Abstract:
:Currently, inhaled corticosteroids (ICSs) are the most effective long-term control therapy for persistent asthma. However, patients show a variable response to ICSs and some exhibit glucocorticoid resistance. At recommended doses, there is little evidence to suggest that ICSs can either prevent or reverse the chronic airflow limitation that develops in some asthma patients. Could an improvement in the therapeutic index and greater accessibility of the drug to peripheral airways improve patient outcomes? Can a more potent ICS overcome glucocorticoid resistance or prevent airway remodeling? An optimal response could be achieved by modifying the drug's pharmacokinetic and pharmacodynamic profile, thus maximizing potency while minimizing adverse effects, creating the "ideal" ICS. Increasing lung deposition by modifying the drug formulation, increasing the fraction of respirable particles and receptor binding affinity, and heightening lipophilicity to facilitate passage of the drug into airway cells all play a role in improving efficacy. Could a drug that undergoes lipid conjugation increase the time the drug remains in the lungs, potentially allowing for once-daily dosing? Improvements in drug safety can be achieved by optimizing half-life and plasma clearance, limiting oropharyngeal deposition by on-site activation in the lungs, and increasing plasma protein binding to reduce the amount of free drug in systemic circulation. Ciclesonide, a novel ICS currently being developed for the treatment of persistent asthma, achieves many of these positive properties. The delivery of this relatively high-potency drug to strategic areas of inflammation, without the development of significant adverse effects, ideally will lead to improved asthma outcomes.
journal_name
Allergy Asthma Procjournal_title
Allergy and asthma proceedingsauthors
Zitt MJsubject
Has Abstractpub_date
2005-05-01 00:00:00pages
173-82issue
3eissn
1088-5412issn
1539-6304journal_volume
26pub_type
杂志文章,评审abstract::Percutaneous skin testing to determine allergies is usually read 15-20 minutes after placement, but the time to reading may be prolonged because of clinic duties or emergencies. The objective of the study was to compare skin-prick testing (SPT) wheal and flare reactions at 10, 30, and 40 minutes with the standard 20 m...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2011.32.3436
更新日期:2011-05-01 00:00:00
abstract::The hydrofluoroalkane (HFA) formulation of the inhaled corticosteroid flunisolide is a modification of the original chlorofluorocarbon formulation. HFA flunisolide substitutes an HFA for a chlorofluorocarbon propellant and uses a built-in spacer in its pressurized metered-dose inhaler. An open-label, randomized, three...
journal_title:Allergy and asthma proceedings
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:2002-09-01 00:00:00
abstract::Rhinosinusitis is one of the most common chronic diseases with significant symptoms and impact on the quality of life. Surgery is indicated when appropriate medical treatment fails. A review of the clinical presentations of rhinosinusitis is presented, as well as an overview of current medical and surgical treatment o...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:
更新日期:2006-01-01 00:00:00
abstract::Asthma, a disease characterized by airway inflammation and reversible bronchoconstriction, manifests a variety of phenotypes, and in some, but not all, asthma leads to a persistent and/or progressive loss of lung function. Conceptually, asthma persistence is identified by a stable decrement in lung function over time,...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/aap.2009.30.3202
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:Asthma guidelines recommend periodic assessment of impairment and risk factors to prevent exacerbations, which can lead to hospitalization and increased health care utilization and cost. According to recent meta-analysis data, fractional exhaled nitric oxide (FeNO) monitoring is associated with a 40-50% redu...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2018.39.4165
更新日期:2018-09-13 00:00:00
abstract::Previous studies suggest cross-reactivity between specific ragweed pollen and melon allergens. This study was designed to clarify the origin of the cross-reactivity between ragweed pollen and the gourd family. One thousand ragweed-allergic subjects were interviewed about the presence of oral allergy syndrome (OAS) ind...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2011.32.3416
更新日期:2011-01-01 00:00:00
abstract::Recurrent episodes of flushing, urticaria, and angioedema raise suspicion for many conditions with a wide differential diagnosis. The diagnostic approach involves consideration of allergic, cardiovascular, gastrointestinal, endocrine, infectious, neurologic, dermatologic, and drug-related causes. We describe a unique ...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2015.36.3836
更新日期:2015-05-01 00:00:00
abstract::Although some older antihistamines have a relatively slow onset of action, modern agents indicate an efficacy between 1 and 3 hours of administration. For patients who use antihistamines regularly, a short onset of action is relatively unimportant. When antihistamines are used as needed, either because of poor complia...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:The effect of allergen avoidance on airway inflammation is similar to that observed with treatment with inhaled steroids, whereas inhaled steroids have no effect on oxidative stress-induced inflammation. OBJECTIVE:The aim of this study was to retrospectively evaluate the potential effect of an antioxidant d...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2016.37.3920
更新日期:2016-01-01 00:00:00
abstract::Each year there are a substantial number of emergency department (ED) visits for angioedema and allergic reactions in the United States. Angioedema is commonly mistaken for an allergic reaction, possibly affecting the treatment rendered. We sought to determine the characteristics of U.S. ED visits for acute angioedema...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2013.34.3640
更新日期:2013-03-01 00:00:00
abstract::The inflammation in asthma involves both the large and the small airways. This study was designed to examine whether mometasone delivered from a dry powder inhaler would improve those parameters thought to reflect patency and obstruction of the small airways (diameter <2 mm). Subjects with mild to moderate asthma, onl...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,随机对照试验
doi:10.2500/aap.2009.30.3235
更新日期:2009-05-01 00:00:00
abstract::Background: Approximately 80% of patients with asthma and chronic obstructive pulmonary disease incorrectly use a metered-dose inhaler and, therefore, fail to obtain full benefit from their inhaler medication. Beclomethasone dipropionate (BDP) hydrofluoroalkane, an inhalation aerosol administered via a breath-actuated...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2019.40.4215
更新日期:2019-05-01 00:00:00
abstract:BACKGROUND:A history of penicillin allergy is associated with an increased risk of nosocomial infections because patients are exposed to non-beta lactam antibiotics. Ruling out inaccurate penicillin allergy during hospitalization decreases prescription of beta lactam antibiotics. However, the utilization of penicillin ...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2018.39.4118
更新日期:2018-05-01 00:00:00
abstract::A series of eight articles from the published literature for the period 2004-2005 was selected for review in this article. Small-airway obstruction in chronic obstructive pulmonary disease (COPD) and its management were the subjects of the first two articles reviewed in this commentary. Progression of COPD from the Gl...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/aap.2006.27.2859
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:Chronic urticaria (CU) is a skin disorder defined as daily or almost daily exhibition of pruritic and transient wheals that last for 6 weeks. CU is divided into two subtypes: chronic spontaneous urticaria (CSU) and chronic inducible urticaria (CIndU). OBJECTIVES:To evaluate the clinical features, possible c...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2016.37.4010
更新日期:2016-11-01 00:00:00
abstract::Mastocytosis comprises several diseases characterized by an abnormal increase in tissue mast cells. Cutaneous mastocytosis (CM) is the most common form of mastocytosis, affects predominantly children, and presents as a mast cell hyperplasia limited to the skin. Systemic mastocytosis (SM) comprises multiple distinct en...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:
更新日期:2004-01-01 00:00:00
abstract::Fever of unknown origin (FUO) is both a clinical and a diagnostic challenge. Furthermore, an FUO case with isolated marrow noncaseating granuloma can further confound diagnosis. However, these two findings together may help narrow down the pathological possibilities. This article presents a case report of FUO and lymp...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:10.2500/aap.2007.28.2982
更新日期:2007-03-01 00:00:00
abstract::Asthma is a clinical problem with social, psychological, and economic burdens. To improve patient disease management and quality of life (QOL), different education programs have been developed. The purpose of this study is to adapt and implement a community-based educational program for patients with asthma. A prospec...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,随机对照试验
doi:10.2500/aap2008.29.3083
更新日期:2008-01-01 00:00:00
abstract::Background: House-dust mites (HDM) allergen is one of the most important allergens in southern China; however, studies on the Dermatophagoides pteronyssinus components are relatively lacking. Objective: This study analyzed the molecular components of D. pteronyssinus in patients with allergic asthma (AS) and/or allerg...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2021.42.200105
更新日期:2021-01-01 00:00:00
abstract::The aim of this study was to detect the best test lung function to identify abnormalities in asthmatic children while asymptomatic. We studied 200 asthmatic children. Patients were evaluated by questionnaire to evaluate the presence of symptoms and drug consumption in the previous 3 months. Allergological evaluation b...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2006.27.2922
更新日期:2006-07-01 00:00:00
abstract::A telephone survey of 100 primary care physicians was performed to assess the awareness of the influence patient preference, patient satisfaction, and other factors have on the selection of nasal steroids for the treatment of allergic rhinitis. Results indicated that physicians believe drug efficacy is the primary rea...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:
更新日期:2001-11-01 00:00:00
abstract::Honey allergy is a very rare, but serious health condition. In this study, we presented six patients who described systemic allergic reactions after ingestion of honey. Three of the six patients had suffered from anaphylaxis. Honey-specific IgE was measured and skin-prick tests for honey were performed to diagnose hon...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2014.35.3718
更新日期:2014-01-01 00:00:00
abstract::High levels of IgE and IgE-mediated reactions represent a typical finding in patients with atopic eczema/dermatitis syndrome (AEDS). However, 10-30% of patients usually do not show any increase of total blood IgE levels and any detectable specific IgE sensitization. We performed this study to evaluate the difference o...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap2007.28.3038
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVE:We evaluated the risk of asthma development in adult patients with inflammatory bowel disease (IBD) in a nationwide population. METHODS:A retrospective cohort study was conducted by using data retrieved from the Taiwan National Health Insurance Research Database. Patients, ages 20 year or older, with newly d...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2015.36.3869
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Many children struggle with albuterol hydrofluoroalkane (HFA) inhalers. Albuterol multidose dry powder inhaler (MDPI) may simplify rescue bronchodilator use in children. OBJECTIVE:To demonstrate the comparability of albuterol MDPI and albuterol HFA in children with asthma. METHODS:This phase II, multicente...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.2500/aap.2016.37.3986
更新日期:2016-09-01 00:00:00
abstract::Allergic bronchopulmonary aspergillosis (ABPA) occurs as a complication of bronchial asthma or cystic fibrosis (CF). The diagnostic criteria speak to an exaggerated type I hypersensitivity response to the ubiquitous organism Aspergillus fumigatus. Immunologic parameters indicative of Aspergillus sensitization in CF ma...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章,评审
doi:
更新日期:2004-11-01 00:00:00
abstract::This randomized, double-blind, parallel, multi-center study was designed to determine whether the addition of salmeterol to existing inhaled corticosteroid therapy provides greater therapeutic benefit than doubling the dose of inhaled corticosteroids in symptomatic patients with asthma. A total of 514 adults were rand...
journal_title:Allergy and asthma proceedings
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.2500/108854199778553028
更新日期:1999-05-01 00:00:00
abstract::Although "atopic march" is a popular concept, the relationship between eczema and subsequent asthma is far from clear. However, some cohort studies have shown the possibility of two different allergic phenotypes in those who present with early eczema in terms of their persistency. We checked the cohort data from 308,...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2013.34.3625
更新日期:2013-01-01 00:00:00
abstract::Treatment guidelines recognize the importance of achieving and maintaining asthma control. This study was designed to assess the prevalence of asthma control in a representative U.S. population. A survey regarding asthma and associated symptoms was sent to a representative national sample of 134,401 households managed...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/aap.2009.30.3276
更新日期:2009-09-01 00:00:00
abstract::The diagnostic value for allergies of the low affinity IgE receptor and its soluble circulating fragment (sCD23) remains unclear. In particular, little is know about seasonal influences on serum sCD23 levels in subjects with pollen allergy. In the present study, to gain insight into pathophysiological role of sCD23, w...
journal_title:Allergy and asthma proceedings
pub_type: 杂志文章
doi:10.2500/108854199778612590
更新日期:1999-03-01 00:00:00