Abstract:
:Flunisolide hydrofluoroalkane (HFA) with integrated spacer is the most recent reformulated inhaled corticosteroid (ICS) for asthma available in the United States. It is the only product that combines a corticosteroid extrafine aerosol with a built-in spacer. The potential clinical benefit of the flunisolide HFA formulation and its integrated spacer for treating persistent asthma was assessed through a comprehensive review of the published literature and data from the past 10 years focusing on (1) flunisolide, the molecule, and the impact of the HFA reformulation; (2) updated information on the anti-inflammatory response to flunisolide HFA, particularly in the distal airways; and (3) the usefulness of an integrated spacer. Flunisolide HFA was found effective and safe in clinical studies and comparable with the chlorofluorocarbon (CFC) formulation, but at about one-third the dose of flunisolide CFC, likely reflecting both the device and the particle size of the reformulated product. Compared with the CFC formulation, the extrafine aerosol and smaller particle size of flunisolide HFA substantially increased pulmonary deposition and decreased oropharyngeal deposition. The integrated spacer further enhanced the pulmonary/oropharyngeal deposition ratio. Examination of lung biopsy specimens indicated a favorable anti-inflammatory response to flunisolide HFA in peripheral airways. Pediatric studies showed no significant effects on growth. The data indicate that flunisolide HFA is a safe and effective maintenance therapy for asthma patients. The integrated spacer may provide an added advantage for patients, especially those who may be more likely to experience adverse effects of ICSs, both local and systemic, including children susceptible to adverse effects on growth.
journal_name
Allergy Asthma Procjournal_title
Allergy and asthma proceedingsauthors
Berger WE,Tashkin DPdoi
10.2500/aap.2015.36.3835subject
Has Abstractpub_date
2015-03-01 00:00:00pages
105-15issue
2eissn
1088-5412issn
1539-6304pii
content-3835journal_volume
36pub_type
杂志文章,评审abstract::The use of complementary and alternative medicine has dramatically increased in the United States, which necessitates that physicians have knowledge of different modalities, possible benefits, and potential adverse reactions. Internet access and numerous magazines are available to patients for self-administration. Num...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/108854197778605473
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journal_title:Allergy and asthma proceedings
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journal_title:Allergy and asthma proceedings
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/108854197778612817
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journal_title:Allergy and asthma proceedings
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journal_title:Allergy and asthma proceedings
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journal_title:Allergy and asthma proceedings
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2002-09-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 临床试验,杂志文章
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journal_title:Allergy and asthma proceedings
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doi:
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journal_title:Allergy and asthma proceedings
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journal_title:Allergy and asthma proceedings
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journal_title:Allergy and asthma proceedings
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