Abstract:
:Anti-IgE therapy with omalizumab, a recombinant humanized monoclonal antibody, has anti-inflammatory effects in allergic asthma and rhinitis. Although omalizumab has been exceptionally safe, reactions after its administration have been reported. The goal of this study was to assess two patients who experienced apparent anaphylaxis after omalizumab administration. Two cases of apparent anaphylaxis after omalizumab administration are reported with diagnostic evaluation using skin testing and unique IgE and IgG anti-omalizumab serological assays. At the time of evaluation, both atopic asthmatic patients had total (free and bound) serum IgE levels of 199 kIU/L (100% free) and 200 kIU/L (80% free and 20% bound), respectively. Epicutaneous skin tests to omalizumab were negative at 150 mg/mL of omalizumab in both subjects and the nonexposed negative control subject. Intradermal skin tests were positive at 0.15 mg/mL in subject 1 and negative at 1.5 mg/mL of omalizumab in subject 2 and the control subject. Intradermal testing to polysorbate produced significant wheal/flare reaction in subject 2 but not in the negative control subject. Serological assays for IgE or IgG antibodies reactive with omalizumab were negative. The in vitro and in vivo immunologic data support the conclusion that the adverse reactions experienced by two patients after omalizumab administration after more than a year of successful omalizumab therapy for asthma were likely anaphylactoid in nature. Polysorbate, an excipient in omalizumab, is known to cause similar reactivity to other medicines and is the most likely cause of these reactions.
journal_name
Allergy Asthma Procjournal_title
Allergy and asthma proceedingsauthors
Price KS,Hamilton RGdoi
10.2500/aap.2007.28.3003subject
Has Abstractpub_date
2007-05-01 00:00:00pages
313-9issue
3eissn
1088-5412issn
1539-6304journal_volume
28pub_type
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2019.40.4257
更新日期:2019-11-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/108854196778606455
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/108854199778681530
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journal_title:Allergy and asthma proceedings
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
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更新日期:2011-03-01 00:00:00
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journal_title:Allergy and asthma proceedings
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journal_title:Allergy and asthma proceedings
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
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更新日期:1998-09-01 00:00:00
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journal_title:Allergy and asthma proceedings
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2015.36.3858
更新日期:2015-09-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/108854101778249258
更新日期:2001-01-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
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更新日期:2017-07-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2500/aap.2012.33.3522
更新日期:2012-01-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/108854197778605473
更新日期:1997-03-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2007.28.2951
更新日期:2007-01-01 00:00:00
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journal_title:Allergy and asthma proceedings
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doi:
更新日期:2006-03-01 00:00:00
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journal_title:Allergy and asthma proceedings
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doi:
更新日期:2003-01-01 00:00:00
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journal_title:Allergy and asthma proceedings
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doi:
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pub_type: 杂志文章,随机对照试验
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更新日期:2012-09-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2019-07-03 00:00:00
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journal_title:Allergy and asthma proceedings
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更新日期:2000-07-01 00:00:00
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journal_title:Allergy and asthma proceedings
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更新日期:2017-09-01 00:00:00
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journal_title:Allergy and asthma proceedings
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更新日期:2008-09-01 00:00:00
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journal_title:Allergy and asthma proceedings
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doi:10.2500/aap.2021.42.200105
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/108854199778251825
更新日期:1999-11-01 00:00:00
abstract::Most allergens are proteins or glycoproteins that range in molecular weight from 5000 to 100,000 Da, although polysaccharides and low-molecular-weight substances may also be allergenic. Common allergens include pollens, fungal spores, house-dust mites, and animal epithelial materials but can also include drugs, biolog...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
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