Fever of unknown origin and isolated noncaseating granuloma of the marrow: could this be sarcoidosis?

Abstract:

:Fever of unknown origin (FUO) is both a clinical and a diagnostic challenge. Furthermore, an FUO case with isolated marrow noncaseating granuloma can further confound diagnosis. However, these two findings together may help narrow down the pathological possibilities. This article presents a case report of FUO and lymphopenia for 2 months. Multiple studies to evaluate infectious etiology were unremarkable. Bone marrow biopsy revealed isolated bone marrow granuloma, suggestive of sarcoid. The patient responded well to glucocorticosteroids with resolution of lymphopenia. Sarcoid should enter the differential of lymphopenia and FUO even without lymphadenopathy or abnormal chest radiography. This article provides a of review of CD4 lymphopenia, noncaseating granuloma of the marrow, and sarcoidosis.

journal_name

Allergy Asthma Proc

authors

Miller AC,Chacko T,Rashid RM,Ledford DK

doi

10.2500/aap.2007.28.2982

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

230-5

issue

2

eissn

1088-5412

issn

1539-6304

journal_volume

28

pub_type

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