High mobility group box 1: Biomarker of inhaled corticosteroid treatment response in children with moderate-severe asthma.

Abstract:

BACKGROUND:High mobility group box 1 (HMGB1) is abnormally expressed in serum and sputum of patients with allergic asthma. OBJECTIVE:The aim of this study was to investigate the role of HMGB1 as guidance for treatment management of children with asthma. METHODS:Thirty children with asthma and 44 healthy children were enrolled. The patients were classified according to Global Initiative for Asthma Guideline disease severity criteria. Sputum HMGB1 levels and lung function index (percentage forced expiratory volume in 1 second [FEV1%]) were recorded in the cohort study at baseline (T0) and after 3 (T3) and 6 (T6) months of inhaled corticosteroids (ICS) treatment. RESULTS:Sputum HMGB1 levels were significantly higher in all the patients with asthma (p < 0.001). An inverse correlation between sputum HMGB1 levels and pulmonary function parameters was observed only in the children with moderate asthma (T0: FEV1%, r = -0.9891, p < 0.001; T3: FEV1%, r = -0.6763, p < 0.001; T6: FEV1%, r = -0.5419, p < 0.05) and in the children with severe asthma (T0: FEV1%, r = -0.8696, p < 0.001; T3: FEV1%, r = -0.6477, p < 0.05; T6: FEV1%, r = -0.8627, p < 0.001). After ICS treatment, a significant decrease of sputum HMGB1 levels was noted in moderate (T0 [93.44 ± 20.65 ng/mL] versus T3 [77.96 ± 1.81 ng/mL] versus T6 [67.75 ± 3.01 ng/mL]; p < 0.0001) and in the children with severe asthma (T0 [130.3 ± 7.48 ng/mL] versus T3 [156.9 ± 1.09 ng/mL] versus T6 [116.08 ± 4.77 ng/mL]; p < 0.0001) data are mean ± standard deviation, respectively. The area under the receiver operating characteristic curve, performed to define the diagnostic profile of sputum HMGB1 levels in identifying the children with asthma, was 0.713. CONCLUSION:In addition to the findings that HMGB1 is a sensitive biomarker of allergic asthma in children, our data demonstrated a significant correlation between the decrease of HMGB1 levels and a successful treatment response.

journal_name

Allergy Asthma Proc

authors

Manti S,Leonardi S,Parisi GF,De Vivo D,Salpietro A,Spinuzza A,Arrigo T,Salpietro C,Cuppari C

doi

10.2500/aap.2017.38.4047

subject

Has Abstract

pub_date

2017-05-01 00:00:00

pages

197-203

issue

3

eissn

1088-5412

issn

1539-6304

journal_volume

38

pub_type

杂志文章
  • Natural history of hay fever: a 23-year follow-up of college students.

    abstract::The purpose of this study is to examine the natural history of hay fever among former college students who were diagnosed with this disease either before or after their freshman year. The diagnosis of hay fever or seasonal allergic rhinitis was based on a history of watery, itchy eyes, rhinorrhea, and sneezing occurri...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/108854198778557728

    authors: Greisner WA 3rd,Settipane RJ,Settipane GA

    更新日期:1998-09-01 00:00:00

  • Nasal reactivity evaluation in children with allergic rhinitis receiving grass pollen sublingual immunotherapy.

    abstract::Background: The European Academy of Allergy and Clinical Immunology guidelines, strongly recommended allergen immunotherapy (AIT) as an effective treatment to achieve long-term clinical benefits and to modify the natural history of allergic diseases. Sublingual immunotherapy (SLIT) offers the possibility of home admin...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2020.41.200063

    authors: Schiavi L,Brindisi G,De Castro G,De Vittori V,Loffredo L,Spalice A,Duse M,Zicari AM

    更新日期:2020-09-01 00:00:00

  • Changing the route of immunotherapy administration: an 18-year survey in pediatric patients with allergic rhinitis and asthma.

    abstract::Immunotherapy can be administered either sublingually (sublingual immunotherapy [SLIT]) or subcutaneously (subcutaneous immunotherapy [SCIT]). The rate of route switching, required by patients, can provide an indirect evaluation of patients' preferences and adherence. The authors retrospectively reviewed patients' fil...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2013.34.3696

    authors: Pajno GB,Caminiti L,Passalacqua G

    更新日期:2013-11-01 00:00:00

  • Utilization and timeliness of an inpatient penicillin allergy evaluation.

    abstract:BACKGROUND:A history of penicillin allergy is associated with an increased risk of nosocomial infections because patients are exposed to non-beta lactam antibiotics. Ruling out inaccurate penicillin allergy during hospitalization decreases prescription of beta lactam antibiotics. However, the utilization of penicillin ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2018.39.4118

    authors: Sacco KA,Chirila R,Libertin C,Hiroto B,Bhasin A,Johnson MM,Pongdee T,Burton MC

    更新日期:2018-05-01 00:00:00

  • Systemic inflammation mediates the detrimental effects of obesity on asthma control.

    abstract:BACKGROUND:Obesity negatively impacts asthma control, but the inflammatory mechanisms are poorly understood. OBJECTIVE:To explore which systemic inflammatory mediators mediate the effects of obesity on asthma control. METHODS:The subjects with stable asthma (n = 108) underwent assessment of clinical characteristics, ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2017.38.4096

    authors: Zhang X,Zheng J,Zhang L,Liu Y,Chen GP,Zhang HP,Wang L,Kang DY,Wood LG,Wang G

    更新日期:2017-10-02 00:00:00

  • Latex protein: a hidden "food" allergen?

    abstract::Avoidance of latex allergens is the primary method to prevent adverse reactions. Natural rubber latex is found in many different products in both the health care industry and in modern society, and consequently results in unexpected exposures of sensitized individuals. The use of latex gloves by food handlers provides...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/108854100778248214

    authors: Beezhold DH,Reschke JE,Allen JH,Kostyal DA,Sussman GL

    更新日期:2000-09-01 00:00:00

  • Effect of the inhaled corticosteroid mometasone on small airway patency in patients with asthma.

    abstract::The inflammation in asthma involves both the large and the small airways. This study was designed to examine whether mometasone delivered from a dry powder inhaler would improve those parameters thought to reflect patency and obstruction of the small airways (diameter <2 mm). Subjects with mild to moderate asthma, onl...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,随机对照试验

    doi:10.2500/aap.2009.30.3235

    authors: Nelson HS,Gallegos CM,Silveira LJ,Newell JD,Gelfand EW

    更新日期:2009-05-01 00:00:00

  • A cost-effective approach to the diagnosis and treatment of the wheezing infant.

    abstract::Wheezing in infancy presents the clinician with at least two broad clinical problems. First is the task of distinguishing the common entities of bronchiolitis and asthma from rare, yet potentially life threatening illnesses that may present with wheezing. The second problem deals with the difficulties in distinguishin...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/108854197778984446

    authors: Mamlok R

    更新日期:1997-05-01 00:00:00

  • Relationship between atopic asthma and the population prevalence rates for asthma or atopy in children: atopic and nonatopic asthma in epidemiology.

    abstract::Innumerable articles have tried to solve the "continuing enigma of atopic and nonatopic asthma" but notwithstanding the strenuous efforts to substantiate the few well-known clinico-epidemiologic differences between these two forms of asthma most studies have hitherto generated inconclusive statements. In a recent stud...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2009.30.3197

    authors: Ronchetti R,Jesenak M,Rennerova Z,Barreto M,Ronchetti F,Villa MP

    更新日期:2009-01-01 00:00:00

  • Biphasic reactions in children undergoing oral food challenges.

    abstract::Literature regarding biphasic reactions in the pediatric population is sparse. We aimed to determine the prevalence of biphasic reactions in children with food allergies undergoing oral food challenges (OFCs) and examine whether any clinical or treatment factors are associated with biphasic reactions. A retrospective ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2013.34.3669

    authors: Lee J,Garrett JP,Brown-Whitehorn T,Spergel JM

    更新日期:2013-05-01 00:00:00

  • Serum levels of soluble CD23 in patients with asthma or rhinitis monosensitive to Parietaria. Its relation to total serum IgE levels and eosinophil cationic protein during and out of the pollen season.

    abstract::The diagnostic value for allergies of the low affinity IgE receptor and its soluble circulating fragment (sCD23) remains unclear. In particular, little is know about seasonal influences on serum sCD23 levels in subjects with pollen allergy. In the present study, to gain insight into pathophysiological role of sCD23, w...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/108854199778612590

    authors: Di Lorenzo G,Drago A,Pellitteri ME,Candore G,Colombo A,Potestio M,Di Salvo A,Mansueto S,Caruso C

    更新日期:1999-03-01 00:00:00

  • Association of inflammatory bowel disease with asthma risk: A nationwide cohort study.

    abstract:OBJECTIVE:We evaluated the risk of asthma development in adult patients with inflammatory bowel disease (IBD) in a nationwide population. METHODS:A retrospective cohort study was conducted by using data retrieved from the Taiwan National Health Insurance Research Database. Patients, ages 20 year or older, with newly d...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2015.36.3869

    authors: Peng YH,Liao WC,Su CH,Chen HJ,Hsia TC,Chu CC,Liu CJ,Kao CH

    更新日期:2015-09-01 00:00:00

  • Antihistamine onset of action: the importance to the patient.

    abstract::Although some older antihistamines have a relatively slow onset of action, modern agents indicate an efficacy between 1 and 3 hours of administration. For patients who use antihistamines regularly, a short onset of action is relatively unimportant. When antihistamines are used as needed, either because of poor complia...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:

    authors: Dolen WK

    更新日期:2004-03-01 00:00:00

  • A late preterm infant with lymphopenia.

    abstract::The newborn screen for severe combined immunodeficiency (SCID) uses real-time quantitative polymerase chain reaction for T-cell receptor excision circles and is highly sensitive for SCID. However, T-cell lymphopenia from other primary and secondary causes, such as DiGeorge syndrome, prematurity, thymic involution from...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2019.40.190015

    authors: Lutfeali S,Khan DA,Wysocki C

    更新日期:2020-03-01 00:00:00

  • Epinephrine auto-injector prescriptions as a reflection of the pattern of anaphylaxis in an Asian population.

    abstract::This study surveyed the prescription patterns of adrenaline auto-injectors (AAs) in Singapore to examine the frequency, triggers, and demographic pattern of anaphylaxis requiring such prescriptions. A 6-year retrospective review of 417 consecutive patients prescribed AAs in Singapore from January 1999 to December 2004...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2008.29.3102

    authors: Tham EH,Tay SY,Lim DL,Shek LP,Goh AE,Giam YC,Chng HH,Lee BW

    更新日期:2008-03-01 00:00:00

  • Multiple physical urticarias: report of three cases and review of the literature.

    abstract::The appearance of more than one physical urticaria (PU) in the same patient has been documented; cold urticaria or dermatographism in association with some other type of PU are encountered more frequently. Three female patients exhibiting multiple PUs simultaneously are presented. In one female patient four different ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:

    authors: Pitsios C,Vithoulka A,Roumana A,Kompoti E,Kontou-Fili K

    更新日期:2003-09-01 00:00:00

  • Hygiene factors associated with childhood food allergy and asthma.

    abstract:BACKGROUND:Childhood food allergy and asthma rates are increasing. The hygiene hypothesis has been proposed as an explanation for the increased incidence of allergic disease. OBJECTIVE:To describe the association of childhood food allergy and asthma with hygiene factors, such as the number of siblings, antibiotic use,...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2016.37.3988

    authors: Gupta RS,Singh AM,Walkner M,Caruso D,Bryce PJ,Wang X,Pongracic JA,Smith BM

    更新日期:2016-11-01 00:00:00

  • Clinical and etiologic evaluation of the children with chronic urticaria.

    abstract:BACKGROUND:Chronic urticaria (CU) is a skin disorder defined as daily or almost daily exhibition of pruritic and transient wheals that last for 6 weeks. CU is divided into two subtypes: chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU). OBJECTIVES:To evaluate the clinical features, possible c...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2016.37.4010

    authors: Azkur D,Civelek E,Toyran M,Mısırlıoğlu ED,Erkoçoğlu M,Kaya A,Vezir E,Giniş T,Akan A,Kocabaş CN

    更新日期:2016-11-01 00:00:00

  • Atopy patch testing for foods: a review of the literature.

    abstract::The atopy patch test (APT) was first reported in 1895 by the German dermatologist, Jadassohn and was used for evaluation of contact dermatitis. The first documented epicutaneous application of aeroallergens was by Rostenberg and Sulzbergen in 1937. Although others including Mitchell and Platts-Mills, further described...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2014.35.3797

    authors: Edwards KP,Martinez BA

    更新日期:2014-11-01 00:00:00

  • Usefulness of offline fractional exhaled nitric oxide measurements in the elderly asthmatic patients.

    abstract::Fractional exhaled nitric oxide (FeNO) measurement is an important noninvasive tool for evaluating eosinophilic inflammation of the airways. However, measurement of online FeNO in elderly people may not be possible if they are unable to perform the expiratory maneuver. The offline FeNO test is an alternative method th...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2013.34.3692

    authors: Hsu JY,Huang WC,Huang PL,Cheng YW,Chou MC

    更新日期:2013-09-01 00:00:00

  • IgE values and T-lymphocyte subsets in children with atopic eczema/dermatitis syndrome.

    abstract::High levels of IgE and IgE-mediated reactions represent a typical finding in patients with atopic eczema/dermatitis syndrome (AEDS). However, 10-30% of patients usually do not show any increase of total blood IgE levels and any detectable specific IgE sensitization. We performed this study to evaluate the difference o...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap2007.28.3038

    authors: Leonardi S,Rotolo N,Vitaliti G,Spicuzza L,La Rosa M

    更新日期:2007-09-01 00:00:00

  • Airway responsiveness in asthma: bronchial challenge with histamine and 4.5% sodium chloride before and after budesonide.

    abstract::Inhalation of histamine is commonly used to assess the severity of and to monitor treatment of asthma. Histamine causes airways to narrow by acting directly on specific receptors. Hyperosmolar saline causes airways of asthmatics to narrow indirectly by endogenously mediated events that are potentially modified by drug...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/108854197778612817

    authors: du Toit JI,Anderson SD,Jenkins CR,Woolcock AJ,Rodwell LT

    更新日期:1997-01-01 00:00:00

  • Medical and economic dimensions linking allergic rhinitis and asthma.

    abstract::Allergic rhinitis and asthma are two of the most common chronic conditions affecting the population. There has been a growing understanding of the link between these disorders as they commonly occur in the same individual, of their relationship with allergies, and of the total economic impact in both direct and indire...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:

    authors: Blaiss MS

    更新日期:2002-07-01 00:00:00

  • Chapter 17: Occupational immunologic lung disease.

    abstract::Occupational immunologic lung disease is characterized by an immunologic response in the lung to an airborne agent inhaled in the work environment and can be subdivided into immunologically mediated occupational asthma (OA) and hypersensitivity pneumonitis (HP). Irritant-induced OA, a separate nonimmunologic entity, ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2012.33.3550

    authors: Sabin BR,Grammer LC

    更新日期:2012-05-01 00:00:00

  • Literature review: the best new articles in the specialty of allergy, asthma, and immunology, 2004-2005.

    abstract::A series of eight articles from the published literature for the period 2004-2005 was selected for review in this article. Small-airway obstruction in chronic obstructive pulmonary disease (COPD) and its management were the subjects of the first two articles reviewed in this commentary. Progression of COPD from the Gl...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2006.27.2859

    authors: Bellanti JA

    更新日期:2006-05-01 00:00:00

  • Anosmia and hyposmia.

    abstract::There has been some renewed interest in recent years in disorders of olfaction. Decreased sense of smell can lead to significant impairment of quality of life, including taste disturbance and loss of pleasure from eating with resulting changes in weight and difficulty in avoiding health risks such as spoiled food or l...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2010.31.3357

    authors: Gaines AD

    更新日期:2010-05-01 00:00:00

  • A comparison of intranasal corticosteroid, leukotriene receptor antagonist, and topical antihistamine in reducing symptoms of perennial allergic rhinitis as assessed through the Rhinitis Severity Score.

    abstract::Rhinitis symptom complex consists of rhinorrhea, congestion, itchy mucosa, itchy eyes, and sneezing. Available medications vary in their benefit for each of these symptoms. It was the purpose of this article to compare symptom reduction with three different classes of medications. Montelukast, azelastine, and budesoni...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2010.31.3308

    authors: Sardana N,Santos C,Lehman E,Craig T

    更新日期:2010-01-01 00:00:00

  • Antioxidant supplementation and exhaled nitric oxide in children with asthma.

    abstract:BACKGROUND:The effect of allergen avoidance on airway inflammation is similar to that observed with treatment with inhaled steroids, whereas inhaled steroids have no effect on oxidative stress-induced inflammation. OBJECTIVE:The aim of this study was to retrospectively evaluate the potential effect of an antioxidant d...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2016.37.3920

    authors: Tenero L,Piazza M,Zanoni L,Bodini A,Peroni D,Piacentini GL

    更新日期:2016-01-01 00:00:00

  • Targeting congestion in allergic rhinitis: the importance of intranasal corticosteroids.

    abstract::The cardinal nasal symptoms of allergic rhinitis (AR) are sustained by an underlying inflammatory process. Congestion is one of the most prominent and distressing symptoms for patients and is strongly associated with a broadly deteriorated quality of life and significant losses in productivity. The purpose of this stu...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2008.29.3110

    authors: Marple BF

    更新日期:2008-05-01 00:00:00

  • The role of antioxidants and 25-hydroxyvitamin D during pregnancy in the development of allergic diseases in early school-age children - Polish Mother and Child Cohort Study.

    abstract::Purpose: Based on the available data, alterations of the antioxidant defense as well as the vitamin status in mothers may affect the prenatal process of lung and immune system development as a pathophysiological background of increased prevalence of allergic diseases. The primary aim of the current study was to assess...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2020.41.190020

    authors: Bobrowska-Korzeniowska M,Jerzyńska J,Polańska K,Gromadzińska J,Hanke W,Wasowicz W,Stelmach I

    更新日期:2020-01-01 00:00:00