Abstract:
:Primary immunodeficiency diseases (PID) are inherited defects of the innate or adaptive arms of the immune system that lead to an increase in the incidence, frequency, or severity of infections. There may be defects in the adaptive arm of the immune system that include combined immunodeficiency and antibody deficiency syndromes or by abnormalities in innate immunity such as disorders of phagocytes, the complement pathway, or Toll-Like receptor (TLR) mediated signaling. Recurrent sinopulmonary infections with encapsulated bacteria such as Haemophilus influenza type B or Streptococcus pneumoniae may be characteristic of an IgG antibody deficiency or dysfunction. Frequent viral, fungal, or protozoal infections may suggest T lymphocyte dysfunction. Multiple staphylococcal skin infections and fungal infections may imply neutrophil dysfunction or the hyper-IgE syndrome, and recurrent neisserial infection is a characteristic manifestation of late complement component (C5-9, or the membrane attack complex) defects. Recurrent viral or pyogenic bacterial infections often without the presence of a significant inflammatory response suggest a defect in TLR signaling. Mycobacterial infections are characteristic of defects in interleukin (IL)-12, interferon (IFN) gamma, or their receptors. Screening of newborns for T-cell lymphopenia using a polymerase chain reaction to amplify T-cell receptor excision circles (TRECs), which are formed when a T cell rearranges the variable region of its receptor, serves as a surrogate for newly synthesized naïve T cells. Because of very low numbers of TRECs, severe combined immunodeficiency, DiGeorge syndrome, and other causes of T-cell lymphopenia have been identified in newborns.
journal_name
Allergy Asthma Procjournal_title
Allergy and asthma proceedingsauthors
Uzzaman A,Fuleihan RLdoi
10.2500/aap.2012.33.3560subject
Has Abstractpub_date
2012-05-01 00:00:00pages
91-95eissn
1088-5412issn
1539-6304journal_volume
33 Suppl 1pub_type
杂志文章,评审abstract::The symptoms of allergic rhinitis vary in severity over the course of the day and often are worse in the morning. This review focuses on data from clinical studies of the antihistamine desloratadine to establish whether it effectively controls the morning symptoms of allergic rhinitis. Studies of desloratadine in pati...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/aap.2006.27.2936
更新日期:2006-11-01 00:00:00
abstract::The purpose of this study is to examine the natural history of hay fever among former college students who were diagnosed with this disease either before or after their freshman year. The diagnosis of hay fever or seasonal allergic rhinitis was based on a history of watery, itchy eyes, rhinorrhea, and sneezing occurri...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/108854198778557728
更新日期:1998-09-01 00:00:00
abstract::A woman with multiple illnesses including allergic rhinitis presented for a follow-up visit at our clinic with constant rhinorrhea for 2 weeks despite regular use of nasal corticosteroids. Two weeks earlier, after alcohol drinking and doubling some of her medications for missed doses, she fell on her face. The Emergen...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2007.28.3061
更新日期:2007-11-01 00:00:00
abstract::Treatment guidelines recognize the importance of achieving and maintaining asthma control. This study was designed to assess the prevalence of asthma control in a representative U.S. population. A survey regarding asthma and associated symptoms was sent to a representative national sample of 134,401 households managed...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2009.30.3276
更新日期:2009-09-01 00:00:00
abstract::Although "atopic march" is a popular concept, the relationship between eczema and subsequent asthma is far from clear. However, some cohort studies have shown the possibility of two different allergic phenotypes in those who present with early eczema in terms of their persistency. We checked the cohort data from 308,...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2013.34.3625
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Obesity negatively impacts asthma control, but the inflammatory mechanisms are poorly understood. OBJECTIVE:To explore which systemic inflammatory mediators mediate the effects of obesity on asthma control. METHODS:The subjects with stable asthma (n = 108) underwent assessment of clinical characteristics, ...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2017.38.4096
更新日期:2017-10-02 00:00:00
abstract:BACKGROUND:Many children struggle with albuterol hydrofluoroalkane (HFA) inhalers. Albuterol multidose dry powder inhaler (MDPI) may simplify rescue bronchodilator use in children. OBJECTIVE:To demonstrate the comparability of albuterol MDPI and albuterol HFA in children with asthma. METHODS:This phase II, multicente...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2500/aap.2016.37.3986
更新日期:2016-09-01 00:00:00
abstract::Quality of life is affected by history of bee sting allergy. In addition, worry about being stung and also the need to use self-injection of medicine can create or increase anxiety, which can further compromise a patient's ability to enjoy the outdoors and participate in activities. We sought to determine the depressi...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2014.35.3751
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Childhood food allergy and asthma rates are increasing. The hygiene hypothesis has been proposed as an explanation for the increased incidence of allergic disease. OBJECTIVE:To describe the association of childhood food allergy and asthma with hygiene factors, such as the number of siblings, antibiotic use,...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2016.37.3988
更新日期:2016-11-01 00:00:00
abstract::Asthma, a disease characterized by airway inflammation and reversible bronchoconstriction, manifests a variety of phenotypes, and in some, but not all, asthma leads to a persistent and/or progressive loss of lung function. Conceptually, asthma persistence is identified by a stable decrement in lung function over time,...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/aap.2009.30.3202
更新日期:2009-03-01 00:00:00
abstract::The newborn screen for severe combined immunodeficiency (SCID) uses real-time quantitative polymerase chain reaction for T-cell receptor excision circles and is highly sensitive for SCID. However, T-cell lymphopenia from other primary and secondary causes, such as DiGeorge syndrome, prematurity, thymic involution from...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2019.40.190015
更新日期:2020-03-01 00:00:00
abstract::The appearance of more than one physical urticaria (PU) in the same patient has been documented; cold urticaria or dermatographism in association with some other type of PU are encountered more frequently. Three female patients exhibiting multiple PUs simultaneously are presented. In one female patient four different ...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:
更新日期:2003-09-01 00:00:00
abstract::Perennial allergic rhinitis (PAR) often causes sleep disturbances and associated daytime somnolence, thus resulting in a poor quality of life. Various clinical interventions in patients suffering from the disorder seek to improve symptoms and quality of life. Additional studies are needed to establish whether the alle...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2008.29.3097
更新日期:2008-03-01 00:00:00
abstract::Although some older antihistamines have a relatively slow onset of action, modern agents indicate an efficacy between 1 and 3 hours of administration. For patients who use antihistamines regularly, a short onset of action is relatively unimportant. When antihistamines are used as needed, either because of poor complia...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:
更新日期:2004-03-01 00:00:00
abstract::Asthma is a clinical problem with social, psychological, and economic burdens. To improve patient disease management and quality of life (QOL), different education programs have been developed. The purpose of this study is to adapt and implement a community-based educational program for patients with asthma. A prospec...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,随机对照试验
doi:10.2500/aap2008.29.3083
更新日期:2008-01-01 00:00:00
abstract::Innumerable articles have tried to solve the "continuing enigma of atopic and nonatopic asthma" but notwithstanding the strenuous efforts to substantiate the few well-known clinico-epidemiologic differences between these two forms of asthma most studies have hitherto generated inconclusive statements. In a recent stud...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/aap.2009.30.3197
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:High anxiety has been reported in patients with drug hypersensitivity reaction (DHR); however, its relationship with the test results was not studied previously. OBJECTIVE:We aimed to investigate the association of patient anxiety with the results of drug tests together with the other contributing factors. ...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2015.36.3878
更新日期:2015-11-01 00:00:00
abstract::Currently, inhaled corticosteroids (ICSs) are the most effective long-term control therapy for persistent asthma. However, patients show a variable response to ICSs and some exhibit glucocorticoid resistance. At recommended doses, there is little evidence to suggest that ICSs can either prevent or reverse the chronic ...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND:Chronic urticaria (CU) is a skin disorder defined as daily or almost daily exhibition of pruritic and transient wheals that last for 6 weeks. CU is divided into two subtypes: chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU). OBJECTIVES:To evaluate the clinical features, possible c...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2016.37.4010
更新日期:2016-11-01 00:00:00
abstract::Dose-response of formoterol via pressurized metered-dose inhaler (pMDI) has not been determined in asthmatic pediatric patients aged 6 to <12 years. This study was designed to assess the bronchodilating dose-response of three formoterol pMDI doses in children with stable asthma aged 6 to <12 years receiving twice-dail...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2500/aap.2014.35.3746
更新日期:2014-03-01 00:00:00
abstract::Background: Peanut allergy is a major health burden in the United States. Treatment is limited to avoidance and acute reaction management. No drug or medical product is approved for use as a peanut oral immunotherapy (POIT) agent. Objective: To examine peanut allergy diagnosis and treatment, peanut challenge protocols...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2019.40.4228
更新日期:2019-07-23 00:00:00
abstract::Previous studies suggest cross-reactivity between specific ragweed pollen and melon allergens. This study was designed to clarify the origin of the cross-reactivity between ragweed pollen and the gourd family. One thousand ragweed-allergic subjects were interviewed about the presence of oral allergy syndrome (OAS) ind...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2011.32.3416
更新日期:2011-01-01 00:00:00
abstract::Background: The first-line method in the diagnosis of patients who describe an immediate reaction after penicillin intake is a skin test (ST) with penicillin reagents. Objectives: We aimed to determine the safety and diagnostic value of penicillin STs in the diagnosis of immediate reactions to penicillins in pediatric...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2020.41.200082
更新日期:2020-11-01 00:00:00
abstract::Rhinitis symptom complex consists of rhinorrhea, congestion, itchy mucosa, itchy eyes, and sneezing. Available medications vary in their benefit for each of these symptoms. It was the purpose of this article to compare symptom reduction with three different classes of medications. Montelukast, azelastine, and budesoni...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/aap.2010.31.3308
更新日期:2010-01-01 00:00:00
abstract::Hereditary angioedema (HAE) is a rare inherited disorder of complement factor C1 inhibitor. HAE is frequently confused with angioedema (AE), and little is known about emergency department (ED) or hospital utilization by patients with attacks in the United States. We examined hospitalizations and ED utilization for HAE...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2010.31.3403
更新日期:2010-11-01 00:00:00
abstract::Despite both efficacy and immunotolerogenic effects, many clinicians still are reluctant to use allergen-specific immunotherapy (SIT) because of the potential for acute allergic reactions. The anti-immunoglobulin E monoclonal antibody, omalizumab, is approved by the U.S. Food and Drug Administration for the treatment ...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:
更新日期:2006-03-01 00:00:00
abstract::Hereditary angioedema (HAE) is a rare, autosomal dominant disease caused by a deficiency in the C1-inhibitor protein. It is characterized by recurrent episodes of nonpruritic, nonpitting, subcutaneous or submucosal edema that typically involves the extremities or the gastrointestinal tract. However, the genitourinary ...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2020.41.200065
更新日期:2020-11-01 00:00:00
abstract::Data support an increase in adverse outcomes in the pregnant woman with asthma, particularly those who are poorly controlled. Additionally, pregnancy is recognized to influence the course of asthma. Hormonal and physiologic changes are felt to direct the eventual course and outcome, but their roles are incompletely un...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/108854101778249258
更新日期:2001-01-01 00:00:00
abstract::Latex immediate hypersensitivity has been documented in 28% to 67% of spina bifida patients, 2.6%-16.9% of health care workers and at least 1% of the general population. Additionally, it has been confirmed in food-sensitive individuals sensitive to cross-reacting foods such as chestnut, avocado, banana, and passion fr...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/108854196778645083
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:Local allergic rhinitis (LAR) is rhinitis with a localized nasal allergic response in the absence of systemic allergy. This study aimed to evaluate the pathogenesis specific to LAR compared with allergic rhinitis (AR) and nonallergic rhinitis (NAR) by using cytokines from polypous tissues. METHODS:We recrui...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2018.39.4135
更新日期:2018-07-01 00:00:00