Abstract：
:Hereditary angioedema (HAE) is a rare, autosomal dominant disease caused by a deficiency in the C1-inhibitor protein. It is characterized by recurrent episodes of nonpruritic, nonpitting, subcutaneous or submucosal edema that typically involves the extremities or the gastrointestinal tract. However, the genitourinary tract, face, oropharynx, and/or larynx may be affected as well. Symptoms often begin in childhood, worsen at puberty, and persist throughout life, with unpredictable severity. Patients who are untreated may have frequent attacks, with intervals that can range from every few days to rare episodes. Minor trauma and stress are frequent precipitants of swelling episodes, but many attacks occur without clear triggers. HAE attacks may be preceded by a prodrome and/or be accompanied by erythema marginatum. The swelling typically worsens over the first 24 hours, before gradually subsiding over the subsequent 48 to 72 hours. Although oropharyngeal swelling is less frequent, more than half of patients have had at least one episode of laryngeal angioedema during their lifetime. Attacks may start in one location and spread to another before resolving. HAE attacks that involve the abdomen or oropharynx have been associated with significant morbidity and mortality. Abdominal attacks can cause severe abdominal pain, nausea, and vomiting. Bowel sounds are often diminished or silent, and guarding and rebound tenderness may be present on physical examination. These findings may lead to unnecessary abdominal imaging and procedures. Fluid shifts into the interstitial space or peritoneal cavity can cause clinically significant hypotension. Laryngeal edema poses the greatest risk for patients with HAE. Although prompt diagnosis and treatment improves outcomes, the variable presentation of HAE can make it difficult to diagnose.
journal_name
Allergy Asthma Procjournal_title
Allergy and asthma proceedingsauthors
Azmy V,Brooks JP,Hsu FIdoi
10.2500/aap.2020.41.200065subject
Has Abstractpub_date
2020-11-01 00:00:00pages
S18-S21issue
Suppl 1eissn
1088-5412issn
1539-6304journal_volume
41pub_type
杂志文章abstract：BACKGROUND:A history of penicillin allergy is associated with an increased risk of nosocomial infections because patients are exposed to non-beta lactam antibiotics. Ruling out inaccurate penicillin allergy during hospitalization decreases prescription of beta lactam antibiotics. However, the utilization of penicillin ...
journal_title：Allergy and asthma proceedings
pub_type： 杂志文章
doi：10.2500/aap.2018.39.4118
更新日期：2018-05-01 00:00:00
abstract：:T helper type 2 (Th2) cells play an important role in the onset and persistence of allergic airway inflammation. Consequently, many authors have attempted to identify cell surface markers associated with a Th2 phenotype. This work was aimed at correlating CD30 and CD57 expression on CD4(+) T cells with interleukin (IL...
journal_title：Allergy and asthma proceedings
pub_type： 杂志文章
doi：10.2500/aap.2007.28.3057
更新日期：2007-11-01 00:00:00
abstract：:The effects of inhaled corticosteroids (ICSs) and long-acting beta 2-agonists (LABAs) on therapeutic targets have significant clinical relevance regarding optimal management of asthma. Asthma pathophysiology involves two main components: smooth muscle dysfunction and airway inflammation. LABAs and ICSs provide complem...
journal_title：Allergy and asthma proceedings
pub_type： 指南,杂志文章,实务指引,评审
doi：
更新日期：2003-03-01 00:00:00
abstract：BACKGROUND:There is still considerable disagreement regarding the role of vitamin D in the development or exacerbation of allergic diseases. OBJECTIVE:To investigate the association between serum vitamin D levels and recent symptoms of allergic diseases in elementary schoolchildren. METHODS:A nationwide cross-section...
journal_title：Allergy and asthma proceedings
pub_type： 杂志文章
doi：10.2500/aap.2016.37.3957
更新日期：2016-07-01 00:00:00
abstract：:Background: Asthma is a chronic and complex lung disease that is not completely understood. It involves airway inflammation, reversible airflow obstruction, and bronchial hyperresponsiveness. The most common symptoms are recurrent wheezing, chest tightness, shortness of breath, and coughing. Objective: The Asthma Insi...
journal_title：Allergy and asthma proceedings
pub_type： 杂志文章,多中心研究
doi：10.2500/aap.2018.39.4180
更新日期：2018-11-16 00:00:00
abstract：:Updated guidelines and new treatments for asthma have become available since the last major survey of asthma management in the United States was completed ∼11 years ago. The Asthma Insight and Management (AIM) survey was conducted to assess the current status of asthma burden in the United States. A geographically str...
journal_title：Allergy and asthma proceedings
pub_type： 杂志文章
doi：10.2500/aap.2011.32.3519
更新日期：2012-01-01 00:00:00
abstract：:Forced oscillometry (FOT) has been reported as a simple method to detect respiratory resistance (Rrs) changes. The aim of this study was to evaluate FOT capacity to detect children with clinical characteristics of asthma in a school setting. One thousand thirty children, 6-7 years old, were investigated by questionnai...
journal_title：Allergy and asthma proceedings
pub_type： 杂志文章,多中心研究
doi：10.2500/aap.2007.28.2965
更新日期：2007-03-01 00:00:00
abstract：:Background: GSP301 is an investigational fixed-dose combination nasal spray that contains the antihistamine, olopatadine hydrochloride (HCl), and the corticosteroid, mometasone furoate. Objective: To evaluate the efficacy and safety of GSP301 in patients with seasonal allergic rhinitis (SAR). Methods: In this double-b...
journal_title：Allergy and asthma proceedings
pub_type： 杂志文章,随机对照试验
doi：10.2500/aap.2019.40.4223
更新日期：2019-07-03 00:00:00
abstract：:Dose-response of formoterol via pressurized metered-dose inhaler (pMDI) has not been determined in asthmatic pediatric patients aged 6 to <12 years. This study was designed to assess the bronchodilating dose-response of three formoterol pMDI doses in children with stable asthma aged 6 to <12 years receiving twice-dail...
journal_title：Allergy and asthma proceedings
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.2500/aap.2014.35.3746
更新日期：2014-03-01 00:00:00
abstract：BACKGROUND:Chronic urticaria (CU) is a skin disorder defined as daily or almost daily exhibition of pruritic and transient wheals that last for 6 weeks. CU is divided into two subtypes: chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU). OBJECTIVES:To evaluate the clinical features, possible c...
journal_title：Allergy and asthma proceedings
pub_type： 杂志文章
doi：10.2500/aap.2016.37.4010
更新日期：2016-11-01 00:00:00
abstract：:Mastocytosis comprises several diseases characterized by an abnormal increase in tissue mast cells. Cutaneous mastocytosis (CM) is the most common form of mastocytosis, affects predominantly children, and presents as a mast cell hyperplasia limited to the skin. Systemic mastocytosis (SM) comprises multiple distinct en...
journal_title：Allergy and asthma proceedings
pub_type： 杂志文章,评审
doi：
更新日期：2004-01-01 00:00:00
abstract：:Antihistamines are the most commonly used drugs for allergic rhinitis, and many antihistamines may cause subclinical side effects which are not noticeable by the patient. These include impaired driving performance, impaired work performance, reduced coordination, reduced motor skills, sleepiness and impaired informati...
journal_title：Allergy and asthma proceedings
pub_type： 杂志文章
doi：10.2500/108854197778605473
更新日期：1997-03-01 00:00:00
abstract：:Rhinosinusitis is one of the most common chronic diseases with significant symptoms and impact on the quality of life. Surgery is indicated when appropriate medical treatment fails. A review of the clinical presentations of rhinosinusitis is presented, as well as an overview of current medical and surgical treatment o...
journal_title：Allergy and asthma proceedings
pub_type： 杂志文章,评审
doi：
更新日期：2006-01-01 00:00:00
abstract：OBJECTIVE:To establish the relationship between vitamin D serum levels, pulmonary function, asthma control, and passive smoking exposure in children with asthma. METHODS:We studied the relationship between 25-hydroxy cholecalciferol (25[OH]D) concentrations and baseline spirometry and levels of asthma control, and the...
journal_title：Allergy and asthma proceedings
pub_type： 杂志文章
doi：10.2500/aap.2018.39.4124
更新日期：2018-05-01 00:00:00
abstract：:Fungi are important aeroallergens. However, fungal allergen sources of consistent quality for clinical testing are not readily available. Because some allergens have been identified as enzymes, we assessed the prevalence of IgE reactivity to commercially available fungal enzymes. The purpose of this study was to deter...
journal_title：Allergy and asthma proceedings
pub_type： 杂志文章
doi：10.2500/aap.2008.29.3174
更新日期：2008-11-01 00:00:00
abstract：:Data support an increase in adverse outcomes in the pregnant woman with asthma, particularly those who are poorly controlled. Additionally, pregnancy is recognized to influence the course of asthma. Hormonal and physiologic changes are felt to direct the eventual course and outcome, but their roles are incompletely un...
journal_title：Allergy and asthma proceedings
pub_type： 杂志文章,评审
doi：10.2500/108854101778249258
更新日期：2001-01-01 00:00:00
abstract：:Asthma is a clinical problem with social, psychological, and economic burdens. To improve patient disease management and quality of life (QOL), different education programs have been developed. The purpose of this study is to adapt and implement a community-based educational program for patients with asthma. A prospec...
journal_title：Allergy and asthma proceedings
pub_type： 杂志文章,随机对照试验
doi：10.2500/aap2008.29.3083
更新日期：2008-01-01 00:00:00
abstract：:Background: The 2017 addendum to the National Institute of Allergy and Infectious Diseases (NIAID) guidelines on peanut allergy prevention significantly altered recommendations for patients at risk of developing peanut allergies. It is unknown if primary care physicians are aware of or are following these guidelines. ...
journal_title：Allergy and asthma proceedings
pub_type： 杂志文章
doi：10.2500/aap.2020.41.200019
更新日期：2020-05-01 00:00:00
abstract：:Background: The first-line method in the diagnosis of patients who describe an immediate reaction after penicillin intake is a skin test (ST) with penicillin reagents. Objectives: We aimed to determine the safety and diagnostic value of penicillin STs in the diagnosis of immediate reactions to penicillins in pediatric...
journal_title：Allergy and asthma proceedings
pub_type： 杂志文章
doi：10.2500/aap.2020.41.200082
更新日期：2020-11-01 00:00:00
abstract：:Suboptimal asthma control may be caused by a combination of factors, such as nonadherence to guidelines, lack of compliance, and poor asthma education. The aim was to assess patients' knowledge of asthma and different management strategies, including patients' attitudes toward involvement in treatment decisions. The p...
journal_title：Allergy and asthma proceedings
pub_type： 杂志文章
doi：10.2500/aap.2007.28.3001
更新日期：2007-05-01 00:00:00
abstract：:Sarcoidosis is a multisystem disorder that is characterized by T helper 1 (Th1)-mediated immune response at the sites of disease. Studies showed that T cells derived from patients with sarcoidosis have been able to release Th2 cytokine profile. However, they are believed to be suppressed and nonactive. This study inve...
journal_title：Allergy and asthma proceedings
pub_type： 杂志文章
doi：
更新日期：2005-03-01 00:00:00
abstract：:Anaphylaxis associated with insect stings has been reported to cause approximately 40 deaths per year in the United States. Immunotherapy with venom extracts is a well-established method of treatment of allergy to insect stings. The duration of therapy is based mainly on the initial symptoms and the presence or absenc...
journal_title：Allergy and asthma proceedings
pub_type： 杂志文章
doi：
更新日期：2003-05-01 00:00:00
abstract：:The newborn screen for severe combined immunodeficiency (SCID) uses real-time quantitative polymerase chain reaction for T-cell receptor excision circles and is highly sensitive for SCID. However, T-cell lymphopenia from other primary and secondary causes, such as DiGeorge syndrome, prematurity, thymic involution from...
journal_title：Allergy and asthma proceedings
pub_type： 杂志文章
doi：10.2500/aap.2019.40.190015
更新日期：2020-03-01 00:00:00
abstract：:A complex interplay of genetic predisposition and environmental influences results in the clinical picture of allergic asthma. This article addresses recently identified genetic markers and environmental factors that contribute to disease development in asthma. Focus is placed on aspects of the innate immune system, i...
journal_title：Allergy and asthma proceedings
pub_type： 杂志文章,评审
doi：10.2500/aap.2010.31.3328
更新日期：2010-03-01 00:00:00
abstract：:The use of complementary and alternative medicine has dramatically increased in the United States, which necessitates that physicians have knowledge of different modalities, possible benefits, and potential adverse reactions. Internet access and numerous magazines are available to patients for self-administration. Num...
journal_title：Allergy and asthma proceedings
pub_type： 杂志文章,评审
doi：
更新日期：2001-07-01 00:00:00
abstract：BACKGROUND:Defective nasal barrier function is implicated in allergic rhinitis, which results in persistent inflammation and clinical symptoms, among which congestion plays a prominent role. In searching ways to improve the efficacy of nasally applied drugs in this condition, we tested the hypothesis that hydroxypropyl...
journal_title：Allergy and asthma proceedings
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.2500/aap.2015.36.3879
更新日期：2015-11-01 00:00:00
abstract：BACKGROUND:Childhood food allergy and asthma rates are increasing. The hygiene hypothesis has been proposed as an explanation for the increased incidence of allergic disease. OBJECTIVE:To describe the association of childhood food allergy and asthma with hygiene factors, such as the number of siblings, antibiotic use,...
journal_title：Allergy and asthma proceedings
pub_type： 杂志文章
doi：10.2500/aap.2016.37.3988
更新日期：2016-11-01 00:00:00
abstract：:Tacrolimus ointment is a topical immunomodulator. Currently, there is available evidence regarding the potential use of topical tacrolimus in a range of dermatological disorders. The aim of this study was to evaluate the efficacy and safety of tacrolimus ointment 0.1% for the nickel sulfate-induced steroid-resistant a...
journal_title：Allergy and asthma proceedings
pub_type： 杂志文章,随机对照试验
doi：10.2500/aap.2006.27.2915
更新日期：2006-11-01 00:00:00
abstract：:IgE-mediated cow's milk allergy (CMA) is a heavy burden for patients, particularly for children and their families. Allergen avoidance represents the only therapeutic option, but oral desensitization protocols have been suggested. Because of the long duration and complexity of these protocols we examined the feasibili...
journal_title：Allergy and asthma proceedings
pub_type： 杂志文章,随机对照试验
doi：10.2500/aap.2009.30.3221
更新日期：2009-07-01 00:00:00
abstract：:The features of the allergic inflammation underlying asthma occur as a consequence of mediators such as the cysteinyl LTs. The generation of the cysteinyl LTs is carefully regulated and dependent on the 5-LO/LTC4S pathway, of which LTC4S is the pivotal and only committed enzyme involved. Although LTC4S is related to o...
journal_title：Allergy and asthma proceedings
pub_type： 杂志文章,评审
doi：10.2500/108854199778251825
更新日期：1999-11-01 00:00:00
