Abstract:
:Vaccines have long been used to boost the immune system and to confer protection against microbial infections. In contrast, immunotherapy based on ribosomal preparations has been proposed to enhance both specific and nonspecific immune responses (in particular, the mucosal immune defense system) against common respiratory tract pathogens. The aim of this review is to summarize current knowledge on the ability of a combination of four immunogenic ribosomal fractions from different bacteria species and of the extracted fraction from the membrane of Klebsiella pneumoniae to modulate several immune functions. The immunomodulatory activity of the ribosome component is attributed to the presence of highly purified epitopes from cellular fractions obtained by bacterial lysis. The ribosomal preparation is hypothesized to induce a T-dependent immune response consequent network with proliferation of B lymphocytes and production of secretory high-affinity antibodies (in particular, IgA), as well as the creation of a specific immune memory. Indeed, this agent stimulates the activity of macrophages, polymorphonuclear cells, and natural killer cells. The "ideal" vaccine is a highly purified protein bound to a carrier and an adjuvant that enhances the vaccination effect.
journal_name
Allergy Asthma Procjournal_title
Allergy and asthma proceedingsauthors
Pregliasco F,Terracciano L,Marcassa S,Zava D,Anselmi Gdoi
10.2500/aap.2009.30.3249subject
Has Abstractpub_date
2009-07-01 00:00:00pages
S5-12eissn
1088-5412issn
1539-6304journal_volume
30 Suppl 1pub_type
杂志文章,评审abstract::Each year there are a substantial number of emergency department (ED) visits for angioedema and allergic reactions in the United States. Angioedema is commonly mistaken for an allergic reaction, possibly affecting the treatment rendered. We sought to determine the characteristics of U.S. ED visits for acute angioedema...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2013.34.3640
更新日期:2013-03-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,多中心研究
doi:10.2500/aap.2015.36.3845
更新日期:2015-07-01 00:00:00
abstract::Background: GSP301 is an investigational fixed-dose combination nasal spray that contains the antihistamine, olopatadine hydrochloride (HCl), and the corticosteroid, mometasone furoate. Objective: To evaluate the efficacy and safety of GSP301 in patients with seasonal allergic rhinitis (SAR). Methods: In this double-b...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,随机对照试验
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更新日期:2019-07-03 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,随机对照试验
doi:10.2500/aap2008.29.3083
更新日期:2008-01-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:
更新日期:2002-01-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/108854197778984446
更新日期:1997-05-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2011.32.3481
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journal_title:Allergy and asthma proceedings
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2500/aap.2015.36.3879
更新日期:2015-11-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2015.36.3808
更新日期:2015-01-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2020.41.200082
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2008.29.3140
更新日期:2008-07-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2018.39.4124
更新日期:2018-05-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/108854199778612590
更新日期:1999-03-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/aap.2006.27.2929
更新日期:2006-09-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/108854199778681530
更新日期:1999-01-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 共识发展会议,杂志文章
doi:10.2500/aap.2006.27.2852
更新日期:2006-05-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/108854101778249258
更新日期:2001-01-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2019.40.4215
更新日期:2019-05-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2015.36.3878
更新日期:2015-11-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2500/108854199778553028
更新日期:1999-05-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:
更新日期:2005-03-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/aap.2007.28.2977
更新日期:2007-01-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/aap.2012.33.3550
更新日期:2012-05-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/aap.2012.33.3537
更新日期:2012-05-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/aap.2009.30.3197
更新日期:2009-01-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/aap.2008.29.3145
更新日期:2008-07-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2014.35.3766
更新日期:2014-07-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2019.40.4228
更新日期:2019-07-23 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:
更新日期:2005-05-01 00:00:00