Abstract:
:Cystic fibrosis (CF) is a complex multisystem disorder caused by mutations in a membrane glycoprotein called the CF transmembrane regulator (CFTR), which has as its major function serving as a Cl- channel. The relationship between defects in CFTR and development of lung disease remains incompletely understood. Chronic lung disease, characterized by persistent infection with a peculiar type of Pseudomonas aeruginosa, bronchiectasis, and airway obstruction is the major cause of morbidity and mortality in CF patients. The inflammatory response to the chronic infection resembles that induced by lipopolysaccharide (LPS) and is mediated primarily by cytokines such as tumor necrosis factor (TNF), interleukin-1 (IL-1), IL-6, and IL-8, whose synthesis is activated by the transcription factor nuclear factor kappa B (NF-kappa B). Large numbers of neutrophils dominate the inflammatory response and excessive concentrations of their products create a vicious cycle that becomes injurious rather than protective and eventually claims the life of the patient.
journal_name
Allergy Asthma Procjournal_title
Allergy and asthma proceedingsauthors
Berger Msubject
Has Abstractpub_date
2002-01-01 00:00:00pages
19-25issue
1eissn
1088-5412issn
1539-6304journal_volume
23pub_type
杂志文章,评审abstract::Flunisolide hydrofluoroalkane (HFA) with integrated spacer is the most recent reformulated inhaled corticosteroid (ICS) for asthma available in the United States. It is the only product that combines a corticosteroid extrafine aerosol with a built-in spacer. The potential clinical benefit of the flunisolide HFA formul...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/aap.2015.36.3835
更新日期:2015-03-01 00:00:00
abstract::Community-acquired pneumonia (CAP), the sixth leading cause of death in the United States, has undergone significant changes in the past 30 years. In addition to the fact that it increasingly is a disease affecting the elderly and those patients with underlying comorbidities, the spectrum of microbiological agents cau...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/108854100778248980
更新日期:2000-01-01 00:00:00
abstract::The features of the allergic inflammation underlying asthma occur as a consequence of mediators such as the cysteinyl LTs. The generation of the cysteinyl LTs is carefully regulated and dependent on the 5-LO/LTC4S pathway, of which LTC4S is the pivotal and only committed enzyme involved. Although LTC4S is related to o...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/108854199778251825
更新日期:1999-11-01 00:00:00
abstract::Infection with respiratory virus has been shown to exacerbate asthma in humans. However, the role of a respiratory virus in the pathogenesis of chronic asthma and/or wheezing in young children has not been clearly defined. It has also been debated whether virus-induced wheezing in young children is one entity and alle...
journal_title:Allergy and asthma proceedings
pub_type: 临床试验,杂志文章
doi:10.2500/108854100778250888
更新日期:2000-03-01 00:00:00
abstract::A new nasal aerosol solution formulation of ciclesonide containing a hydrofluoroalkane propellant (CIC-HFA) delivered via a metered-dose inhaler is currently in clinical development as a potential treatment for allergic rhinitis (AR). This study evaluated the efficacy and tolerability of CIC-HFA 74- or 148-microgram d...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2500/aap.2012.33.3522
更新日期:2012-01-01 00:00:00
abstract::Several decades ago, the skin was considered to be little more than a simple barrier to dehydration, environmental toxins, and extrinsic bacteria; however, we now recognize that the skin is a complex immune organ that is fully integrated with the immune functions of the bone marrow, lymph nodes, liver, and spleen. Lym...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/108854199778251933
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND:Childhood food allergy and asthma rates are increasing. The hygiene hypothesis has been proposed as an explanation for the increased incidence of allergic disease. OBJECTIVE:To describe the association of childhood food allergy and asthma with hygiene factors, such as the number of siblings, antibiotic use,...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2016.37.3988
更新日期:2016-11-01 00:00:00
abstract::The complexity of care of some patients in an allergy-immunology practice may be increased by behavioral abnormalities of the patients. Facilitating adherence through the use of social support may be the most effective treatment strategy for some of the most difficult of these patients. We report three patients whose ...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/108854100778248845
更新日期:2000-07-01 00:00:00
abstract::The nonallergic rhinitis with eosinophilia syndrome (NARES) is a type of chronic rhinitis, characterized by intense (> 20%) eosinophilia of the nasal secretions. In this study, screening for NARES in 81 patients with nonallergic chronic rhinitis was performed using a modified nasal lavage cytometric method. Twenty-one...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/108854197778558061
更新日期:1997-11-01 00:00:00
abstract:BACKGROUND:Induction of specific immunoglobulin G4 (sIgG4) response (so-called blocking antibodies) in patients who receive specific immunotherapy (SIT) has been observed for many years. Although many other mechanisms have been identified as key regulators of immunologic processes in peripheral tolerance to allergens, ...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2016.37.3926
更新日期:2016-03-01 00:00:00
abstract::A case of vocal cord dysfunction (VCD) is presented, followed by a discussion of the clinical characteristics, pathogenesis, diagnosis, and management of this disorder. Special emphasis is given to clinical pearls and pitfalls for the practicing allergist. VCD is a common condition that mimics asthma. Dyspnea, cough, ...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/aap.2006.27.2871
更新日期:2006-07-01 00:00:00
abstract::Each year there are a substantial number of emergency department (ED) visits for angioedema and allergic reactions in the United States. Angioedema is commonly mistaken for an allergic reaction, possibly affecting the treatment rendered. We sought to determine the characteristics of U.S. ED visits for acute angioedema...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2013.34.3640
更新日期:2013-03-01 00:00:00
abstract::There is well-established evidence that histamine plays a significant role as a chemical mediator in asthma. However, although antihistamines are commonly used for the treatment of allergic rhinitis, their use in asthma has been somewhat controversial. Mechanistically, their application for asthma appears logical. In ...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:
更新日期:2003-07-01 00:00:00
abstract::The role of Toll-like receptor (TLR) 2 in modulating allergy-induced asthma is contradictory. We investigated the effect of TLR2 gene deletion in a murine model of ovalbumin (OVA)-challenged asthma. TLR2 wild-type (TLR2(+/+)) and TLR2-deficient (TLR2(-/-)) mice were sensitized to soluble OVA antigens and challenged wi...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2014.35.3735
更新日期:2014-03-01 00:00:00
abstract::Nasal polyps are inflammatory outgrowths of paranasal sinus mucosa caused by chronic mucosal inflammation that typically arise from the middle meatus and ethmoid region. The main symptoms of nasal polyps are perennial nasal congestion, nasal obstruction, and anosmia or hyposmia. Unlike patients with chronic rhinosinu...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/aap.2012.33.3537
更新日期:2012-05-01 00:00:00
abstract::Antihistamines are the most commonly used drugs for allergic rhinitis, and many antihistamines may cause subclinical side effects which are not noticeable by the patient. These include impaired driving performance, impaired work performance, reduced coordination, reduced motor skills, sleepiness and impaired informati...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/108854197778605473
更新日期:1997-03-01 00:00:00
abstract::The HRQL (Health Related Quality of Life) is considered a relevant aspect of pharmacological treatment, since it evaluates the outcomes from the patient's viewpoint. This article reviews the currently available information about HRQL as an outcome measure in Respiratory Allergy. Pertinent abstracts and articles were c...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/108854101778148746
更新日期:2001-05-01 00:00:00
abstract::Mast cells have been implicated in the pathogenesis of allergic diseases and in inflammatory responses associated with pathological immune and disease-related processes including fibrosis, autoimmune pathology, and neoplasia. Recent findings in animal models of bacterial infection also suggest that mast cells may have...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/108854101778148764
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND:Atopic dermatitis (AD) is a chronic inflammatory skin disease. Clusterin is a sensitive cellular biosensor of oxidative stress and has been studied as a marker to assess inflammatory diseases. The clusterin levels in AD have not been evaluated thus far. OBJECTIVE:We evaluated serum clusterin levels in child...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2016.37.3953
更新日期:2016-07-01 00:00:00
abstract::Quality of life is affected by history of bee sting allergy. In addition, worry about being stung and also the need to use self-injection of medicine can create or increase anxiety, which can further compromise a patient's ability to enjoy the outdoors and participate in activities. We sought to determine the depressi...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2014.35.3751
更新日期:2014-05-01 00:00:00
abstract::Data support an increase in adverse outcomes in the pregnant woman with asthma, particularly those who are poorly controlled. Additionally, pregnancy is recognized to influence the course of asthma. Hormonal and physiologic changes are felt to direct the eventual course and outcome, but their roles are incompletely un...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/108854101778249258
更新日期:2001-01-01 00:00:00
abstract::Avoidance of latex allergens is the primary method to prevent adverse reactions. Natural rubber latex is found in many different products in both the health care industry and in modern society, and consequently results in unexpected exposures of sensitized individuals. The use of latex gloves by food handlers provides...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/108854100778248214
更新日期:2000-09-01 00:00:00
abstract::The use of complementary and alternative medicine has dramatically increased in the United States, which necessitates that physicians have knowledge of different modalities, possible benefits, and potential adverse reactions. Internet access and numerous magazines are available to patients for self-administration. Num...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:
更新日期:2001-07-01 00:00:00
abstract::Suboptimal asthma control may be caused by a combination of factors, such as nonadherence to guidelines, lack of compliance, and poor asthma education. The aim was to assess patients' knowledge of asthma and different management strategies, including patients' attitudes toward involvement in treatment decisions. The p...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2007.28.3001
更新日期:2007-05-01 00:00:00
abstract::As immunologists, we are frequently asked to evaluate patients with recurrent infections. These infections can provide us with clues regarding what pathways might be aberrant in a given patient, e.g., specific pyogenic bacteria with Toll-like receptor problems, atypical mycobacteria with interferon gamma receptor auto...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2014.35.3776
更新日期:2014-09-01 00:00:00
abstract::Asthma, a disease characterized by airway inflammation and reversible bronchoconstriction, manifests a variety of phenotypes, and in some, but not all, asthma leads to a persistent and/or progressive loss of lung function. Conceptually, asthma persistence is identified by a stable decrement in lung function over time,...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/aap.2009.30.3202
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:Hereditary angioedema (HAE) is a rare, potentially life-threatening disease characterized by recurrent angioedema attacks. Abdominal symptoms of HAE typically mimic numerous abdominal emergencies, which may result in a delay of correct diagnosis and inappropriate treatments. OBJECTIVE:We aimed to evaluate t...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2016.37.3905
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Breath-actuated inhalers (BAI) eliminate the need for hand-breath coordination and, therefore, simplify the delivery of inhaled medication. OBJECTIVE:To evaluate the efficacy and safety of beclomethasone dipropionate BAI and metered-dose inhaler (MDI) versus placebo in pediatric patients ages 4-11 years wit...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,随机对照试验
doi:10.2500/aap.2017.38.4078
更新日期:2017-09-14 00:00:00
abstract::Rhinitis symptom complex consists of rhinorrhea, congestion, itchy mucosa, itchy eyes, and sneezing. Available medications vary in their benefit for each of these symptoms. It was the purpose of this article to compare symptom reduction with three different classes of medications. Montelukast, azelastine, and budesoni...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/aap.2010.31.3308
更新日期:2010-01-01 00:00:00
abstract::Anti-IgE therapy with omalizumab, a recombinant humanized monoclonal antibody, has anti-inflammatory effects in allergic asthma and rhinitis. Although omalizumab has been exceptionally safe, reactions after its administration have been reported. The goal of this study was to assess two patients who experienced apparen...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2007.28.3003
更新日期:2007-05-01 00:00:00