Abstract:
:Asthma, a disease characterized by airway inflammation and reversible bronchoconstriction, manifests a variety of phenotypes, and in some, but not all, asthma leads to a persistent and/or progressive loss of lung function. Conceptually, asthma persistence is identified by a stable decrement in lung function over time, and asthma progression can be identified by a gradual loss in pulmonary function associated with increasing symptoms. Whether these phenotypes are determined by distinct cellular and molecular mechanisms or whether unique genotypes define asthma persistence versus progression remains unknown. Recent evidence suggests that airway remodeling in some is associated with asthma persistence and/or progression, although the direct link of airway remodeling to these phenotypes remains tenuous. The development of in vitro cell models using nontransformed human airway smooth muscle (ASM) cells has been a useful approach in defining corticosteroid sensitivity and bronchodilator response. New evidence suggests some, but not all, immunomodulatory function of ASM is modulated by corticosteroid treatment. Additionally, the combinations of interferon and TNF-alpha render ASM insensitive to corticosteroids. The further development of cellular and ex vivo systems that can predict corticosteroid sensitivity and bronchodilator unresponsiveness may be useful in identifying new biomarkers and therapeutic approaches to address asthma persistence and progression.
journal_name
Allergy Asthma Procjournal_title
Allergy and asthma proceedingsauthors
Panettieri RA Jrdoi
10.2500/aap.2009.30.3202subject
Has Abstractpub_date
2009-03-01 00:00:00pages
103-8issue
2eissn
1088-5412issn
1539-6304journal_volume
30pub_type
杂志文章,评审abstract::A telephone survey of 100 primary care physicians was performed to assess the awareness of the influence patient preference, patient satisfaction, and other factors have on the selection of nasal steroids for the treatment of allergic rhinitis. Results indicated that physicians believe drug efficacy is the primary rea...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:
更新日期:2001-11-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2010.31.3403
更新日期:2010-11-01 00:00:00
abstract::Barbiturates, a class of medications commonly used as antiepileptics and sedatives, are known to cause adverse reaction, with the most commonly reported immune-mediated reactions being anticonvulsant hypersensitivity syndrome. Other types of allergic reactions such as immediate hypersensitivity reactions also can occu...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:
更新日期:2004-07-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2012.33.3574
更新日期:2012-05-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2021.42.200090
更新日期:2021-01-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:
更新日期:2001-07-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,多中心研究
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2020.41.200065
更新日期:2020-11-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/108854199778612590
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/108854199778681530
更新日期:1999-01-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,随机对照试验
doi:10.2500/aap2008.29.3083
更新日期:2008-01-01 00:00:00
abstract::The atopy patch test (APT) was first reported in 1895 by the German dermatologist, Jadassohn and was used for evaluation of contact dermatitis. The first documented epicutaneous application of aeroallergens was by Rostenberg and Sulzbergen in 1937. Although others including Mitchell and Platts-Mills, further described...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/aap.2014.35.3797
更新日期:2014-11-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2017.38.4096
更新日期:2017-10-02 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2500/108854199778553028
更新日期:1999-05-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/aap.2012.33.3512
更新日期:2012-03-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:
更新日期:2004-03-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2017.38.4009
更新日期:2017-01-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2016.37.3926
更新日期:2016-03-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/aap.2009.30.3272
更新日期:2009-09-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap2007.28.3038
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2016.37.3935
更新日期:2016-05-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2015.36.3827
更新日期:2015-03-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,随机对照试验
doi:10.2500/aap.2009.30.3235
更新日期:2009-05-01 00:00:00
abstract::Recurrent episodes of flushing, urticaria, and angioedema raise suspicion for many conditions with a wide differential diagnosis. The diagnostic approach involves consideration of allergic, cardiovascular, gastrointestinal, endocrine, infectious, neurologic, dermatologic, and drug-related causes. We describe a unique ...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2015.36.3836
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Hereditary angioedema (HAE) is a rare, potentially life-threatening disease characterized by recurrent angioedema attacks. Abdominal symptoms of HAE typically mimic numerous abdominal emergencies, which may result in a delay of correct diagnosis and inappropriate treatments. OBJECTIVE:We aimed to evaluate t...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2016.37.3905
更新日期:2016-01-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
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更新日期:2019-01-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2015-11-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:
更新日期:2002-07-01 00:00:00
abstract::Complementary and Alternative Medicine (CAM) therapies such as herbal therapy, acupuncture, yoga, homeopathy, chiropractic medicine, and massage therapy, continue to gain popularity as modalities for the treatment of asthma. In the Chinese, Japanese, Korean, Indian, and Western cultures, herbal therapies appear to be ...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:
更新日期:2004-09-01 00:00:00