Evaluation of anxiety levels and factors associated with positive test results in patients with drug hypersensitivity.

Abstract:

BACKGROUND:High anxiety has been reported in patients with drug hypersensitivity reaction (DHR); however, its relationship with the test results was not studied previously. OBJECTIVE:We aimed to investigate the association of patient anxiety with the results of drug tests together with the other contributing factors. METHODS:Sixty-seven patients were included in the study between November 2012 and April 2013, in whom drug tests were performed after clinical evaluation and application of the Penn State Worry Questionnaire (PSWQ). RESULTS:The mean ± standard deviation (SD) age was 43.5 ± 12.9 years, and 73.1% of the patients were females. The patient group had significantly higher mean ± SD PSWQ score than 35 control subjects without histories of DHRs and major psychiatric disorders (47.95 ± 14.64 versus 40.22 ± 11.86, p = 0.008). However, the mean ± SD. PSWQ score of the patients with positive drug test results was not significantly different from the patients with negative drug test results (46.06 ± 13.41 versus 50.47 ± 18.02, p = 0.32). Panic attack symptoms were more common in the reactions with positive test results than in the reactions with negative test results (74.0% versus 48.9%, p = 0.01). However, presence of panic attack symptoms [odds ratio (OR): 1.25, 95% confidence interval (CI): 0.44-3.54; p = 0.67] was not found independently associated with positive test results in the multiple logistic regression model. CONCLUSION:Patients with DHR have high levels of anxiety; however, this is not related to the results of drug tests. Because panic reaction symptoms may accompany the objective symptoms of DHR, a complete clinical work-up is required before deciding whether the reaction is related to panic or a "true DHR."

journal_name

Allergy Asthma Proc

authors

Comert S,Erdogan T,Demir AU,Karakaya G,Kalyoncu AF

doi

10.2500/aap.2015.36.3878

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

439-46

issue

6

eissn

1088-5412

issn

1539-6304

journal_volume

36

pub_type

杂志文章
  • Solar urticaria.

    abstract::A case of solar urticaria is presented, followed by a discussion of the clinical characteristics, pathophysiology, diagnosis, and management of this disease. Special emphasis is given to clinical pearls and pitfalls for the practicing allergist. Solar urticaria is a physical urticaria that can be difficult to diagnose...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2009.30.3273

    authors: Webb LM,Mikita CP

    更新日期:2009-09-01 00:00:00

  • Antihistamine onset of action: the importance to the patient.

    abstract::Although some older antihistamines have a relatively slow onset of action, modern agents indicate an efficacy between 1 and 3 hours of administration. For patients who use antihistamines regularly, a short onset of action is relatively unimportant. When antihistamines are used as needed, either because of poor complia...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:

    authors: Dolen WK

    更新日期:2004-03-01 00:00:00

  • Altered L-arginine metabolism in children with controlled asthma.

    abstract::Decreased level of L-arginine may lead to airway hyperresponsiveness, inflammation, and airway remodeling. Changes in L-arginine metabolism were observed earlier in adult asthmatic patients. Studies on L-arginine metabolism in children with bronchial asthma are limited. Because biosynthesis of L-arginine is insufficie...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2014.35.3777

    authors: Kraj L,Krawiec M,Koter M,Graboń W,Kraj G,Chołojczyk M,Kulus M,Barańczyk-Kuźma A

    更新日期:2014-09-01 00:00:00

  • The tale of the allergist's life: a series of interesting case reports.

    abstract::The practicing allergist has the unique opportunity to see an extraordinary variety of fascinating patients. Identifying the precise cause of the patient's complaints makes for a satisfying intellectual endeavor. This is exemplified by the description of nine cases seen in a university allergy clinic. The cases includ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2008.29.3140

    authors: Slavin RG

    更新日期:2008-07-01 00:00:00

  • Serum clusterin level in children with atopic dermatitis.

    abstract:BACKGROUND:Atopic dermatitis (AD) is a chronic inflammatory skin disease. Clusterin is a sensitive cellular biosensor of oxidative stress and has been studied as a marker to assess inflammatory diseases. The clusterin levels in AD have not been evaluated thus far. OBJECTIVE:We evaluated serum clusterin levels in child...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2016.37.3953

    authors: Sol IS,Kim YH,Lee KE,Hong JY,Kim MN,Kim YS,Oh MS,Kim MJ,Yoon SH,Park YA,Kim KW,Sohn MH,Kim KE

    更新日期:2016-07-01 00:00:00

  • Human factors study of a newly approved prefilled syringe of epinephrine for the treatment of anaphylaxis.

    abstract:BACKGROUND:Epinephrine remains the treatment of choice for acute anaphylaxis. However, currently available autoinjectors are costly, and studies have demonstrated human factor issues that result in incorrect use as well as device failures. OBJECTIVE:A recent U.S. Food and Drug Administration approved prefilled syringe...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2018.39.4154

    authors: Moss RB,Moll T,Daniels K,Carlo DJ

    更新日期:2018-09-01 00:00:00

  • Epinephrine auto-injector prescriptions as a reflection of the pattern of anaphylaxis in an Asian population.

    abstract::This study surveyed the prescription patterns of adrenaline auto-injectors (AAs) in Singapore to examine the frequency, triggers, and demographic pattern of anaphylaxis requiring such prescriptions. A 6-year retrospective review of 417 consecutive patients prescribed AAs in Singapore from January 1999 to December 2004...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2008.29.3102

    authors: Tham EH,Tay SY,Lim DL,Shek LP,Goh AE,Giam YC,Chng HH,Lee BW

    更新日期:2008-03-01 00:00:00

  • Airway responsiveness in asthma: bronchial challenge with histamine and 4.5% sodium chloride before and after budesonide.

    abstract::Inhalation of histamine is commonly used to assess the severity of and to monitor treatment of asthma. Histamine causes airways to narrow by acting directly on specific receptors. Hyperosmolar saline causes airways of asthmatics to narrow indirectly by endogenously mediated events that are potentially modified by drug...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/108854197778612817

    authors: du Toit JI,Anderson SD,Jenkins CR,Woolcock AJ,Rodwell LT

    更新日期:1997-01-01 00:00:00

  • Device mechanics and evaluation of inspiratory flow rate required of the beclomethasone dipropionate breath-actuated inhaler.

    abstract::Background: Approximately 80% of patients with asthma and chronic obstructive pulmonary disease incorrectly use a metered-dose inhaler and, therefore, fail to obtain full benefit from their inhaler medication. Beclomethasone dipropionate (BDP) hydrofluoroalkane, an inhalation aerosol administered via a breath-actuated...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2019.40.4215

    authors: Mansfield LE,Hampel FC,Sfeir B,Small CJ,Walsh D,Dunphy L

    更新日期:2019-05-01 00:00:00

  • Nasal reactivity evaluation in children with allergic rhinitis receiving grass pollen sublingual immunotherapy.

    abstract::Background: The European Academy of Allergy and Clinical Immunology guidelines, strongly recommended allergen immunotherapy (AIT) as an effective treatment to achieve long-term clinical benefits and to modify the natural history of allergic diseases. Sublingual immunotherapy (SLIT) offers the possibility of home admin...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2020.41.200063

    authors: Schiavi L,Brindisi G,De Castro G,De Vittori V,Loffredo L,Spalice A,Duse M,Zicari AM

    更新日期:2020-09-01 00:00:00

  • HAE update: special considerations in the female patient with hereditary angioedema.

    abstract::This review on hereditary angioedema (HAE) focuses on special topics regarding HAE in female patients. HAE is a bradykinin-mediated disorder, and the role of hormonal regulation of disease expression will be discussed focusing on the effect of estrogen on disease mechanism. The impact of exogenous estrogen on symptom...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2013.34.3635

    authors: Geng B,Riedl MA

    更新日期:2013-01-01 00:00:00

  • Latex hypersensitivity in a horse farmer.

    abstract::Latex immediate hypersensitivity has been documented in 28% to 67% of spina bifida patients, 2.6%-16.9% of health care workers and at least 1% of the general population. Additionally, it has been confirmed in food-sensitive individuals sensitive to cross-reacting foods such as chestnut, avocado, banana, and passion fr...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/108854196778645083

    authors: Randolph C,Fraser B

    更新日期:1996-03-01 00:00:00

  • Anaphylactoid reactions in two patients after omalizumab administration after successful long-term therapy.

    abstract::Anti-IgE therapy with omalizumab, a recombinant humanized monoclonal antibody, has anti-inflammatory effects in allergic asthma and rhinitis. Although omalizumab has been exceptionally safe, reactions after its administration have been reported. The goal of this study was to assess two patients who experienced apparen...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2007.28.3003

    authors: Price KS,Hamilton RG

    更新日期:2007-05-01 00:00:00

  • Pharmaceutical care for asthma patients: a community pharmacy-based pilot project.

    abstract::Asthma is a clinical problem with social, psychological, and economic burdens. To improve patient disease management and quality of life (QOL), different education programs have been developed. The purpose of this study is to adapt and implement a community-based educational program for patients with asthma. A prospec...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,随机对照试验

    doi:10.2500/aap2008.29.3083

    authors: Petkova VB

    更新日期:2008-01-01 00:00:00

  • An integrated analysis of the efficacy of fluticasone furoate nasal spray on individual nasal and ocular symptoms of seasonal allergic rhinitis.

    abstract::Intranasal steroids have been shown to affect ocular symptoms of allergic rhinitis (AR). The results of the published literature, however, are not uniform across all products. This study was designed to evaluate whether the effects of fluticasone furoate nasal spray (FFNS) are consistent across different allergy seaso...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2010.31.3397

    authors: Maspero JF,Walters RD,Wu W,Philpot EE,Naclerio RM,Fokkens WJ

    更新日期:2010-11-01 00:00:00

  • Difficulties encountered in the emergency department by patients with hereditary angioedema experiencing acute attacks.

    abstract:BACKGROUND:Hereditary angioedema (HAE) is a rare, potentially life-threatening disease characterized by recurrent angioedema attacks. Abdominal symptoms of HAE typically mimic numerous abdominal emergencies, which may result in a delay of correct diagnosis and inappropriate treatments. OBJECTIVE:We aimed to evaluate t...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2016.37.3905

    authors: Ucar R,Arslan S,Baran M,Caliskaner AZ

    更新日期:2016-01-01 00:00:00

  • Albuterol multidose dry powder inhaler and albuterol hydrofluoroalkane versus placebo in children with persistent asthma.

    abstract:BACKGROUND:Many children struggle with albuterol hydrofluoroalkane (HFA) inhalers. Albuterol multidose dry powder inhaler (MDPI) may simplify rescue bronchodilator use in children. OBJECTIVE:To demonstrate the comparability of albuterol MDPI and albuterol HFA in children with asthma. METHODS:This phase II, multicente...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.2500/aap.2016.37.3986

    authors: Qaqundah PY,Taveras H,Iverson H,Shore P

    更新日期:2016-09-01 00:00:00

  • Community-acquired pneumonia: an approach to antimicrobial therapy.

    abstract::Community-acquired pneumonia (CAP), the sixth leading cause of death in the United States, has undergone significant changes in the past 30 years. In addition to the fact that it increasingly is a disease affecting the elderly and those patients with underlying comorbidities, the spectrum of microbiological agents cau...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/108854100778248980

    authors: Lange M

    更新日期:2000-01-01 00:00:00

  • A cost-effective approach to the diagnosis and treatment of the wheezing infant.

    abstract::Wheezing in infancy presents the clinician with at least two broad clinical problems. First is the task of distinguishing the common entities of bronchiolitis and asthma from rare, yet potentially life threatening illnesses that may present with wheezing. The second problem deals with the difficulties in distinguishin...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/108854197778984446

    authors: Mamlok R

    更新日期:1997-05-01 00:00:00

  • Effect of desloratadine on the control of morning symptoms in patients with seasonal and perennial allergic rhinitis.

    abstract::The symptoms of allergic rhinitis vary in severity over the course of the day and often are worse in the morning. This review focuses on data from clinical studies of the antihistamine desloratadine to establish whether it effectively controls the morning symptoms of allergic rhinitis. Studies of desloratadine in pati...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2006.27.2936

    authors: Schenkel EJ

    更新日期:2006-11-01 00:00:00

  • Epinephrine auto-injector use and demographics in a Veterans Administration population.

    abstract::The epinephrine auto-injector has been widely used over a long period of time. Certain aspects of this therapy and demographic data, however, have not been well studied. This study investigates patient use and understanding of epinephrine auto-injector use. As part of an ongoing quality assurance program, we evaluated...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2010.31.3351

    authors: Amirzadeh A,Verma P,Lee S,Klaustermeyer W

    更新日期:2010-07-01 00:00:00

  • Allergic bronchopulmonary aspergillosis in an HIV-infected individual.

    abstract::Aspergilloma and invasive aspergillosis have been reported in HIV-infected individuals. Allergic Bronchopulmonary Aspergillosis (ABPA) is a lung disease marked by a hypersensitivity response to inhaled aspergillus species, most commonly Aspergillus fumigatus (Af). This manifestation of Af has previously not been repor...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/108854100778249051

    authors: Jain M

    更新日期:2000-11-01 00:00:00

  • Clinical diagnosis and management of anaphylaxis in infancy.

    abstract:BACKGROUND:Anaphylaxis is increasingly reported in infancy. Diagnosis and management of anaphylaxis is difficult, and data are limited in infants. The aim of the present study was to determine the clinical course and management strategies used for anaphylaxis in infancy. METHODS:Patients attending to our clinic and wh...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2017.38.4009

    authors: Dibek Misirlioglu E,Vezir E,Toyran M,Capanoglu M,Guvenir H,Civelek E,Kocabas CN

    更新日期:2017-01-01 00:00:00

  • Chronic sinusitis: a surgical perspective.

    abstract::Rhinosinusitis is one of the most common chronic diseases with significant symptoms and impact on the quality of life. Surgery is indicated when appropriate medical treatment fails. A review of the clinical presentations of rhinosinusitis is presented, as well as an overview of current medical and surgical treatment o...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:

    authors: Fried MP,Cuellar H,Sadoughi B

    更新日期:2006-01-01 00:00:00

  • Immunobiologic treatments for severe asthma, atopic dermatitis, and chronic urticaria.

    abstract::Immunobiologic agents are an important therapeutic alternative for severe asthma, atopic dermatitis, and chronic urticaria. In this article, we reviewed the most relevant studies that addressed the use of anti-immunoglobulin E (omalizumab), anti-IL-5 (mepolizumab, reslizumab, and benralizumab), and anti-IL-4/IL-13 (du...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2019.40.4277

    authors: Chiarella SE

    更新日期:2019-11-01 00:00:00

  • Cost impact of monitoring exhaled nitric oxide in asthma management.

    abstract:BACKGROUND:Asthma guidelines recommend periodic assessment of impairment and risk factors to prevent exacerbations, which can lead to hospitalization and increased health care utilization and cost. According to recent meta-analysis data, fractional exhaled nitric oxide (FeNO) monitoring is associated with a 40-50% redu...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2018.39.4165

    authors: Arnold RJG,Layton A,Massanari M

    更新日期:2018-09-13 00:00:00

  • An overview of allergens.

    abstract::Most allergens are proteins or glycoproteins that range in molecular weight from 5000 to 100,000 Da, although polysaccharides and low-molecular-weight substances may also be allergenic. Common allergens include pollens, fungal spores, house-dust mites, and animal epithelial materials but can also include drugs, biolog...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2019.40.4247

    authors: Lei DK,Grammer LC

    更新日期:2019-11-01 00:00:00

  • Effect of omalizumab on outcomes in patients with aspirin-exacerbated respiratory disease.

    abstract::Background: The current treatment for patients with aspirin-exacerbated respiratory disease (AERD) who have uncontrolled asthma or chronic rhinosinusitis is aspirin desensitization. For patients who are unable to undergo or do not benefit from aspirin desensitization, treatment with biologics is an option, although ef...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2019.40.4241

    authors: Jean T,Eng V,Sheikh J,Kaplan MS,Goldberg B,Jau Yang S,Samant S

    更新日期:2019-09-01 00:00:00

  • Systemic reaction rates to field stings among imported fire ant-sensitive patients receiving >3 years of immunotherapy versus

    abstract::As imported fire ants (IFAs) expand their range, hypersensitivity reactions to their stings are becoming a significant cause of morbidity and mortality in the United States. Currently, IFAs whole body extract (WBE) immunotherapy is the mainstay of treatment for IFA hypersensitivity but the optimal duration of treatmen...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2007.28.3021

    authors: Forester JP,Johnson TL,Arora R,Quinn JM

    更新日期:2007-07-01 00:00:00

  • Multiple physical urticarias: report of three cases and review of the literature.

    abstract::The appearance of more than one physical urticaria (PU) in the same patient has been documented; cold urticaria or dermatographism in association with some other type of PU are encountered more frequently. Three female patients exhibiting multiple PUs simultaneously are presented. In one female patient four different ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:

    authors: Pitsios C,Vithoulka A,Roumana A,Kompoti E,Kontou-Fili K

    更新日期:2003-09-01 00:00:00