Mast cells in allergy and host defense.

Abstract:

:Mast cells have been implicated in the pathogenesis of allergic diseases and in inflammatory responses associated with pathological immune and disease-related processes including fibrosis, autoimmune pathology, and neoplasia. Recent findings in animal models of bacterial infection also suggest that mast cells may have a protective role in host defense against pathogens in innate immunity along with the probable role of mast cells in acquired immunity against parasitic infections. Mast cells are strategically located at the host-environment interface and may provide an early defense against an invading pathogen. Mast cells express an array of adhesion and immune receptors that may assist in the recognition of invading pathogens. When activated, these cells then synthesize and release key immunoregulatory cytokines, one consequence of which is to mobilize a rapid and vigorous inflammatory response. However, although it has been demonstrated that mast cells may have a role in innate immunity in defined in vitro and animal models, it remains to be determined whether mast cells are protective in innate immune responses in humans.

journal_name

Allergy Asthma Proc

authors

Taylor ML,Metcalfe DD

doi

10.2500/108854101778148764

subject

Has Abstract

pub_date

2001-05-01 00:00:00

pages

115-9

issue

3

eissn

1088-5412

issn

1539-6304

journal_volume

22

pub_type

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