Updates on the role of adrenal steroidogenesis inhibitors in Cushing's syndrome: a focus on novel therapies.

abstract：:A diabetic acromegalic man, not cured after surgery and radiosurgery, received lanreotide i.m. with great clinical and biochemical improvement. He required NPH insulin (76 to 84 units/day) to control his diabetes mellitus. Thirty-six hours after changing to LAR-octreotide (20 mg i.m/month) he presented symptomatic hyp...

journal_title：Pituitary

authors： Webb SM,Ortega E,Rodríguez-Espinosa J,Mato ME,Corcoy R

更新日期：2001-09-01 00:00:00

abstract：:Adequate ADH secretion, adrenal and thyroid functions are vital during the acute and post-acute phases of TBI. Deficiencies of these functions as a result of TBI are increasingly recognized. During the acute phase of TBI the incidence of severe DI is 2.9%; the incidence of less severe forms of DI is 21.6-26%. The deve...

journal_title：Pituitary

authors： Tsagarakis S,Tzanela M,Dimopoulou I

更新日期：2005-01-01 00:00:00

abstract：:Twenty years after the first description of combined hypopituitarism (CPHD) caused by PROP1 mutations, the phenotype of affected subjects is still challenging for clinicians. These patients suffer from pituitary hormone deficits ranging from IGHD to panhypopituitarism. ACTH deficiency usually develops later in life. P...

journal_title：Pituitary

authors： Doknic M,Gasic V,Stojanovic M,Pavlovic S,Marinkovic S,Miljic D,Pekic S,Manojlovic-Gacic E,Damjanovic D,Soldatovic I,Petakov M

更新日期：2020-08-01 00:00:00

abstract：:We report the results of long-term (6-year) treatment of Nelson's syndrome with the long-acting dopamine agonist, cabergoline, in a 55-year-old woman. The disease presented 26 years after bilateral adrenalectomy and radiation treatment for Cushing's disease, followed by glucocorticoid and mineralocorticoid replacement...

journal_title：Pituitary

authors： Shraga-Slutzky I,Shimon I,Weinshtein R

更新日期：2006-01-01 00:00:00

abstract：:Medications commonly cause hyperprolactinemia and their use must be differentiated from pathologic causes. The most common medications to cause hyperprolactinemia are the antipsychotic agents, although some of the newer atypical antipsychotics do not do so. Other medications causing hyperprolactinemia include antidepr...

journal_title：Pituitary

authors： Molitch ME

更新日期：2008-01-01 00:00:00

abstract：:Apart from the radiologic features regarding size and invasiveness, we had noticed some differences in morphology among types of pituitary adenomas. We conducted this study to verify the differences in radiologic morphology between growth hormone producing pituitary adenomas (GHoma) and nonfunctioning pituitary adenom...

journal_title：Pituitary

authors： Bakhtiar Y,Hanaya R,Tokimura H,Hirano H,Oyoshi T,Fujio S,Bohara M,Arita K

更新日期：2014-04-01 00:00:00

abstract：PURPOSE:Granular cell tumors of the neurohypophysis are rare, solitary lesions, mostly presenting in the adult age. They rarely grow to a sufficient size to cause mass effect related symptoms and they may be found in most cases incidentally at autopsy. Because of their rarity as of now they have been described only as ...

journal_title：Pituitary

authors： Gagliardi F,Spina A,Barzaghi LR,Bailo M,Losa M,Terreni MR,Mortini P

更新日期：2016-06-01 00:00:00

abstract：:Wegener's granulomatosis (WG) is an anti-neutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis of small and medium-sized vessels. Pituitary involvement in WG is rare with only 22 previous case reports in the English medical literature between 1966 and 2006. Herein we report another patient with WG-rela...

journal_title：Pituitary

authors： Yong TY,Li JY,Amato L,Mahadevan K,Phillips PJ,Coates PS,Coates PT

更新日期：2008-01-01 00:00:00

abstract：:A young female patient presented as an acute medical emergency with hypoglycaemia. Investigations revealed panhypopituitarism and an inflammatory pituitary mass. An antibody screen was negative for anti-neutrophil cytoplasmic antibodies with cytoplasmic distribution (cANCA). Pituitary histology showed lymphocytic infi...

journal_title：Pituitary

authors： McIntyre EA,Perros P

更新日期：2007-01-01 00:00:00

abstract：:Published data on the effects of androgen deficiency and testosterone administration on body composition in men and women are reviewed. In experimental paradigms, androgen deprivation decreases lean body mass and increases fat mass in men, and physiologic replacement reverses these abnormalities. The anabolic effects ...

journal_title：Pituitary

authors： Miller KK

更新日期：2009-01-01 00:00:00

abstract：:The availability of various first-line treatment modalities for acromegaly and evolving surgical techniques emphasize the need for accurately defined predictors of surgical outcome. We retrospectively analysed the outcome of 30 patients with acromegaly after initial endoscopic transsphenoidal surgery in two university...

journal_title：Pituitary

authors： van Bunderen CC,van Varsseveld NC,Baayen JC,van Furth WR,Aliaga ES,Hazewinkel MJ,Majoie CB,Freling NJ,Lips P,Fliers E,Bisschop PH,Drent ML

更新日期：2013-06-01 00:00:00

abstract：:Silent growth hormone adenomas (SGHA) are a rare entity of non-functioning pituitary neuroendocrine tumors. Diagnosis is invariably made post-operatively of a tumor immunopositive for GH (and Pit-1 in selected cases) but without clinical acromegaly. Mainly young females are affected, and tumors are often uncovered by ...

journal_title：Pituitary

authors： Langlois F,Woltjer R,Cetas JS,Fleseriu M

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Suprasellar pituitary adenomas (SPAs) are a special type of pituitary adenoma. Although dozens of SPA cases have been reported, the exact definition and the characteristics of SPA have not been exhaustively discussed before. METHODS:In a retrospective electronic medical records review, 13 patients with SPA ...

journal_title：Pituitary

authors： Zhu J,Wang Z,Zhang Y,Liu J,Li X,Deng K,Lu L,Yao Y

更新日期：2020-08-01 00:00:00

abstract：:Patients with adult GH deficiency (AGHD) have a high cardiovascular risk and probably an alteration of the oxidative balance, although evidence is lacking. To evaluate the presence of endothelial dysfunction and oxidative stress in patients with AGHD. Biochemical parameters of oxidative stress and endothelial dysfunct...

journal_title：Pituitary

authors： González-Duarte D,Madrazo-Atutxa A,Soto-Moreno A,Leal-Cerro A

更新日期：2012-12-01 00:00:00

abstract：PURPOSE:To evaluate the effects of somatostatin analogs and disease activity status on the upper gastrointestinal system in patients with acromegaly. METHODS:One hundred eighty-one patients with acromegaly were retrospectively assessed. The demographic, biochemical, pathologic, and radiologic data of the patients were...

journal_title：Pituitary

authors： Sahin S,Icli TB,Durcan E,Sulu C,Ozkaya HM,Hatemi AI,Kadioglu P

更新日期：2020-10-19 00:00:00

abstract：INTRODUCTION:Early disease onset, clinical manifestation, histomorphology, and increased tendency to relapse distinguish the adamantinomatous craniopharyngioma (adaCP) from the more favorable papillary variant (papCP). A molecular hallmark of adaCP is the activated Wnt signaling pathway indicated by nuclear β-catenin a...

journal_title：Pituitary

authors： Hölsken A,Stache C,Schlaffer SM,Flitsch J,Fahlbusch R,Buchfelder M,Buslei R

更新日期：2014-12-01 00:00:00

abstract：:In this case report we describe a 38 year-old-female with galactorrhea several months after the birth of an anencephalic child. She had hyperpolactemia and imaging of the pituitary gland revealed a midline defect and a nasopharyngeal mass compatible with a meningo-(hypophyso-) encephalocele and possibly an ectopic ter...

journal_title：Pituitary

authors： Rabelink NM,Lips P,Castelijns JA

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND/PURPOSE:During the early phase of sepsis, hypotension is accompanied by increase of plasma vasopressin hormone (AVP) levels, which decline during the late phase. This hypotension is due in part to increase of nitric oxide (NO) synthesis by nitric oxide synthase (NOS) enzyme. Neuronal isoform of this enzyme (...

journal_title：Pituitary

authors： Coelho CH,Martins TF,Oliveira-Pelegrin GR,da Rocha MJA

更新日期：2017-06-01 00:00:00

abstract：PURPOSE:Doses of growth hormone in adults with growth hormone deficiency are now lower than previously. However, it is not clear they are as effective as higher doses. The objective of this meta-analysis was to assess efficacy of low to moderate dose (LD) GH replacement on standard endpoints of GH compared to higher do...

journal_title：Pituitary

authors： Newman CB,Carmichael JD,Kleinberg DL

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Autoimmune hypophysitis (AH) is a rare autoimmune inflammatory disorder of pituitary gland. OBJECTIVE:To analyse clinical, hormonal, radiological features and management outcomes of AH. DESIGN:Retrospective analysis of patients with primary hypophysitis (where secondary causes of hypophysitis were ruled ou...

journal_title：Pituitary

authors： Khare S,Jagtap VS,Budyal SR,Kasaliwal R,Kakade HR,Bukan A,Sankhe S,Lila AR,Bandgar T,Menon PS,Shah NS

更新日期：2015-02-01 00:00:00

abstract：:The metabolic consequences of thyroxine replacement in patients with central hypothyroidism (CH) need to be evaluated. The aim was to examine the outcome of thyroxine replacement in CH. Adult hypopituitary patients (n = 1595) with and without CH from KIMS (Pfizer International Metabolic Database) were studied before a...

journal_title：Pituitary

authors： Filipsson Nyström H,Feldt-Rasmussen U,Kourides I,Popovic V,Koltowska-Häggström M,Jonsson B,Johannsson G

更新日期：2012-12-01 00:00:00

abstract：:Lanreotide depot (LD; commercial name Somatuline(®) Depot) is an injectable, extended-release formulation of the synthetic somatostatin analog (SSA) lanreotide. In recent clinical trials, LD was found to be suitable for self or partner administration, avoiding the need to travel to a medical facility. The Somatuline(®...

journal_title：Pituitary

authors： Salvatori R,Woodmansee WW,Molitch M,Gordon MB,Lomax KG

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to define safety and efficacy of medical therapy in the treatment of nonfunctioning pituitary tumours. DESIGN:We studied thirteen patients with a clinically nonfunctioning pituitary macroadenoma for response to cabergoline treatment for 1 year. Twelve/13 patients were already op...

journal_title：Pituitary

authors： Lohmann T,Trantakis C,Biesold M,Prothmann S,Guenzel S,Schober R,Paschke R

更新日期：2001-08-01 00:00:00

abstract：PURPOSE:Recent guidelines suggest that a single prolactin measurement is adequate to confirm hyperprolactinaemia. This may lead to unnecessary investigation of artefactual hyperprolactinaemia. Prolactin measurement drawn from an indwelling cannula after rest removes stress as a confounding variable. The objective was t...

journal_title：Pituitary

authors： Whyte MB,Pramodh S,Srikugan L,Gilbert JA,Miell JP,Sherwood RA,McGregor AM,Aylwin SJ

更新日期：2015-06-01 00:00:00

abstract：:The modern views on the anatomical and physiological interactions between the hypothalamus, pituitary and thyroid gland have emerged only in the last fifty years, although their historical roots may be found in a number of ancient and still not widely known ideas and observations. The regulation of energy body stores ...

journal_title：Pituitary

authors： Toni R

更新日期：2000-10-01 00:00:00

abstract：:Dopamine agonists have been shown to reduce growth hormone secretion in some patients with acromegaly, but their effect on adenoma size has not been well appreciated. We describe a 69 year-old woman with acromegaly caused by a somatotroph macroadenoma who received primary treatment with the dopamine agonist cabergolin...

journal_title：Pituitary

authors： Rickels MR,Snyder PJ

更新日期：2004-01-01 00:00:00

abstract：:Pituitary cysts are usually craniopharyngiomas or remnants of Rathke's cleft. Histologically craniopharyngiomas are lined by stratified squamous epithelium whereas Rathke's cleft cysts are lined by cuboidal or columnar epithelium. The management of pituitary cysts remains difficult because of the risks associated with...

journal_title：Pituitary

authors： Dashora U,Mathias D,James A,Zammit-Maempel I,Perros P

更新日期：2002-01-01 00:00:00

abstract：:Non-functioning pituitary carcinomas (NFPC) are defined as tumours of adenophyseal origin with craniospinal or systemic dissemination, with the absence of a hormonal hypersecretion syndrome. These are a histologically heterogenous group of tumours, comprising gonadotroph, null cell, "silent" tumours of corticotroph, s...

journal_title：Pituitary

authors： Lenders N,McCormack A

更新日期：2018-04-01 00:00:00

abstract：:Clinically inapparent adrenal masses, or adrenal incidentalomas, are discovered inadvertently in the course of workup or treatment of unrelated disorders. Cortical adenoma is the most frequent type of adrenal incidentaloma accounting for approximately 50% of cases in surgical series and even greater shares in medical ...

journal_title：Pituitary

authors： Terzolo M,Reimondo G,Bovio S,Angeli A

更新日期：2004-01-01 00:00:00

abstract：:Lactotroph adenomas, also called prolactinomas and prolactin-secreting adenomas, constitute nearly 80% of functioning pituitary tumors and about 30-50% of all adenomas in the clinical practice. Lactotroph adenomas occur in the general population at a prevalence of 45/100,000, are more common in women, but also involve...

journal_title：Pituitary

authors： Lopes MBS

更新日期：2020-02-01 00:00:00