Anti-immunoglobulin E monoclonal antibody administered with immunotherapy.


:Despite both efficacy and immunotolerogenic effects, many clinicians still are reluctant to use allergen-specific immunotherapy (SIT) because of the potential for acute allergic reactions. The anti-immunoglobulin E monoclonal antibody, omalizumab, is approved by the U.S. Food and Drug Administration for the treatment of moderate-to-severe allergic asthma and has proven to be a relatively safe agent. Knowledge of the distinct immunologic changes elicited by allergen SIT and omalizumab has established a rationale for investigation into their combined use for the management of allergic diseases. This review summarizes two investigative studies examining the safety and efficacy of the combination of omalizumab + allergen SIT for the treatment of allergic rhinitis. Both studies show that the combination of omalizumab and allergen SIT confer added efficacy to either treatment alone. Pretreatment of patients with omalizumab before rush allergen immunotherapy also showed added safety to rush immunotherapy with the prevention of acute allergic reactions. Results thus far provide the opportunity to develop strategies using omalizumab pretreatment to enhance the safety and efficacy of allergen-immunotherapy to treat a wide variety of allergic diseases.


Allergy Asthma Proc


Parks KW,Casale TB


Has Abstract


2006-03-01 00:00:00




2 Suppl 1








  • Difficulties encountered in the emergency department by patients with hereditary angioedema experiencing acute attacks.

    abstract:BACKGROUND:Hereditary angioedema (HAE) is a rare, potentially life-threatening disease characterized by recurrent angioedema attacks. Abdominal symptoms of HAE typically mimic numerous abdominal emergencies, which may result in a delay of correct diagnosis and inappropriate treatments. OBJECTIVE:We aimed to evaluate t...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Ucar R,Arslan S,Baran M,Caliskaner AZ

    更新日期:2016-01-01 00:00:00

  • Clinical presentation of hereditary angioedema.

    abstract::Hereditary angioedema (HAE) is a rare, autosomal dominant disease caused by a deficiency in the C1-inhibitor protein. It is characterized by recurrent episodes of nonpruritic, nonpitting, subcutaneous or submucosal edema that typically involves the extremities or the gastrointestinal tract. However, the genitourinary ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Azmy V,Brooks JP,Hsu FI

    更新日期:2020-11-01 00:00:00

  • Reducing asthma attacks in patients with severe asthma: The role of bronchial thermoplasty.

    abstract::Asthma remains one of the most common diseases worldwide and results in significant societal health care costs and in morbidity and mortality to those afflicted. Despite currently available medications, 5-10% of patients with asthma have severe disease with debilitating symptoms and/or life-threatening exacerbations. ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审


    authors: Dunn R,Wechsler ME

    更新日期:2015-07-01 00:00:00

  • The tale of the allergist's life: a series of interesting case reports.

    abstract::The practicing allergist has the unique opportunity to see an extraordinary variety of fascinating patients. Identifying the precise cause of the patient's complaints makes for a satisfying intellectual endeavor. This is exemplified by the description of nine cases seen in a university allergy clinic. The cases includ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Slavin RG

    更新日期:2008-07-01 00:00:00

  • Nonsteroidal anti-inflammatory drug hypersensitivity among children.

    abstract:BACKGROUND:Nonsteroidal anti-inflammatory drugs (NSAID) are the second-most frequent drugs that cause hypersensitivity reactions among children. Studies related to NSAIDs hypersensitivity in children are limited. In this study, we aimed to evaluate children admitted with suspicion of NSAIDs reaction. METHOD:Between Ja...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Guvenir H,Dibek Misirlioglu E,Vezir E,Toyran M,Ginis T,Civelek E,Kocabas CN

    更新日期:2015-09-01 00:00:00

  • Anosmia and hyposmia.

    abstract::There has been some renewed interest in recent years in disorders of olfaction. Decreased sense of smell can lead to significant impairment of quality of life, including taste disturbance and loss of pleasure from eating with resulting changes in weight and difficulty in avoiding health risks such as spoiled food or l...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审


    authors: Gaines AD

    更新日期:2010-05-01 00:00:00

  • Oxidative stress markers in patients with hymenoptera venom allergy.

    abstract::Oxidative stress occurs in many allergic and immunologic disorders as a result of the imbalance between the endogenous production of free reactive oxygen species (ROS) and/or the reduction of antioxidant defense mechanisms. Advanced glycation end products (AGEs), advanced oxidation protein products (AOPPs), and nitros...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Patella V,Incorvaia C,Minciullo PL,Oricchio C,Saitta S,Florio G,Saija A,Gangemi S

    更新日期:2015-01-01 00:00:00

  • Chapter 7: Nasal polyps.

    abstract::Nasal polyps are inflammatory outgrowths of paranasal sinus mucosa caused by chronic mucosal inflammation that typically arise from the middle meatus and ethmoid region. The main symptoms of nasal polyps are perennial nasal congestion, nasal obstruction, and anosmia or hyposmia. Unlike patients with chronic rhinosinu...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审


    authors: Georgy MS,Peters AT

    更新日期:2012-05-01 00:00:00

  • Successful treatment of coronavirus disease 2019 in a patient with asthma.

    abstract::Underlying lung disease, especially asthma, has recently been found to be associated with a higher risk of hospitalization with coronavirus disease 2019 (COVID-19) infection. Inhaled corticosteroids (ICS) are the most commonly used controller medications in patients with asthma. It is unclear whether ICS use increases...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Joshi AY,Mullakary RM,Iyer VN

    更新日期:2020-07-01 00:00:00

  • New developments in inhaled corticosteroids.

    abstract::Inhaled corticosteroids (ICSs) are the foundation of pharmacotherapy in persistent asthma because they control airway inflammation. The anti-inflammatory effect of ICSs is primarily topical, at their site of deposition in the airways. Consequently, deposition characteristics of the ICS and its formulation and inhalati...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审


    authors: Colice GL

    更新日期:2006-09-01 00:00:00

  • Human factors study of a newly approved prefilled syringe of epinephrine for the treatment of anaphylaxis.

    abstract:BACKGROUND:Epinephrine remains the treatment of choice for acute anaphylaxis. However, currently available autoinjectors are costly, and studies have demonstrated human factor issues that result in incorrect use as well as device failures. OBJECTIVE:A recent U.S. Food and Drug Administration approved prefilled syringe...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Moss RB,Moll T,Daniels K,Carlo DJ

    更新日期:2018-09-01 00:00:00

  • Systemic reaction rates to field stings among imported fire ant-sensitive patients receiving >3 years of immunotherapy versus

    abstract::As imported fire ants (IFAs) expand their range, hypersensitivity reactions to their stings are becoming a significant cause of morbidity and mortality in the United States. Currently, IFAs whole body extract (WBE) immunotherapy is the mainstay of treatment for IFA hypersensitivity but the optimal duration of treatmen...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Forester JP,Johnson TL,Arora R,Quinn JM

    更新日期:2007-07-01 00:00:00

  • Physician prescribing practices: the role of patient preference in the selection of nasal steroids.

    abstract::A telephone survey of 100 primary care physicians was performed to assess the awareness of the influence patient preference, patient satisfaction, and other factors have on the selection of nasal steroids for the treatment of allergic rhinitis. Results indicated that physicians believe drug efficacy is the primary rea...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Kaliner MA

    更新日期:2001-11-01 00:00:00

  • Pentobarbital desensitization in a 3-month-old child.

    abstract::Barbiturates, a class of medications commonly used as antiepileptics and sedatives, are known to cause adverse reaction, with the most commonly reported immune-mediated reactions being anticonvulsant hypersensitivity syndrome. Other types of allergic reactions such as immediate hypersensitivity reactions also can occu...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Butte MJ,Dodson B,Dioun A

    更新日期:2004-07-01 00:00:00

  • Rhinorrhea not responding to nasal corticosteroids.

    abstract::A woman with multiple illnesses including allergic rhinitis presented for a follow-up visit at our clinic with constant rhinorrhea for 2 weeks despite regular use of nasal corticosteroids. Two weeks earlier, after alcohol drinking and doubling some of her medications for missed doses, she fell on her face. The Emergen...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Patel PN,Oyefara B,Aarstad R,Bahna SL

    更新日期:2007-11-01 00:00:00

  • Effect of the inhaled corticosteroid mometasone on small airway patency in patients with asthma.

    abstract::The inflammation in asthma involves both the large and the small airways. This study was designed to examine whether mometasone delivered from a dry powder inhaler would improve those parameters thought to reflect patency and obstruction of the small airways (diameter <2 mm). Subjects with mild to moderate asthma, onl...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,随机对照试验


    authors: Nelson HS,Gallegos CM,Silveira LJ,Newell JD,Gelfand EW

    更新日期:2009-05-01 00:00:00

  • The status of asthma control in the U.S. adult population.

    abstract::Treatment guidelines recognize the importance of achieving and maintaining asthma control. This study was designed to assess the prevalence of asthma control in a representative U.S. population. A survey regarding asthma and associated symptoms was sent to a representative national sample of 134,401 households managed...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Fuhlbrigge A,Reed ML,Stempel DA,Ortega HO,Fanning K,Stanford RH

    更新日期:2009-09-01 00:00:00

  • The autoimmune nature of chronic urticaria.

    abstract::The association between chronic urticaria (CU) and autoimmune disease has been recognized for some time, especially with autoimmune thyroid disease. More recently, functional IgG autoantibodies against FcepsilonRIalpha and less commonly against IgE have been reported in a subset of patients with CU. These patients hav...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审


    authors: Boguniewicz M

    更新日期:2008-09-01 00:00:00

  • Anaphylaxis/angioedema caused by honey ingestion.

    abstract::Honey allergy is a very rare, but serious health condition. In this study, we presented six patients who described systemic allergic reactions after ingestion of honey. Three of the six patients had suffered from anaphylaxis. Honey-specific IgE was measured and skin-prick tests for honey were performed to diagnose hon...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Vezir E,Kaya A,Toyran M,Azkur D,Dibek Mısırlıoğlu E,Kocabaş CN

    更新日期:2014-01-01 00:00:00

  • Epinephrine auto-injector prescriptions as a reflection of the pattern of anaphylaxis in an Asian population.

    abstract::This study surveyed the prescription patterns of adrenaline auto-injectors (AAs) in Singapore to examine the frequency, triggers, and demographic pattern of anaphylaxis requiring such prescriptions. A 6-year retrospective review of 417 consecutive patients prescribed AAs in Singapore from January 1999 to December 2004...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Tham EH,Tay SY,Lim DL,Shek LP,Goh AE,Giam YC,Chng HH,Lee BW

    更新日期:2008-03-01 00:00:00

  • The emotional needs of allergic and asthmatic patients and their families.

    abstract::This article describes the emotional needs of allergic and asthmatic patients and their families that must addressed if optimal management and well-being is to be achieved. Health care professionals need to recognize the psychosocial issues of patients and parents, which include the effect of stressors, illness percep...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Wallerstedt DB,Bellanti JA

    更新日期:1998-07-01 00:00:00

  • Allergic rhinitis, histamine, and otitis media.

    abstract::Otitis media (OM) is a common and costly medical condition, especially in children. Most episodes of OM are associated with an upper respiratory viral infection and are short-lived and self-limiting with or without medical treatment. However, chronic OM with effusion (OME) has significant sequelae, is refractory to mo...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审


    authors: Skoner AR,Skoner KR,Skoner DP

    更新日期:2009-09-01 00:00:00

  • In vitro induction of T regulatory cells by a methylated CpG DNA sequence in humans: Potential therapeutic applications in allergic and autoimmune diseases.

    abstract:BACKGROUND:Allergic and autoimmune diseases comprise a group of inflammatory disorders caused by aberrant immune responses in which CD25+ Forkhead box P3-positive (FOXP3+) T regulatory (Treg) cells that normally suppress inflammatory events are often poorly functioning. This has stimulated an intensive investigative ef...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Lawless OJ,Bellanti JA,Brown ML,Sandberg K,Umans JG,Zhou L,Chen W,Wang J,Wang K,Zheng SG

    更新日期:2018-03-01 00:00:00

  • Quality of life in respiratory allergy.

    abstract::The HRQL (Health Related Quality of Life) is considered a relevant aspect of pharmacological treatment, since it evaluates the outcomes from the patient's viewpoint. This article reviews the currently available information about HRQL as an outcome measure in Respiratory Allergy. Pertinent abstracts and articles were c...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审


    authors: Baiardini I,Pasquali M,Giardini A,Majani G,Canonica GW

    更新日期:2001-05-01 00:00:00

  • Hereditary and acquired angioedema.

    abstract::Hereditary angioedema (HAE) is an autosomal dominant disorder defined by a deficiency of functional C1 esterase inhibitor (C1-INH). Acquired angioedema is due to either consumption (type 1) or inactivation (type 2) of CI-INH. Both HAE and acquired angioedema can be life-threatening. Of the three types of HAE, type 1 i...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审


    authors: Patel G,Pongracic JA

    更新日期:2019-11-01 00:00:00

  • Natural history of hay fever: a 23-year follow-up of college students.

    abstract::The purpose of this study is to examine the natural history of hay fever among former college students who were diagnosed with this disease either before or after their freshman year. The diagnosis of hay fever or seasonal allergic rhinitis was based on a history of watery, itchy eyes, rhinorrhea, and sneezing occurri...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审


    authors: Greisner WA 3rd,Settipane RJ,Settipane GA

    更新日期:1998-09-01 00:00:00

  • Immunomodulation in dermatology: lessons learned in the treatment of psoriasis.

    abstract::With the widespread recognition that T-cells are the key mediators of psoriasis, current treatment strategies have focused on reducing the population of these cells or modulating their activity through the use of immunosuppressive treatments such as methotrexate, cyclosporine, and psoralens plus ultraviolet A radiatio...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审


    authors: Charlesworth EN

    更新日期:2006-03-01 00:00:00

  • Cost impact of monitoring exhaled nitric oxide in asthma management.

    abstract:BACKGROUND:Asthma guidelines recommend periodic assessment of impairment and risk factors to prevent exacerbations, which can lead to hospitalization and increased health care utilization and cost. According to recent meta-analysis data, fractional exhaled nitric oxide (FeNO) monitoring is associated with a 40-50% redu...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Arnold RJG,Layton A,Massanari M

    更新日期:2018-09-13 00:00:00

  • Expanding choices in intranasal steroid therapy: summary of a roundtable meeting.

    abstract::Intranasal steroids (INSs) are recommended as first-line treatment for allergic rhinitis (AR) and a wealth of data exist supporting them as safe and effective. Our goal was to develop a consensus to help physicians choose between INSs by focusing on clinical profiles and patient preferences and providing expert advice...

    journal_title:Allergy and asthma proceedings

    pub_type: 共识发展会议,杂志文章


    authors: Blaiss MS,Benninger MS,Fromer L,Gross G,Mabry R,Mahr T,Marple B,Stoloff S

    更新日期:2006-05-01 00:00:00

  • A late preterm infant with lymphopenia.

    abstract::The newborn screen for severe combined immunodeficiency (SCID) uses real-time quantitative polymerase chain reaction for T-cell receptor excision circles and is highly sensitive for SCID. However, T-cell lymphopenia from other primary and secondary causes, such as DiGeorge syndrome, prematurity, thymic involution from...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章


    authors: Lutfeali S,Khan DA,Wysocki C

    更新日期:2020-03-01 00:00:00