Immunomodulation in dermatology: lessons learned in the treatment of psoriasis.


:With the widespread recognition that T-cells are the key mediators of psoriasis, current treatment strategies have focused on reducing the population of these cells or modulating their activity through the use of immunosuppressive treatments such as methotrexate, cyclosporine, and psoralens plus ultraviolet A radiation. Now, a greater understanding of the immunologic basis of psoriasis based on scientific advances are enabling the development of rationally designed, biologic agents that selectively target specific elements in the immune system that are directly involved in the pathophysiology of psoriasis. This review discusses several basic strategies for biologic therapies for psoriasis and concludes that the allergist/immunologist is eminently qualified to treat this immune skin disorder.


Allergy Asthma Proc


Charlesworth EN


Has Abstract


2006-03-01 00:00:00












  • Reliability of skin test results when read at different time points.

    abstract::Percutaneous skin testing to determine allergies is usually read 15-20 minutes after placement, but the time to reading may be prolonged because of clinic duties or emergencies. The objective of the study was to compare skin-prick testing (SPT) wheal and flare reactions at 10, 30, and 40 minutes with the standard 20 m...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Seibert SM,King TS,Kline D,Mende C,Craig T

    更新日期:2011-05-01 00:00:00

  • IgE values and T-lymphocyte subsets in children with atopic eczema/dermatitis syndrome.

    abstract::High levels of IgE and IgE-mediated reactions represent a typical finding in patients with atopic eczema/dermatitis syndrome (AEDS). However, 10-30% of patients usually do not show any increase of total blood IgE levels and any detectable specific IgE sensitization. We performed this study to evaluate the difference o...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Leonardi S,Rotolo N,Vitaliti G,Spicuzza L,La Rosa M

    更新日期:2007-09-01 00:00:00

  • In vitro induction of T regulatory cells by a methylated CpG DNA sequence in humans: Potential therapeutic applications in allergic and autoimmune diseases.

    abstract:BACKGROUND:Allergic and autoimmune diseases comprise a group of inflammatory disorders caused by aberrant immune responses in which CD25+ Forkhead box P3-positive (FOXP3+) T regulatory (Treg) cells that normally suppress inflammatory events are often poorly functioning. This has stimulated an intensive investigative ef...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Lawless OJ,Bellanti JA,Brown ML,Sandberg K,Umans JG,Zhou L,Chen W,Wang J,Wang K,Zheng SG

    更新日期:2018-03-01 00:00:00

  • Clinical efficacy, mechanisms of action, and adverse effects of complementary and alternative medicine therapies for asthma.

    abstract::Complementary and Alternative Medicine (CAM) therapies such as herbal therapy, acupuncture, yoga, homeopathy, chiropractic medicine, and massage therapy, continue to gain popularity as modalities for the treatment of asthma. In the Chinese, Japanese, Korean, Indian, and Western cultures, herbal therapies appear to be ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审


    authors: Bielory L,Russin J,Zuckerman GB

    更新日期:2004-09-01 00:00:00

  • Comparative efficacy of cetirizine and fexofenadine for seasonal allergic rhinitis, 5-12 hours postdose, in the environmental exposure unit.

    abstract::In a previous study, cetirizine and fexofenadine similarly relieved seasonal allergic rhinitis symptoms in the first 5 hours, but cetirizine was more effective at 21-24 hours postdose. This randomized, double-blind, placebo-controlled study compared the response to treatment between 5 and 12 hours. Eligible ragweed al...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,随机对照试验


    authors: Day JH,Briscoe MP,Rafeiro E,Ratz JD,Ellis AK,Frankish CW,Chapman D,deGuia EC,Kramer B,Warner C

    更新日期:2005-07-01 00:00:00

  • Efficacy and safety of once-daily treatment with beclomethasone dipropionate nasal aerosol in subjects with seasonal allergic rhinitis.

    abstract::An aerosol formulation may be preferred by some allergic rhinitis (AR) patients, to avoid the "wet feeling" and nasal runoff associated with aqueous nasal corticosteroid sprays. Beclomethasone dipropionate (BDP) hydrofluoroalkane nasal aerosol is a recently developed, nonaqueous, nonchlorofluorocarbon formulation of ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,随机对照试验


    authors: van Bavel JH,Ratner PH,Amar NJ,Hampel FC Jr,Melchior A,Dunbar SA,Dorinsky PM,Tantry SK

    更新日期:2012-09-01 00:00:00

  • Device mechanics and evaluation of inspiratory flow rate required of the beclomethasone dipropionate breath-actuated inhaler.

    abstract::Background: Approximately 80% of patients with asthma and chronic obstructive pulmonary disease incorrectly use a metered-dose inhaler and, therefore, fail to obtain full benefit from their inhaler medication. Beclomethasone dipropionate (BDP) hydrofluoroalkane, an inhalation aerosol administered via a breath-actuated...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Mansfield LE,Hampel FC,Sfeir B,Small CJ,Walsh D,Dunphy L

    更新日期:2019-05-01 00:00:00

  • Differences in cytokine levels between the nasal polyps of adolescents with local allergic and adolescents with allergic or nonallergic rhinitis.

    abstract:BACKGROUND:Local allergic rhinitis (LAR) is rhinitis with a localized nasal allergic response in the absence of systemic allergy. This study aimed to evaluate the pathogenesis specific to LAR compared with allergic rhinitis (AR) and nonallergic rhinitis (NAR) by using cytokines from polypous tissues. METHODS:We recrui...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Choi YJ,Kang HN,Kim JH,Oh JW,Jeong JH

    更新日期:2018-07-01 00:00:00

  • Hygiene factors associated with childhood food allergy and asthma.

    abstract:BACKGROUND:Childhood food allergy and asthma rates are increasing. The hygiene hypothesis has been proposed as an explanation for the increased incidence of allergic disease. OBJECTIVE:To describe the association of childhood food allergy and asthma with hygiene factors, such as the number of siblings, antibiotic use,...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Gupta RS,Singh AM,Walkner M,Caruso D,Bryce PJ,Wang X,Pongracic JA,Smith BM

    更新日期:2016-11-01 00:00:00

  • Treatment of allergic rhinitis: effects of allergic rhinitis and antihistamines on performance.

    abstract::Antihistamines are the most commonly used drugs for allergic rhinitis, and many antihistamines may cause subclinical side effects which are not noticeable by the patient. These include impaired driving performance, impaired work performance, reduced coordination, reduced motor skills, sleepiness and impaired informati...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Storms WW

    更新日期:1997-03-01 00:00:00

  • An overview of allergens.

    abstract::Most allergens are proteins or glycoproteins that range in molecular weight from 5000 to 100,000 Da, although polysaccharides and low-molecular-weight substances may also be allergenic. Common allergens include pollens, fungal spores, house-dust mites, and animal epithelial materials but can also include drugs, biolog...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审


    authors: Lei DK,Grammer LC

    更新日期:2019-11-01 00:00:00

  • Current management and use of oral immunotherapy in the United States for patients with peanut allergy.

    abstract::Background: Peanut allergy is a major health burden in the United States. Treatment is limited to avoidance and acute reaction management. No drug or medical product is approved for use as a peanut oral immunotherapy (POIT) agent. Objective: To examine peanut allergy diagnosis and treatment, peanut challenge protocols...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Blaiss MS,Tilles S,Petroni D,Zigmont E,Cassese M,Kwak B,Georgitseas N,Liebermann J

    更新日期:2019-07-23 00:00:00

  • Solar urticaria.

    abstract::A case of solar urticaria is presented, followed by a discussion of the clinical characteristics, pathophysiology, diagnosis, and management of this disease. Special emphasis is given to clinical pearls and pitfalls for the practicing allergist. Solar urticaria is a physical urticaria that can be difficult to diagnose...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Webb LM,Mikita CP

    更新日期:2009-09-01 00:00:00

  • Oral allergy syndrome (pollen-food allergy syndrome).

    abstract::A case of Oral Allergy syndrome or Pollen-Food Allergy Syndrome is briefly discussed. The clinical characteristics, diagnosis, pathogenesis, and management of this syndrome are discussed followed by clinical pearls and pitfalls for the practicing allergist. Symptoms generally occur with the ingestion of raw fruits/veg...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Purohit-Sheth TS,Carr WW

    更新日期:2005-05-01 00:00:00

  • Long-term omalizumab outcomes in chronic idiopathic urticaria: a real-world study.

    abstract::Background: Although clinical trials documented omalizumab's efficacy in U.S. patients with chronic idiopathic urticaria (CIU), the real-world evidence on its long-term effectiveness is lacking. Objective: To assess omalizumab use and the long-term response in a large sample of U.S. real-world patients. Methods: Patie...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Kavati A,Zhdanava M,Ortiz B,LeCocq J,Schiffman B,Pilon D,Ching Cheung H,Lefebvre P,Stone BD

    更新日期:2019-09-01 00:00:00

  • New developments in inhaled corticosteroids.

    abstract::Inhaled corticosteroids (ICSs) are the foundation of pharmacotherapy in persistent asthma because they control airway inflammation. The anti-inflammatory effect of ICSs is primarily topical, at their site of deposition in the airways. Consequently, deposition characteristics of the ICS and its formulation and inhalati...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审


    authors: Colice GL

    更新日期:2006-09-01 00:00:00

  • Literature review: the best new articles in the specialty of allergy, asthma, and immunology, 2004-2005.

    abstract::A series of eight articles from the published literature for the period 2004-2005 was selected for review in this article. Small-airway obstruction in chronic obstructive pulmonary disease (COPD) and its management were the subjects of the first two articles reviewed in this commentary. Progression of COPD from the Gl...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审


    authors: Bellanti JA

    更新日期:2006-05-01 00:00:00

  • The association between hypovitaminosis D and pediatric allergic diseases: A Korean nationwide population-based study.

    abstract:BACKGROUND:There is still considerable disagreement regarding the role of vitamin D in the development or exacerbation of allergic diseases. OBJECTIVE:To investigate the association between serum vitamin D levels and recent symptoms of allergic diseases in elementary schoolchildren. METHODS:A nationwide cross-section...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Yang HK,Choi J,Kim WK,Lee SY,Park YM,Han MY,Kim HY,Hahm MI,Chae Y,Lee KJ,Kwon HJ,Ahn K,Kim J

    更新日期:2016-07-01 00:00:00

  • A cost-effective approach to the diagnosis and treatment of the wheezing infant.

    abstract::Wheezing in infancy presents the clinician with at least two broad clinical problems. First is the task of distinguishing the common entities of bronchiolitis and asthma from rare, yet potentially life threatening illnesses that may present with wheezing. The second problem deals with the difficulties in distinguishin...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审


    authors: Mamlok R

    更新日期:1997-05-01 00:00:00

  • Biphasic reactions in children undergoing oral food challenges.

    abstract::Literature regarding biphasic reactions in the pediatric population is sparse. We aimed to determine the prevalence of biphasic reactions in children with food allergies undergoing oral food challenges (OFCs) and examine whether any clinical or treatment factors are associated with biphasic reactions. A retrospective ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Lee J,Garrett JP,Brown-Whitehorn T,Spergel JM

    更新日期:2013-05-01 00:00:00

  • Immunobiologic treatments for severe asthma, atopic dermatitis, and chronic urticaria.

    abstract::Immunobiologic agents are an important therapeutic alternative for severe asthma, atopic dermatitis, and chronic urticaria. In this article, we reviewed the most relevant studies that addressed the use of anti-immunoglobulin E (omalizumab), anti-IL-5 (mepolizumab, reslizumab, and benralizumab), and anti-IL-4/IL-13 (du...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审


    authors: Chiarella SE

    更新日期:2019-11-01 00:00:00

  • The relationship between insect sting allergy treatment and patient anxiety and depression.

    abstract::Quality of life is affected by history of bee sting allergy. In addition, worry about being stung and also the need to use self-injection of medicine can create or increase anxiety, which can further compromise a patient's ability to enjoy the outdoors and participate in activities. We sought to determine the depressi...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Findeis S,Craig T

    更新日期:2014-05-01 00:00:00

  • A new protocol for specific oral tolerance induction in children with IgE-mediated cow's milk allergy.

    abstract::IgE-mediated cow's milk allergy (CMA) is a heavy burden for patients, particularly for children and their families. Allergen avoidance represents the only therapeutic option, but oral desensitization protocols have been suggested. Because of the long duration and complexity of these protocols we examined the feasibili...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,随机对照试验


    authors: Caminiti L,Passalacqua G,Barberi S,Vita D,Barberio G,De Luca R,Pajno GB

    更新日期:2009-07-01 00:00:00

  • Effect of the inhaled corticosteroid mometasone on small airway patency in patients with asthma.

    abstract::The inflammation in asthma involves both the large and the small airways. This study was designed to examine whether mometasone delivered from a dry powder inhaler would improve those parameters thought to reflect patency and obstruction of the small airways (diameter <2 mm). Subjects with mild to moderate asthma, onl...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,随机对照试验


    authors: Nelson HS,Gallegos CM,Silveira LJ,Newell JD,Gelfand EW

    更新日期:2009-05-01 00:00:00

  • Clinical presentation of hereditary angioedema.

    abstract::Hereditary angioedema (HAE) is a rare, autosomal dominant disease caused by a deficiency in the C1-inhibitor protein. It is characterized by recurrent episodes of nonpruritic, nonpitting, subcutaneous or submucosal edema that typically involves the extremities or the gastrointestinal tract. However, the genitourinary ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Azmy V,Brooks JP,Hsu FI

    更新日期:2020-11-01 00:00:00

  • The burden of hospitalizations and emergency department visits with hereditary angioedema and angioedema in the United States, 2007.

    abstract::Hereditary angioedema (HAE) is a rare inherited disorder of complement factor C1 inhibitor. HAE is frequently confused with angioedema (AE), and little is known about emergency department (ED) or hospital utilization by patients with attacks in the United States. We examined hospitalizations and ED utilization for HAE...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Zilberberg MD,Jacobsen T,Tillotson G

    更新日期:2010-11-01 00:00:00

  • Aeroallergen sensitization in asthma: genetics, environment, and pathophysiology.

    abstract::A complex interplay of genetic predisposition and environmental influences results in the clinical picture of allergic asthma. This article addresses recently identified genetic markers and environmental factors that contribute to disease development in asthma. Focus is placed on aspects of the innate immune system, i...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审


    authors: Long A

    更新日期:2010-03-01 00:00:00

  • Defining the effects of an inhaled corticosteroid and long-acting beta-agonist on therapeutic targets.

    abstract::The effects of inhaled corticosteroids (ICSs) and long-acting beta 2-agonists (LABAs) on therapeutic targets have significant clinical relevance regarding optimal management of asthma. Asthma pathophysiology involves two main components: smooth muscle dysfunction and airway inflammation. LABAs and ICSs provide complem...

    journal_title:Allergy and asthma proceedings

    pub_type: 指南,杂志文章,实务指引,评审


    authors: Settipane RA,National Asthma Education and Prevention Program (NAEPP).

    更新日期:2003-03-01 00:00:00

  • An integrated analysis of the efficacy of fluticasone furoate nasal spray on individual nasal and ocular symptoms of seasonal allergic rhinitis.

    abstract::Intranasal steroids have been shown to affect ocular symptoms of allergic rhinitis (AR). The results of the published literature, however, are not uniform across all products. This study was designed to evaluate whether the effects of fluticasone furoate nasal spray (FFNS) are consistent across different allergy seaso...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Maspero JF,Walters RD,Wu W,Philpot EE,Naclerio RM,Fokkens WJ

    更新日期:2010-11-01 00:00:00

  • Onset and duration of action of nasal sprays in seasonal allergic rhinitis patients: olopatadine hydrochloride versus mometasone furoate monohydrate.

    abstract::Rapid relief of symptoms should be one of the primary goals of treatment for allergic rhinitis (AR). The onset and duration of action of olopatadine hydrochloride nasal spray, 665 mcg (OLO; Patanese), for seasonal AR (SAR) was evaluated in this study. This study was performed to determine the onset and duration of act...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,随机对照试验


    authors: Patel D,Garadi R,Brubaker M,Conroy JP,Kaji Y,Crenshaw K,Whitling A,Wall GM

    更新日期:2007-09-01 00:00:00