Biphasic reactions in children undergoing oral food challenges.

Abstract:

:Literature regarding biphasic reactions in the pediatric population is sparse. We aimed to determine the prevalence of biphasic reactions in children with food allergies undergoing oral food challenges (OFCs) and examine whether any clinical or treatment factors are associated with biphasic reactions. A retrospective chart review of OFCs conducted between July 2007 and March 2011 was performed. Charts were reviewed from time of challenge to 48 hours after challenge to capture data on any biphasic reactions. Uniphasic and biphasic reactions were compared in terms of specific clinical features and treatments. Of 614 positive challenges, 9 resulted in a biphasic reaction (1.5%). Six of the biphasic reactions occurred in challenges where the initial reaction met anaphylaxis criteria. The biphasic reactions were to eggs (4), peanuts (3), and milk (2). The symptom-free interval ranged from 2 to 24 hours. There were no statistically significant differences in clinical features between uniphasic and biphasic reactions, but there appeared to be a higher percentage of initial reactions with multiple organ involvement and meeting anaphylaxis criteria in the biphasic group. Biphasic reactors were significantly more likely to have received steroids for their initial reaction. A higher percentage of biphasic reactors also appeared to have received epinephrine, multiple doses of epinephrine, and antihistamines for their initial reactions. Biphasic reactions are rare in children undergoing OFCs and may be associated with more severe allergic reactions. Children with severe reactions may benefit from a 24-hour period of observation.

journal_name

Allergy Asthma Proc

authors

Lee J,Garrett JP,Brown-Whitehorn T,Spergel JM

doi

10.2500/aap.2013.34.3669

subject

Has Abstract

pub_date

2013-05-01 00:00:00

pages

220-6

issue

3

eissn

1088-5412

issn

1539-6304

journal_volume

34

pub_type

杂志文章
  • ECP level in nasopharyngeal secretions and serum from children with respiratory virus infections and asthmatic children.

    abstract::Infection with respiratory virus has been shown to exacerbate asthma in humans. However, the role of a respiratory virus in the pathogenesis of chronic asthma and/or wheezing in young children has not been clearly defined. It has also been debated whether virus-induced wheezing in young children is one entity and alle...

    journal_title:Allergy and asthma proceedings

    pub_type: 临床试验,杂志文章

    doi:10.2500/108854100778250888

    authors: Oh JW,Lee HB,Yum MK,Kim CR,Kang JO,Park IK

    更新日期:2000-03-01 00:00:00

  • Increased expression of CD30 and CD57 molecules on CD4(+) T cells from children with atopic asthma: a preliminary report.

    abstract::T helper type 2 (Th2) cells play an important role in the onset and persistence of allergic airway inflammation. Consequently, many authors have attempted to identify cell surface markers associated with a Th2 phenotype. This work was aimed at correlating CD30 and CD57 expression on CD4(+) T cells with interleukin (IL...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2007.28.3057

    authors: Rojas-Ramos E,Garfias Y,Jiménez-Martínez Mdel C,Martínez-Jiménez N,Zenteno E,Gorocica P,Lascurain R

    更新日期:2007-11-01 00:00:00

  • Skin rash in a 2-week-old infant.

    abstract::We presented a case of a male infant with annular patchy rash on his torso since 2 weeks of age. This was initially diagnosed as tinea corporis but did not respond to oral antifungal treatment. Because of the appearance of the rash and a history of a certain disease in a maternal aunt, we suspected the most probable c...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2017.38.4044

    authors: Nassiri M,Bahna SL

    更新日期:2017-09-01 00:00:00

  • Ovalbumin-induced experimental allergic asthma is Toll-like receptor 2 dependent.

    abstract::The role of Toll-like receptor (TLR) 2 in modulating allergy-induced asthma is contradictory. We investigated the effect of TLR2 gene deletion in a murine model of ovalbumin (OVA)-challenged asthma. TLR2 wild-type (TLR2(+/+)) and TLR2-deficient (TLR2(-/-)) mice were sensitized to soluble OVA antigens and challenged wi...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2014.35.3735

    authors: Li X,Chen Q,Chu C,You H,Jin M,Zhao X,Zhu X,Zhou W,Ji W

    更新日期:2014-03-01 00:00:00

  • Potentially (near) fatal asthma.

    abstract::Potentially (near) fatal asthma (PFA) defines a subset of patients with asthma who are at increased risk for death from their disease. The diagnosis of PFA should motivate treating physicians, health professionals, and patients to be more aggressive in the monitoring, treatment, and control of this high-risk type of a...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2019.40.4257

    authors: Greenberger PA

    更新日期:2019-11-01 00:00:00

  • A comparison of intranasal corticosteroid, leukotriene receptor antagonist, and topical antihistamine in reducing symptoms of perennial allergic rhinitis as assessed through the Rhinitis Severity Score.

    abstract::Rhinitis symptom complex consists of rhinorrhea, congestion, itchy mucosa, itchy eyes, and sneezing. Available medications vary in their benefit for each of these symptoms. It was the purpose of this article to compare symptom reduction with three different classes of medications. Montelukast, azelastine, and budesoni...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2010.31.3308

    authors: Sardana N,Santos C,Lehman E,Craig T

    更新日期:2010-01-01 00:00:00

  • The autoimmune nature of chronic urticaria.

    abstract::The association between chronic urticaria (CU) and autoimmune disease has been recognized for some time, especially with autoimmune thyroid disease. More recently, functional IgG autoantibodies against FcepsilonRIalpha and less commonly against IgE have been reported in a subset of patients with CU. These patients hav...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2008.29.3148

    authors: Boguniewicz M

    更新日期:2008-09-01 00:00:00

  • Current Allergic Rhinitis Experiences Survey (CARES): Consumers' awareness, attitudes and practices.

    abstract::Allergic rhinitis (AR) affects ~60 million people in the United States. This study evaluates awareness, attitudes, and behaviors of AR sufferers on the management of their condition. This U.S.-based survey evaluated 1600 adult AR sufferers to assess their perceptions of AR diagnosis, treatment preferences, and interac...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2014.35.3766

    authors: Fromer LM,Blaiss MS,Jacob-Nara JA,Long RM,Mannion KM,Lauersen LA

    更新日期:2014-07-01 00:00:00

  • Emergency department treatment of adults with acute asthma exacerbations: effect on exhaled nitric oxide levels.

    abstract::Measurement of exhaled nitric oxide levels (eNO) from asthmatic patients is a noninvasive marker of airway inflammation in both adults and children and has been used as an outpatient measure of asthma control. We examined eNO in acute asthma exacerbations and how it is affected by treatment in the emergency departmen...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,随机对照试验

    doi:10.2500/aap.2012.33.3613

    authors: Silverberg JI,Rodenas M,Sinert R,Joks R

    更新日期:2012-11-01 00:00:00

  • Nonsteroidal anti-inflammatory drug hypersensitivity among children.

    abstract:BACKGROUND:Nonsteroidal anti-inflammatory drugs (NSAID) are the second-most frequent drugs that cause hypersensitivity reactions among children. Studies related to NSAIDs hypersensitivity in children are limited. In this study, we aimed to evaluate children admitted with suspicion of NSAIDs reaction. METHOD:Between Ja...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2015.36.3858

    authors: Guvenir H,Dibek Misirlioglu E,Vezir E,Toyran M,Ginis T,Civelek E,Kocabas CN

    更新日期:2015-09-01 00:00:00

  • Effect of indoor air quality on the natural history of asthma in an urban population in Poland.

    abstract::Background: Indoor air pollution may have an impact on asthma. Objective: To evaluate the influence of indoor air pollution on the natural history of asthma. Methods: Data collection by using the European Community Respiratory Health Survey and International Study of Asthma and Allergies in Childhood standardized ques...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2018.39.4176

    authors: Piekarska B,Stankiewicz-Choroszucha BL,Sybilski AJ,Furmańczyk K,Jaworski S,Białoszewski AZ,Kłak A,Lipiec A,Walkiewicz A,Tomaszewska A,Raciborski F,Samoliński BK

    更新日期:2018-11-01 00:00:00

  • Correlation between vitamin D serum levels and passive smoking exposure in children with asthma.

    abstract:OBJECTIVE:To establish the relationship between vitamin D serum levels, pulmonary function, asthma control, and passive smoking exposure in children with asthma. METHODS:We studied the relationship between 25-hydroxy cholecalciferol (25[OH]D) concentrations and baseline spirometry and levels of asthma control, and the...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2018.39.4124

    authors: Chinellato I,Piazza M,Sandri M,Paiola G,Tezza G,Boner AL

    更新日期:2018-05-01 00:00:00

  • Properties of the ideal corticosteroid therapy.

    abstract::Currently, inhaled corticosteroids (ICSs) are the most effective long-term control therapy for persistent asthma. However, patients show a variable response to ICSs and some exhibit glucocorticoid resistance. At recommended doses, there is little evidence to suggest that ICSs can either prevent or reverse the chronic ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:

    authors: Zitt MJ

    更新日期:2005-05-01 00:00:00

  • An overview of allergens.

    abstract::Most allergens are proteins or glycoproteins that range in molecular weight from 5000 to 100,000 Da, although polysaccharides and low-molecular-weight substances may also be allergenic. Common allergens include pollens, fungal spores, house-dust mites, and animal epithelial materials but can also include drugs, biolog...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2019.40.4247

    authors: Lei DK,Grammer LC

    更新日期:2019-11-01 00:00:00

  • Herbal therapies: what allergist-immunologists should know regarding patient use of complementary and alternative medicine.

    abstract::The use of complementary and alternative medicine has dramatically increased in the United States, which necessitates that physicians have knowledge of different modalities, possible benefits, and potential adverse reactions. Internet access and numerous magazines are available to patients for self-administration. Num...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:

    authors: Frieri M

    更新日期:2001-07-01 00:00:00

  • Effect of omalizumab on outcomes in patients with aspirin-exacerbated respiratory disease.

    abstract::Background: The current treatment for patients with aspirin-exacerbated respiratory disease (AERD) who have uncontrolled asthma or chronic rhinosinusitis is aspirin desensitization. For patients who are unable to undergo or do not benefit from aspirin desensitization, treatment with biologics is an option, although ef...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2019.40.4241

    authors: Jean T,Eng V,Sheikh J,Kaplan MS,Goldberg B,Jau Yang S,Samant S

    更新日期:2019-09-01 00:00:00

  • The natural course of eczema from birth to age 7 years and the association with asthma and allergic rhinitis: a population-based birth cohort study.

    abstract::Although "atopic march" is a popular concept, the relationship between eczema and subsequent asthma is far from clear. However, some cohort studies have shown the possibility of two different allergic phenotypes in those who present with early eczema in terms of their persistency. We checked the cohort data from 308,...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2013.34.3625

    authors: Shen CY,Lin MC,Lin HK,Lin CH,Fu LS,Fu YC

    更新日期:2013-01-01 00:00:00

  • Long-term omalizumab outcomes in chronic idiopathic urticaria: a real-world study.

    abstract::Background: Although clinical trials documented omalizumab's efficacy in U.S. patients with chronic idiopathic urticaria (CIU), the real-world evidence on its long-term effectiveness is lacking. Objective: To assess omalizumab use and the long-term response in a large sample of U.S. real-world patients. Methods: Patie...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2019.40.4236

    authors: Kavati A,Zhdanava M,Ortiz B,LeCocq J,Schiffman B,Pilon D,Ching Cheung H,Lefebvre P,Stone BD

    更新日期:2019-09-01 00:00:00

  • Chronic urticaria as a presenting sign of hairy cell leukemia.

    abstract::Chronic urticaria is a common clinical disorder that is idiopathic in over 75% of cases. Less commonly, urticaria may be the presenting manifestation of an allergic or infectious disease, endocrinopathy, inherited syndrome, or autoimmune disorder. Rarely, urticaria may be a sign of underlying malignancy, including leu...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/108854199778681530

    authors: Clore LS Jr,Stafford CT

    更新日期:1999-01-01 00:00:00

  • The tale of the allergist's life: a series of interesting case reports.

    abstract::The practicing allergist has the unique opportunity to see an extraordinary variety of fascinating patients. Identifying the precise cause of the patient's complaints makes for a satisfying intellectual endeavor. This is exemplified by the description of nine cases seen in a university allergy clinic. The cases includ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2008.29.3140

    authors: Slavin RG

    更新日期:2008-07-01 00:00:00

  • The role of montelukast on perennial allergic rhinitis and associated sleep disturbances and daytime somnolence.

    abstract::Perennial allergic rhinitis (PAR) often causes sleep disturbances and associated daytime somnolence, thus resulting in a poor quality of life. Various clinical interventions in patients suffering from the disorder seek to improve symptoms and quality of life. Additional studies are needed to establish whether the alle...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2008.29.3097

    authors: Santos CB,Hanks C,McCann J,Lehman EB,Pratt E,Craig TJ

    更新日期:2008-03-01 00:00:00

  • Mast cells in allergy and host defense.

    abstract::Mast cells have been implicated in the pathogenesis of allergic diseases and in inflammatory responses associated with pathological immune and disease-related processes including fibrosis, autoimmune pathology, and neoplasia. Recent findings in animal models of bacterial infection also suggest that mast cells may have...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/108854101778148764

    authors: Taylor ML,Metcalfe DD

    更新日期:2001-05-01 00:00:00

  • Clinical benefits of aspirin desensitization in patients with nonsteroidal anti-inflammatory drug exacerbated respiratory disease are not related to urinary eicosanoid release and are accompanied with decreased urine creatinine.

    abstract:BACKGROUND:Treatment with acetylsalicylic acid (ASA) after desensitization may be a therapeutic option in patients with nonsteroidal anti-inflammatory drug exacerbated respiratory disease (NERD). The mechanisms that lead to improvement in rhinosinusitis and asthma symptoms remain unknown. AIM:To attribute the document...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2016.37.3935

    authors: Makowska JS,Olszewska-Ziąber A,Bieńkiewicz B,Lewandowska-Polak A,Kurowski M,Woźniakowski B,Rotkiewicz A,Kowalski ML

    更新日期:2016-05-01 00:00:00

  • Community-acquired pneumonia: an approach to antimicrobial therapy.

    abstract::Community-acquired pneumonia (CAP), the sixth leading cause of death in the United States, has undergone significant changes in the past 30 years. In addition to the fact that it increasingly is a disease affecting the elderly and those patients with underlying comorbidities, the spectrum of microbiological agents cau...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/108854100778248980

    authors: Lange M

    更新日期:2000-01-01 00:00:00

  • A 60-year-old woman with recurrent episodes of flushing, urticaria, and angioedema.

    abstract::Recurrent episodes of flushing, urticaria, and angioedema raise suspicion for many conditions with a wide differential diagnosis. The diagnostic approach involves consideration of allergic, cardiovascular, gastrointestinal, endocrine, infectious, neurologic, dermatologic, and drug-related causes. We describe a unique ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2015.36.3836

    authors: Patel SV,Baldwin JL

    更新日期:2015-05-01 00:00:00

  • Serum levels of soluble CD23 in patients with asthma or rhinitis monosensitive to Parietaria. Its relation to total serum IgE levels and eosinophil cationic protein during and out of the pollen season.

    abstract::The diagnostic value for allergies of the low affinity IgE receptor and its soluble circulating fragment (sCD23) remains unclear. In particular, little is know about seasonal influences on serum sCD23 levels in subjects with pollen allergy. In the present study, to gain insight into pathophysiological role of sCD23, w...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/108854199778612590

    authors: Di Lorenzo G,Drago A,Pellitteri ME,Candore G,Colombo A,Potestio M,Di Salvo A,Mansueto S,Caruso C

    更新日期:1999-03-01 00:00:00

  • Flunisolide hydrofluoroalkane with integrated spacer for treating asthma: an updated review.

    abstract::Flunisolide hydrofluoroalkane (HFA) with integrated spacer is the most recent reformulated inhaled corticosteroid (ICS) for asthma available in the United States. It is the only product that combines a corticosteroid extrafine aerosol with a built-in spacer. The potential clinical benefit of the flunisolide HFA formul...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2015.36.3835

    authors: Berger WE,Tashkin DP

    更新日期:2015-03-01 00:00:00

  • Anaphylaxis and epinephrine prescribing patterns in a military hospital: underutilization of the intramuscular route.

    abstract::Epinephrine is the only definitive treatment of anaphylaxis, and recent evidence suggests that the intramuscular route has superior pharmacokinetics to subcutaneous administration. There is little data regarding what route is commonly used in clinical practice. The objective of this article is to determine the rate of...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:

    authors: Haymore BR,Carr WW,Frank WT

    更新日期:2005-09-01 00:00:00

  • Atopy patch testing for foods: a review of the literature.

    abstract::The atopy patch test (APT) was first reported in 1895 by the German dermatologist, Jadassohn and was used for evaluation of contact dermatitis. The first documented epicutaneous application of aeroallergens was by Rostenberg and Sulzbergen in 1937. Although others including Mitchell and Platts-Mills, further described...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2014.35.3797

    authors: Edwards KP,Martinez BA

    更新日期:2014-11-01 00:00:00

  • Chronic sinusitis: a surgical perspective.

    abstract::Rhinosinusitis is one of the most common chronic diseases with significant symptoms and impact on the quality of life. Surgery is indicated when appropriate medical treatment fails. A review of the clinical presentations of rhinosinusitis is presented, as well as an overview of current medical and surgical treatment o...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:

    authors: Fried MP,Cuellar H,Sadoughi B

    更新日期:2006-01-01 00:00:00