Abstract:
:The role of Toll-like receptor (TLR) 2 in modulating allergy-induced asthma is contradictory. We investigated the effect of TLR2 gene deletion in a murine model of ovalbumin (OVA)-challenged asthma. TLR2 wild-type (TLR2(+/+)) and TLR2-deficient (TLR2(-/-)) mice were sensitized to soluble OVA antigens and challenged with OVA, and the extent of allergic airways disease was analyzed in both groups of mice at day 8 after being challenged with OVA aerosol. At day 8 post-OVA, TLR2(-/-) mice exhibited significantly lower airway hyperresponsiveness, airway inflammation, and whole lung T-helper type 2 (Th2) cytokine levels compared with the TLR2(+/+) group. TLR2 deletion also significantly reduced mucus cell metaplasia and peribronchial fibrosis in mice at day 8 after challenged by OVA. The p38/AKT/nuclear factor kappaB (NF-kappaB) p65 and phosphate extracellular signal-regulated kinase (ERK)/p38/AKT was decreased in TLR2(-/-) mouse lungs. Thus, during OVA asthma in mice, TLR2 is a major contributor to the maintenance of the adaptive Th2-cytokine-driven inflammatory disorder and ERK/p38 as well as AKT/NF-κB playing a role in it.
journal_name
Allergy Asthma Procjournal_title
Allergy and asthma proceedingsauthors
Li X,Chen Q,Chu C,You H,Jin M,Zhao X,Zhu X,Zhou W,Ji Wdoi
10.2500/aap.2014.35.3735subject
Has Abstractpub_date
2014-03-01 00:00:00pages
e15-20issue
2eissn
1088-5412issn
1539-6304journal_volume
35pub_type
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
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journal_title:Allergy and asthma proceedings
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pub_type: 共识发展会议,杂志文章
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/108854199778251825
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更新日期:2019-09-01 00:00:00
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pub_type: 杂志文章
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/108854199778251933
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journal_title:Allergy and asthma proceedings
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00
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pub_type: 杂志文章,评审
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