Clinical benefits of aspirin desensitization in patients with nonsteroidal anti-inflammatory drug exacerbated respiratory disease are not related to urinary eicosanoid release and are accompanied with decreased urine creatinine.

Abstract:

BACKGROUND:Treatment with acetylsalicylic acid (ASA) after desensitization may be a therapeutic option in patients with nonsteroidal anti-inflammatory drug exacerbated respiratory disease (NERD). The mechanisms that lead to improvement in rhinosinusitis and asthma symptoms remain unknown. AIM:To attribute the documented clinical effects of ASA treatment of chronic rhinosinusitis and/or asthma to the release of eicosanoid metabolites in urine. METHODS:Fourteen patients with NERD were successfully desensitized, and, eventually, eight patients were treated with 650 mg of ASA daily for 3 months. In addition to clinical assessments, nuclear magnetic resonance imaging and smell test were performed before and after treatment with ASA. Venous blood and urine were collected before desensitization and after 1 and 3 months of treatment. The levels of urinary leukotrienes (LT) (cysteinyl LT and LTE4) and tetranor PGDM (metabolite of prostaglandin D2) were measured by enzyme-linked immunosorbent assay. RESULTS:Treatment with ASA after desensitization alleviated symptoms of rhinosinusitis, improved nasal patency (mean, 50% decrease in peak nasal inspiratory flow) and sense of smell (fourfold increase in smell test score) in as early as 4 weeks. Clinical improvements were not accompanied by any change in sinonasal mucosa thickness as assessed with nuclear magnetic resonance. Urinary cysteinyl LTs, LTE4, and prostaglandin D2 metabolite remained relatively stable during ASA treatment and did not correlate with clinical improvements. Desensitization was associated with a progressive decrease of urinary creatinine. CONCLUSION:Clinical improvement in rhinosinusitis and/or asthma after ASA desensitization was not related to concentrations of urinary eicosanoid metabolites. A decrease of urinary creatinine requires further study to determine the renal safety of long-term treatment with ASA after desensitization.

journal_name

Allergy Asthma Proc

authors

Makowska JS,Olszewska-Ziąber A,Bieńkiewicz B,Lewandowska-Polak A,Kurowski M,Woźniakowski B,Rotkiewicz A,Kowalski ML

doi

10.2500/aap.2016.37.3935

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

216-24

issue

3

eissn

1088-5412

issn

1539-6304

journal_volume

37

pub_type

杂志文章
  • Effect of desloratadine on the control of morning symptoms in patients with seasonal and perennial allergic rhinitis.

    abstract::The symptoms of allergic rhinitis vary in severity over the course of the day and often are worse in the morning. This review focuses on data from clinical studies of the antihistamine desloratadine to establish whether it effectively controls the morning symptoms of allergic rhinitis. Studies of desloratadine in pati...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2006.27.2936

    authors: Schenkel EJ

    更新日期:2006-11-01 00:00:00

  • High mobility group box 1: Biomarker of inhaled corticosteroid treatment response in children with moderate-severe asthma.

    abstract:BACKGROUND:High mobility group box 1 (HMGB1) is abnormally expressed in serum and sputum of patients with allergic asthma. OBJECTIVE:The aim of this study was to investigate the role of HMGB1 as guidance for treatment management of children with asthma. METHODS:Thirty children with asthma and 44 healthy children were...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2017.38.4047

    authors: Manti S,Leonardi S,Parisi GF,De Vivo D,Salpietro A,Spinuzza A,Arrigo T,Salpietro C,Cuppari C

    更新日期:2017-05-01 00:00:00

  • Hypodense eosinophils: characterization of surface molecule expression.

    abstract::Distinct eosinophil populations have been characterized on the basis of discontinuous Percoll density gradients. In peripheral blood, normal individuals show a low number of normodense and hypodense eosinophils, contrasting with the high amount of hypodense cells in patients who have allergies. To characterize these t...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:

    authors: Conesa A,Tassinari P,Rivera H,De Sanctis JB,Bianco N,Aldrey O

    更新日期:2002-03-01 00:00:00

  • Effect of indoor air quality on the natural history of asthma in an urban population in Poland.

    abstract::Background: Indoor air pollution may have an impact on asthma. Objective: To evaluate the influence of indoor air pollution on the natural history of asthma. Methods: Data collection by using the European Community Respiratory Health Survey and International Study of Asthma and Allergies in Childhood standardized ques...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2018.39.4176

    authors: Piekarska B,Stankiewicz-Choroszucha BL,Sybilski AJ,Furmańczyk K,Jaworski S,Białoszewski AZ,Kłak A,Lipiec A,Walkiewicz A,Tomaszewska A,Raciborski F,Samoliński BK

    更新日期:2018-11-01 00:00:00

  • Reevaluation of pollen quantitation by an automatic pollen counter.

    abstract::Accurate and detailed pollen monitoring is useful for selection of medication and for allergen avoidance in patients with allergic rhinitis. Burkard and Durham pollen samplers are commonly used, but are labor and time intensive. In contrast, automatic pollen counters allow simple real-time pollen counting; however, th...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2010.31.3354

    authors: Muradil M,Okamoto Y,Yonekura S,Chazono H,Hisamitsu M,Horiguchi S,Hanazawa T,Takahashi Y,Yokota K,Okumura S

    更新日期:2010-09-01 00:00:00

  • The role of outcome studies in allergy and clinical immunology.

    abstract::Outcomes research is becoming an integral part of the sweeping changes occurring in the U.S. health care system. By developing outcomes monitoring systems in allergic disorders, allergists will be able to collect information showing their commitment to excellent clinical care, which improves the patient's quality of l...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/108854196778606455

    authors: Blaiss MS

    更新日期:1996-11-01 00:00:00

  • Concurrent use of salmeterol with inhaled corticosteroids is more effective than inhaled corticosteroid dose increases.

    abstract::This randomized, double-blind, parallel, multi-center study was designed to determine whether the addition of salmeterol to existing inhaled corticosteroid therapy provides greater therapeutic benefit than doubling the dose of inhaled corticosteroids in symptomatic patients with asthma. A total of 514 adults were rand...

    journal_title:Allergy and asthma proceedings

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.2500/108854199778553028

    authors: Murray JJ,Church NL,Anderson WH,Bernstein DI,Wenzel SE,Emmett A,Rickard KA

    更新日期:1999-05-01 00:00:00

  • Flunisolide hydrofluoroalkane with integrated spacer for treating asthma: an updated review.

    abstract::Flunisolide hydrofluoroalkane (HFA) with integrated spacer is the most recent reformulated inhaled corticosteroid (ICS) for asthma available in the United States. It is the only product that combines a corticosteroid extrafine aerosol with a built-in spacer. The potential clinical benefit of the flunisolide HFA formul...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2015.36.3835

    authors: Berger WE,Tashkin DP

    更新日期:2015-03-01 00:00:00

  • Effect of omalizumab on outcomes in patients with aspirin-exacerbated respiratory disease.

    abstract::Background: The current treatment for patients with aspirin-exacerbated respiratory disease (AERD) who have uncontrolled asthma or chronic rhinosinusitis is aspirin desensitization. For patients who are unable to undergo or do not benefit from aspirin desensitization, treatment with biologics is an option, although ef...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2019.40.4241

    authors: Jean T,Eng V,Sheikh J,Kaplan MS,Goldberg B,Jau Yang S,Samant S

    更新日期:2019-09-01 00:00:00

  • National estimates of emergency department visits for angioedema and allergic reactions in the United States.

    abstract::Each year there are a substantial number of emergency department (ED) visits for angioedema and allergic reactions in the United States. Angioedema is commonly mistaken for an allergic reaction, possibly affecting the treatment rendered. We sought to determine the characteristics of U.S. ED visits for acute angioedema...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2013.34.3640

    authors: Kelly M,Donnelly JP,McAnnally JR,Wang HE

    更新日期:2013-03-01 00:00:00

  • Changing the route of immunotherapy administration: an 18-year survey in pediatric patients with allergic rhinitis and asthma.

    abstract::Immunotherapy can be administered either sublingually (sublingual immunotherapy [SLIT]) or subcutaneously (subcutaneous immunotherapy [SCIT]). The rate of route switching, required by patients, can provide an indirect evaluation of patients' preferences and adherence. The authors retrospectively reviewed patients' fil...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2013.34.3696

    authors: Pajno GB,Caminiti L,Passalacqua G

    更新日期:2013-11-01 00:00:00

  • Anaphylaxis to insect sting associated with urticaria pigmentosa.

    abstract::Anaphylaxis associated with insect stings has been reported to cause approximately 40 deaths per year in the United States. Immunotherapy with venom extracts is a well-established method of treatment of allergy to insect stings. The duration of therapy is based mainly on the initial symptoms and the presence or absenc...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:

    authors: Kim DC,Horan R

    更新日期:2003-05-01 00:00:00

  • Functional assessment of allergic asthmatic children while asymptomatic.

    abstract::The aim of this study was to detect the best test lung function to identify abnormalities in asthmatic children while asymptomatic. We studied 200 asthmatic children. Patients were evaluated by questionnaire to evaluate the presence of symptoms and drug consumption in the previous 3 months. Allergological evaluation b...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2006.27.2922

    authors: Verini M,Peroni DG,Rossi N,Nicodemo A,De Stradis R,Spagnolo C,Chiarelli F,Boner AL

    更新日期:2006-07-01 00:00:00

  • The role of nonsedating antihistamines in asthma therapy.

    abstract::There is well-established evidence that histamine plays a significant role as a chemical mediator in asthma. However, although antihistamines are commonly used for the treatment of allergic rhinitis, their use in asthma has been somewhat controversial. Mechanistically, their application for asthma appears logical. In ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:

    authors: Zitt MJ

    更新日期:2003-07-01 00:00:00

  • Reliability of skin test results when read at different time points.

    abstract::Percutaneous skin testing to determine allergies is usually read 15-20 minutes after placement, but the time to reading may be prolonged because of clinic duties or emergencies. The objective of the study was to compare skin-prick testing (SPT) wheal and flare reactions at 10, 30, and 40 minutes with the standard 20 m...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2011.32.3436

    authors: Seibert SM,King TS,Kline D,Mende C,Craig T

    更新日期:2011-05-01 00:00:00

  • Novel cytokines and cytokine-producing T cells in allergic disorders.

    abstract::Allergic diseases reflect various pathways of T lymphocyte inflammation and largely comprise T helper (Th) 2-associated processes. Recent investigations have identified pathways involved in promoting Th2 responses. Additionally, novel T-cell subtypes, each with its own distinct cytokine profile, contribute to the hete...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2011.32.3428

    authors: Wisniewski JA,Borish L

    更新日期:2011-03-01 00:00:00

  • Defining the effects of an inhaled corticosteroid and long-acting beta-agonist on therapeutic targets.

    abstract::The effects of inhaled corticosteroids (ICSs) and long-acting beta 2-agonists (LABAs) on therapeutic targets have significant clinical relevance regarding optimal management of asthma. Asthma pathophysiology involves two main components: smooth muscle dysfunction and airway inflammation. LABAs and ICSs provide complem...

    journal_title:Allergy and asthma proceedings

    pub_type: 指南,杂志文章,实务指引,评审

    doi:

    authors: Settipane RA,National Asthma Education and Prevention Program (NAEPP).

    更新日期:2003-03-01 00:00:00

  • Mast cells in allergy and host defense.

    abstract::Mast cells have been implicated in the pathogenesis of allergic diseases and in inflammatory responses associated with pathological immune and disease-related processes including fibrosis, autoimmune pathology, and neoplasia. Recent findings in animal models of bacterial infection also suggest that mast cells may have...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/108854101778148764

    authors: Taylor ML,Metcalfe DD

    更新日期:2001-05-01 00:00:00

  • Epinephrine auto-injector prescriptions as a reflection of the pattern of anaphylaxis in an Asian population.

    abstract::This study surveyed the prescription patterns of adrenaline auto-injectors (AAs) in Singapore to examine the frequency, triggers, and demographic pattern of anaphylaxis requiring such prescriptions. A 6-year retrospective review of 417 consecutive patients prescribed AAs in Singapore from January 1999 to December 2004...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2008.29.3102

    authors: Tham EH,Tay SY,Lim DL,Shek LP,Goh AE,Giam YC,Chng HH,Lee BW

    更新日期:2008-03-01 00:00:00

  • Managing rhinitis: Strategies for improved patient outcomes.

    abstract::Allergic rhinitis affects more than 40 million Americans, with estimated costs reaching $5.3 billion annually. The global impact includes negative effects on quality of life (QOL), sleep, diminished work productivity, and exacerbation of comorbid conditions. An accurate diagnosis of allergic or nonallergic rhinitis is...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2008.29.3145

    authors: Carr WW,Nelson MR,Hadley JA

    更新日期:2008-07-01 00:00:00

  • Community-acquired pneumonia: an approach to antimicrobial therapy.

    abstract::Community-acquired pneumonia (CAP), the sixth leading cause of death in the United States, has undergone significant changes in the past 30 years. In addition to the fact that it increasingly is a disease affecting the elderly and those patients with underlying comorbidities, the spectrum of microbiological agents cau...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/108854100778248980

    authors: Lange M

    更新日期:2000-01-01 00:00:00

  • Efficacy and safety of once-daily treatment with beclomethasone dipropionate nasal aerosol in subjects with seasonal allergic rhinitis.

    abstract::An aerosol formulation may be preferred by some allergic rhinitis (AR) patients, to avoid the "wet feeling" and nasal runoff associated with aqueous nasal corticosteroid sprays. Beclomethasone dipropionate (BDP) hydrofluoroalkane nasal aerosol is a recently developed, nonaqueous, nonchlorofluorocarbon formulation of ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,随机对照试验

    doi:10.2500/aap.2012.33.3593

    authors: van Bavel JH,Ratner PH,Amar NJ,Hampel FC Jr,Melchior A,Dunbar SA,Dorinsky PM,Tantry SK

    更新日期:2012-09-01 00:00:00

  • Immunobiologic treatments for severe asthma, atopic dermatitis, and chronic urticaria.

    abstract::Immunobiologic agents are an important therapeutic alternative for severe asthma, atopic dermatitis, and chronic urticaria. In this article, we reviewed the most relevant studies that addressed the use of anti-immunoglobulin E (omalizumab), anti-IL-5 (mepolizumab, reslizumab, and benralizumab), and anti-IL-4/IL-13 (du...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2019.40.4277

    authors: Chiarella SE

    更新日期:2019-11-01 00:00:00

  • Chronic sinusitis: a surgical perspective.

    abstract::Rhinosinusitis is one of the most common chronic diseases with significant symptoms and impact on the quality of life. Surgery is indicated when appropriate medical treatment fails. A review of the clinical presentations of rhinosinusitis is presented, as well as an overview of current medical and surgical treatment o...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:

    authors: Fried MP,Cuellar H,Sadoughi B

    更新日期:2006-01-01 00:00:00

  • The nature of melon allergy in ragweed-allergic subjects: A study of 1000 patients.

    abstract::Previous studies suggest cross-reactivity between specific ragweed pollen and melon allergens. This study was designed to clarify the origin of the cross-reactivity between ragweed pollen and the gourd family. One thousand ragweed-allergic subjects were interviewed about the presence of oral allergy syndrome (OAS) ind...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2011.32.3416

    authors: Asero R,Mistrello G,Amato S

    更新日期:2011-01-01 00:00:00

  • Antihistamine onset of action: the importance to the patient.

    abstract::Although some older antihistamines have a relatively slow onset of action, modern agents indicate an efficacy between 1 and 3 hours of administration. For patients who use antihistamines regularly, a short onset of action is relatively unimportant. When antihistamines are used as needed, either because of poor complia...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:

    authors: Dolen WK

    更新日期:2004-03-01 00:00:00

  • Two puffs of 90 microg albuterol prior to 3% saline sputum induction results in less FEV-1 decline than single concentration 25 mg/ml methacholine challenge.

    abstract:BACKGROUND:Assessment of sputum eosinophilia has shown benefit in the diagnosis and monitoring of asthma. However, the possibility of bronchospasm related to the hypertonic saline used in sputum induction appears to have limited this procedure's acceptance in clinical practice. OBJECTIVE:Because the methacholine (MCH)...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2006.27.2900

    authors: Hagan JB,Madaan A,Kim CK

    更新日期:2006-09-01 00:00:00

  • Leukotriene C4 synthase: a candidate gene for the aspirin-intolerant asthmatic phenotype.

    abstract::The features of the allergic inflammation underlying asthma occur as a consequence of mediators such as the cysteinyl LTs. The generation of the cysteinyl LTs is carefully regulated and dependent on the 5-LO/LTC4S pathway, of which LTC4S is the pivotal and only committed enzyme involved. Although LTC4S is related to o...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/108854199778251825

    authors: Penrose JF,Baldasaro MH

    更新日期:1999-11-01 00:00:00

  • Oral allergy syndrome (pollen-food allergy syndrome).

    abstract::A case of Oral Allergy syndrome or Pollen-Food Allergy Syndrome is briefly discussed. The clinical characteristics, diagnosis, pathogenesis, and management of this syndrome are discussed followed by clinical pearls and pitfalls for the practicing allergist. Symptoms generally occur with the ingestion of raw fruits/veg...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:

    authors: Purohit-Sheth TS,Carr WW

    更新日期:2005-05-01 00:00:00

  • Emergency department treatment of adults with acute asthma exacerbations: effect on exhaled nitric oxide levels.

    abstract::Measurement of exhaled nitric oxide levels (eNO) from asthmatic patients is a noninvasive marker of airway inflammation in both adults and children and has been used as an outpatient measure of asthma control. We examined eNO in acute asthma exacerbations and how it is affected by treatment in the emergency departmen...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,随机对照试验

    doi:10.2500/aap.2012.33.3613

    authors: Silverberg JI,Rodenas M,Sinert R,Joks R

    更新日期:2012-11-01 00:00:00