Abstract:
:Lanreotide depot (LD; commercial name Somatuline(®) Depot) is an injectable, extended-release formulation of the synthetic somatostatin analog (SSA) lanreotide. In recent clinical trials, LD was found to be suitable for self or partner administration, avoiding the need to travel to a medical facility. The Somatuline(®) Depot for Acromegaly (SODA) study is an ongoing, multicenter, observational study in the US investigating the efficacy, safety, convenience and symptom relief provided by LD in patients with acromegaly. Sub-analyses explore outcomes according to who administered the injection: patient, partner, healthcare provider (HCP) or a combination. Data reported here reflect one year of patient experience. Patients are eligible for inclusion if they have a diagnosis of acromegaly, are treated with LD and can give signed informed consent. Baseline data include patient demographics, previous acromegaly treatment and investigations, GH and IGF-I levels, LD dose and dose adjustment frequency. Symptom frequency, injection pain and treatment convenience are assessed using patient-reported questionnaires. As of 18 April 2012, 166 patients had enrolled in SODA. Most (72 %) achieved normal IGF-I levels after 12 months of LD treatment. Disease control was similar in self or partner injectors and in patients who received injections from their HCP, although self or partner injecting was deemed more convenient. LD was well-tolerated irrespective of who performed the injection. Self injection led to more injection-site reactions, but this did not increase the rate of treatment interruption. Acromegaly symptoms remained stable. Biochemical, safety and convenience data support the clinical validity of injecting LD at home.
journal_name
Pituitaryjournal_title
Pituitaryauthors
Salvatori R,Woodmansee WW,Molitch M,Gordon MB,Lomax KGdoi
10.1007/s11102-012-0460-2subject
Has Abstractpub_date
2014-02-01 00:00:00pages
13-21issue
1eissn
1386-341Xissn
1573-7403journal_volume
17pub_type
杂志文章,多中心研究相关文献
Pituitary文献大全abstract::Symptomatic cerebral vasospasm (CVS) after transsphenoidal surgery (TSS) is very rare compared with vasospasm resulting from aneurysmal subarachnoid hemorrhage (SAH). Fewer than six cases documented by cerebral angiography have been reported. We evaluated the records of 15 patients in whom SAH developed after TSS. The...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-012-0415-7
更新日期:2013-06-01 00:00:00
abstract::Apart from the radiologic features regarding size and invasiveness, we had noticed some differences in morphology among types of pituitary adenomas. We conducted this study to verify the differences in radiologic morphology between growth hormone producing pituitary adenomas (GHoma) and nonfunctioning pituitary adenom...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-013-0479-z
更新日期:2014-04-01 00:00:00
abstract:INTRODUCTION:Cushing's syndrome (CS) is a rare disease characterized by a collection of signs and symptoms, also common in the general population without elevated cortisol secretion. During the last years more patients with CS are identified earlier and with milder disease. Many of these patients are diagnosed during s...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-015-0634-9
更新日期:2015-04-01 00:00:00
abstract:PURPOSE:To evaluate the effects of somatostatin analogs and disease activity status on the upper gastrointestinal system in patients with acromegaly. METHODS:One hundred eighty-one patients with acromegaly were retrospectively assessed. The demographic, biochemical, pathologic, and radiologic data of the patients were...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-020-01095-3
更新日期:2020-10-19 00:00:00
abstract::Postoperative serum cortisol is used as an indicator of Cushing's disease (CD) remission following transsphenoidal surgery (TSS) and guides (controversially) the need for immediate adjuvant treatment for CD. We investigated postoperative cortisol and adrenocorticotropic hormone (ACTH) levels as predictors of remission...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-012-0455-z
更新日期:2013-12-01 00:00:00
abstract::The role of pituitary radiotherapy (RT) in the management of clinically non-functioning pituitary tumors (NFTs) remains controversial. Observational studies suggest that RT is effective in preventing the regrowth of NFT remnants following initial surgical debulking. However, not all tumor remnants will regrow in the a...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1023/b:pitu.0000004801.95086.e2
更新日期:2003-09-01 00:00:00
abstract::We describe two young men with cystic pituitary enlargement on magnetic resonance imaging (MRI) causing hypopituitarism. The first patient presented acutely unwell with headache and vomiting associated with anterior and posterior pituitary dysfunction. The second patient presented with hypopituitarism after a long his...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1023/b:pitu.0000011177.43408.56
更新日期:2003-01-01 00:00:00
abstract::Growth hormone releasing hormone (GHRH) signals via G protein-coupled receptors (GHRH-R) to enhance intracellular Galphas/adenylyl cyclase/cAMP signaling, which in turn has positive effects on GH synthesis and release, as well as proliferation of the GH-producing cells of the anterior pituitary gland. Some GH-producin...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-005-5245-4
更新日期:2005-01-01 00:00:00
abstract::Arterial bleeding during transsphenoidal surgery for pituitary adenoma is known complication. This usually happens due to rupture of intracavernous carotid or delayed hemorrhage due to the carotico-cavernous fistula and/or pseudoaneurysm. There is also evidence that cavernous carotid aneurysms may occur with pituitary...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-009-0198-7
更新日期:2010-06-01 00:00:00
abstract:BACKGROUND:Suprasellar pituitary adenomas (SPAs) are a special type of pituitary adenoma. Although dozens of SPA cases have been reported, the exact definition and the characteristics of SPA have not been exhaustively discussed before. METHODS:In a retrospective electronic medical records review, 13 patients with SPA ...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-020-01043-1
更新日期:2020-08-01 00:00:00
abstract::The molecular pathogenesis of prolactinomas has resisted elucidation; with the exception of a RAS mutation in a single aggressive prolactinoma, no mutational changes have been identified. In prolactinomas, a further obstacle has been the paucity of surgical specimens suitable for molecular analysis since prolactionoma...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-007-0082-2
更新日期:2008-01-01 00:00:00
abstract::Although leptin was originally viewed as an antiobesity hormone, it is now evident that it may have more pleiotropic actions. Experiments in rodents have shown that leptin activates the sympathetic nervous system, is involved in regulation of blood pressure, hematopoiesis, immune function, angiogenesis and brain, bone...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1023/a:1012938308654
更新日期:2001-01-01 00:00:00
abstract:PURPOSE:The pituitary gland is an unusual site for metastatic spread, but as patients with metastatic malignancy are living longer, it may become more prevalent. Compression of important anatomy adjacent to the sella may produce disabling symptoms and endocrine derangement, leading to significant morbidity. METHODS:An...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-018-0899-x
更新日期:2018-10-01 00:00:00
abstract::Lactotroph adenomas, also called prolactinomas and prolactin-secreting adenomas, constitute nearly 80% of functioning pituitary tumors and about 30-50% of all adenomas in the clinical practice. Lactotroph adenomas occur in the general population at a prevalence of 45/100,000, are more common in women, but also involve...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-019-00997-1
更新日期:2020-02-01 00:00:00
abstract::In order to explore the presence of, and the potential role of, secretagogin in human pituitary adenomas, an analytical strategy that integrated comparative proteomics and comparative transcriptomics was used to detect the protein and the mRNA expression, respectively, of secretagogin in human non-functional pituitary...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1023/b:pitu.0000023426.99808.40
更新日期:2003-01-01 00:00:00
abstract::We evaluated the efficacy of Gamma knife stereotactic radiosurgery (GKSR) as an adjunctive management modality for patients with drug resistant or intolerant cavernous sinus invasive prolactinomas. Twenty-two patients with cavernous sinus invasive prolactinoma underwent GKSR between 1994 and 2009. Thirteen patients we...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-012-0376-x
更新日期:2013-03-01 00:00:00
abstract::Cis-unsaturated free fatty acids (FFA) like oleic acid are strong blockers of both basal and stimulated GH secretion in vivo by acting directly on the somatotroph cell. Several lines of evidence suggest that this inhibitory action is the result of a perturbation of the function of several plasma membrane integral prot...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1023/a:1009962624036
更新日期:1998-04-01 00:00:00
abstract::Non-functioning pituitary neuroendocrine tumors do not cause endocrine symptoms related to hypersecretion of adenohypophyseal hormones and are clinically characterized by symptoms due to growing sellar tumor mass. Histopathological classification of this tumor group has always been challenging due to their heterogenei...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-017-0855-1
更新日期:2018-04-01 00:00:00
abstract:PURPOSE:Survivin is an apoptosis inhibitor, expressed in almost all types of human malignancies, but rarely in differentiated normal tissues. Recently, survivin gene splice variants with different anti-apoptotic activities have been reported. The current study was undertaken to examine the expression of survivin and it...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-014-0590-9
更新日期:2015-06-01 00:00:00
abstract::We report a 59-year-old acromegalic woman, who presented with generalized bone pain, weakness, fatigue and foamy urine, who was found to have multiple myeloma (MM); and a 60-year-old acromegalic woman with dizziness, vomiting and abdominal pain, high blood pressure and splenomegaly that was posteriorly diagnosed as ha...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-009-0176-0
更新日期:2011-12-01 00:00:00
abstract::Acute lymphoblastic leukaemia (ALL) is the most common childhood malignancy. The survival rate in the Scandinavian countries is now around 85 %. ALL patients treated with cranial radiotherapy (CRT) are at risk for growth hormone deficiency (GHD), but little is known about other pituitary insufficiencies, e.g. ACTH. Ad...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-012-0459-8
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVE:Lymphocytic hypophysitis (LH) is a rare chronic inflammatory disorder characterized by lymphocytic infiltration of the pituitary gland commonly affecting women during pregnancy or post-partum period. The pathogenesis remains uncertain, however an autoimmune process is frequently implicated. There is limited d...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-008-0119-1
更新日期:2009-01-01 00:00:00
abstract::Nonfunctioning pituitary adenomas (NFPA) are typically benign neoplasms that can cause significant morbidity through local mass effects. MIB-1/Ki-67 and p53 immuno-reactivity are used to predict aggressive behavior but have known limitations. No marker to date is widely used to reliably predict tumor progression. Phos...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-011-0367-3
更新日期:2012-12-01 00:00:00
abstract::Isolated familial somatotropinomas (IFS) rarely occurs in the absence of multiple endocrine neoplasia type I (MEN1) or the Carney complex. In the present study we report two Italian siblings affected by GH-secreting adenomas. There was no history of parental consanguinity. The sister presented at 18 years of age with ...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1023/a:1022193015993
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVES:Although the effectiveness of gamma knife radiosurgery (GKRS) in controlling the size of pituitary adenomas has been well demonstrated in many studies, the time period in which significant changes in tumor size occurs has been investigated in a limited fashion. It is important to determine the therapeutic wi...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-014-0603-8
更新日期:2015-08-01 00:00:00
abstract:PURPOSE:Secondary empty sella syndrome (SESS) following pituitary surgery remains a diagnostic and therapeutic challenge. The aim of this study was to specify the diagnostic criteria, surgical indications and results of chiasmapexy in the SESS. METHODS:Three cases from two experienced neurosurgical centers were collec...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-020-01104-5
更新日期:2020-11-02 00:00:00
abstract::Published data on the effects of androgen deficiency and testosterone administration on body composition in men and women are reviewed. In experimental paradigms, androgen deprivation decreases lean body mass and increases fat mass in men, and physiologic replacement reverses these abnormalities. The anabolic effects ...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-008-0121-7
更新日期:2009-01-01 00:00:00
abstract::Adipsic diabetes insipidus (ADI) is a rare condition in which thirst, an essential clinical feature for the prevention of hypernatraemic dehydration, is absent. We report the first case of adipsic diabetes insipidus to occur following surgery for a pituitary macroprolactinoma, with loss of both osmoregulated and baror...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-006-8280-x
更新日期:2006-01-01 00:00:00
abstract::We report a case of hepatolithiasis (intrahepatic stone) complicated by gram-negative sepsis in a 37 year old male with acromegaly being treated with octreotide. As a child, he had suffered a traumatic injury to his liver requiring the surgical repair of a laceration. This is the first reported case of hepatolithiasis...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1023/a:1012880113759
更新日期:2000-12-01 00:00:00
abstract::Pituitary cysts are usually craniopharyngiomas or remnants of Rathke's cleft. Histologically craniopharyngiomas are lined by stratified squamous epithelium whereas Rathke's cleft cysts are lined by cuboidal or columnar epithelium. The management of pituitary cysts remains difficult because of the risks associated with...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1023/a:1025373715860
更新日期:2002-01-01 00:00:00