Allergy and asthma proceedings

    pub_type: 信件

    doi:10.2500/aap.2019.40.4219

    authors: De Vittori V,Pacilio A,Indinnimeo L,Marazzato M,De Castro G,Brindisi G,Schiavi L,Tosca M,Duse M,Zicari AM

    更新日期:2019-05-01 00:00:00

  • Successful treatment of coronavirus disease 2019 in a patient with asthma.

    abstract::Underlying lung disease, especially asthma, has recently been found to be associated with a higher risk of hospitalization with coronavirus disease 2019 (COVID-19) infection. Inhaled corticosteroids (ICS) are the most commonly used controller medications in patients with asthma. It is unclear whether ICS use increases...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2020.41.200044

    authors: Joshi AY,Mullakary RM,Iyer VN

    更新日期:2020-07-01 00:00:00

  • ECP level in nasopharyngeal secretions and serum from children with respiratory virus infections and asthmatic children.

    abstract::Infection with respiratory virus has been shown to exacerbate asthma in humans. However, the role of a respiratory virus in the pathogenesis of chronic asthma and/or wheezing in young children has not been clearly defined. It has also been debated whether virus-induced wheezing in young children is one entity and alle...

    journal_title:Allergy and asthma proceedings

    pub_type: 临床试验,杂志文章

    doi:10.2500/108854100778250888

    authors: Oh JW,Lee HB,Yum MK,Kim CR,Kang JO,Park IK

    更新日期:2000-03-01 00:00:00

  • Are fish oil supplements safe in finned fish-allergic patients?

    abstract::Fish oil supplements are popular alternative medicines. Many manufacturers label their products with the warning "avoid this product if you are allergic to fish." The objective of this study was to determine if finned fish (FF)-allergic patients could safely tolerate fish oil supplements. Six FF-sensitive subjects as ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2008.29.3159

    authors: Mark BJ,Beaty AD,Slavin RG

    更新日期:2008-09-01 00:00:00

  • Human factors study of a newly approved prefilled syringe of epinephrine for the treatment of anaphylaxis.

    abstract:BACKGROUND:Epinephrine remains the treatment of choice for acute anaphylaxis. However, currently available autoinjectors are costly, and studies have demonstrated human factor issues that result in incorrect use as well as device failures. OBJECTIVE:A recent U.S. Food and Drug Administration approved prefilled syringe...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2018.39.4154

    authors: Moss RB,Moll T,Daniels K,Carlo DJ

    更新日期:2018-09-01 00:00:00

  • A late preterm infant with lymphopenia.

    abstract::The newborn screen for severe combined immunodeficiency (SCID) uses real-time quantitative polymerase chain reaction for T-cell receptor excision circles and is highly sensitive for SCID. However, T-cell lymphopenia from other primary and secondary causes, such as DiGeorge syndrome, prematurity, thymic involution from...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2019.40.190015

    authors: Lutfeali S,Khan DA,Wysocki C

    更新日期:2020-03-01 00:00:00

  • Differences in cytokine levels between the nasal polyps of adolescents with local allergic and adolescents with allergic or nonallergic rhinitis.

    abstract:BACKGROUND:Local allergic rhinitis (LAR) is rhinitis with a localized nasal allergic response in the absence of systemic allergy. This study aimed to evaluate the pathogenesis specific to LAR compared with allergic rhinitis (AR) and nonallergic rhinitis (NAR) by using cytokines from polypous tissues. METHODS:We recrui...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2018.39.4135

    authors: Choi YJ,Kang HN,Kim JH,Oh JW,Jeong JH

    更新日期:2018-07-01 00:00:00

  • Bronchodilator effect of single-dose formoterol administered by pressurized metered-dose inhaler in children with asthma aged 6 to

    abstract::Dose-response of formoterol via pressurized metered-dose inhaler (pMDI) has not been determined in asthmatic pediatric patients aged 6 to <12 years. This study was designed to assess the bronchodilating dose-response of three formoterol pMDI doses in children with stable asthma aged 6 to <12 years receiving twice-dail...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2500/aap.2014.35.3746

    authors: Berger WE,Gillen M,Eckerwall G,Uryniak T,Trudo FJ,Lampl KL

    更新日期:2014-03-01 00:00:00

  • Monitoring of peanut-allergic patients with peanut-specific IgE.

    abstract::Peanut allergy affects approximately 1% of the population. Double-blind placebo-controlled food challenges are gold standard for diagnosis. Serum peanut-specific IgE (PN-IgE) is used in clinical practice as an additional diagnostic and monitoring tool. The purpose of this study was to characterize the clinical feature...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2008.29.3117

    authors: Borici-Mazi R,Mazza JA,Moote DW,Payton KB

    更新日期:2008-05-01 00:00:00

  • Chronic urticaria as a presenting sign of hairy cell leukemia.

    abstract::Chronic urticaria is a common clinical disorder that is idiopathic in over 75% of cases. Less commonly, urticaria may be the presenting manifestation of an allergic or infectious disease, endocrinopathy, inherited syndrome, or autoimmune disorder. Rarely, urticaria may be a sign of underlying malignancy, including leu...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/108854199778681530

    authors: Clore LS Jr,Stafford CT

    更新日期:1999-01-01 00:00:00

  • IgE values and T-lymphocyte subsets in children with atopic eczema/dermatitis syndrome.

    abstract::High levels of IgE and IgE-mediated reactions represent a typical finding in patients with atopic eczema/dermatitis syndrome (AEDS). However, 10-30% of patients usually do not show any increase of total blood IgE levels and any detectable specific IgE sensitization. We performed this study to evaluate the difference o...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap2007.28.3038

    authors: Leonardi S,Rotolo N,Vitaliti G,Spicuzza L,La Rosa M

    更新日期:2007-09-01 00:00:00

  • Leukotriene C4 synthase: a candidate gene for the aspirin-intolerant asthmatic phenotype.

    abstract::The features of the allergic inflammation underlying asthma occur as a consequence of mediators such as the cysteinyl LTs. The generation of the cysteinyl LTs is carefully regulated and dependent on the 5-LO/LTC4S pathway, of which LTC4S is the pivotal and only committed enzyme involved. Although LTC4S is related to o...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/108854199778251825

    authors: Penrose JF,Baldasaro MH

    更新日期:1999-11-01 00:00:00

  • Fifty-five-year-old man with chronic yeast infections.

    abstract::As immunologists, we are frequently asked to evaluate patients with recurrent infections. These infections can provide us with clues regarding what pathways might be aberrant in a given patient, e.g., specific pyogenic bacteria with Toll-like receptor problems, atypical mycobacteria with interferon gamma receptor auto...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2014.35.3776

    authors: Kennedy JL,Schroeder N,Palacios T,Rosen LB,Martinez B,Browne S,Borish L

    更新日期:2014-09-01 00:00:00

  • Inflammatory mediators in cystic fibrosis lung disease.

    abstract::Cystic fibrosis (CF) is a complex multisystem disorder caused by mutations in a membrane glycoprotein called the CF transmembrane regulator (CFTR), which has as its major function serving as a Cl- channel. The relationship between defects in CFTR and development of lung disease remains incompletely understood. Chronic...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:

    authors: Berger M

    更新日期:2002-01-01 00:00:00

  • Aeroallergen sensitization in asthma: genetics, environment, and pathophysiology.

    abstract::A complex interplay of genetic predisposition and environmental influences results in the clinical picture of allergic asthma. This article addresses recently identified genetic markers and environmental factors that contribute to disease development in asthma. Focus is placed on aspects of the innate immune system, i...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2010.31.3328

    authors: Long A

    更新日期:2010-03-01 00:00:00

  • Airway hyperreactivity: managing outcomes and new directions.

    abstract::Bronchial hyperreactivity is defined as an increased sensitivity to bronchoconstrictor stimuli. It is regarded as the physiological hallmark of bronchial asthma. It is usually associated with a positive family history of asthma, atopy, and evaluated total serum immunoglobulin E. Its prevalence in the normal population...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:

    authors: Bardana EJ Jr

    更新日期:2002-11-01 00:00:00

  • Tacrolimus ointment in nickel sulphate-induced steroid-resistant allergic contact dermatitis.

    abstract::Tacrolimus ointment is a topical immunomodulator. Currently, there is available evidence regarding the potential use of topical tacrolimus in a range of dermatological disorders. The aim of this study was to evaluate the efficacy and safety of tacrolimus ointment 0.1% for the nickel sulfate-induced steroid-resistant a...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,随机对照试验

    doi:10.2500/aap.2006.27.2915

    authors: Pacor ML,Di Lorenzo G,Martinelli N,Mansueto P,Friso S,Pellitteri ME,Di Fede G,Rini G,Corrocher R

    更新日期:2006-11-01 00:00:00

  • Allergy immunotherapy for inhalant allergens: Strategies to improve efficacy.

    abstract::Background: Allergy immunotherapy (AIT), both subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT), is an effective and safe treatment for allergic rhinitis and allergic asthma due to inhalant allergens. However, there are many variables in how it is administered. Objective: To review the evidence tha...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2020.41.190013

    authors: Nelson HS

    更新日期:2020-01-01 00:00:00

  • Fever of unknown origin and isolated noncaseating granuloma of the marrow: could this be sarcoidosis?

    abstract::Fever of unknown origin (FUO) is both a clinical and a diagnostic challenge. Furthermore, an FUO case with isolated marrow noncaseating granuloma can further confound diagnosis. However, these two findings together may help narrow down the pathological possibilities. This article presents a case report of FUO and lymp...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2007.28.2982

    authors: Miller AC,Chacko T,Rashid RM,Ledford DK

    更新日期:2007-03-01 00:00:00

  • Defining the effects of an inhaled corticosteroid and long-acting beta-agonist on therapeutic targets.

    abstract::The effects of inhaled corticosteroids (ICSs) and long-acting beta 2-agonists (LABAs) on therapeutic targets have significant clinical relevance regarding optimal management of asthma. Asthma pathophysiology involves two main components: smooth muscle dysfunction and airway inflammation. LABAs and ICSs provide complem...

    journal_title:Allergy and asthma proceedings

    pub_type: 指南,杂志文章,实务指引,评审

    doi:

    authors: Settipane RA,National Asthma Education and Prevention Program (NAEPP).

    更新日期:2003-03-01 00:00:00