Abstract:
:Background: Probiotic supplementary therapy to prevent allergic diseases, including asthma in children, has been widely explored in many randomized controlled trials. However, there is conflicting evidence on the effect of probiotic supplementation during pregnancy and infancy to the incidence of asthma and allergic rhinitis. Method: This study was designed to systematically explore the potential effects of probiotic supplementation on the occurrence and development of asthma, wheeze, and allergic rhinitis. Randomized controlled trials were searched in several medical literature data bases. A meta-analysis was undertaken by using the fixed-effects model or the random effects model to calculate the pooled risk of significant heterogeneity. Two writers were designated to perform the study selection and data extraction. The primary outcome was clinically diagnosed asthma; the secondary outcomes included wheeze, allergic rhinitis, and a positive aeroallergen skin-prick test result. Results: Seventeen randomized controlled trials, which composed a total of 5264 children, were analyzed. The pooled data for risk of developing asthma after probiotic supplementation showed no significant reduction compared with controls (risk ratio [RR] 0.86 [95% confidence interval {CI}, 0.73-1.01]; I² = 0%; p = 0.06). A subgroup of strains indicated that Lactobacillus rhamnosus GG supplementation only had a reduction to the occurrence of asthma (RR 0.75 [95% CI, 0.57-0.99]; I² = 11%; p = 0.04). The supplement in the postnatal group had a similar result, but the incorporated data were limited. Meanwhile, it is failed to identify that probiotic supplementary therapy have a clear benefit to the secondary outcomes: wheeze, allergic rhinitis, positive aeroallergen skin-prick test result. Conclusion: This study showed a significant benefit that supplementation with probiotics in pre- and postnatal periods was likely to play an essential strategic role in the prevention of asthma. However, these effects were based on the type of probiotics used, which also need more large-sample and high-quality RCTs to confirm the reliability of this study.
journal_name
Allergy Asthma Procjournal_title
Allergy and asthma proceedingsauthors
Du X,Wang L,Wu S,Yuan L,Tang S,Xiang Y,Qu X,Liu H,Qin X,Liu Cdoi
10.2500/aap.2019.40.4227subject
Has Abstractpub_date
2019-07-01 00:00:00pages
250-260issue
4eissn
1088-5412issn
1539-6304journal_volume
40pub_type
杂志文章,meta分析abstract::Immediate-hypersensitivity reactions related to latex products have increased rapidly in recent years. However, a reliable diagnosis is hampered by lack of purified and well characterized latex allergens. We have purified allergens in natural rubber latex (NRL) after SDS-PAGE by electroelution, and tested specific IgE...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/108854196778996921
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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doi:10.2500/aap.2018.39.4176
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2007.28.3061
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:
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journal_title:Allergy and asthma proceedings
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
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更新日期:2009-03-01 00:00:00
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journal_title:Allergy and asthma proceedings
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/108854198778557845
更新日期:1998-07-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,随机对照试验
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更新日期:2019-07-03 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
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journal_title:Allergy and asthma proceedings
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journal_title:Allergy and asthma proceedings
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abstract:BACKGROUND:Treatment with acetylsalicylic acid (ASA) after desensitization may be a therapeutic option in patients with nonsteroidal anti-inflammatory drug exacerbated respiratory disease (NERD). The mechanisms that lead to improvement in rhinosinusitis and asthma symptoms remain unknown. AIM:To attribute the document...
journal_title:Allergy and asthma proceedings
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更新日期:2016-05-01 00:00:00
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journal_title:Allergy and asthma proceedings
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abstract::Tacrolimus ointment is a topical immunomodulator. Currently, there is available evidence regarding the potential use of topical tacrolimus in a range of dermatological disorders. The aim of this study was to evaluate the efficacy and safety of tacrolimus ointment 0.1% for the nickel sulfate-induced steroid-resistant a...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,随机对照试验
doi:10.2500/aap.2006.27.2915
更新日期:2006-11-01 00:00:00
abstract:BACKGROUND:The effect of allergen avoidance on airway inflammation is similar to that observed with treatment with inhaled steroids, whereas inhaled steroids have no effect on oxidative stress-induced inflammation. OBJECTIVE:The aim of this study was to retrospectively evaluate the potential effect of an antioxidant d...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2016.37.3920
更新日期:2016-01-01 00:00:00
abstract::The purpose of this study is to examine the natural history of hay fever among former college students who were diagnosed with this disease either before or after their freshman year. The diagnosis of hay fever or seasonal allergic rhinitis was based on a history of watery, itchy eyes, rhinorrhea, and sneezing occurri...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/108854198778557728
更新日期:1998-09-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2015.36.3878
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Anaphylaxis is increasingly reported in infancy. Diagnosis and management of anaphylaxis is difficult, and data are limited in infants. The aim of the present study was to determine the clinical course and management strategies used for anaphylaxis in infancy. METHODS:Patients attending to our clinic and wh...
journal_title:Allergy and asthma proceedings
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doi:10.2500/aap.2017.38.4009
更新日期:2017-01-01 00:00:00