Abstract:
:The hydrofluoroalkane (HFA) formulation of the inhaled corticosteroid flunisolide is a modification of the original chlorofluorocarbon formulation. HFA flunisolide substitutes an HFA for a chlorofluorocarbon propellant and uses a built-in spacer in its pressurized metered-dose inhaler. An open-label, randomized, three-way crossover, multiple-dose study evaluated the dose proportionality of three doses of flunisolide HFA. Twenty-one healthy volunteers received the following doses twice daily for 4.5 days: 85, 170, and 340 micrograms. Plasma levels of flunisolide and of the flunisolide metabolite 6 beta-OH flunisolide were measured after single- and multiple-dose administration. After a single dose, dose proportionality was observed across the three dose levels for peak plasma concentration (Cmax) and the area under the plasma concentration-time curve (AUC) up to both the time corresponding to the last measurable concentration (AUC0-tau) and the time to infinity (AUC0-infinity). After multiple doses, dose proportionality was observed for both Cmax and AUC at the medium and high doses. Predose plasma levels of flunisolide measured on day 4 were below the limit of detection. The elimination half-life of flunisolide ranged from 0.95 to 1.34 hours. After both single and multiple doses, dose proportionality was observed in dose-adjusted Cmax and AUC0-infinity for the inactive 6 beta-OH metabolite. HFA flunisolide was well tolerated. The lack of accumulation after repeated administration of HFA flunisolide suggests that the systemic exposure of flunisolide is low, which is a safety goal for inhaled corticosteroids.
journal_name
Allergy Asthma Procjournal_title
Allergy and asthma proceedingsauthors
Nolting A,Abramowitz Wsubject
Has Abstractpub_date
2002-09-01 00:00:00pages
311-8issue
5eissn
1088-5412issn
1539-6304journal_volume
23pub_type
临床试验,杂志文章,随机对照试验abstract::Immunotherapy can be administered either sublingually (sublingual immunotherapy [SLIT]) or subcutaneously (subcutaneous immunotherapy [SCIT]). The rate of route switching, required by patients, can provide an indirect evaluation of patients' preferences and adherence. The authors retrospectively reviewed patients' fil...
journal_title:Allergy and asthma proceedings
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journal_title:Allergy and asthma proceedings
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abstract::Hereditary angioedema (HAE) is a rare inherited disorder of complement factor C1 inhibitor. HAE is frequently confused with angioedema (AE), and little is known about emergency department (ED) or hospital utilization by patients with attacks in the United States. We examined hospitalizations and ED utilization for HAE...
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pub_type: 临床试验,杂志文章,随机对照试验
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doi:10.2500/aap.2010.31.3351
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pub_type: 杂志文章,评审
doi:10.2500/108854101778148746
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pub_type: 杂志文章,随机对照试验
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更新日期:2007-07-01 00:00:00
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2500/aap.2012.33.3522
更新日期:2012-01-01 00:00:00
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abstract:BACKGROUND:Allergic and autoimmune diseases comprise a group of inflammatory disorders caused by aberrant immune responses in which CD25+ Forkhead box P3-positive (FOXP3+) T regulatory (Treg) cells that normally suppress inflammatory events are often poorly functioning. This has stimulated an intensive investigative ef...
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journal_title:Allergy and asthma proceedings
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2500/108854199778553028
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journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,评审
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journal_title:Allergy and asthma proceedings
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abstract::Occupational immunologic lung disease is characterized by an immunologic response in the lung to an airborne agent inhaled in the work environment and can be subdivided into immunologically mediated occupational asthma (OA) and hypersensitivity pneumonitis (HP). Irritant-induced OA, a separate nonimmunologic entity, ...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
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abstract::Background: Although clinical trials documented omalizumab's efficacy in U.S. patients with chronic idiopathic urticaria (CIU), the real-world evidence on its long-term effectiveness is lacking. Objective: To assess omalizumab use and the long-term response in a large sample of U.S. real-world patients. Methods: Patie...
journal_title:Allergy and asthma proceedings
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doi:10.2500/aap.2019.40.4236
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journal_title:Allergy and asthma proceedings
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doi:10.2500/aap.2017.38.4047
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doi:10.2500/aap.2009.30.3273
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abstract::Inhalation of histamine is commonly used to assess the severity of and to monitor treatment of asthma. Histamine causes airways to narrow by acting directly on specific receptors. Hyperosmolar saline causes airways of asthmatics to narrow indirectly by endogenously mediated events that are potentially modified by drug...
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pub_type: 杂志文章
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