Abstract:
OBJECTIVE:To establish the relationship between vitamin D serum levels, pulmonary function, asthma control, and passive smoking exposure in children with asthma. METHODS:We studied the relationship between 25-hydroxy cholecalciferol (25[OH]D) concentrations and baseline spirometry and levels of asthma control, and the effect of parental tobacco smoke exposure in 152 white children (84 boys [55.3%]) with a mean age ± standard deviation of 9.9 ± 2.0 years (range 5-15 years) in a cross-sectional study carried out during the winter and early spring. RESULTS:Only 9.9% of our children had a sufficient serum 25(OH)D level (at least 30-40 ng/mL). A significant positive correlation was found between the force vital capacity % predicted, forced expiratory volume in the first second of expiration % predicted, and serum 25(OH)D level (r = 0.36, p < 0.001 for both). The subjects with controlled asthma had higher serum levels of 25(OH)D than children with partially controlled or noncontrolled asthma, both according to Global Initiative for Asthma parameters and the Test for the control of asthma in childhood (p = 0.011). Children with both nonsmoking parents presented significantly higher serum levels of 25(OH)D than children with both smoking parents (median, 20.5 ng/mL [interquartile range {IQR}, 16.6-24.0 ng/mL] versus median, 14.5 ng/mL [IQR, 11.1-19.1 ng/mL], respectively; p < 0.001), with intermediate values for children exposed to single maternal (median, 20.3 ng/mL [IQR, 13.0-23.2 ng/mL]) or to paternal smoking (median, 17.8 ng/mL [IQR, 14.7-22.1 ng/mL]). CONCLUSION:Our results indicated that hypovitaminosis D was frequent in children with asthma who lived in a Mediterranean country. In these children, lower levels of vitamin D were associated with reduced asthma control and passive smoking exposure.
journal_name
Allergy Asthma Procjournal_title
Allergy and asthma proceedingsauthors
Chinellato I,Piazza M,Sandri M,Paiola G,Tezza G,Boner ALdoi
10.2500/aap.2018.39.4124subject
Has Abstractpub_date
2018-05-01 00:00:00pages
8-14issue
3eissn
1088-5412issn
1539-6304journal_volume
39pub_type
杂志文章abstract::An aerosol formulation may be preferred by some allergic rhinitis (AR) patients, to avoid the "wet feeling" and nasal runoff associated with aqueous nasal corticosteroid sprays. Beclomethasone dipropionate (BDP) hydrofluoroalkane nasal aerosol is a recently developed, nonaqueous, nonchlorofluorocarbon formulation of ...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,随机对照试验
doi:10.2500/aap.2012.33.3593
更新日期:2012-09-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:
更新日期:2002-01-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2011-11-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 指南,杂志文章,实务指引,评审
doi:
更新日期:2003-03-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2017.38.4009
更新日期:2017-01-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
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更新日期:2017-10-02 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
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更新日期:2018-01-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
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更新日期:2001-11-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2019.40.4215
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:
更新日期:2003-11-01 00:00:00
abstract::The cardinal nasal symptoms of allergic rhinitis (AR) are sustained by an underlying inflammatory process. Congestion is one of the most prominent and distressing symptoms for patients and is strongly associated with a broadly deteriorated quality of life and significant losses in productivity. The purpose of this stu...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,随机对照试验
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journal_title:Allergy and asthma proceedings
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journal_title:Allergy and asthma proceedings
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2500/108854199778553028
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pub_type: 杂志文章
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更新日期:2014-07-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/108854196778645083
更新日期:1996-03-01 00:00:00
abstract::Hereditary angioedema (HAE) is a rare, autosomal dominant disease caused by a deficiency in the C1-inhibitor protein. It is characterized by recurrent episodes of nonpruritic, nonpitting, subcutaneous or submucosal edema that typically involves the extremities or the gastrointestinal tract. However, the genitourinary ...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
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更新日期:2020-11-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/108854100778248214
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
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更新日期:2018-09-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2007-07-01 00:00:00
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pub_type: 杂志文章,评审
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