Nasal reactivity evaluation in children with allergic rhinitis receiving grass pollen sublingual immunotherapy.


:Background: The European Academy of Allergy and Clinical Immunology guidelines, strongly recommended allergen immunotherapy (AIT) as an effective treatment to achieve long-term clinical benefits and to modify the natural history of allergic diseases. Sublingual immunotherapy (SLIT) offers the possibility of home administration, which improves patient comfort and compliance. Objective: The primary outcome of this study was to assess the change in nasal reactivity after grass-pollen AIT treatment. Methods: This was a monocentric, prospective, observational study conducted in Rome from September 2016 to June 2018, in the Pediatric Department of Policlinico Umberto I. We enrolled children, ages between 6 and 12 years, with persistent allergic rhinitis (AR), sensitized to grass pollen. At the first visit (V0, September 2016), one group received the first dose of oral immunotherapy for grass-pollen spray buccal and the other group continued only standard therapy. All the patients had nasal specific immunoglobulin I (IgE) assay (Phl p1, Phl p5), active anterior rhinomanometry with a nasal provocation test (NPT), and spirometry. The patients attended two follow-up visits, in May 2017 (V1) and May 2018 (V2), with the same examinations as at V0. Results: During the treatment, we observed, in the treated group, a significant increase in the mean nasal flow compared with untreated children (p < 0.001). In the AIT group, we found an improvement of nasal function and only 21.05% of all the children in the active group with a positive NPT result at V2. In the control group, we found, at V2, a worsening of nasal function, with 89.47% of the children with a positive NPT result. Furthermore, we found a significant reduction of nasal specific IgE levels at the end of the observation period in the treated group. Conclusion: Analysis of our data provided evidence for a clinical effect of SLIT in inducing clinical changes and allergen tolerance in children with AR.


Allergy Asthma Proc


Schiavi L,Brindisi G,De Castro G,De Vittori V,Loffredo L,Spalice A,Duse M,Zicari AM




Has Abstract


2020-09-01 00:00:00












  • Purified natural rubber latex antigens show variable reactivity with IgE in the sera of latex allergic patients.

    abstract::Immediate-hypersensitivity reactions related to latex products have increased rapidly in recent years. However, a reliable diagnosis is hampered by lack of purified and well characterized latex allergens. We have purified allergens in natural rubber latex (NRL) after SDS-PAGE by electroelution, and tested specific IgE...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Lu L,Kurup VP,Kelly KJ,Fink JN

    更新日期:1996-07-01 00:00:00

  • Rationale for the clinical use of a ribosome-component immune modulator.

    abstract::Vaccines have long been used to boost the immune system and to confer protection against microbial infections. In contrast, immunotherapy based on ribosomal preparations has been proposed to enhance both specific and nonspecific immune responses (in particular, the mucosal immune defense system) against common respira...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审


    authors: Pregliasco F,Terracciano L,Marcassa S,Zava D,Anselmi G

    更新日期:2009-07-01 00:00:00

  • Antioxidant supplementation and exhaled nitric oxide in children with asthma.

    abstract:BACKGROUND:The effect of allergen avoidance on airway inflammation is similar to that observed with treatment with inhaled steroids, whereas inhaled steroids have no effect on oxidative stress-induced inflammation. OBJECTIVE:The aim of this study was to retrospectively evaluate the potential effect of an antioxidant d...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Tenero L,Piazza M,Zanoni L,Bodini A,Peroni D,Piacentini GL

    更新日期:2016-01-01 00:00:00

  • Hygiene factors associated with childhood food allergy and asthma.

    abstract:BACKGROUND:Childhood food allergy and asthma rates are increasing. The hygiene hypothesis has been proposed as an explanation for the increased incidence of allergic disease. OBJECTIVE:To describe the association of childhood food allergy and asthma with hygiene factors, such as the number of siblings, antibiotic use,...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Gupta RS,Singh AM,Walkner M,Caruso D,Bryce PJ,Wang X,Pongracic JA,Smith BM

    更新日期:2016-11-01 00:00:00

  • Effect of omalizumab on outcomes in patients with aspirin-exacerbated respiratory disease.

    abstract::Background: The current treatment for patients with aspirin-exacerbated respiratory disease (AERD) who have uncontrolled asthma or chronic rhinosinusitis is aspirin desensitization. For patients who are unable to undergo or do not benefit from aspirin desensitization, treatment with biologics is an option, although ef...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Jean T,Eng V,Sheikh J,Kaplan MS,Goldberg B,Jau Yang S,Samant S

    更新日期:2019-09-01 00:00:00

  • The status of asthma control in the U.S. adult population.

    abstract::Treatment guidelines recognize the importance of achieving and maintaining asthma control. This study was designed to assess the prevalence of asthma control in a representative U.S. population. A survey regarding asthma and associated symptoms was sent to a representative national sample of 134,401 households managed...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Fuhlbrigge A,Reed ML,Stempel DA,Ortega HO,Fanning K,Stanford RH

    更新日期:2009-09-01 00:00:00

  • Flunisolide hydrofluoroalkane with integrated spacer for treating asthma: an updated review.

    abstract::Flunisolide hydrofluoroalkane (HFA) with integrated spacer is the most recent reformulated inhaled corticosteroid (ICS) for asthma available in the United States. It is the only product that combines a corticosteroid extrafine aerosol with a built-in spacer. The potential clinical benefit of the flunisolide HFA formul...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审


    authors: Berger WE,Tashkin DP

    更新日期:2015-03-01 00:00:00

  • Serum interleukin 17, interleukin 23, and interleukin 10 values in children with atopic eczema/dermatitis syndrome (AEDS): association with clinical severity and phenotype.

    abstract::To date cytokines profile in AEDS is poorly described in children. We evaluated the interleukin (IL)-17, IL-23, and IL-10 levels in atopic eczema/dermatitis syndrome (AEDS) children and healthy controls, in atopic AEDS (aAEDS) and nonatopic (naAEDS) subtypes and their relationship with disease severity. A total of 181...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Leonardi S,Cuppari C,Manti S,Filippelli M,Parisi GF,Borgia F,Briuglia S,Cannavò P,Salpietro A,Arrigo T,Salpietro C

    更新日期:2015-01-01 00:00:00

  • Rhinorrhea not responding to nasal corticosteroids.

    abstract::A woman with multiple illnesses including allergic rhinitis presented for a follow-up visit at our clinic with constant rhinorrhea for 2 weeks despite regular use of nasal corticosteroids. Two weeks earlier, after alcohol drinking and doubling some of her medications for missed doses, she fell on her face. The Emergen...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Patel PN,Oyefara B,Aarstad R,Bahna SL

    更新日期:2007-11-01 00:00:00

  • Baker's asthma in bread factory workers.

    abstract::Background: Baker's asthma (BA) is one of the most common causes of occupational asthma. Prevalence of BA varies from 3 to 24% in various studies; however, in our country, there are not enough data on its prevalence. Objective: The aim of this study was to evaluate wheat flour sensitivity and to determine the rate of ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Aydın Ö,Sözener ZÇ,Demirel YS,Seçil D,Mungan D

    更新日期:2021-01-01 00:00:00

  • Are fish oil supplements safe in finned fish-allergic patients?

    abstract::Fish oil supplements are popular alternative medicines. Many manufacturers label their products with the warning "avoid this product if you are allergic to fish." The objective of this study was to determine if finned fish (FF)-allergic patients could safely tolerate fish oil supplements. Six FF-sensitive subjects as ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Mark BJ,Beaty AD,Slavin RG

    更新日期:2008-09-01 00:00:00

  • Medical and economic dimensions linking allergic rhinitis and asthma.

    abstract::Allergic rhinitis and asthma are two of the most common chronic conditions affecting the population. There has been a growing understanding of the link between these disorders as they commonly occur in the same individual, of their relationship with allergies, and of the total economic impact in both direct and indire...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Blaiss MS

    更新日期:2002-07-01 00:00:00

  • Effect of desloratadine on the control of morning symptoms in patients with seasonal and perennial allergic rhinitis.

    abstract::The symptoms of allergic rhinitis vary in severity over the course of the day and often are worse in the morning. This review focuses on data from clinical studies of the antihistamine desloratadine to establish whether it effectively controls the morning symptoms of allergic rhinitis. Studies of desloratadine in pati...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审


    authors: Schenkel EJ

    更新日期:2006-11-01 00:00:00

  • Serum clusterin level in children with atopic dermatitis.

    abstract:BACKGROUND:Atopic dermatitis (AD) is a chronic inflammatory skin disease. Clusterin is a sensitive cellular biosensor of oxidative stress and has been studied as a marker to assess inflammatory diseases. The clusterin levels in AD have not been evaluated thus far. OBJECTIVE:We evaluated serum clusterin levels in child...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Sol IS,Kim YH,Lee KE,Hong JY,Kim MN,Kim YS,Oh MS,Kim MJ,Yoon SH,Park YA,Kim KW,Sohn MH,Kim KE

    更新日期:2016-07-01 00:00:00

  • Clinical and etiologic evaluation of the children with chronic urticaria.

    abstract:BACKGROUND:Chronic urticaria (CU) is a skin disorder defined as daily or almost daily exhibition of pruritic and transient wheals that last for 6 weeks. CU is divided into two subtypes: chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU). OBJECTIVES:To evaluate the clinical features, possible c...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Azkur D,Civelek E,Toyran M,Mısırlıoğlu ED,Erkoçoğlu M,Kaya A,Vezir E,Giniş T,Akan A,Kocabaş CN

    更新日期:2016-11-01 00:00:00

  • Allergic bronchopulmonary aspergillosis in an HIV-infected individual.

    abstract::Aspergilloma and invasive aspergillosis have been reported in HIV-infected individuals. Allergic Bronchopulmonary Aspergillosis (ABPA) is a lung disease marked by a hypersensitivity response to inhaled aspergillus species, most commonly Aspergillus fumigatus (Af). This manifestation of Af has previously not been repor...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Jain M

    更新日期:2000-11-01 00:00:00

  • Functional assessment of allergic asthmatic children while asymptomatic.

    abstract::The aim of this study was to detect the best test lung function to identify abnormalities in asthmatic children while asymptomatic. We studied 200 asthmatic children. Patients were evaluated by questionnaire to evaluate the presence of symptoms and drug consumption in the previous 3 months. Allergological evaluation b...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Verini M,Peroni DG,Rossi N,Nicodemo A,De Stradis R,Spagnolo C,Chiarelli F,Boner AL

    更新日期:2006-07-01 00:00:00

  • Lack of correlation between clinical patterns of asthma and airway obstruction.

    abstract::To evaluate the relationship between the classification of asthma and obstruction of airways, we have studied 100 children suffering from allergic asthma: 65 males and 35 females, aged 4.2-16.3 years (mean, 7.6 +/- 2.8 years), who were evaluated at least 1 month after the last attack of airway obstruction. We analyzed...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Verini M,Rossi N,Dalfino T,Verrotti A,Di Gioacchino M,Chiarelli F

    更新日期:2001-09-01 00:00:00

  • Systemic inflammation mediates the detrimental effects of obesity on asthma control.

    abstract:BACKGROUND:Obesity negatively impacts asthma control, but the inflammatory mechanisms are poorly understood. OBJECTIVE:To explore which systemic inflammatory mediators mediate the effects of obesity on asthma control. METHODS:The subjects with stable asthma (n = 108) underwent assessment of clinical characteristics, ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Zhang X,Zheng J,Zhang L,Liu Y,Chen GP,Zhang HP,Wang L,Kang DY,Wood LG,Wang G

    更新日期:2017-10-02 00:00:00

  • When asthma and rhinitis coexist, could rhinitis reduce asthma control in children?

    abstract:Background:Bronchial asthma and rhinitis are among the most common diseases in children and frequently coexist in the patient. The primary aim of anti-asthmatic therapy is disease control. Several questionnaires can be used in pediatrics to assess asthma control and the Children Asthma Control Test (C-ACT) is one of th...

    journal_title:Allergy and asthma proceedings

    pub_type: 信件


    authors: De Vittori V,Pacilio A,Indinnimeo L,Marazzato M,De Castro G,Brindisi G,Schiavi L,Tosca M,Duse M,Zicari AM

    更新日期:2019-05-01 00:00:00

  • Vocal cord dysfunction.

    abstract::A case of vocal cord dysfunction (VCD) is presented, followed by a discussion of the clinical characteristics, pathogenesis, diagnosis, and management of this disorder. Special emphasis is given to clinical pearls and pitfalls for the practicing allergist. VCD is a common condition that mimics asthma. Dyspnea, cough, ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审


    authors: Mikita JA,Mikita CP

    更新日期:2006-07-01 00:00:00

  • Mastocytosis: classification, diagnosis, and clinical presentation.

    abstract::Mastocytosis comprises several diseases characterized by an abnormal increase in tissue mast cells. Cutaneous mastocytosis (CM) is the most common form of mastocytosis, affects predominantly children, and presents as a mast cell hyperplasia limited to the skin. Systemic mastocytosis (SM) comprises multiple distinct en...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审


    authors: Castells MC

    更新日期:2004-01-01 00:00:00

  • Expanding choices in intranasal steroid therapy: summary of a roundtable meeting.

    abstract::Intranasal steroids (INSs) are recommended as first-line treatment for allergic rhinitis (AR) and a wealth of data exist supporting them as safe and effective. Our goal was to develop a consensus to help physicians choose between INSs by focusing on clinical profiles and patient preferences and providing expert advice...

    journal_title:Allergy and asthma proceedings

    pub_type: 共识发展会议,杂志文章


    authors: Blaiss MS,Benninger MS,Fromer L,Gross G,Mabry R,Mahr T,Marple B,Stoloff S

    更新日期:2006-05-01 00:00:00

  • High mobility group box 1: Biomarker of inhaled corticosteroid treatment response in children with moderate-severe asthma.

    abstract:BACKGROUND:High mobility group box 1 (HMGB1) is abnormally expressed in serum and sputum of patients with allergic asthma. OBJECTIVE:The aim of this study was to investigate the role of HMGB1 as guidance for treatment management of children with asthma. METHODS:Thirty children with asthma and 44 healthy children were...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Manti S,Leonardi S,Parisi GF,De Vivo D,Salpietro A,Spinuzza A,Arrigo T,Salpietro C,Cuppari C

    更新日期:2017-05-01 00:00:00

  • Onset and duration of attenuation of exercise-induced bronchoconstriction in children by single-dose of montelukast.

    abstract::Single-dose montelukast attenuates exercise-induced bronchoconstriction (EIB) in adults within 2 hours postdose and lasting through 24 hours. This study evaluated the onset and duration of EIB attenuation in children after a single dose of montelukast. A randomized, double-blind, placebo-controlled, two-period crossov...

    journal_title:Allergy and asthma proceedings

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Wasfi YS,Kemp JP,Villarán C,Massaad R,Xin W,Smugar SS,Knorr BA,Philip G

    更新日期:2011-11-01 00:00:00

  • Comparison of serum-specific IgE (ImmunoCAP) and skin-prick test results for 53 inhalant allergens in patients with chronic rhinitis.

    abstract::Prior studies comparing skin testing to serum-specific IgE testing for inhalant allergy focused on older technologies or small numbers of allergens. The purpose of this study was to compare ImmunoCAP (CAP) testing to skin prick testing (ST) for 53 inhalant allergens. Subjects > or =18 years old with chronic rhinitis a...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Calabria CW,Dietrich J,Hagan L

    更新日期:2009-07-01 00:00:00

  • A cost-effective approach to the diagnosis and treatment of the wheezing infant.

    abstract::Wheezing in infancy presents the clinician with at least two broad clinical problems. First is the task of distinguishing the common entities of bronchiolitis and asthma from rare, yet potentially life threatening illnesses that may present with wheezing. The second problem deals with the difficulties in distinguishin...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审


    authors: Mamlok R

    更新日期:1997-05-01 00:00:00

  • Immunomodulation in dermatology: lessons learned in the treatment of psoriasis.

    abstract::With the widespread recognition that T-cells are the key mediators of psoriasis, current treatment strategies have focused on reducing the population of these cells or modulating their activity through the use of immunosuppressive treatments such as methotrexate, cyclosporine, and psoralens plus ultraviolet A radiatio...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审


    authors: Charlesworth EN

    更新日期:2006-03-01 00:00:00

  • Shrimp and cockroach co-sensitization in Southern China: Association with moth sensitization.

    abstract::Background: Moth is a common allergen in southern China. Shrimp sensitization might be related to the moth allergen. Objective: This study investigated sensitization to moth allergen in patients in southern China sensitized to shrimp and explored the effect of moth sensitization on different allergic diseases. Methods...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Liao C,Hu H,Huang Z,Lin Q,Huang H,Liu X,Luo W,Sun B

    更新日期:2020-05-01 00:00:00

  • Successful treatment of coronavirus disease 2019 in a patient with asthma.

    abstract::Underlying lung disease, especially asthma, has recently been found to be associated with a higher risk of hospitalization with coronavirus disease 2019 (COVID-19) infection. Inhaled corticosteroids (ICS) are the most commonly used controller medications in patients with asthma. It is unclear whether ICS use increases...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Joshi AY,Mullakary RM,Iyer VN

    更新日期:2020-07-01 00:00:00