National estimates of emergency department visits for angioedema and allergic reactions in the United States.

Abstract:

:Each year there are a substantial number of emergency department (ED) visits for angioedema and allergic reactions in the United States. Angioedema is commonly mistaken for an allergic reaction, possibly affecting the treatment rendered. We sought to determine the characteristics of U.S. ED visits for acute angioedema and to determine their differences from visits for allergic reactions. We used 2001-2009 data from the National Hospital Ambulatory Medical Care Survey. Using ED diagnoses (defined by the International Classification of Diseases, 9th Revision codes), we identified visits involving angioedema (ICD-9 277.6 and 995.1) or allergic reaction (ICD-9 995.6, 995.0, 995.4, 995.3, and 708). Accounting for the weighted sampling design, we determined the annual number of angioedema and allergic reaction cases, the characteristics of the affected patients, course of care, and patient outcomes. During 2001-2009 there were 1.05 billion ED visits, including 979,342 for angioedema and 8,814,601 for allergic reactions. These figures corresponded to 108,816 (95% CI, 82,246-132,386) annual visits for angioedema and 979,400 (CI, 874,562-1,084,238) annual visits for allergic reactions. Angioedema patients spent >3 hours in the ED and 11% were admitted to the hospital. Steroids and antihistamines were the most common treatments rendered for both angioedema and allergic reaction patients. There are >100,000 annual visits for angioedema in the United States, with key differences and similarities between allergic reaction and angioedema cases. These findings underscore the large number of angioedema cases presenting to U.S. EDs and the opportunities for novel angioedema therapy use in this setting.

journal_name

Allergy Asthma Proc

authors

Kelly M,Donnelly JP,McAnnally JR,Wang HE

doi

10.2500/aap.2013.34.3640

subject

Has Abstract

pub_date

2013-03-01 00:00:00

pages

150-4

issue

2

eissn

1088-5412

issn

1539-6304

journal_volume

34

pub_type

杂志文章
  • Cross-sectional study on Asthma Insights and Management in the Gulf and Russia.

    abstract::Background: Asthma is a chronic and complex lung disease that is not completely understood. It involves airway inflammation, reversible airflow obstruction, and bronchial hyperresponsiveness. The most common symptoms are recurrent wheezing, chest tightness, shortness of breath, and coughing. Objective: The Asthma Insi...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,多中心研究

    doi:10.2500/aap.2018.39.4180

    authors: Alzaabi A,Idrees M,Behbehani N,Khaitov MR,Tunceli K,Urdaneta E,Awad N,Safwat M

    更新日期:2018-11-16 00:00:00

  • Ovalbumin-induced experimental allergic asthma is Toll-like receptor 2 dependent.

    abstract::The role of Toll-like receptor (TLR) 2 in modulating allergy-induced asthma is contradictory. We investigated the effect of TLR2 gene deletion in a murine model of ovalbumin (OVA)-challenged asthma. TLR2 wild-type (TLR2(+/+)) and TLR2-deficient (TLR2(-/-)) mice were sensitized to soluble OVA antigens and challenged wi...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2014.35.3735

    authors: Li X,Chen Q,Chu C,You H,Jin M,Zhao X,Zhu X,Zhou W,Ji W

    更新日期:2014-03-01 00:00:00

  • The nature of melon allergy in ragweed-allergic subjects: A study of 1000 patients.

    abstract::Previous studies suggest cross-reactivity between specific ragweed pollen and melon allergens. This study was designed to clarify the origin of the cross-reactivity between ragweed pollen and the gourd family. One thousand ragweed-allergic subjects were interviewed about the presence of oral allergy syndrome (OAS) ind...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2011.32.3416

    authors: Asero R,Mistrello G,Amato S

    更新日期:2011-01-01 00:00:00

  • Heterogeneity of asthma and the risk of celiac disease in children.

    abstract:BACKGROUND:Although human leukocyte antigen (HLA)-DR and HLA-DQ genes and gluten play crucial roles in developing celiac disease (CD), most patients with these risk factors still do not develop CD, which indicates additional unrecognized risk factors. OBJECTIVE:To determine the association between asthma and the risk ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2018.39.4100

    authors: Patel B,Wi CI,Hasassri ME,Divekar R,Absah I,Almallouhi E,Ryu E,King K,Juhn YJ

    更新日期:2018-01-01 00:00:00

  • Epinephrine auto-injector use and demographics in a Veterans Administration population.

    abstract::The epinephrine auto-injector has been widely used over a long period of time. Certain aspects of this therapy and demographic data, however, have not been well studied. This study investigates patient use and understanding of epinephrine auto-injector use. As part of an ongoing quality assurance program, we evaluated...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2010.31.3351

    authors: Amirzadeh A,Verma P,Lee S,Klaustermeyer W

    更新日期:2010-07-01 00:00:00

  • Difficulties encountered in the emergency department by patients with hereditary angioedema experiencing acute attacks.

    abstract:BACKGROUND:Hereditary angioedema (HAE) is a rare, potentially life-threatening disease characterized by recurrent angioedema attacks. Abdominal symptoms of HAE typically mimic numerous abdominal emergencies, which may result in a delay of correct diagnosis and inappropriate treatments. OBJECTIVE:We aimed to evaluate t...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2016.37.3905

    authors: Ucar R,Arslan S,Baran M,Caliskaner AZ

    更新日期:2016-01-01 00:00:00

  • Prevalence of IgE reactivities in mold-allergic subjects to commercially available fungal enzymes.

    abstract::Fungi are important aeroallergens. However, fungal allergen sources of consistent quality for clinical testing are not readily available. Because some allergens have been identified as enzymes, we assessed the prevalence of IgE reactivity to commercially available fungal enzymes. The purpose of this study was to deter...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2008.29.3174

    authors: Horner WE,Armstrong M,El-Dahr J,McCants M,Reese G,Kobernick AK,Lehrer SB

    更新日期:2008-11-01 00:00:00

  • Delayed food-dependent, exercise-induced anaphylaxis.

    abstract::Food-dependent, exercise-induced anaphylaxis (FDEIA) is a clinically distinct form of anaphylaxis in which symptoms occur only when the patient exercises within a few hours of eating the food. Its precise mechanism remains unclear and has been reported to have a wide spectrum of presentations. The objective of this re...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2007.28.2951

    authors: Oyefara BI,Bahna SL

    更新日期:2007-01-01 00:00:00

  • Rapid diagnosis of Mycobacterium tuberculosis infection in children using interferon-gamma release assays (IGRAs).

    abstract::Diagnosis of tuberculosis (TB) in children by the tuberculin skin test (TST) poses a diagnostic challenge for physicians due to its low specificity and cross-reactivity with nontuberculous mycobacteria and bacille Calmette-Guerin (BCG). Although interferon-gamma release assays (IGRAs) have been shown as novel TST alte...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2012.33.3574

    authors: Riazi S,Zeligs B,Yeager H,Peters SM,Benavides GA,Di Mita O,Bellanti JA

    更新日期:2012-05-01 00:00:00

  • Fifty-five-year-old man with chronic yeast infections.

    abstract::As immunologists, we are frequently asked to evaluate patients with recurrent infections. These infections can provide us with clues regarding what pathways might be aberrant in a given patient, e.g., specific pyogenic bacteria with Toll-like receptor problems, atypical mycobacteria with interferon gamma receptor auto...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2014.35.3776

    authors: Kennedy JL,Schroeder N,Palacios T,Rosen LB,Martinez B,Browne S,Borish L

    更新日期:2014-09-01 00:00:00

  • High mobility group box 1: Biomarker of inhaled corticosteroid treatment response in children with moderate-severe asthma.

    abstract:BACKGROUND:High mobility group box 1 (HMGB1) is abnormally expressed in serum and sputum of patients with allergic asthma. OBJECTIVE:The aim of this study was to investigate the role of HMGB1 as guidance for treatment management of children with asthma. METHODS:Thirty children with asthma and 44 healthy children were...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2017.38.4047

    authors: Manti S,Leonardi S,Parisi GF,De Vivo D,Salpietro A,Spinuzza A,Arrigo T,Salpietro C,Cuppari C

    更新日期:2017-05-01 00:00:00

  • Comparative efficacy of cetirizine and fexofenadine for seasonal allergic rhinitis, 5-12 hours postdose, in the environmental exposure unit.

    abstract::In a previous study, cetirizine and fexofenadine similarly relieved seasonal allergic rhinitis symptoms in the first 5 hours, but cetirizine was more effective at 21-24 hours postdose. This randomized, double-blind, placebo-controlled study compared the response to treatment between 5 and 12 hours. Eligible ragweed al...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,随机对照试验

    doi:

    authors: Day JH,Briscoe MP,Rafeiro E,Ratz JD,Ellis AK,Frankish CW,Chapman D,deGuia EC,Kramer B,Warner C

    更新日期:2005-07-01 00:00:00

  • Increased expression of CD30 and CD57 molecules on CD4(+) T cells from children with atopic asthma: a preliminary report.

    abstract::T helper type 2 (Th2) cells play an important role in the onset and persistence of allergic airway inflammation. Consequently, many authors have attempted to identify cell surface markers associated with a Th2 phenotype. This work was aimed at correlating CD30 and CD57 expression on CD4(+) T cells with interleukin (IL...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2007.28.3057

    authors: Rojas-Ramos E,Garfias Y,Jiménez-Martínez Mdel C,Martínez-Jiménez N,Zenteno E,Gorocica P,Lascurain R

    更新日期:2007-11-01 00:00:00

  • Airway responsiveness in asthma: bronchial challenge with histamine and 4.5% sodium chloride before and after budesonide.

    abstract::Inhalation of histamine is commonly used to assess the severity of and to monitor treatment of asthma. Histamine causes airways to narrow by acting directly on specific receptors. Hyperosmolar saline causes airways of asthmatics to narrow indirectly by endogenously mediated events that are potentially modified by drug...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/108854197778612817

    authors: du Toit JI,Anderson SD,Jenkins CR,Woolcock AJ,Rodwell LT

    更新日期:1997-01-01 00:00:00

  • Rhinorrhea not responding to nasal corticosteroids.

    abstract::A woman with multiple illnesses including allergic rhinitis presented for a follow-up visit at our clinic with constant rhinorrhea for 2 weeks despite regular use of nasal corticosteroids. Two weeks earlier, after alcohol drinking and doubling some of her medications for missed doses, she fell on her face. The Emergen...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2007.28.3061

    authors: Patel PN,Oyefara B,Aarstad R,Bahna SL

    更新日期:2007-11-01 00:00:00

  • Altered L-arginine metabolism in children with controlled asthma.

    abstract::Decreased level of L-arginine may lead to airway hyperresponsiveness, inflammation, and airway remodeling. Changes in L-arginine metabolism were observed earlier in adult asthmatic patients. Studies on L-arginine metabolism in children with bronchial asthma are limited. Because biosynthesis of L-arginine is insufficie...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2014.35.3777

    authors: Kraj L,Krawiec M,Koter M,Graboń W,Kraj G,Chołojczyk M,Kulus M,Barańczyk-Kuźma A

    更新日期:2014-09-01 00:00:00

  • Onset and duration of action of nasal sprays in seasonal allergic rhinitis patients: olopatadine hydrochloride versus mometasone furoate monohydrate.

    abstract::Rapid relief of symptoms should be one of the primary goals of treatment for allergic rhinitis (AR). The onset and duration of action of olopatadine hydrochloride nasal spray, 665 mcg (OLO; Patanese), for seasonal AR (SAR) was evaluated in this study. This study was performed to determine the onset and duration of act...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,随机对照试验

    doi:10.2500/aap2007.28.3033

    authors: Patel D,Garadi R,Brubaker M,Conroy JP,Kaji Y,Crenshaw K,Whitling A,Wall GM

    更新日期:2007-09-01 00:00:00

  • Evaluation of anxiety levels and factors associated with positive test results in patients with drug hypersensitivity.

    abstract:BACKGROUND:High anxiety has been reported in patients with drug hypersensitivity reaction (DHR); however, its relationship with the test results was not studied previously. OBJECTIVE:We aimed to investigate the association of patient anxiety with the results of drug tests together with the other contributing factors. ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2015.36.3878

    authors: Comert S,Erdogan T,Demir AU,Karakaya G,Kalyoncu AF

    更新日期:2015-11-01 00:00:00

  • The status of asthma control in the U.S. adult population.

    abstract::Treatment guidelines recognize the importance of achieving and maintaining asthma control. This study was designed to assess the prevalence of asthma control in a representative U.S. population. A survey regarding asthma and associated symptoms was sent to a representative national sample of 134,401 households managed...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2009.30.3276

    authors: Fuhlbrigge A,Reed ML,Stempel DA,Ortega HO,Fanning K,Stanford RH

    更新日期:2009-09-01 00:00:00

  • Relationship between atopic asthma and the population prevalence rates for asthma or atopy in children: atopic and nonatopic asthma in epidemiology.

    abstract::Innumerable articles have tried to solve the "continuing enigma of atopic and nonatopic asthma" but notwithstanding the strenuous efforts to substantiate the few well-known clinico-epidemiologic differences between these two forms of asthma most studies have hitherto generated inconclusive statements. In a recent stud...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2009.30.3197

    authors: Ronchetti R,Jesenak M,Rennerova Z,Barreto M,Ronchetti F,Villa MP

    更新日期:2009-01-01 00:00:00

  • Biphasic reactions in children undergoing oral food challenges.

    abstract::Literature regarding biphasic reactions in the pediatric population is sparse. We aimed to determine the prevalence of biphasic reactions in children with food allergies undergoing oral food challenges (OFCs) and examine whether any clinical or treatment factors are associated with biphasic reactions. A retrospective ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2013.34.3669

    authors: Lee J,Garrett JP,Brown-Whitehorn T,Spergel JM

    更新日期:2013-05-01 00:00:00

  • Pentobarbital desensitization in a 3-month-old child.

    abstract::Barbiturates, a class of medications commonly used as antiepileptics and sedatives, are known to cause adverse reaction, with the most commonly reported immune-mediated reactions being anticonvulsant hypersensitivity syndrome. Other types of allergic reactions such as immediate hypersensitivity reactions also can occu...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:

    authors: Butte MJ,Dodson B,Dioun A

    更新日期:2004-07-01 00:00:00

  • Current management and use of oral immunotherapy in the United States for patients with peanut allergy.

    abstract::Background: Peanut allergy is a major health burden in the United States. Treatment is limited to avoidance and acute reaction management. No drug or medical product is approved for use as a peanut oral immunotherapy (POIT) agent. Objective: To examine peanut allergy diagnosis and treatment, peanut challenge protocols...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2019.40.4228

    authors: Blaiss MS,Tilles S,Petroni D,Zigmont E,Cassese M,Kwak B,Georgitseas N,Liebermann J

    更新日期:2019-07-23 00:00:00

  • IgE values and T-lymphocyte subsets in children with atopic eczema/dermatitis syndrome.

    abstract::High levels of IgE and IgE-mediated reactions represent a typical finding in patients with atopic eczema/dermatitis syndrome (AEDS). However, 10-30% of patients usually do not show any increase of total blood IgE levels and any detectable specific IgE sensitization. We performed this study to evaluate the difference o...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap2007.28.3038

    authors: Leonardi S,Rotolo N,Vitaliti G,Spicuzza L,La Rosa M

    更新日期:2007-09-01 00:00:00

  • Potentially (near) fatal asthma.

    abstract::Potentially (near) fatal asthma (PFA) defines a subset of patients with asthma who are at increased risk for death from their disease. The diagnosis of PFA should motivate treating physicians, health professionals, and patients to be more aggressive in the monitoring, treatment, and control of this high-risk type of a...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2019.40.4257

    authors: Greenberger PA

    更新日期:2019-11-01 00:00:00

  • Current Allergic Rhinitis Experiences Survey (CARES): Consumers' awareness, attitudes and practices.

    abstract::Allergic rhinitis (AR) affects ~60 million people in the United States. This study evaluates awareness, attitudes, and behaviors of AR sufferers on the management of their condition. This U.S.-based survey evaluated 1600 adult AR sufferers to assess their perceptions of AR diagnosis, treatment preferences, and interac...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2014.35.3766

    authors: Fromer LM,Blaiss MS,Jacob-Nara JA,Long RM,Mannion KM,Lauersen LA

    更新日期:2014-07-01 00:00:00

  • The role of nonsedating antihistamines in asthma therapy.

    abstract::There is well-established evidence that histamine plays a significant role as a chemical mediator in asthma. However, although antihistamines are commonly used for the treatment of allergic rhinitis, their use in asthma has been somewhat controversial. Mechanistically, their application for asthma appears logical. In ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:

    authors: Zitt MJ

    更新日期:2003-07-01 00:00:00

  • Serum levels of specific immunoglobulin E to Dermatophagoides pteronyssinus allergen components in patients with allergic rhinitis or/and asthma.

    abstract::Background: House-dust mites (HDM) allergen is one of the most important allergens in southern China; however, studies on the Dermatophagoides pteronyssinus components are relatively lacking. Objective: This study analyzed the molecular components of D. pteronyssinus in patients with allergic asthma (AS) and/or allerg...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2021.42.200105

    authors: Zou X,Hu H,Huang Z,Liao C,Huang L,Luo W,Jiang M,Sun B

    更新日期:2021-01-01 00:00:00

  • Leukotriene C4 synthase: a candidate gene for the aspirin-intolerant asthmatic phenotype.

    abstract::The features of the allergic inflammation underlying asthma occur as a consequence of mediators such as the cysteinyl LTs. The generation of the cysteinyl LTs is carefully regulated and dependent on the 5-LO/LTC4S pathway, of which LTC4S is the pivotal and only committed enzyme involved. Although LTC4S is related to o...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/108854199778251825

    authors: Penrose JF,Baldasaro MH

    更新日期:1999-11-01 00:00:00

  • Multiple physical urticarias: report of three cases and review of the literature.

    abstract::The appearance of more than one physical urticaria (PU) in the same patient has been documented; cold urticaria or dermatographism in association with some other type of PU are encountered more frequently. Three female patients exhibiting multiple PUs simultaneously are presented. In one female patient four different ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:

    authors: Pitsios C,Vithoulka A,Roumana A,Kompoti E,Kontou-Fili K

    更新日期:2003-09-01 00:00:00