Natural history of hay fever: a 23-year follow-up of college students.

Abstract:

:The purpose of this study is to examine the natural history of hay fever among former college students who were diagnosed with this disease either before or after their freshman year. The diagnosis of hay fever or seasonal allergic rhinitis was based on a history of watery, itchy eyes, rhinorrhea, and sneezing occurring for at least 2 consecutive years during the same seasonal period. A total of 738 former Brown University students (69% males and 31% females) who were evaluated and underwent skin testing during their freshman year completed a 23-year follow-up questionnaire inquiring of their history of allergies and asthma. The mean age of this group at the time of the follow-up study was 40 years. During the 23 years subsequent to the original study, 131 developed new hay fever in addition to the 175 who had hay fever as college freshman, totaling 306. At the time of the 23-year follow-up, improvement was noted by 84.8% (28/33) of those with hay fever onset 1-5 years, 63.6% (56/88) of those with onset 6-12 years, 55.6% (40/72) of those with onset 13-19 years, and 38.7% (41/106) of those with onset 20 years and older. Among those with an unknown age of onset, 42.9% (3/7) reported improvement of hay fever symptoms. The trend of increasing percentage of improvement with younger age of onset of hay fever is of statistical significance (p value of < 0.0001) using the chi-squared test for trend. A total of 54.9% (168/306) had noted improvement, of which 22.9% (70/306) reported being symptom free and 32.0% (98/306) reported being better but not symptom free. Of the remaining 45.1% (138/306), the hay fever was unchanged in 33.3% (102/306), worsened in 9.2% (28/306), and unknown in 2.6% (8/306). This study suggests that over a long period of time, hay fever symptoms will improve in the majority of individuals.

journal_name

Allergy Asthma Proc

authors

Greisner WA 3rd,Settipane RJ,Settipane GA

doi

10.2500/108854198778557728

subject

Has Abstract

pub_date

1998-09-01 00:00:00

pages

271-5

issue

5

eissn

1088-5412

issn

1539-6304

journal_volume

19

pub_type

杂志文章,评审
  • Nonsteroidal anti-inflammatory drug hypersensitivity among children.

    abstract:BACKGROUND:Nonsteroidal anti-inflammatory drugs (NSAID) are the second-most frequent drugs that cause hypersensitivity reactions among children. Studies related to NSAIDs hypersensitivity in children are limited. In this study, we aimed to evaluate children admitted with suspicion of NSAIDs reaction. METHOD:Between Ja...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2015.36.3858

    authors: Guvenir H,Dibek Misirlioglu E,Vezir E,Toyran M,Ginis T,Civelek E,Kocabas CN

    更新日期:2015-09-01 00:00:00

  • Oral allergy syndrome (pollen-food allergy syndrome).

    abstract::A case of Oral Allergy syndrome or Pollen-Food Allergy Syndrome is briefly discussed. The clinical characteristics, diagnosis, pathogenesis, and management of this syndrome are discussed followed by clinical pearls and pitfalls for the practicing allergist. Symptoms generally occur with the ingestion of raw fruits/veg...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:

    authors: Purohit-Sheth TS,Carr WW

    更新日期:2005-05-01 00:00:00

  • Serum interleukin 17, interleukin 23, and interleukin 10 values in children with atopic eczema/dermatitis syndrome (AEDS): association with clinical severity and phenotype.

    abstract::To date cytokines profile in AEDS is poorly described in children. We evaluated the interleukin (IL)-17, IL-23, and IL-10 levels in atopic eczema/dermatitis syndrome (AEDS) children and healthy controls, in atopic AEDS (aAEDS) and nonatopic (naAEDS) subtypes and their relationship with disease severity. A total of 181...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2015.36.3808

    authors: Leonardi S,Cuppari C,Manti S,Filippelli M,Parisi GF,Borgia F,Briuglia S,Cannavò P,Salpietro A,Arrigo T,Salpietro C

    更新日期:2015-01-01 00:00:00

  • New and evolving therapies for hereditary angioedema.

    abstract::Hereditary angioedema (HAE) is a rare, autosomal dominant, genetic disorder associated with a deficiency in C1 inhibitor protein. HAE is characterized by recurrent and unpredictable episodes of swelling of the extremities, abdomen, face, and upper airway. There are several newly approved drugs as well as investigation...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2019.40.4195

    authors: Barmettler S,Li Y,Banerji A

    更新日期:2019-01-01 00:00:00

  • A new protocol for specific oral tolerance induction in children with IgE-mediated cow's milk allergy.

    abstract::IgE-mediated cow's milk allergy (CMA) is a heavy burden for patients, particularly for children and their families. Allergen avoidance represents the only therapeutic option, but oral desensitization protocols have been suggested. Because of the long duration and complexity of these protocols we examined the feasibili...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,随机对照试验

    doi:10.2500/aap.2009.30.3221

    authors: Caminiti L,Passalacqua G,Barberi S,Vita D,Barberio G,De Luca R,Pajno GB

    更新日期:2009-07-01 00:00:00

  • Mast cells in allergy and host defense.

    abstract::Mast cells have been implicated in the pathogenesis of allergic diseases and in inflammatory responses associated with pathological immune and disease-related processes including fibrosis, autoimmune pathology, and neoplasia. Recent findings in animal models of bacterial infection also suggest that mast cells may have...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/108854101778148764

    authors: Taylor ML,Metcalfe DD

    更新日期:2001-05-01 00:00:00

  • Biphasic reactions in children undergoing oral food challenges.

    abstract::Literature regarding biphasic reactions in the pediatric population is sparse. We aimed to determine the prevalence of biphasic reactions in children with food allergies undergoing oral food challenges (OFCs) and examine whether any clinical or treatment factors are associated with biphasic reactions. A retrospective ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2013.34.3669

    authors: Lee J,Garrett JP,Brown-Whitehorn T,Spergel JM

    更新日期:2013-05-01 00:00:00

  • Literature review: the best new articles in the specialty of allergy, asthma, and immunology, 2004-2005.

    abstract::A series of eight articles from the published literature for the period 2004-2005 was selected for review in this article. Small-airway obstruction in chronic obstructive pulmonary disease (COPD) and its management were the subjects of the first two articles reviewed in this commentary. Progression of COPD from the Gl...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2006.27.2859

    authors: Bellanti JA

    更新日期:2006-05-01 00:00:00

  • Inflammatory mediators in cystic fibrosis lung disease.

    abstract::Cystic fibrosis (CF) is a complex multisystem disorder caused by mutations in a membrane glycoprotein called the CF transmembrane regulator (CFTR), which has as its major function serving as a Cl- channel. The relationship between defects in CFTR and development of lung disease remains incompletely understood. Chronic...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:

    authors: Berger M

    更新日期:2002-01-01 00:00:00

  • An integrated analysis of the efficacy of fluticasone furoate nasal spray on individual nasal and ocular symptoms of seasonal allergic rhinitis.

    abstract::Intranasal steroids have been shown to affect ocular symptoms of allergic rhinitis (AR). The results of the published literature, however, are not uniform across all products. This study was designed to evaluate whether the effects of fluticasone furoate nasal spray (FFNS) are consistent across different allergy seaso...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2010.31.3397

    authors: Maspero JF,Walters RD,Wu W,Philpot EE,Naclerio RM,Fokkens WJ

    更新日期:2010-11-01 00:00:00

  • Efficacy and safety of once-daily treatment with beclomethasone dipropionate nasal aerosol in subjects with seasonal allergic rhinitis.

    abstract::An aerosol formulation may be preferred by some allergic rhinitis (AR) patients, to avoid the "wet feeling" and nasal runoff associated with aqueous nasal corticosteroid sprays. Beclomethasone dipropionate (BDP) hydrofluoroalkane nasal aerosol is a recently developed, nonaqueous, nonchlorofluorocarbon formulation of ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,随机对照试验

    doi:10.2500/aap.2012.33.3593

    authors: van Bavel JH,Ratner PH,Amar NJ,Hampel FC Jr,Melchior A,Dunbar SA,Dorinsky PM,Tantry SK

    更新日期:2012-09-01 00:00:00

  • New insights into the pathophysiology of allergic rhinitis.

    abstract::The immune response to an allergen is dependent on an initial sensitization process, with future exposures triggering a two-part allergic response including an early and a late phase. The process by which an allergen is recognized as such, including which cell types and cytokines are involved in the sensitization proc...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2007.28.2977

    authors: Rosenwasser L

    更新日期:2007-01-01 00:00:00

  • Anaphylaxis and epinephrine prescribing patterns in a military hospital: underutilization of the intramuscular route.

    abstract::Epinephrine is the only definitive treatment of anaphylaxis, and recent evidence suggests that the intramuscular route has superior pharmacokinetics to subcutaneous administration. There is little data regarding what route is commonly used in clinical practice. The objective of this article is to determine the rate of...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:

    authors: Haymore BR,Carr WW,Frank WT

    更新日期:2005-09-01 00:00:00

  • Onset and duration of action of nasal sprays in seasonal allergic rhinitis patients: olopatadine hydrochloride versus mometasone furoate monohydrate.

    abstract::Rapid relief of symptoms should be one of the primary goals of treatment for allergic rhinitis (AR). The onset and duration of action of olopatadine hydrochloride nasal spray, 665 mcg (OLO; Patanese), for seasonal AR (SAR) was evaluated in this study. This study was performed to determine the onset and duration of act...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,随机对照试验

    doi:10.2500/aap2007.28.3033

    authors: Patel D,Garadi R,Brubaker M,Conroy JP,Kaji Y,Crenshaw K,Whitling A,Wall GM

    更新日期:2007-09-01 00:00:00

  • High mobility group box 1: Biomarker of inhaled corticosteroid treatment response in children with moderate-severe asthma.

    abstract:BACKGROUND:High mobility group box 1 (HMGB1) is abnormally expressed in serum and sputum of patients with allergic asthma. OBJECTIVE:The aim of this study was to investigate the role of HMGB1 as guidance for treatment management of children with asthma. METHODS:Thirty children with asthma and 44 healthy children were...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2017.38.4047

    authors: Manti S,Leonardi S,Parisi GF,De Vivo D,Salpietro A,Spinuzza A,Arrigo T,Salpietro C,Cuppari C

    更新日期:2017-05-01 00:00:00

  • Reevaluation of pollen quantitation by an automatic pollen counter.

    abstract::Accurate and detailed pollen monitoring is useful for selection of medication and for allergen avoidance in patients with allergic rhinitis. Burkard and Durham pollen samplers are commonly used, but are labor and time intensive. In contrast, automatic pollen counters allow simple real-time pollen counting; however, th...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2010.31.3354

    authors: Muradil M,Okamoto Y,Yonekura S,Chazono H,Hisamitsu M,Horiguchi S,Hanazawa T,Takahashi Y,Yokota K,Okumura S

    更新日期:2010-09-01 00:00:00

  • Anaphylaxis/angioedema caused by honey ingestion.

    abstract::Honey allergy is a very rare, but serious health condition. In this study, we presented six patients who described systemic allergic reactions after ingestion of honey. Three of the six patients had suffered from anaphylaxis. Honey-specific IgE was measured and skin-prick tests for honey were performed to diagnose hon...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2014.35.3718

    authors: Vezir E,Kaya A,Toyran M,Azkur D,Dibek Mısırlıoğlu E,Kocabaş CN

    更新日期:2014-01-01 00:00:00

  • ECP level in nasopharyngeal secretions and serum from children with respiratory virus infections and asthmatic children.

    abstract::Infection with respiratory virus has been shown to exacerbate asthma in humans. However, the role of a respiratory virus in the pathogenesis of chronic asthma and/or wheezing in young children has not been clearly defined. It has also been debated whether virus-induced wheezing in young children is one entity and alle...

    journal_title:Allergy and asthma proceedings

    pub_type: 临床试验,杂志文章

    doi:10.2500/108854100778250888

    authors: Oh JW,Lee HB,Yum MK,Kim CR,Kang JO,Park IK

    更新日期:2000-03-01 00:00:00

  • The role of outcome studies in allergy and clinical immunology.

    abstract::Outcomes research is becoming an integral part of the sweeping changes occurring in the U.S. health care system. By developing outcomes monitoring systems in allergic disorders, allergists will be able to collect information showing their commitment to excellent clinical care, which improves the patient's quality of l...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/108854196778606455

    authors: Blaiss MS

    更新日期:1996-11-01 00:00:00

  • Fever of unknown origin and isolated noncaseating granuloma of the marrow: could this be sarcoidosis?

    abstract::Fever of unknown origin (FUO) is both a clinical and a diagnostic challenge. Furthermore, an FUO case with isolated marrow noncaseating granuloma can further confound diagnosis. However, these two findings together may help narrow down the pathological possibilities. This article presents a case report of FUO and lymp...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2007.28.2982

    authors: Miller AC,Chacko T,Rashid RM,Ledford DK

    更新日期:2007-03-01 00:00:00

  • Atopic eczema and the allergist.

    abstract::Several decades ago, the skin was considered to be little more than a simple barrier to dehydration, environmental toxins, and extrinsic bacteria; however, we now recognize that the skin is a complex immune organ that is fully integrated with the immune functions of the bone marrow, lymph nodes, liver, and spleen. Lym...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/108854199778251933

    authors: Charlesworth EN

    更新日期:1999-09-01 00:00:00

  • Usefulness of offline fractional exhaled nitric oxide measurements in the elderly asthmatic patients.

    abstract::Fractional exhaled nitric oxide (FeNO) measurement is an important noninvasive tool for evaluating eosinophilic inflammation of the airways. However, measurement of online FeNO in elderly people may not be possible if they are unable to perform the expiratory maneuver. The offline FeNO test is an alternative method th...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2013.34.3692

    authors: Hsu JY,Huang WC,Huang PL,Cheng YW,Chou MC

    更新日期:2013-09-01 00:00:00

  • The relationship between insect sting allergy treatment and patient anxiety and depression.

    abstract::Quality of life is affected by history of bee sting allergy. In addition, worry about being stung and also the need to use self-injection of medicine can create or increase anxiety, which can further compromise a patient's ability to enjoy the outdoors and participate in activities. We sought to determine the depressi...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2014.35.3751

    authors: Findeis S,Craig T

    更新日期:2014-05-01 00:00:00

  • Nasal lavage cytometry in the diagnosis of nonallergic rhinitis with eosinophilia syndrome (NARES).

    abstract::The nonallergic rhinitis with eosinophilia syndrome (NARES) is a type of chronic rhinitis, characterized by intense (> 20%) eosinophilia of the nasal secretions. In this study, screening for NARES in 81 patients with nonallergic chronic rhinitis was performed using a modified nasal lavage cytometric method. Twenty-one...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/108854197778558061

    authors: Schiavino D,Nucera E,Milani A,Della Corte AM,D'Ambrosio C,Pagliari G,Patriarca G

    更新日期:1997-11-01 00:00:00

  • Pharmaceutical care for asthma patients: a community pharmacy-based pilot project.

    abstract::Asthma is a clinical problem with social, psychological, and economic burdens. To improve patient disease management and quality of life (QOL), different education programs have been developed. The purpose of this study is to adapt and implement a community-based educational program for patients with asthma. A prospec...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,随机对照试验

    doi:10.2500/aap2008.29.3083

    authors: Petkova VB

    更新日期:2008-01-01 00:00:00

  • Effect of staphylococcal enterotoxin B on specific antibody production in children with atopic dermatitis.

    abstract::Exotoxins secreted by Staphylococcus aureus have been identified as a possible trigger factor in atopic dermatitis (AD). We investigated the production and role of circulating antibodies, with specificity to staphylococcal enterotoxin B (SEB), in children with AD compared with those of healthy controls. The children w...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:

    authors: Sohn MH,Kim CH,Kim WK,Jang GC,Kim KE

    更新日期:2003-01-01 00:00:00

  • Current management and use of oral immunotherapy in the United States for patients with peanut allergy.

    abstract::Background: Peanut allergy is a major health burden in the United States. Treatment is limited to avoidance and acute reaction management. No drug or medical product is approved for use as a peanut oral immunotherapy (POIT) agent. Objective: To examine peanut allergy diagnosis and treatment, peanut challenge protocols...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2019.40.4228

    authors: Blaiss MS,Tilles S,Petroni D,Zigmont E,Cassese M,Kwak B,Georgitseas N,Liebermann J

    更新日期:2019-07-23 00:00:00

  • Cost impact of monitoring exhaled nitric oxide in asthma management.

    abstract:BACKGROUND:Asthma guidelines recommend periodic assessment of impairment and risk factors to prevent exacerbations, which can lead to hospitalization and increased health care utilization and cost. According to recent meta-analysis data, fractional exhaled nitric oxide (FeNO) monitoring is associated with a 40-50% redu...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:10.2500/aap.2018.39.4165

    authors: Arnold RJG,Layton A,Massanari M

    更新日期:2018-09-13 00:00:00

  • Vocal cord dysfunction.

    abstract::A case of vocal cord dysfunction (VCD) is presented, followed by a discussion of the clinical characteristics, pathogenesis, diagnosis, and management of this disorder. Special emphasis is given to clinical pearls and pitfalls for the practicing allergist. VCD is a common condition that mimics asthma. Dyspnea, cough, ...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章,评审

    doi:10.2500/aap.2006.27.2871

    authors: Mikita JA,Mikita CP

    更新日期:2006-07-01 00:00:00

  • Anaphylaxis to insect sting associated with urticaria pigmentosa.

    abstract::Anaphylaxis associated with insect stings has been reported to cause approximately 40 deaths per year in the United States. Immunotherapy with venom extracts is a well-established method of treatment of allergy to insect stings. The duration of therapy is based mainly on the initial symptoms and the presence or absenc...

    journal_title:Allergy and asthma proceedings

    pub_type: 杂志文章

    doi:

    authors: Kim DC,Horan R

    更新日期:2003-05-01 00:00:00