Abstract:
BACKGROUND:The relationship between sensitization to Dermatophagoides species and solar irradiation, as reflected by vitamin D, remains elusive. OBJECTIVE:We investigated the lag time and the cumulative and maximum effects of exposure to solar irradiation on sensitization to house-dust mites. METHODS:A time series study design was applied to solar irradiation (MJ/m(2)) and relative humidity (%) for specific immunoglobulin E (IgE) levels against Dermatophagoides pteronyssinus (n = 20,451) and Dermatophagoides farinae (n = 22,824). We used the distributed lag nonlinear model to assess the difference of log IgE to house-dust mites in relation to climate variables. RESULTS:Compared with specific IgE levels of those exposed to 18 MJ/m(2), the maximum increase in sensitization to D. pteronyssinus was observed at a solar irradiation of 10 MJ/m(2) at peak 0 week (difference of log IgE 0.368 [95% confidence interval (CI), 0.209-0.529], p < 0.001), and this increase continued for 3 weeks. The IgE level was significantly affected by the relative humidity of the 3rd- to 12th-lag week, and the effect reached its peak at 75% on the 8th week (difference of log IgE 0.394 [95% CI, 0.221-0.566], p < 0.001). The logistic regression analysis showed that solar irradiation was associated with a decreased risk to sensitization to D. pteronyssinus (odds ratio 0.988 per 1 MJ/m(2) [95% CI, 0.979-0.997], p < 0.013) on the testing week after controlling for humidity and temperature. CONCLUSION:This study demonstrated that low solar irradiation immediately increased the risk of sensitization to two house-dust mite species. Further research is warranted to delineate the underlying mechanism of the effect of solar irradiation on aeroallergen sensitization.
journal_name
Allergy Asthma Procjournal_title
Allergy and asthma proceedingsauthors
Lee SW,Cho E,Koh HY,Shin J,Baek JH,Shin YH,Jee HM,Kim HM,Han MYdoi
10.2500/aap.2015.36.3845subject
Has Abstractpub_date
2015-07-01 00:00:00pages
44-50issue
4eissn
1088-5412issn
1539-6304journal_volume
36pub_type
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