HAE update: special considerations in the female patient with hereditary angioedema.

Abstract:

:This review on hereditary angioedema (HAE) focuses on special topics regarding HAE in female patients. HAE is a bradykinin-mediated disorder, and the role of hormonal regulation of disease expression will be discussed focusing on the effect of estrogen on disease mechanism. The impact of exogenous estrogen on symptom exacerbation leads to special consideration regarding choice of contraceptives and safety of hormone replacement therapy. The effects of pregnancy and childbirth will be examined on the course of disease control. Unique considerations regarding therapeutic management for female HAE patients will be addressed, including the role of C1 inhibitor (C1-INH), ecallantide, and icatibant. Finally, this review will provide an overview of the more recently characterized HAE with normal C1-INH (HAE type III) that predominantly affects women and is in some cases associated with factor XII gene mutations.

journal_name

Allergy Asthma Proc

authors

Geng B,Riedl MA

doi

10.2500/aap.2013.34.3635

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

13-8

issue

1

eissn

1088-5412

issn

1539-6304

journal_volume

34

pub_type

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