Abstract:
:Single-dose montelukast attenuates exercise-induced bronchoconstriction (EIB) in adults within 2 hours postdose and lasting through 24 hours. This study evaluated the onset and duration of EIB attenuation in children after a single dose of montelukast. A randomized, double-blind, placebo-controlled, two-period crossover study was performed. Patients (n = 66) aged 4-14 years, with preexercise forced expiratory volume in 1 second of (FEV(1)) ≥70% predicted and maximum percentage fall in FEV(1) of ≥20% at two screening exercise challenges were eligible. Patients were to receive single-dose montelukast (4 or 5 mg) or placebo before performing standardized exercise challenges at 2 and 24 hours postdose. A 3- to-7-day washout separated the two crossover periods. The primary end point was maximum percentage fall in FEV(1) after exercise challenge 2 hours postdose. Secondary end points included maximum percentage fall in FEV(1) after the 24-hour postdose challenge; each of the following at 2 and 24 hours postdose-maximum percentage fall in FEV(1) categorized as <10%, 10-20%, or >20%; area under the curve (AUC) during 60 minutes postchallenge; time to recovery of FEV(1) to within 5% of preexercise baseline; and need for rescue medication. The mean maximum percentage fall in FEV(1) after the 2-hour postdose exercise challenge was significantly attenuated after single-dose montelukast compared with placebo (15.35% versus 20.00%; p = 0.020). Montelukast was also significantly more effective than placebo for maximum percentage fall after the 24-hour challenge (12.92% versus 17.25%; p = 0.005), the categorized maximum percent fall in FEV(1) at 2 hours (p = 0.034), and AUC at 2 hours (p = 0.022) and 24 hours (p = 0.013). Single-dose montelukast provided rapid and sustained EIB attenuation in children. Clinicaltrials.gov identifier: NCT00534976.
journal_name
Allergy Asthma Procjournal_title
Allergy and asthma proceedingsauthors
Wasfi YS,Kemp JP,Villarán C,Massaad R,Xin W,Smugar SS,Knorr BA,Philip Gdoi
10.2500/aap.2011.32.3482subject
Has Abstractpub_date
2011-11-01 00:00:00pages
453-9issue
6eissn
1088-5412issn
1539-6304journal_volume
32pub_type
临床试验,杂志文章,多中心研究,随机对照试验abstract::Exotoxins secreted by Staphylococcus aureus have been identified as a possible trigger factor in atopic dermatitis (AD). We investigated the production and role of circulating antibodies, with specificity to staphylococcal enterotoxin B (SEB), in children with AD compared with those of healthy controls. The children w...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:
更新日期:2003-01-01 00:00:00
abstract::Infection with respiratory virus has been shown to exacerbate asthma in humans. However, the role of a respiratory virus in the pathogenesis of chronic asthma and/or wheezing in young children has not been clearly defined. It has also been debated whether virus-induced wheezing in young children is one entity and alle...
journal_title:Allergy and asthma proceedings
pub_type: 临床试验,杂志文章
doi:10.2500/108854100778250888
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abstract::Previous studies suggest cross-reactivity between specific ragweed pollen and melon allergens. This study was designed to clarify the origin of the cross-reactivity between ragweed pollen and the gourd family. One thousand ragweed-allergic subjects were interviewed about the presence of oral allergy syndrome (OAS) ind...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2011.32.3416
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journal_title:Allergy and asthma proceedings
pub_type: 共识发展会议,杂志文章
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abstract::A case of solar urticaria is presented, followed by a discussion of the clinical characteristics, pathophysiology, diagnosis, and management of this disease. Special emphasis is given to clinical pearls and pitfalls for the practicing allergist. Solar urticaria is a physical urticaria that can be difficult to diagnose...
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doi:10.2500/aap.2009.30.3273
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pub_type: 杂志文章
doi:10.2500/aap.2013.34.3696
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abstract::Background: Probiotic supplementary therapy to prevent allergic diseases, including asthma in children, has been widely explored in many randomized controlled trials. However, there is conflicting evidence on the effect of probiotic supplementation during pregnancy and infancy to the incidence of asthma and allergic r...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,meta分析
doi:10.2500/aap.2019.40.4227
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abstract::Eotaxin is the major eosinophil chemoattractant found in bronchoalveolar lavage (BAL) fluid from sensitized guinea pigs after antigen challenge. In this study we have performed immunostaining for eotaxin in airways obtained from challenged animals and examined purified guinea pig lung cells (epithelial cells > 98% pur...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/108854198778557926
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abstract::Latex immediate hypersensitivity has been documented in 28% to 67% of spina bifida patients, 2.6%-16.9% of health care workers and at least 1% of the general population. Additionally, it has been confirmed in food-sensitive individuals sensitive to cross-reacting foods such as chestnut, avocado, banana, and passion fr...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/108854196778645083
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abstract::A telephone survey of 100 primary care physicians was performed to assess the awareness of the influence patient preference, patient satisfaction, and other factors have on the selection of nasal steroids for the treatment of allergic rhinitis. Results indicated that physicians believe drug efficacy is the primary rea...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
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abstract::Aeroallergens may trigger symptoms in sensitized children with asthma. Documentation of sensitization is crucial to enable effective implementation of measures to prevent asthma exacerbations. To document the sensitization patterns of very young children (≤2 years) with asthma, we retrospectively analyzed the skin-pri...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2013.34.3655
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2016.37.3988
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abstract::Innumerable articles have tried to solve the "continuing enigma of atopic and nonatopic asthma" but notwithstanding the strenuous efforts to substantiate the few well-known clinico-epidemiologic differences between these two forms of asthma most studies have hitherto generated inconclusive statements. In a recent stud...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,随机对照试验
doi:10.2500/aap.2019.40.4223
更新日期:2019-07-03 00:00:00
abstract::Background: Asthma is a chronic and complex lung disease that is not completely understood. It involves airway inflammation, reversible airflow obstruction, and bronchial hyperresponsiveness. The most common symptoms are recurrent wheezing, chest tightness, shortness of breath, and coughing. Objective: The Asthma Insi...
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pub_type: 杂志文章,多中心研究
doi:10.2500/aap.2018.39.4180
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abstract::Allergic rhinitis and asthma are two of the most common chronic conditions affecting the population. There has been a growing understanding of the link between these disorders as they commonly occur in the same individual, of their relationship with allergies, and of the total economic impact in both direct and indire...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:
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abstract:BACKGROUND:Many children struggle with albuterol hydrofluoroalkane (HFA) inhalers. Albuterol multidose dry powder inhaler (MDPI) may simplify rescue bronchodilator use in children. OBJECTIVE:To demonstrate the comparability of albuterol MDPI and albuterol HFA in children with asthma. METHODS:This phase II, multicente...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2500/aap.2016.37.3986
更新日期:2016-09-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
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pub_type: 杂志文章
doi:10.2500/aap.2016.37.3953
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
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abstract:BACKGROUND:Chronic urticaria (CU) is a skin disorder defined as daily or almost daily exhibition of pruritic and transient wheals that last for 6 weeks. CU is divided into two subtypes: chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU). OBJECTIVES:To evaluate the clinical features, possible c...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:
更新日期:2001-11-01 00:00:00
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journal_title:Allergy and asthma proceedings
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doi:10.2500/aap.2008.29.3174
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abstract:BACKGROUND:Hereditary angioedema (HAE) is a rare, potentially life-threatening disease characterized by recurrent angioedema attacks. Abdominal symptoms of HAE typically mimic numerous abdominal emergencies, which may result in a delay of correct diagnosis and inappropriate treatments. OBJECTIVE:We aimed to evaluate t...
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pub_type: 杂志文章
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,随机对照试验
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更新日期:2009-05-01 00:00:00
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pub_type: 杂志文章
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:
更新日期:2003-07-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
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