New developments in inhaled corticosteroids.

Abstract:

:Inhaled corticosteroids (ICSs) are the foundation of pharmacotherapy in persistent asthma because they control airway inflammation. The anti-inflammatory effect of ICSs is primarily topical, at their site of deposition in the airways. Consequently, deposition characteristics of the ICS and its formulation and inhalation device, in addition to intrinsic properties of the corticosteroid, influence clinical efficacy. Small-particle formulations, especially those developed in a metered-dose inhaler with the new hydrofluoroalkane propellant, may have improved lung deposition characteristics along with possibly improved clinical efficacy. Lipid conjugation of ICSs within the lungs may allow prolonged duration of effect, enabling once-daily dosing. Safety concerns of ICSs are related to systemic absorption and oropharyngeal deposition. An ICS with a longer serum half-life, especially one with a higher affinity for the corticosteroid receptor, may be associated with greater systemic effects. Increased protein binding of an ICS within the systemic circulation and high systemic clearance of an ICS may reduce the risk for systemic effects. Reduced oropharyngeal deposition and administration of a prodrug may result in fewer oropharyngeal side effects. The ideal ICS will have increased lung deposition and reduced deposition in the upper airway, resulting in better clinical efficacy and less risk for upper airway adverse effects. An ICS with high plasma protein binding and rapid clearance might pose much less risk for systemic adverse effects than currently available drugs in this class.

journal_name

Allergy Asthma Proc

authors

Colice GL

doi

10.2500/aap.2006.27.2929

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

332-40

issue

5

eissn

1088-5412

issn

1539-6304

journal_volume

27

pub_type

杂志文章,评审
  • Anti-immunoglobulin E monoclonal antibody administered with immunotherapy.

    abstract::Despite both efficacy and immunotolerogenic effects, many clinicians still are reluctant to use allergen-specific immunotherapy (SIT) because of the potential for acute allergic reactions. The anti-immunoglobulin E monoclonal antibody, omalizumab, is approved by the U.S. Food and Drug Administration for the treatment ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:

    authors: Parks KW,Casale TB

    更新日期:2006-03-01 00:00:00

  • Nasal lavage cytometry in the diagnosis of nonallergic rhinitis with eosinophilia syndrome (NARES).

    abstract::The nonallergic rhinitis with eosinophilia syndrome (NARES) is a type of chronic rhinitis, characterized by intense (> 20%) eosinophilia of the nasal secretions. In this study, screening for NARES in 81 patients with nonallergic chronic rhinitis was performed using a modified nasal lavage cytometric method. Twenty-one...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/108854197778558061

    authors: Schiavino D,Nucera E,Milani A,Della Corte AM,D'Ambrosio C,Pagliari G,Patriarca G

    更新日期:1997-11-01 00:00:00

  • High mobility group box 1: Biomarker of inhaled corticosteroid treatment response in children with moderate-severe asthma.

    abstract:BACKGROUND:High mobility group box 1 (HMGB1) is abnormally expressed in serum and sputum of patients with allergic asthma. OBJECTIVE:The aim of this study was to investigate the role of HMGB1 as guidance for treatment management of children with asthma. METHODS:Thirty children with asthma and 44 healthy children were...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2017.38.4047

    authors: Manti S,Leonardi S,Parisi GF,De Vivo D,Salpietro A,Spinuzza A,Arrigo T,Salpietro C,Cuppari C

    更新日期:2017-05-01 00:00:00

  • Community-acquired pneumonia: an approach to antimicrobial therapy.

    abstract::Community-acquired pneumonia (CAP), the sixth leading cause of death in the United States, has undergone significant changes in the past 30 years. In addition to the fact that it increasingly is a disease affecting the elderly and those patients with underlying comorbidities, the spectrum of microbiological agents cau...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/108854100778248980

    authors: Lange M

    更新日期:2000-01-01 00:00:00

  • Utilization and timeliness of an inpatient penicillin allergy evaluation.

    abstract:BACKGROUND:A history of penicillin allergy is associated with an increased risk of nosocomial infections because patients are exposed to non-beta lactam antibiotics. Ruling out inaccurate penicillin allergy during hospitalization decreases prescription of beta lactam antibiotics. However, the utilization of penicillin ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2018.39.4118

    authors: Sacco KA,Chirila R,Libertin C,Hiroto B,Bhasin A,Johnson MM,Pongdee T,Burton MC

    更新日期:2018-05-01 00:00:00

  • Anaphylactoid reactions in two patients after omalizumab administration after successful long-term therapy.

    abstract::Anti-IgE therapy with omalizumab, a recombinant humanized monoclonal antibody, has anti-inflammatory effects in allergic asthma and rhinitis. Although omalizumab has been exceptionally safe, reactions after its administration have been reported. The goal of this study was to assess two patients who experienced apparen...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2007.28.3003

    authors: Price KS,Hamilton RG

    更新日期:2007-05-01 00:00:00

  • Vocal cord dysfunction.

    abstract::A case of vocal cord dysfunction (VCD) is presented, followed by a discussion of the clinical characteristics, pathogenesis, diagnosis, and management of this disorder. Special emphasis is given to clinical pearls and pitfalls for the practicing allergist. VCD is a common condition that mimics asthma. Dyspnea, cough, ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2006.27.2871

    authors: Mikita JA,Mikita CP

    更新日期:2006-07-01 00:00:00

  • Clinical presentation of hereditary angioedema.

    abstract::Hereditary angioedema (HAE) is a rare, autosomal dominant disease caused by a deficiency in the C1-inhibitor protein. It is characterized by recurrent episodes of nonpruritic, nonpitting, subcutaneous or submucosal edema that typically involves the extremities or the gastrointestinal tract. However, the genitourinary ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2020.41.200065

    authors: Azmy V,Brooks JP,Hsu FI

    更新日期:2020-11-01 00:00:00

  • Two puffs of 90 microg albuterol prior to 3% saline sputum induction results in less FEV-1 decline than single concentration 25 mg/ml methacholine challenge.

    abstract:BACKGROUND:Assessment of sputum eosinophilia has shown benefit in the diagnosis and monitoring of asthma. However, the possibility of bronchospasm related to the hypertonic saline used in sputum induction appears to have limited this procedure's acceptance in clinical practice. OBJECTIVE:Because the methacholine (MCH)...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2006.27.2900

    authors: Hagan JB,Madaan A,Kim CK

    更新日期:2006-09-01 00:00:00

  • When asthma and rhinitis coexist, could rhinitis reduce asthma control in children?

    abstract:Background:Bronchial asthma and rhinitis are among the most common diseases in children and frequently coexist in the patient. The primary aim of anti-asthmatic therapy is disease control. Several questionnaires can be used in pediatrics to assess asthma control and the Children Asthma Control Test (C-ACT) is one of th...

    journal_title:Allergy and asthma proceedings

    pub_type: 信件

    doi:10.2500/aap.2019.40.4219

    authors: De Vittori V,Pacilio A,Indinnimeo L,Marazzato M,De Castro G,Brindisi G,Schiavi L,Tosca M,Duse M,Zicari AM

    更新日期:2019-05-01 00:00:00

  • IgE values and T-lymphocyte subsets in children with atopic eczema/dermatitis syndrome.

    abstract::High levels of IgE and IgE-mediated reactions represent a typical finding in patients with atopic eczema/dermatitis syndrome (AEDS). However, 10-30% of patients usually do not show any increase of total blood IgE levels and any detectable specific IgE sensitization. We performed this study to evaluate the difference o...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap2007.28.3038

    authors: Leonardi S,Rotolo N,Vitaliti G,Spicuzza L,La Rosa M

    更新日期:2007-09-01 00:00:00

  • Latex protein: a hidden "food" allergen?

    abstract::Avoidance of latex allergens is the primary method to prevent adverse reactions. Natural rubber latex is found in many different products in both the health care industry and in modern society, and consequently results in unexpected exposures of sensitized individuals. The use of latex gloves by food handlers provides...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/108854100778248214

    authors: Beezhold DH,Reschke JE,Allen JH,Kostyal DA,Sussman GL

    更新日期:2000-09-01 00:00:00

  • Purified natural rubber latex antigens show variable reactivity with IgE in the sera of latex allergic patients.

    abstract::Immediate-hypersensitivity reactions related to latex products have increased rapidly in recent years. However, a reliable diagnosis is hampered by lack of purified and well characterized latex allergens. We have purified allergens in natural rubber latex (NRL) after SDS-PAGE by electroelution, and tested specific IgE...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/108854196778996921

    authors: Lu L,Kurup VP,Kelly KJ,Fink JN

    更新日期:1996-07-01 00:00:00

  • Airway hyperreactivity: managing outcomes and new directions.

    abstract::Bronchial hyperreactivity is defined as an increased sensitivity to bronchoconstrictor stimuli. It is regarded as the physiological hallmark of bronchial asthma. It is usually associated with a positive family history of asthma, atopy, and evaluated total serum immunoglobulin E. Its prevalence in the normal population...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:

    authors: Bardana EJ Jr

    更新日期:2002-11-01 00:00:00

  • Lack of correlation between clinical patterns of asthma and airway obstruction.

    abstract::To evaluate the relationship between the classification of asthma and obstruction of airways, we have studied 100 children suffering from allergic asthma: 65 males and 35 females, aged 4.2-16.3 years (mean, 7.6 +/- 2.8 years), who were evaluated at least 1 month after the last attack of airway obstruction. We analyzed...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:

    authors: Verini M,Rossi N,Dalfino T,Verrotti A,Di Gioacchino M,Chiarelli F

    更新日期:2001-09-01 00:00:00

  • Relationship between atopic asthma and the population prevalence rates for asthma or atopy in children: atopic and nonatopic asthma in epidemiology.

    abstract::Innumerable articles have tried to solve the "continuing enigma of atopic and nonatopic asthma" but notwithstanding the strenuous efforts to substantiate the few well-known clinico-epidemiologic differences between these two forms of asthma most studies have hitherto generated inconclusive statements. In a recent stud...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2009.30.3197

    authors: Ronchetti R,Jesenak M,Rennerova Z,Barreto M,Ronchetti F,Villa MP

    更新日期:2009-01-01 00:00:00

  • Are primary care physicians following National Institute of Allergy and Infectious Disease guidelines for the prevention of peanut allergy? A survey-based study.

    abstract::Background: The 2017 addendum to the National Institute of Allergy and Infectious Diseases (NIAID) guidelines on peanut allergy prevention significantly altered recommendations for patients at risk of developing peanut allergies. It is unknown if primary care physicians are aware of or are following these guidelines. ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2020.41.200019

    authors: Alvarez A,Gupta M,Poowuttikul P,Baptist AP

    更新日期:2020-05-01 00:00:00

  • An integrated analysis of the efficacy of fluticasone furoate nasal spray on individual nasal and ocular symptoms of seasonal allergic rhinitis.

    abstract::Intranasal steroids have been shown to affect ocular symptoms of allergic rhinitis (AR). The results of the published literature, however, are not uniform across all products. This study was designed to evaluate whether the effects of fluticasone furoate nasal spray (FFNS) are consistent across different allergy seaso...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2010.31.3397

    authors: Maspero JF,Walters RD,Wu W,Philpot EE,Naclerio RM,Fokkens WJ

    更新日期:2010-11-01 00:00:00

  • Clinical diagnosis and management of anaphylaxis in infancy.

    abstract:BACKGROUND:Anaphylaxis is increasingly reported in infancy. Diagnosis and management of anaphylaxis is difficult, and data are limited in infants. The aim of the present study was to determine the clinical course and management strategies used for anaphylaxis in infancy. METHODS:Patients attending to our clinic and wh...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2017.38.4009

    authors: Dibek Misirlioglu E,Vezir E,Toyran M,Capanoglu M,Guvenir H,Civelek E,Kocabas CN

    更新日期:2017-01-01 00:00:00

  • Efficacy and safety of once-daily treatment with beclomethasone dipropionate nasal aerosol in subjects with seasonal allergic rhinitis.

    abstract::An aerosol formulation may be preferred by some allergic rhinitis (AR) patients, to avoid the "wet feeling" and nasal runoff associated with aqueous nasal corticosteroid sprays. Beclomethasone dipropionate (BDP) hydrofluoroalkane nasal aerosol is a recently developed, nonaqueous, nonchlorofluorocarbon formulation of ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,随机对照试验

    doi:10.2500/aap.2012.33.3593

    authors: van Bavel JH,Ratner PH,Amar NJ,Hampel FC Jr,Melchior A,Dunbar SA,Dorinsky PM,Tantry SK

    更新日期:2012-09-01 00:00:00

  • Effect of desloratadine on the control of morning symptoms in patients with seasonal and perennial allergic rhinitis.

    abstract::The symptoms of allergic rhinitis vary in severity over the course of the day and often are worse in the morning. This review focuses on data from clinical studies of the antihistamine desloratadine to establish whether it effectively controls the morning symptoms of allergic rhinitis. Studies of desloratadine in pati...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2006.27.2936

    authors: Schenkel EJ

    更新日期:2006-11-01 00:00:00

  • Concurrent use of salmeterol with inhaled corticosteroids is more effective than inhaled corticosteroid dose increases.

    abstract::This randomized, double-blind, parallel, multi-center study was designed to determine whether the addition of salmeterol to existing inhaled corticosteroid therapy provides greater therapeutic benefit than doubling the dose of inhaled corticosteroids in symptomatic patients with asthma. A total of 514 adults were rand...

    journal_title:Allergy and asthma proceedings

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.2500/108854199778553028

    authors: Murray JJ,Church NL,Anderson WH,Bernstein DI,Wenzel SE,Emmett A,Rickard KA

    更新日期:1999-05-01 00:00:00

  • Onset and duration of attenuation of exercise-induced bronchoconstriction in children by single-dose of montelukast.

    abstract::Single-dose montelukast attenuates exercise-induced bronchoconstriction (EIB) in adults within 2 hours postdose and lasting through 24 hours. This study evaluated the onset and duration of EIB attenuation in children after a single dose of montelukast. A randomized, double-blind, placebo-controlled, two-period crossov...

    journal_title:Allergy and asthma proceedings

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.2500/aap.2011.32.3482

    authors: Wasfi YS,Kemp JP,Villarán C,Massaad R,Xin W,Smugar SS,Knorr BA,Philip G

    更新日期:2011-11-01 00:00:00

  • Serum clusterin level in children with atopic dermatitis.

    abstract:BACKGROUND:Atopic dermatitis (AD) is a chronic inflammatory skin disease. Clusterin is a sensitive cellular biosensor of oxidative stress and has been studied as a marker to assess inflammatory diseases. The clusterin levels in AD have not been evaluated thus far. OBJECTIVE:We evaluated serum clusterin levels in child...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2016.37.3953

    authors: Sol IS,Kim YH,Lee KE,Hong JY,Kim MN,Kim YS,Oh MS,Kim MJ,Yoon SH,Park YA,Kim KW,Sohn MH,Kim KE

    更新日期:2016-07-01 00:00:00

  • Hereditary and acquired angioedema.

    abstract::Hereditary angioedema (HAE) is an autosomal dominant disorder defined by a deficiency of functional C1 esterase inhibitor (C1-INH). Acquired angioedema is due to either consumption (type 1) or inactivation (type 2) of CI-INH. Both HAE and acquired angioedema can be life-threatening. Of the three types of HAE, type 1 i...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2019.40.4267

    authors: Patel G,Pongracic JA

    更新日期:2019-11-01 00:00:00

  • Chronic sinusitis: a surgical perspective.

    abstract::Rhinosinusitis is one of the most common chronic diseases with significant symptoms and impact on the quality of life. Surgery is indicated when appropriate medical treatment fails. A review of the clinical presentations of rhinosinusitis is presented, as well as an overview of current medical and surgical treatment o...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:

    authors: Fried MP,Cuellar H,Sadoughi B

    更新日期:2006-01-01 00:00:00

  • HAE update: special considerations in the female patient with hereditary angioedema.

    abstract::This review on hereditary angioedema (HAE) focuses on special topics regarding HAE in female patients. HAE is a bradykinin-mediated disorder, and the role of hormonal regulation of disease expression will be discussed focusing on the effect of estrogen on disease mechanism. The impact of exogenous estrogen on symptom...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2013.34.3635

    authors: Geng B,Riedl MA

    更新日期:2013-01-01 00:00:00

  • Management of asthma in adults: do the patients get what they need--and want?

    abstract::Suboptimal asthma control may be caused by a combination of factors, such as nonadherence to guidelines, lack of compliance, and poor asthma education. The aim was to assess patients' knowledge of asthma and different management strategies, including patients' attitudes toward involvement in treatment decisions. The p...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2007.28.3001

    authors: Backer V,Ulrik CS,Harving H,Lange P,Søes-Petersen U,Plaschke PP

    更新日期:2007-05-01 00:00:00

  • Rhinorrhea not responding to nasal corticosteroids.

    abstract::A woman with multiple illnesses including allergic rhinitis presented for a follow-up visit at our clinic with constant rhinorrhea for 2 weeks despite regular use of nasal corticosteroids. Two weeks earlier, after alcohol drinking and doubling some of her medications for missed doses, she fell on her face. The Emergen...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2007.28.3061

    authors: Patel PN,Oyefara B,Aarstad R,Bahna SL

    更新日期:2007-11-01 00:00:00

  • A new protocol for specific oral tolerance induction in children with IgE-mediated cow's milk allergy.

    abstract::IgE-mediated cow's milk allergy (CMA) is a heavy burden for patients, particularly for children and their families. Allergen avoidance represents the only therapeutic option, but oral desensitization protocols have been suggested. Because of the long duration and complexity of these protocols we examined the feasibili...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,随机对照试验

    doi:10.2500/aap.2009.30.3221

    authors: Caminiti L,Passalacqua G,Barberi S,Vita D,Barberio G,De Luca R,Pajno GB

    更新日期:2009-07-01 00:00:00