Allergy immunotherapy for inhalant allergens: Strategies to improve efficacy.

Abstract:

:Background: Allergy immunotherapy (AIT), both subcutaneous immunotherapy (SCIT) and sublingual immunotherapy (SLIT), is an effective and safe treatment for allergic rhinitis and allergic asthma due to inhalant allergens. However, there are many variables in how it is administered. Objective: To review the evidence that suggests the optimum practices to enhance the efficacy of AIT. Methods: Articles that reported the results of various approaches to the practice of AIT and evidence-based guidelines were consulted for guidance on what approaches would enhance the efficacy of AIT. Results: Evidence is presented that supports optimum dosing for SCIT, a discussion of dosing with liquid SLIT, the management of the patient who is polyallergic, considerations in mixing allergen extracts, advantages and disadvantages of different up-dosing regimens with SCIT, the optimum duration of AIT, the comparative efficacy of SCIT and SLIT, and improving adherence to AIT. Also reviewed were two approaches, the use of adjuvants and of alternative routes of administration of currently available extracts, which may be useful in the future after further studies have defined their effectiveness. Conclusion: Although there is still controversy about some aspects of AIT, there is literature to support approaches that enhance the efficacy of both SCIT and SLIT.

journal_name

Allergy Asthma Proc

authors

Nelson HS

doi

10.2500/aap.2020.41.190013

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

26-37

issue

1

eissn

1088-5412

issn

1539-6304

journal_volume

41

pub_type

杂志文章,评审
  • A new protocol for specific oral tolerance induction in children with IgE-mediated cow's milk allergy.

    abstract::IgE-mediated cow's milk allergy (CMA) is a heavy burden for patients, particularly for children and their families. Allergen avoidance represents the only therapeutic option, but oral desensitization protocols have been suggested. Because of the long duration and complexity of these protocols we examined the feasibili...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,随机对照试验

    doi:10.2500/aap.2009.30.3221

    authors: Caminiti L,Passalacqua G,Barberi S,Vita D,Barberio G,De Luca R,Pajno GB

    更新日期:2009-07-01 00:00:00

  • New insights into the pathophysiology of allergic rhinitis.

    abstract::The immune response to an allergen is dependent on an initial sensitization process, with future exposures triggering a two-part allergic response including an early and a late phase. The process by which an allergen is recognized as such, including which cell types and cytokines are involved in the sensitization proc...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2007.28.2977

    authors: Rosenwasser L

    更新日期:2007-01-01 00:00:00

  • Managing rhinitis: Strategies for improved patient outcomes.

    abstract::Allergic rhinitis affects more than 40 million Americans, with estimated costs reaching $5.3 billion annually. The global impact includes negative effects on quality of life (QOL), sleep, diminished work productivity, and exacerbation of comorbid conditions. An accurate diagnosis of allergic or nonallergic rhinitis is...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2008.29.3145

    authors: Carr WW,Nelson MR,Hadley JA

    更新日期:2008-07-01 00:00:00

  • Efficacy and safety of once-daily treatment with beclomethasone dipropionate nasal aerosol in subjects with seasonal allergic rhinitis.

    abstract::An aerosol formulation may be preferred by some allergic rhinitis (AR) patients, to avoid the "wet feeling" and nasal runoff associated with aqueous nasal corticosteroid sprays. Beclomethasone dipropionate (BDP) hydrofluoroalkane nasal aerosol is a recently developed, nonaqueous, nonchlorofluorocarbon formulation of ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,随机对照试验

    doi:10.2500/aap.2012.33.3593

    authors: van Bavel JH,Ratner PH,Amar NJ,Hampel FC Jr,Melchior A,Dunbar SA,Dorinsky PM,Tantry SK

    更新日期:2012-09-01 00:00:00

  • Asthma burden in the United States: results of the 2009 Asthma Insight and Management survey.

    abstract::Updated guidelines and new treatments for asthma have become available since the last major survey of asthma management in the United States was completed ∼11 years ago. The Asthma Insight and Management (AIM) survey was conducted to assess the current status of asthma burden in the United States. A geographically str...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2011.32.3519

    authors: Meltzer EO,Blaiss MS,Nathan RA,Doherty DE,Murphy KR,Stoloff SW

    更新日期:2012-01-01 00:00:00

  • Efficacy of olopatadine ophthalmic solution 0.2% in reducing signs and symptoms of allergic conjunctivitis.

    abstract::Olopatadine hydrochloride ophthalmic solution 0.2% (Pataday, Alcon) is a new formulation of olopatadine hydrochloride ophthalmic solution, the first topical ocular antiallergic agent indicated for once-daily dosing. The aim of this study was to evaluate the safety, efficacy, onset, and duration of action of olopatadin...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,随机对照试验

    doi:10.2500/aap.2007.28.3014

    authors: Abelson MB,Gomes PJ,Pasquine T,Edwards MR,Gross RD,Robertson SM

    更新日期:2007-07-01 00:00:00

  • Atopy patch testing for foods: a review of the literature.

    abstract::The atopy patch test (APT) was first reported in 1895 by the German dermatologist, Jadassohn and was used for evaluation of contact dermatitis. The first documented epicutaneous application of aeroallergens was by Rostenberg and Sulzbergen in 1937. Although others including Mitchell and Platts-Mills, further described...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2014.35.3797

    authors: Edwards KP,Martinez BA

    更新日期:2014-11-01 00:00:00

  • A comparison of intranasal corticosteroid, leukotriene receptor antagonist, and topical antihistamine in reducing symptoms of perennial allergic rhinitis as assessed through the Rhinitis Severity Score.

    abstract::Rhinitis symptom complex consists of rhinorrhea, congestion, itchy mucosa, itchy eyes, and sneezing. Available medications vary in their benefit for each of these symptoms. It was the purpose of this article to compare symptom reduction with three different classes of medications. Montelukast, azelastine, and budesoni...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2010.31.3308

    authors: Sardana N,Santos C,Lehman E,Craig T

    更新日期:2010-01-01 00:00:00

  • Oxidative stress markers in patients with hymenoptera venom allergy.

    abstract::Oxidative stress occurs in many allergic and immunologic disorders as a result of the imbalance between the endogenous production of free reactive oxygen species (ROS) and/or the reduction of antioxidant defense mechanisms. Advanced glycation end products (AGEs), advanced oxidation protein products (AOPPs), and nitros...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2015.36.3814

    authors: Patella V,Incorvaia C,Minciullo PL,Oricchio C,Saitta S,Florio G,Saija A,Gangemi S

    更新日期:2015-01-01 00:00:00

  • Chapter 17: Occupational immunologic lung disease.

    abstract::Occupational immunologic lung disease is characterized by an immunologic response in the lung to an airborne agent inhaled in the work environment and can be subdivided into immunologically mediated occupational asthma (OA) and hypersensitivity pneumonitis (HP). Irritant-induced OA, a separate nonimmunologic entity, ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2012.33.3550

    authors: Sabin BR,Grammer LC

    更新日期:2012-05-01 00:00:00

  • Functional assessment of allergic asthmatic children while asymptomatic.

    abstract::The aim of this study was to detect the best test lung function to identify abnormalities in asthmatic children while asymptomatic. We studied 200 asthmatic children. Patients were evaluated by questionnaire to evaluate the presence of symptoms and drug consumption in the previous 3 months. Allergological evaluation b...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2006.27.2922

    authors: Verini M,Peroni DG,Rossi N,Nicodemo A,De Stradis R,Spagnolo C,Chiarelli F,Boner AL

    更新日期:2006-07-01 00:00:00

  • Relation of indoor and outdoor airborne fungal spore levels in the Kansas City metropolitan area.

    abstract:BACKGROUND:Environmental control is an important component of asthma management for persons with asthma. A damp indoor environment and elevated airborne spore levels are factors in housing environmental control. OBJECTIVES:We investigated if indoor airborne fungal spore levels correlated with outdoor ground-level airb...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2017.38.4030

    authors: Jara D,Portnoy J,Dhar M,Barnes C

    更新日期:2017-03-01 00:00:00

  • Nonsteroidal anti-inflammatory drug hypersensitivity among children.

    abstract:BACKGROUND:Nonsteroidal anti-inflammatory drugs (NSAID) are the second-most frequent drugs that cause hypersensitivity reactions among children. Studies related to NSAIDs hypersensitivity in children are limited. In this study, we aimed to evaluate children admitted with suspicion of NSAIDs reaction. METHOD:Between Ja...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2015.36.3858

    authors: Guvenir H,Dibek Misirlioglu E,Vezir E,Toyran M,Ginis T,Civelek E,Kocabas CN

    更新日期:2015-09-01 00:00:00

  • Aeroallergen sensitization in asthma: genetics, environment, and pathophysiology.

    abstract::A complex interplay of genetic predisposition and environmental influences results in the clinical picture of allergic asthma. This article addresses recently identified genetic markers and environmental factors that contribute to disease development in asthma. Focus is placed on aspects of the innate immune system, i...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2010.31.3328

    authors: Long A

    更新日期:2010-03-01 00:00:00

  • The tale of the allergist's life: a series of interesting case reports.

    abstract::The practicing allergist has the unique opportunity to see an extraordinary variety of fascinating patients. Identifying the precise cause of the patient's complaints makes for a satisfying intellectual endeavor. This is exemplified by the description of nine cases seen in a university allergy clinic. The cases includ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2008.29.3140

    authors: Slavin RG

    更新日期:2008-07-01 00:00:00

  • The spectrum of aeroallergen sensitization in children diagnosed with asthma during first 2 years of life.

    abstract::Aeroallergens may trigger symptoms in sensitized children with asthma. Documentation of sensitization is crucial to enable effective implementation of measures to prevent asthma exacerbations. To document the sensitization patterns of very young children (≤2 years) with asthma, we retrospectively analyzed the skin-pri...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2013.34.3655

    authors: Sahiner UM,Buyuktiryaki AB,Yavuz ST,Arik Yilmaz E,Cavkaytar O,Tuncer A,Sekerel BE

    更新日期:2013-07-01 00:00:00

  • Rapid diagnosis of Mycobacterium tuberculosis infection in children using interferon-gamma release assays (IGRAs).

    abstract::Diagnosis of tuberculosis (TB) in children by the tuberculin skin test (TST) poses a diagnostic challenge for physicians due to its low specificity and cross-reactivity with nontuberculous mycobacteria and bacille Calmette-Guerin (BCG). Although interferon-gamma release assays (IGRAs) have been shown as novel TST alte...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2012.33.3574

    authors: Riazi S,Zeligs B,Yeager H,Peters SM,Benavides GA,Di Mita O,Bellanti JA

    更新日期:2012-05-01 00:00:00

  • The burden of hospitalizations and emergency department visits with hereditary angioedema and angioedema in the United States, 2007.

    abstract::Hereditary angioedema (HAE) is a rare inherited disorder of complement factor C1 inhibitor. HAE is frequently confused with angioedema (AE), and little is known about emergency department (ED) or hospital utilization by patients with attacks in the United States. We examined hospitalizations and ED utilization for HAE...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2010.31.3403

    authors: Zilberberg MD,Jacobsen T,Tillotson G

    更新日期:2010-11-01 00:00:00

  • Serum levels of soluble CD23 in patients with asthma or rhinitis monosensitive to Parietaria. Its relation to total serum IgE levels and eosinophil cationic protein during and out of the pollen season.

    abstract::The diagnostic value for allergies of the low affinity IgE receptor and its soluble circulating fragment (sCD23) remains unclear. In particular, little is know about seasonal influences on serum sCD23 levels in subjects with pollen allergy. In the present study, to gain insight into pathophysiological role of sCD23, w...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/108854199778612590

    authors: Di Lorenzo G,Drago A,Pellitteri ME,Candore G,Colombo A,Potestio M,Di Salvo A,Mansueto S,Caruso C

    更新日期:1999-03-01 00:00:00

  • Treatment of allergic rhinitis: effects of allergic rhinitis and antihistamines on performance.

    abstract::Antihistamines are the most commonly used drugs for allergic rhinitis, and many antihistamines may cause subclinical side effects which are not noticeable by the patient. These include impaired driving performance, impaired work performance, reduced coordination, reduced motor skills, sleepiness and impaired informati...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/108854197778605473

    authors: Storms WW

    更新日期:1997-03-01 00:00:00

  • Inflammatory mediators in cystic fibrosis lung disease.

    abstract::Cystic fibrosis (CF) is a complex multisystem disorder caused by mutations in a membrane glycoprotein called the CF transmembrane regulator (CFTR), which has as its major function serving as a Cl- channel. The relationship between defects in CFTR and development of lung disease remains incompletely understood. Chronic...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:

    authors: Berger M

    更新日期:2002-01-01 00:00:00

  • Preparation of benzylpenicilloyl-polylysine: a preliminary study.

    abstract::The manufacturing of PrePen (benzylpenicilloyl-polylysine) was suspended from September 2000 through November 2001 because of Food and Drug Administration intervention. PrePen is penicilloyl bound to polylysine and is considered to be the major determinant of penicillin metabolism; it is used as a skin-testing reagent...

    journal_title:Allergy and asthma proceedings

    pub_type: 临床试验,杂志文章

    doi:

    authors: Vemuri P,Harris KE,Suh LA,Grammer LC

    更新日期:2004-05-01 00:00:00

  • Oral allergy syndrome (pollen-food allergy syndrome).

    abstract::A case of Oral Allergy syndrome or Pollen-Food Allergy Syndrome is briefly discussed. The clinical characteristics, diagnosis, pathogenesis, and management of this syndrome are discussed followed by clinical pearls and pitfalls for the practicing allergist. Symptoms generally occur with the ingestion of raw fruits/veg...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:

    authors: Purohit-Sheth TS,Carr WW

    更新日期:2005-05-01 00:00:00

  • Multiple-dose proportionality study of flunisolide hydrofluoroalkane.

    abstract::The hydrofluoroalkane (HFA) formulation of the inhaled corticosteroid flunisolide is a modification of the original chlorofluorocarbon formulation. HFA flunisolide substitutes an HFA for a chlorofluorocarbon propellant and uses a built-in spacer in its pressurized metered-dose inhaler. An open-label, randomized, three...

    journal_title:Allergy and asthma proceedings

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Nolting A,Abramowitz W

    更新日期:2002-09-01 00:00:00

  • Solar urticaria.

    abstract::A case of solar urticaria is presented, followed by a discussion of the clinical characteristics, pathophysiology, diagnosis, and management of this disease. Special emphasis is given to clinical pearls and pitfalls for the practicing allergist. Solar urticaria is a physical urticaria that can be difficult to diagnose...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2009.30.3273

    authors: Webb LM,Mikita CP

    更新日期:2009-09-01 00:00:00

  • Emergency department treatment of adults with acute asthma exacerbations: effect on exhaled nitric oxide levels.

    abstract::Measurement of exhaled nitric oxide levels (eNO) from asthmatic patients is a noninvasive marker of airway inflammation in both adults and children and has been used as an outpatient measure of asthma control. We examined eNO in acute asthma exacerbations and how it is affected by treatment in the emergency departmen...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,随机对照试验

    doi:10.2500/aap.2012.33.3613

    authors: Silverberg JI,Rodenas M,Sinert R,Joks R

    更新日期:2012-11-01 00:00:00

  • Efficacy of probiotic supplementary therapy for asthma, allergic rhinitis, and wheeze: a meta-analysis of randomized controlled trials.

    abstract::Background: Probiotic supplementary therapy to prevent allergic diseases, including asthma in children, has been widely explored in many randomized controlled trials. However, there is conflicting evidence on the effect of probiotic supplementation during pregnancy and infancy to the incidence of asthma and allergic r...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,meta分析

    doi:10.2500/aap.2019.40.4227

    authors: Du X,Wang L,Wu S,Yuan L,Tang S,Xiang Y,Qu X,Liu H,Qin X,Liu C

    更新日期:2019-07-01 00:00:00

  • Bronchodilator effect of single-dose formoterol administered by pressurized metered-dose inhaler in children with asthma aged 6 to

    abstract::Dose-response of formoterol via pressurized metered-dose inhaler (pMDI) has not been determined in asthmatic pediatric patients aged 6 to <12 years. This study was designed to assess the bronchodilating dose-response of three formoterol pMDI doses in children with stable asthma aged 6 to <12 years receiving twice-dail...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2500/aap.2014.35.3746

    authors: Berger WE,Gillen M,Eckerwall G,Uryniak T,Trudo FJ,Lampl KL

    更新日期:2014-03-01 00:00:00

  • Two puffs of 90 microg albuterol prior to 3% saline sputum induction results in less FEV-1 decline than single concentration 25 mg/ml methacholine challenge.

    abstract:BACKGROUND:Assessment of sputum eosinophilia has shown benefit in the diagnosis and monitoring of asthma. However, the possibility of bronchospasm related to the hypertonic saline used in sputum induction appears to have limited this procedure's acceptance in clinical practice. OBJECTIVE:Because the methacholine (MCH)...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2006.27.2900

    authors: Hagan JB,Madaan A,Kim CK

    更新日期:2006-09-01 00:00:00

  • Indoor allergen sensitization and the risk of asthma and eczema in children in Pittsburgh.

    abstract::Several studies have shown that sensitization to cockroach and mouse allergens is correlated with presence and severity of asthma, especially among children living in inner cities. This study evaluated the prevalence of positive skin testing to indoor allergens in the Pittsburgh area and the association with asthma an...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2011.32.3456

    authors: McHugh BM,MacGinnitie AJ

    更新日期:2011-09-01 00:00:00