Leukotriene C4 synthase: a candidate gene for the aspirin-intolerant asthmatic phenotype.

Abstract:

:The features of the allergic inflammation underlying asthma occur as a consequence of mediators such as the cysteinyl LTs. The generation of the cysteinyl LTs is carefully regulated and dependent on the 5-LO/LTC4S pathway, of which LTC4S is the pivotal and only committed enzyme involved. Although LTC4S is related to other proteins involved in eicosanoid metabolism, it is clearly a distinct member within a novel gene family, and site directed mutagenic studies of LTC4S have identified two critical residues necessary for its specific conjugation of LTA4 to GSH. This observation, as well as the limited cellular distribution, and chromosomal localization are consistent with LTC4S as a candidate gene for asthma, having diverged from its other gene family members. More specifically, profound overexpression of LTC4S in aspirin-induced asthma seems to be a principal determinant of the respiratory reactions to aspirin, and a single-nucleotide polymorphism in the 5' regulatory region associates significantly with the aspirin-intolerant phenotype in Polish patients. This data strongly support LTC4S as a candidate gene in this phenotype of asthma, and further characterization of LTC4S in terms of enzymatic function and gene regulation will likely contribute to the understanding of the gene as one potentially responsible for the allergic inflammation underlying aspirin-intolerance. Additionally, discovery of additional polymorphism within this gene may lead to identification of susceptibility to adverse aspirin reactions, and inhibition of this enzyme may represent a therapeutic target for compounds useful in the treatment of asthma and allergic diseases.

journal_name

Allergy Asthma Proc

authors

Penrose JF,Baldasaro MH

doi

10.2500/108854199778251825

subject

Has Abstract

pub_date

1999-11-01 00:00:00

pages

353-60

issue

6

eissn

1088-5412

issn

1539-6304

journal_volume

20

pub_type

杂志文章,评审
  • Emergency department treatment of adults with acute asthma exacerbations: effect on exhaled nitric oxide levels.

    abstract::Measurement of exhaled nitric oxide levels (eNO) from asthmatic patients is a noninvasive marker of airway inflammation in both adults and children and has been used as an outpatient measure of asthma control. We examined eNO in acute asthma exacerbations and how it is affected by treatment in the emergency departmen...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,随机对照试验

    doi:10.2500/aap.2012.33.3613

    authors: Silverberg JI,Rodenas M,Sinert R,Joks R

    更新日期:2012-11-01 00:00:00

  • Rhinorrhea not responding to nasal corticosteroids.

    abstract::A woman with multiple illnesses including allergic rhinitis presented for a follow-up visit at our clinic with constant rhinorrhea for 2 weeks despite regular use of nasal corticosteroids. Two weeks earlier, after alcohol drinking and doubling some of her medications for missed doses, she fell on her face. The Emergen...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2007.28.3061

    authors: Patel PN,Oyefara B,Aarstad R,Bahna SL

    更新日期:2007-11-01 00:00:00

  • Antioxidant supplementation and exhaled nitric oxide in children with asthma.

    abstract:BACKGROUND:The effect of allergen avoidance on airway inflammation is similar to that observed with treatment with inhaled steroids, whereas inhaled steroids have no effect on oxidative stress-induced inflammation. OBJECTIVE:The aim of this study was to retrospectively evaluate the potential effect of an antioxidant d...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2016.37.3920

    authors: Tenero L,Piazza M,Zanoni L,Bodini A,Peroni D,Piacentini GL

    更新日期:2016-01-01 00:00:00

  • Managing rhinitis: Strategies for improved patient outcomes.

    abstract::Allergic rhinitis affects more than 40 million Americans, with estimated costs reaching $5.3 billion annually. The global impact includes negative effects on quality of life (QOL), sleep, diminished work productivity, and exacerbation of comorbid conditions. An accurate diagnosis of allergic or nonallergic rhinitis is...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2008.29.3145

    authors: Carr WW,Nelson MR,Hadley JA

    更新日期:2008-07-01 00:00:00

  • Anaphylaxis/angioedema caused by honey ingestion.

    abstract::Honey allergy is a very rare, but serious health condition. In this study, we presented six patients who described systemic allergic reactions after ingestion of honey. Three of the six patients had suffered from anaphylaxis. Honey-specific IgE was measured and skin-prick tests for honey were performed to diagnose hon...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2014.35.3718

    authors: Vezir E,Kaya A,Toyran M,Azkur D,Dibek Mısırlıoğlu E,Kocabaş CN

    更新日期:2014-01-01 00:00:00

  • Biphasic reactions in children undergoing oral food challenges.

    abstract::Literature regarding biphasic reactions in the pediatric population is sparse. We aimed to determine the prevalence of biphasic reactions in children with food allergies undergoing oral food challenges (OFCs) and examine whether any clinical or treatment factors are associated with biphasic reactions. A retrospective ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2013.34.3669

    authors: Lee J,Garrett JP,Brown-Whitehorn T,Spergel JM

    更新日期:2013-05-01 00:00:00

  • Altered L-arginine metabolism in children with controlled asthma.

    abstract::Decreased level of L-arginine may lead to airway hyperresponsiveness, inflammation, and airway remodeling. Changes in L-arginine metabolism were observed earlier in adult asthmatic patients. Studies on L-arginine metabolism in children with bronchial asthma are limited. Because biosynthesis of L-arginine is insufficie...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2014.35.3777

    authors: Kraj L,Krawiec M,Koter M,Graboń W,Kraj G,Chołojczyk M,Kulus M,Barańczyk-Kuźma A

    更新日期:2014-09-01 00:00:00

  • The relationship between insect sting allergy treatment and patient anxiety and depression.

    abstract::Quality of life is affected by history of bee sting allergy. In addition, worry about being stung and also the need to use self-injection of medicine can create or increase anxiety, which can further compromise a patient's ability to enjoy the outdoors and participate in activities. We sought to determine the depressi...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2014.35.3751

    authors: Findeis S,Craig T

    更新日期:2014-05-01 00:00:00

  • Immunomodulation in dermatology: lessons learned in the treatment of psoriasis.

    abstract::With the widespread recognition that T-cells are the key mediators of psoriasis, current treatment strategies have focused on reducing the population of these cells or modulating their activity through the use of immunosuppressive treatments such as methotrexate, cyclosporine, and psoralens plus ultraviolet A radiatio...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:

    authors: Charlesworth EN

    更新日期:2006-03-01 00:00:00

  • Forced oscillometry is applicable to epidemiological settings to detect asthmatic children.

    abstract::Forced oscillometry (FOT) has been reported as a simple method to detect respiratory resistance (Rrs) changes. The aim of this study was to evaluate FOT capacity to detect children with clinical characteristics of asthma in a school setting. One thousand thirty children, 6-7 years old, were investigated by questionnai...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,多中心研究

    doi:10.2500/aap.2007.28.2965

    authors: Boccaccino A,Peroni DG,Pietrobelli A,Piacentini GL,Aversano MP,Spinosa E,Boner AL

    更新日期:2007-03-01 00:00:00

  • The role of montelukast on perennial allergic rhinitis and associated sleep disturbances and daytime somnolence.

    abstract::Perennial allergic rhinitis (PAR) often causes sleep disturbances and associated daytime somnolence, thus resulting in a poor quality of life. Various clinical interventions in patients suffering from the disorder seek to improve symptoms and quality of life. Additional studies are needed to establish whether the alle...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2008.29.3097

    authors: Santos CB,Hanks C,McCann J,Lehman EB,Pratt E,Craig TJ

    更新日期:2008-03-01 00:00:00

  • The status of asthma control in the U.S. adult population.

    abstract::Treatment guidelines recognize the importance of achieving and maintaining asthma control. This study was designed to assess the prevalence of asthma control in a representative U.S. population. A survey regarding asthma and associated symptoms was sent to a representative national sample of 134,401 households managed...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2009.30.3276

    authors: Fuhlbrigge A,Reed ML,Stempel DA,Ortega HO,Fanning K,Stanford RH

    更新日期:2009-09-01 00:00:00

  • In vitro induction of T regulatory cells by a methylated CpG DNA sequence in humans: Potential therapeutic applications in allergic and autoimmune diseases.

    abstract:BACKGROUND:Allergic and autoimmune diseases comprise a group of inflammatory disorders caused by aberrant immune responses in which CD25+ Forkhead box P3-positive (FOXP3+) T regulatory (Treg) cells that normally suppress inflammatory events are often poorly functioning. This has stimulated an intensive investigative ef...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2018.39.4113

    authors: Lawless OJ,Bellanti JA,Brown ML,Sandberg K,Umans JG,Zhou L,Chen W,Wang J,Wang K,Zheng SG

    更新日期:2018-03-01 00:00:00

  • Quality of life in respiratory allergy.

    abstract::The HRQL (Health Related Quality of Life) is considered a relevant aspect of pharmacological treatment, since it evaluates the outcomes from the patient's viewpoint. This article reviews the currently available information about HRQL as an outcome measure in Respiratory Allergy. Pertinent abstracts and articles were c...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/108854101778148746

    authors: Baiardini I,Pasquali M,Giardini A,Majani G,Canonica GW

    更新日期:2001-05-01 00:00:00

  • Serum interleukin 17, interleukin 23, and interleukin 10 values in children with atopic eczema/dermatitis syndrome (AEDS): association with clinical severity and phenotype.

    abstract::To date cytokines profile in AEDS is poorly described in children. We evaluated the interleukin (IL)-17, IL-23, and IL-10 levels in atopic eczema/dermatitis syndrome (AEDS) children and healthy controls, in atopic AEDS (aAEDS) and nonatopic (naAEDS) subtypes and their relationship with disease severity. A total of 181...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2015.36.3808

    authors: Leonardi S,Cuppari C,Manti S,Filippelli M,Parisi GF,Borgia F,Briuglia S,Cannavò P,Salpietro A,Arrigo T,Salpietro C

    更新日期:2015-01-01 00:00:00

  • Chapter 27: Approach to primary immunodeficiency.

    abstract::Primary immunodeficiency diseases (PID) are inherited defects of the innate or adaptive arms of the immune system that lead to an increase in the incidence, frequency, or severity of infections. There may be defects in the adaptive arm of the immune system that include combined immunodeficiency and antibody deficienc...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2012.33.3560

    authors: Uzzaman A,Fuleihan RL

    更新日期:2012-05-01 00:00:00

  • Evaluation of anxiety levels and factors associated with positive test results in patients with drug hypersensitivity.

    abstract:BACKGROUND:High anxiety has been reported in patients with drug hypersensitivity reaction (DHR); however, its relationship with the test results was not studied previously. OBJECTIVE:We aimed to investigate the association of patient anxiety with the results of drug tests together with the other contributing factors. ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2015.36.3878

    authors: Comert S,Erdogan T,Demir AU,Karakaya G,Kalyoncu AF

    更新日期:2015-11-01 00:00:00

  • Serum clusterin level in children with atopic dermatitis.

    abstract:BACKGROUND:Atopic dermatitis (AD) is a chronic inflammatory skin disease. Clusterin is a sensitive cellular biosensor of oxidative stress and has been studied as a marker to assess inflammatory diseases. The clusterin levels in AD have not been evaluated thus far. OBJECTIVE:We evaluated serum clusterin levels in child...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2016.37.3953

    authors: Sol IS,Kim YH,Lee KE,Hong JY,Kim MN,Kim YS,Oh MS,Kim MJ,Yoon SH,Park YA,Kim KW,Sohn MH,Kim KE

    更新日期:2016-07-01 00:00:00

  • The spectrum of aeroallergen sensitization in children diagnosed with asthma during first 2 years of life.

    abstract::Aeroallergens may trigger symptoms in sensitized children with asthma. Documentation of sensitization is crucial to enable effective implementation of measures to prevent asthma exacerbations. To document the sensitization patterns of very young children (≤2 years) with asthma, we retrospectively analyzed the skin-pri...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2013.34.3655

    authors: Sahiner UM,Buyuktiryaki AB,Yavuz ST,Arik Yilmaz E,Cavkaytar O,Tuncer A,Sekerel BE

    更新日期:2013-07-01 00:00:00

  • Central serous chorioretinopathy secondary to corticosteroids in patients with atopic disease.

    abstract::Central serous chorioretinopathy (CSCR) is of unknown etiology and is the most common cause of retinopathy after age-related macular degeneration, diabetic retinopathy, and retinal vein occlusion. Vision loss results from fluid leakage and serous detachment in the macula. Five percent of patients develop chronic CSCR....

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2015.36.3827

    authors: Ricketti PA,Unkle DW,Cleri DJ,Prenner JL,Coluccielo M,Ricketti AJ

    更新日期:2015-03-01 00:00:00

  • Association of inflammatory bowel disease with asthma risk: A nationwide cohort study.

    abstract:OBJECTIVE:We evaluated the risk of asthma development in adult patients with inflammatory bowel disease (IBD) in a nationwide population. METHODS:A retrospective cohort study was conducted by using data retrieved from the Taiwan National Health Insurance Research Database. Patients, ages 20 year or older, with newly d...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2015.36.3869

    authors: Peng YH,Liao WC,Su CH,Chen HJ,Hsia TC,Chu CC,Liu CJ,Kao CH

    更新日期:2015-09-01 00:00:00

  • Flunisolide hydrofluoroalkane with integrated spacer for treating asthma: an updated review.

    abstract::Flunisolide hydrofluoroalkane (HFA) with integrated spacer is the most recent reformulated inhaled corticosteroid (ICS) for asthma available in the United States. It is the only product that combines a corticosteroid extrafine aerosol with a built-in spacer. The potential clinical benefit of the flunisolide HFA formul...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2015.36.3835

    authors: Berger WE,Tashkin DP

    更新日期:2015-03-01 00:00:00

  • The emotional needs of allergic and asthmatic patients and their families.

    abstract::This article describes the emotional needs of allergic and asthmatic patients and their families that must addressed if optimal management and well-being is to be achieved. Health care professionals need to recognize the psychosocial issues of patients and parents, which include the effect of stressors, illness percep...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/108854198778557845

    authors: Wallerstedt DB,Bellanti JA

    更新日期:1998-07-01 00:00:00

  • Concurrent use of salmeterol with inhaled corticosteroids is more effective than inhaled corticosteroid dose increases.

    abstract::This randomized, double-blind, parallel, multi-center study was designed to determine whether the addition of salmeterol to existing inhaled corticosteroid therapy provides greater therapeutic benefit than doubling the dose of inhaled corticosteroids in symptomatic patients with asthma. A total of 514 adults were rand...

    journal_title:Allergy and asthma proceedings

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.2500/108854199778553028

    authors: Murray JJ,Church NL,Anderson WH,Bernstein DI,Wenzel SE,Emmett A,Rickard KA

    更新日期:1999-05-01 00:00:00

  • Epinephrine auto-injector use and demographics in a Veterans Administration population.

    abstract::The epinephrine auto-injector has been widely used over a long period of time. Certain aspects of this therapy and demographic data, however, have not been well studied. This study investigates patient use and understanding of epinephrine auto-injector use. As part of an ongoing quality assurance program, we evaluated...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2010.31.3351

    authors: Amirzadeh A,Verma P,Lee S,Klaustermeyer W

    更新日期:2010-07-01 00:00:00

  • Lack of correlation between clinical patterns of asthma and airway obstruction.

    abstract::To evaluate the relationship between the classification of asthma and obstruction of airways, we have studied 100 children suffering from allergic asthma: 65 males and 35 females, aged 4.2-16.3 years (mean, 7.6 +/- 2.8 years), who were evaluated at least 1 month after the last attack of airway obstruction. We analyzed...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:

    authors: Verini M,Rossi N,Dalfino T,Verrotti A,Di Gioacchino M,Chiarelli F

    更新日期:2001-09-01 00:00:00

  • Epithelial cells are a major cellular source of the chemokine eotaxin in the guinea pig lung.

    abstract::Eotaxin is the major eosinophil chemoattractant found in bronchoalveolar lavage (BAL) fluid from sensitized guinea pigs after antigen challenge. In this study we have performed immunostaining for eotaxin in airways obtained from challenged animals and examined purified guinea pig lung cells (epithelial cells > 98% pur...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/108854198778557926

    authors: Cook EB,Stahl JL,Lilly CM,Haley KJ,Sanchez H,Luster AD,Graziano FM,Rothenberg ME

    更新日期:1998-01-01 00:00:00

  • Treatment of allergic rhinitis: effects of allergic rhinitis and antihistamines on performance.

    abstract::Antihistamines are the most commonly used drugs for allergic rhinitis, and many antihistamines may cause subclinical side effects which are not noticeable by the patient. These include impaired driving performance, impaired work performance, reduced coordination, reduced motor skills, sleepiness and impaired informati...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/108854197778605473

    authors: Storms WW

    更新日期:1997-03-01 00:00:00

  • Asthma in the female: hormonal effect and pregnancy.

    abstract::Data support an increase in adverse outcomes in the pregnant woman with asthma, particularly those who are poorly controlled. Additionally, pregnancy is recognized to influence the course of asthma. Hormonal and physiologic changes are felt to direct the eventual course and outcome, but their roles are incompletely un...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/108854101778249258

    authors: Beck SA

    更新日期:2001-01-01 00:00:00

  • The role of antioxidants and 25-hydroxyvitamin D during pregnancy in the development of allergic diseases in early school-age children - Polish Mother and Child Cohort Study.

    abstract::Purpose: Based on the available data, alterations of the antioxidant defense as well as the vitamin status in mothers may affect the prenatal process of lung and immune system development as a pathophysiological background of increased prevalence of allergic diseases. The primary aim of the current study was to assess...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2020.41.190020

    authors: Bobrowska-Korzeniowska M,Jerzyńska J,Polańska K,Gromadzińska J,Hanke W,Wasowicz W,Stelmach I

    更新日期:2020-01-01 00:00:00