Abstract:
:Current asthma management guidelines emphasize the importance of disease control. Although effective drug therapies are available, real-life data indicate that the general level of asthma control is still low. Fixed-dose combinations of inhaled corticosteroids/long-acting beta(2)-agonists (ICS/LABAs) are now increasingly used in the management of asthma. A number of studies have compared the clinical benefits of ICS/LABA fixed combinations with the monocomponents administered using two separate inhalers. We conducted a database search to identify all published studies that have assessed whether fixed-dose combinations achieve greater asthma control compared with administration by separate inhalers. Among fixed combinations, only extrafine beclomethasone/formoterol provided significantly greater asthma control compared with separate inhalers administered as larger aerosol particles. This greater effect may be explained by increased delivery to the small airways by the extrafine formulation.
journal_name
Allergy Asthma Procjournal_title
Allergy and asthma proceedingsauthors
Barnes PJ,Nicolini G,Bizzi A,Spinola M,Singh Ddoi
10.2500/aap.2012.33.3512subject
Has Abstractpub_date
2012-03-01 00:00:00pages
140-4issue
2eissn
1088-5412issn
1539-6304journal_volume
33pub_type
杂志文章,评审abstract::Previous studies suggest cross-reactivity between specific ragweed pollen and melon allergens. This study was designed to clarify the origin of the cross-reactivity between ragweed pollen and the gourd family. One thousand ragweed-allergic subjects were interviewed about the presence of oral allergy syndrome (OAS) ind...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2011.32.3416
更新日期:2011-01-01 00:00:00
abstract::The manufacturing of PrePen (benzylpenicilloyl-polylysine) was suspended from September 2000 through November 2001 because of Food and Drug Administration intervention. PrePen is penicilloyl bound to polylysine and is considered to be the major determinant of penicillin metabolism; it is used as a skin-testing reagent...
journal_title:Allergy and asthma proceedings
pub_type: 临床试验,杂志文章
doi:
更新日期:2004-05-01 00:00:00
abstract::To date cytokines profile in AEDS is poorly described in children. We evaluated the interleukin (IL)-17, IL-23, and IL-10 levels in atopic eczema/dermatitis syndrome (AEDS) children and healthy controls, in atopic AEDS (aAEDS) and nonatopic (naAEDS) subtypes and their relationship with disease severity. A total of 181...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2015.36.3808
更新日期:2015-01-01 00:00:00
abstract::Immunotherapy can be administered either sublingually (sublingual immunotherapy [SLIT]) or subcutaneously (subcutaneous immunotherapy [SCIT]). The rate of route switching, required by patients, can provide an indirect evaluation of patients' preferences and adherence. The authors retrospectively reviewed patients' fil...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2013.34.3696
更新日期:2013-11-01 00:00:00
abstract::Perennial allergic rhinitis (PAR) often causes sleep disturbances and associated daytime somnolence, thus resulting in a poor quality of life. Various clinical interventions in patients suffering from the disorder seek to improve symptoms and quality of life. Additional studies are needed to establish whether the alle...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2008.29.3097
更新日期:2008-03-01 00:00:00
abstract::Anti-IgE therapy with omalizumab, a recombinant humanized monoclonal antibody, has anti-inflammatory effects in allergic asthma and rhinitis. Although omalizumab has been exceptionally safe, reactions after its administration have been reported. The goal of this study was to assess two patients who experienced apparen...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2007.28.3003
更新日期:2007-05-01 00:00:00
abstract::Fungi are important aeroallergens. However, fungal allergen sources of consistent quality for clinical testing are not readily available. Because some allergens have been identified as enzymes, we assessed the prevalence of IgE reactivity to commercially available fungal enzymes. The purpose of this study was to deter...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2008.29.3174
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND:Allergic and autoimmune diseases comprise a group of inflammatory disorders caused by aberrant immune responses in which CD25+ Forkhead box P3-positive (FOXP3+) T regulatory (Treg) cells that normally suppress inflammatory events are often poorly functioning. This has stimulated an intensive investigative ef...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2018.39.4113
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:The relationship between sensitization to Dermatophagoides species and solar irradiation, as reflected by vitamin D, remains elusive. OBJECTIVE:We investigated the lag time and the cumulative and maximum effects of exposure to solar irradiation on sensitization to house-dust mites. METHODS:A time series st...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,多中心研究
doi:10.2500/aap.2015.36.3845
更新日期:2015-07-01 00:00:00
abstract::Allergic bronchopulmonary aspergillosis (ABPA) occurs as a complication of bronchial asthma or cystic fibrosis (CF). The diagnostic criteria speak to an exaggerated type I hypersensitivity response to the ubiquitous organism Aspergillus fumigatus. Immunologic parameters indicative of Aspergillus sensitization in CF ma...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:
更新日期:2004-11-01 00:00:00
abstract::Peanut allergy affects approximately 1% of the population. Double-blind placebo-controlled food challenges are gold standard for diagnosis. Serum peanut-specific IgE (PN-IgE) is used in clinical practice as an additional diagnostic and monitoring tool. The purpose of this study was to characterize the clinical feature...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2008.29.3117
更新日期:2008-05-01 00:00:00
abstract::Fever of unknown origin (FUO) is both a clinical and a diagnostic challenge. Furthermore, an FUO case with isolated marrow noncaseating granuloma can further confound diagnosis. However, these two findings together may help narrow down the pathological possibilities. This article presents a case report of FUO and lymp...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/aap.2007.28.2982
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND:Defective nasal barrier function is implicated in allergic rhinitis, which results in persistent inflammation and clinical symptoms, among which congestion plays a prominent role. In searching ways to improve the efficacy of nasally applied drugs in this condition, we tested the hypothesis that hydroxypropyl...
journal_title:Allergy and asthma proceedings
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.2500/aap.2015.36.3879
更新日期:2015-11-01 00:00:00
abstract::Oxidative stress occurs in many allergic and immunologic disorders as a result of the imbalance between the endogenous production of free reactive oxygen species (ROS) and/or the reduction of antioxidant defense mechanisms. Advanced glycation end products (AGEs), advanced oxidation protein products (AOPPs), and nitros...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2015.36.3814
更新日期:2015-01-01 00:00:00
abstract::Although "atopic march" is a popular concept, the relationship between eczema and subsequent asthma is far from clear. However, some cohort studies have shown the possibility of two different allergic phenotypes in those who present with early eczema in terms of their persistency. We checked the cohort data from 308,...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2013.34.3625
更新日期:2013-01-01 00:00:00
abstract::Several decades ago, the skin was considered to be little more than a simple barrier to dehydration, environmental toxins, and extrinsic bacteria; however, we now recognize that the skin is a complex immune organ that is fully integrated with the immune functions of the bone marrow, lymph nodes, liver, and spleen. Lym...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/108854199778251933
更新日期:1999-09-01 00:00:00
abstract::Allergic rhinitis and asthma are two of the most common chronic conditions affecting the population. There has been a growing understanding of the link between these disorders as they commonly occur in the same individual, of their relationship with allergies, and of the total economic impact in both direct and indire...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:
更新日期:2002-07-01 00:00:00
abstract::Dose-response of formoterol via pressurized metered-dose inhaler (pMDI) has not been determined in asthmatic pediatric patients aged 6 to <12 years. This study was designed to assess the bronchodilating dose-response of three formoterol pMDI doses in children with stable asthma aged 6 to <12 years receiving twice-dail...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2500/aap.2014.35.3746
更新日期:2014-03-01 00:00:00
abstract::Eotaxin is the major eosinophil chemoattractant found in bronchoalveolar lavage (BAL) fluid from sensitized guinea pigs after antigen challenge. In this study we have performed immunostaining for eotaxin in airways obtained from challenged animals and examined purified guinea pig lung cells (epithelial cells > 98% pur...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/108854198778557926
更新日期:1998-01-01 00:00:00
abstract::A case of Oral Allergy syndrome or Pollen-Food Allergy Syndrome is briefly discussed. The clinical characteristics, diagnosis, pathogenesis, and management of this syndrome are discussed followed by clinical pearls and pitfalls for the practicing allergist. Symptoms generally occur with the ingestion of raw fruits/veg...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:
更新日期:2005-05-01 00:00:00
abstract::Nasal polyps are inflammatory outgrowths of paranasal sinus mucosa caused by chronic mucosal inflammation that typically arise from the middle meatus and ethmoid region. The main symptoms of nasal polyps are perennial nasal congestion, nasal obstruction, and anosmia or hyposmia. Unlike patients with chronic rhinosinu...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/aap.2012.33.3537
更新日期:2012-05-01 00:00:00
abstract::Immediate-hypersensitivity reactions related to latex products have increased rapidly in recent years. However, a reliable diagnosis is hampered by lack of purified and well characterized latex allergens. We have purified allergens in natural rubber latex (NRL) after SDS-PAGE by electroelution, and tested specific IgE...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/108854196778996921
更新日期:1996-07-01 00:00:00
abstract::Background: The 2017 addendum to the National Institute of Allergy and Infectious Diseases (NIAID) guidelines on peanut allergy prevention significantly altered recommendations for patients at risk of developing peanut allergies. It is unknown if primary care physicians are aware of or are following these guidelines. ...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2020.41.200019
更新日期:2020-05-01 00:00:00
abstract::Background: The majority of patients for elective surgery and with a history of penicillin allergy are placed on alternative prophylactic antibiotic therapies, which have been associated with the emergence of multidrug-resistant pathogens and increased morbidity and mortality rates. However, self-reporting of penicill...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,meta分析
doi:10.2500/aap.2018.39.4178
更新日期:2018-11-01 00:00:00
abstract::Quality of life is affected by history of bee sting allergy. In addition, worry about being stung and also the need to use self-injection of medicine can create or increase anxiety, which can further compromise a patient's ability to enjoy the outdoors and participate in activities. We sought to determine the depressi...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2014.35.3751
更新日期:2014-05-01 00:00:00
abstract::As imported fire ants (IFAs) expand their range, hypersensitivity reactions to their stings are becoming a significant cause of morbidity and mortality in the United States. Currently, IFAs whole body extract (WBE) immunotherapy is the mainstay of treatment for IFA hypersensitivity but the optimal duration of treatmen...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2007.28.3021
更新日期:2007-07-01 00:00:00
abstract::Complementary and Alternative Medicine (CAM) therapies such as herbal therapy, acupuncture, yoga, homeopathy, chiropractic medicine, and massage therapy, continue to gain popularity as modalities for the treatment of asthma. In the Chinese, Japanese, Korean, Indian, and Western cultures, herbal therapies appear to be ...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:
更新日期:2004-09-01 00:00:00
abstract::Intranasal corticosteroids (INCSs) provide safe and effective treatment of allergic rhinitis (AR). Currently available INCSs differ in terms of the components included in each formulation that may influence efficacy, tolerability, and patient preference for treatment. Patient preference for a specific INCS is largely ...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/aap.2007.28.2993
更新日期:2007-05-01 00:00:00
abstract::Anaphylaxis associated with insect stings has been reported to cause approximately 40 deaths per year in the United States. Immunotherapy with venom extracts is a well-established method of treatment of allergy to insect stings. The duration of therapy is based mainly on the initial symptoms and the presence or absenc...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:
更新日期:2003-05-01 00:00:00
abstract::Background: GSP301 is an investigational fixed-dose combination nasal spray that contains the antihistamine, olopatadine hydrochloride (HCl), and the corticosteroid, mometasone furoate. Objective: To evaluate the efficacy and safety of GSP301 in patients with seasonal allergic rhinitis (SAR). Methods: In this double-b...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,随机对照试验
doi:10.2500/aap.2019.40.4223
更新日期:2019-07-03 00:00:00