Efficacy of olopatadine ophthalmic solution 0.2% in reducing signs and symptoms of allergic conjunctivitis.

Abstract:

:Olopatadine hydrochloride ophthalmic solution 0.2% (Pataday, Alcon) is a new formulation of olopatadine hydrochloride ophthalmic solution, the first topical ocular antiallergic agent indicated for once-daily dosing. The aim of this study was to evaluate the safety, efficacy, onset, and duration of action of olopatadine 0.2% in the treatment of allergic conjunctivitis. Using the conjunctival allergen challenge, this double-masked, randomized by eye, parallel-group study included four visits over a 5-week period. Subjects were screened for eligibility (visit 1) and their ocular allergic responses were confirmed at visit 2. The efficacy of olopatadine in reducing the signs and symptoms of allergic conjunctivitis was evaluated at onset of action (visit 4) and 16 hours (visit 3) after masked medication instillation. The primary efficacy parameter was ocular itching. Safety parameters were also evaluated. Ninety subjects were evaluated. Olopatadine 0.2% was significantly (p < 0.001) more effective than placebo in the treatment of ocular itching at all time points at both the onset of action and the 16-hour allergen challenges. Olopatadine 0.2% was significantly (p < 0.03) more effective than placebo in the reduction of conjunctival redness, chemosis, and eyelid swelling at all time points (with the exception of conjunctival redness, which was significantly reduced at five of six time points). There were no serious adverse events and no treatment-related adverse events. Once-daily dosing with olopatadine 0.2% reduced the signs and symptoms of allergic conjunctivitis with a rapid and prolonged duration of action. Safety analyses indicated that olopatadine 0.2% was safe and well tolerated in subjects with a history of allergic conjunctivitis.

journal_name

Allergy Asthma Proc

authors

Abelson MB,Gomes PJ,Pasquine T,Edwards MR,Gross RD,Robertson SM

doi

10.2500/aap.2007.28.3014

subject

Has Abstract

pub_date

2007-07-01 00:00:00

pages

427-33

issue

4

eissn

1088-5412

issn

1539-6304

journal_volume

28

pub_type

杂志文章,随机对照试验
  • An overview of allergic bronchopulmonary aspergillosis with some new insights.

    abstract::Allergic bronchopulmonary aspergillosis (ABPA) occurs as a complication of bronchial asthma or cystic fibrosis (CF). The diagnostic criteria speak to an exaggerated type I hypersensitivity response to the ubiquitous organism Aspergillus fumigatus. Immunologic parameters indicative of Aspergillus sensitization in CF ma...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:

    authors: Slavin RG,Hutcheson PS,Chauhan B,Bellone CJ

    更新日期:2004-11-01 00:00:00

  • Antioxidant supplementation and exhaled nitric oxide in children with asthma.

    abstract:BACKGROUND:The effect of allergen avoidance on airway inflammation is similar to that observed with treatment with inhaled steroids, whereas inhaled steroids have no effect on oxidative stress-induced inflammation. OBJECTIVE:The aim of this study was to retrospectively evaluate the potential effect of an antioxidant d...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2016.37.3920

    authors: Tenero L,Piazza M,Zanoni L,Bodini A,Peroni D,Piacentini GL

    更新日期:2016-01-01 00:00:00

  • Anaphylaxis/angioedema caused by honey ingestion.

    abstract::Honey allergy is a very rare, but serious health condition. In this study, we presented six patients who described systemic allergic reactions after ingestion of honey. Three of the six patients had suffered from anaphylaxis. Honey-specific IgE was measured and skin-prick tests for honey were performed to diagnose hon...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2014.35.3718

    authors: Vezir E,Kaya A,Toyran M,Azkur D,Dibek Mısırlıoğlu E,Kocabaş CN

    更新日期:2014-01-01 00:00:00

  • Preparation of benzylpenicilloyl-polylysine: a preliminary study.

    abstract::The manufacturing of PrePen (benzylpenicilloyl-polylysine) was suspended from September 2000 through November 2001 because of Food and Drug Administration intervention. PrePen is penicilloyl bound to polylysine and is considered to be the major determinant of penicillin metabolism; it is used as a skin-testing reagent...

    journal_title:Allergy and asthma proceedings

    pub_type: 临床试验,杂志文章

    doi:

    authors: Vemuri P,Harris KE,Suh LA,Grammer LC

    更新日期:2004-05-01 00:00:00

  • Rationale for the clinical use of a ribosome-component immune modulator.

    abstract::Vaccines have long been used to boost the immune system and to confer protection against microbial infections. In contrast, immunotherapy based on ribosomal preparations has been proposed to enhance both specific and nonspecific immune responses (in particular, the mucosal immune defense system) against common respira...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2009.30.3249

    authors: Pregliasco F,Terracciano L,Marcassa S,Zava D,Anselmi G

    更新日期:2009-07-01 00:00:00

  • Chapter 7: Nasal polyps.

    abstract::Nasal polyps are inflammatory outgrowths of paranasal sinus mucosa caused by chronic mucosal inflammation that typically arise from the middle meatus and ethmoid region. The main symptoms of nasal polyps are perennial nasal congestion, nasal obstruction, and anosmia or hyposmia. Unlike patients with chronic rhinosinu...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2012.33.3537

    authors: Georgy MS,Peters AT

    更新日期:2012-05-01 00:00:00

  • Oxidative stress markers in patients with hymenoptera venom allergy.

    abstract::Oxidative stress occurs in many allergic and immunologic disorders as a result of the imbalance between the endogenous production of free reactive oxygen species (ROS) and/or the reduction of antioxidant defense mechanisms. Advanced glycation end products (AGEs), advanced oxidation protein products (AOPPs), and nitros...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2015.36.3814

    authors: Patella V,Incorvaia C,Minciullo PL,Oricchio C,Saitta S,Florio G,Saija A,Gangemi S

    更新日期:2015-01-01 00:00:00

  • Multiple physical urticarias: report of three cases and review of the literature.

    abstract::The appearance of more than one physical urticaria (PU) in the same patient has been documented; cold urticaria or dermatographism in association with some other type of PU are encountered more frequently. Three female patients exhibiting multiple PUs simultaneously are presented. In one female patient four different ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:

    authors: Pitsios C,Vithoulka A,Roumana A,Kompoti E,Kontou-Fili K

    更新日期:2003-09-01 00:00:00

  • New and evolving therapies for hereditary angioedema.

    abstract::Hereditary angioedema (HAE) is a rare, autosomal dominant, genetic disorder associated with a deficiency in C1 inhibitor protein. HAE is characterized by recurrent and unpredictable episodes of swelling of the extremities, abdomen, face, and upper airway. There are several newly approved drugs as well as investigation...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2019.40.4195

    authors: Barmettler S,Li Y,Banerji A

    更新日期:2019-01-01 00:00:00

  • Monitoring of peanut-allergic patients with peanut-specific IgE.

    abstract::Peanut allergy affects approximately 1% of the population. Double-blind placebo-controlled food challenges are gold standard for diagnosis. Serum peanut-specific IgE (PN-IgE) is used in clinical practice as an additional diagnostic and monitoring tool. The purpose of this study was to characterize the clinical feature...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2008.29.3117

    authors: Borici-Mazi R,Mazza JA,Moote DW,Payton KB

    更新日期:2008-05-01 00:00:00

  • Latex hypersensitivity in a horse farmer.

    abstract::Latex immediate hypersensitivity has been documented in 28% to 67% of spina bifida patients, 2.6%-16.9% of health care workers and at least 1% of the general population. Additionally, it has been confirmed in food-sensitive individuals sensitive to cross-reacting foods such as chestnut, avocado, banana, and passion fr...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/108854196778645083

    authors: Randolph C,Fraser B

    更新日期:1996-03-01 00:00:00

  • Lack of correlation between clinical patterns of asthma and airway obstruction.

    abstract::To evaluate the relationship between the classification of asthma and obstruction of airways, we have studied 100 children suffering from allergic asthma: 65 males and 35 females, aged 4.2-16.3 years (mean, 7.6 +/- 2.8 years), who were evaluated at least 1 month after the last attack of airway obstruction. We analyzed...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:

    authors: Verini M,Rossi N,Dalfino T,Verrotti A,Di Gioacchino M,Chiarelli F

    更新日期:2001-09-01 00:00:00

  • Effect of staphylococcal enterotoxin B on specific antibody production in children with atopic dermatitis.

    abstract::Exotoxins secreted by Staphylococcus aureus have been identified as a possible trigger factor in atopic dermatitis (AD). We investigated the production and role of circulating antibodies, with specificity to staphylococcal enterotoxin B (SEB), in children with AD compared with those of healthy controls. The children w...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:

    authors: Sohn MH,Kim CH,Kim WK,Jang GC,Kim KE

    更新日期:2003-01-01 00:00:00

  • Asthma in the female: hormonal effect and pregnancy.

    abstract::Data support an increase in adverse outcomes in the pregnant woman with asthma, particularly those who are poorly controlled. Additionally, pregnancy is recognized to influence the course of asthma. Hormonal and physiologic changes are felt to direct the eventual course and outcome, but their roles are incompletely un...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/108854101778249258

    authors: Beck SA

    更新日期:2001-01-01 00:00:00

  • A 60-year-old woman with recurrent episodes of flushing, urticaria, and angioedema.

    abstract::Recurrent episodes of flushing, urticaria, and angioedema raise suspicion for many conditions with a wide differential diagnosis. The diagnostic approach involves consideration of allergic, cardiovascular, gastrointestinal, endocrine, infectious, neurologic, dermatologic, and drug-related causes. We describe a unique ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2015.36.3836

    authors: Patel SV,Baldwin JL

    更新日期:2015-05-01 00:00:00

  • Anaphylactoid reactions in two patients after omalizumab administration after successful long-term therapy.

    abstract::Anti-IgE therapy with omalizumab, a recombinant humanized monoclonal antibody, has anti-inflammatory effects in allergic asthma and rhinitis. Although omalizumab has been exceptionally safe, reactions after its administration have been reported. The goal of this study was to assess two patients who experienced apparen...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2007.28.3003

    authors: Price KS,Hamilton RG

    更新日期:2007-05-01 00:00:00

  • Community-acquired pneumonia: an approach to antimicrobial therapy.

    abstract::Community-acquired pneumonia (CAP), the sixth leading cause of death in the United States, has undergone significant changes in the past 30 years. In addition to the fact that it increasingly is a disease affecting the elderly and those patients with underlying comorbidities, the spectrum of microbiological agents cau...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/108854100778248980

    authors: Lange M

    更新日期:2000-01-01 00:00:00

  • The burden of hospitalizations and emergency department visits with hereditary angioedema and angioedema in the United States, 2007.

    abstract::Hereditary angioedema (HAE) is a rare inherited disorder of complement factor C1 inhibitor. HAE is frequently confused with angioedema (AE), and little is known about emergency department (ED) or hospital utilization by patients with attacks in the United States. We examined hospitalizations and ED utilization for HAE...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2010.31.3403

    authors: Zilberberg MD,Jacobsen T,Tillotson G

    更新日期:2010-11-01 00:00:00

  • Immunobiologic treatments for severe asthma, atopic dermatitis, and chronic urticaria.

    abstract::Immunobiologic agents are an important therapeutic alternative for severe asthma, atopic dermatitis, and chronic urticaria. In this article, we reviewed the most relevant studies that addressed the use of anti-immunoglobulin E (omalizumab), anti-IL-5 (mepolizumab, reslizumab, and benralizumab), and anti-IL-4/IL-13 (du...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2019.40.4277

    authors: Chiarella SE

    更新日期:2019-11-01 00:00:00

  • The tale of the allergist's life: a series of interesting case reports.

    abstract::The practicing allergist has the unique opportunity to see an extraordinary variety of fascinating patients. Identifying the precise cause of the patient's complaints makes for a satisfying intellectual endeavor. This is exemplified by the description of nine cases seen in a university allergy clinic. The cases includ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2008.29.3140

    authors: Slavin RG

    更新日期:2008-07-01 00:00:00

  • Pentobarbital desensitization in a 3-month-old child.

    abstract::Barbiturates, a class of medications commonly used as antiepileptics and sedatives, are known to cause adverse reaction, with the most commonly reported immune-mediated reactions being anticonvulsant hypersensitivity syndrome. Other types of allergic reactions such as immediate hypersensitivity reactions also can occu...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:

    authors: Butte MJ,Dodson B,Dioun A

    更新日期:2004-07-01 00:00:00

  • Central serous chorioretinopathy secondary to corticosteroids in patients with atopic disease.

    abstract::Central serous chorioretinopathy (CSCR) is of unknown etiology and is the most common cause of retinopathy after age-related macular degeneration, diabetic retinopathy, and retinal vein occlusion. Vision loss results from fluid leakage and serous detachment in the macula. Five percent of patients develop chronic CSCR....

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2015.36.3827

    authors: Ricketti PA,Unkle DW,Cleri DJ,Prenner JL,Coluccielo M,Ricketti AJ

    更新日期:2015-03-01 00:00:00

  • Atopic status in patients with sarcoidosis.

    abstract::Sarcoidosis is a multisystem disorder that is characterized by T helper 1 (Th1)-mediated immune response at the sites of disease. Studies showed that T cells derived from patients with sarcoidosis have been able to release Th2 cytokine profile. However, they are believed to be suppressed and nonactive. This study inve...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:

    authors: Kokturk N,Han ER,Turktas H

    更新日期:2005-03-01 00:00:00

  • Novel cytokines and cytokine-producing T cells in allergic disorders.

    abstract::Allergic diseases reflect various pathways of T lymphocyte inflammation and largely comprise T helper (Th) 2-associated processes. Recent investigations have identified pathways involved in promoting Th2 responses. Additionally, novel T-cell subtypes, each with its own distinct cytokine profile, contribute to the hete...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2011.32.3428

    authors: Wisniewski JA,Borish L

    更新日期:2011-03-01 00:00:00

  • Vocal cord dysfunction.

    abstract::A case of vocal cord dysfunction (VCD) is presented, followed by a discussion of the clinical characteristics, pathogenesis, diagnosis, and management of this disorder. Special emphasis is given to clinical pearls and pitfalls for the practicing allergist. VCD is a common condition that mimics asthma. Dyspnea, cough, ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2006.27.2871

    authors: Mikita JA,Mikita CP

    更新日期:2006-07-01 00:00:00

  • Chapter 17: Occupational immunologic lung disease.

    abstract::Occupational immunologic lung disease is characterized by an immunologic response in the lung to an airborne agent inhaled in the work environment and can be subdivided into immunologically mediated occupational asthma (OA) and hypersensitivity pneumonitis (HP). Irritant-induced OA, a separate nonimmunologic entity, ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2012.33.3550

    authors: Sabin BR,Grammer LC

    更新日期:2012-05-01 00:00:00

  • Chronic urticaria as a presenting sign of hairy cell leukemia.

    abstract::Chronic urticaria is a common clinical disorder that is idiopathic in over 75% of cases. Less commonly, urticaria may be the presenting manifestation of an allergic or infectious disease, endocrinopathy, inherited syndrome, or autoimmune disorder. Rarely, urticaria may be a sign of underlying malignancy, including leu...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/108854199778681530

    authors: Clore LS Jr,Stafford CT

    更新日期:1999-01-01 00:00:00

  • Inflammatory mediators in cystic fibrosis lung disease.

    abstract::Cystic fibrosis (CF) is a complex multisystem disorder caused by mutations in a membrane glycoprotein called the CF transmembrane regulator (CFTR), which has as its major function serving as a Cl- channel. The relationship between defects in CFTR and development of lung disease remains incompletely understood. Chronic...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:

    authors: Berger M

    更新日期:2002-01-01 00:00:00

  • Ovalbumin-induced experimental allergic asthma is Toll-like receptor 2 dependent.

    abstract::The role of Toll-like receptor (TLR) 2 in modulating allergy-induced asthma is contradictory. We investigated the effect of TLR2 gene deletion in a murine model of ovalbumin (OVA)-challenged asthma. TLR2 wild-type (TLR2(+/+)) and TLR2-deficient (TLR2(-/-)) mice were sensitized to soluble OVA antigens and challenged wi...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2014.35.3735

    authors: Li X,Chen Q,Chu C,You H,Jin M,Zhao X,Zhu X,Zhou W,Ji W

    更新日期:2014-03-01 00:00:00

  • The natural course of eczema from birth to age 7 years and the association with asthma and allergic rhinitis: a population-based birth cohort study.

    abstract::Although "atopic march" is a popular concept, the relationship between eczema and subsequent asthma is far from clear. However, some cohort studies have shown the possibility of two different allergic phenotypes in those who present with early eczema in terms of their persistency. We checked the cohort data from 308,...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2013.34.3625

    authors: Shen CY,Lin MC,Lin HK,Lin CH,Fu LS,Fu YC

    更新日期:2013-01-01 00:00:00