Abstract:
INTRODUCTION:Cushing's syndrome (CS) is a rare disease characterized by a collection of signs and symptoms, also common in the general population without elevated cortisol secretion. During the last years more patients with CS are identified earlier and with milder disease. Many of these patients are diagnosed during screening efforts performed for certain or isolated complaints like weight gain, diabetes mellitus (DM), hypertension, osteoporosis, elevated white blood cell counts and more. METHODS:In this review article the most popular screening test performed in the studies cited was the 1-mg dexamethasone suppression test. CONCLUSIONS:Cushing is not frequent enough to support the use of routine screening in patients with morbid obesity and type 2 DM. Also only 1% of hypertensive patients have secondary hypertension due to CS. However, screening should be considered in young patients with resistant DM and/or hypertension. Among patients with osteoporosis and vertebral fractures up to 5% were diagnosed with subclinical hypercortisolism; most of these had adrenal adenoma. Screening for CS is important in subjects with adrenal incidentaloma, and many studies show a high prevalence (~10%) of Cushing or subclinical CS in these patients.
journal_name
Pituitaryjournal_title
Pituitaryauthors
Shimon Idoi
10.1007/s11102-015-0634-9subject
Has Abstractpub_date
2015-04-01 00:00:00pages
201-5issue
2eissn
1386-341Xissn
1573-7403journal_volume
18pub_type
杂志文章,评审相关文献
Pituitary文献大全abstract:CONTEXT:Outcome of acromegaly surgery is assessed by IGF-1 and glucose-suppressed GH, but whether the latter provides additional clinically relevant information when IGF-1 is normal is unclear. The role of GH suppression testing after surgery requires clarification. METHODS:We studied 97 acromegaly patients with norma...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-020-01094-4
更新日期:2020-10-30 00:00:00
abstract::A diabetic acromegalic man, not cured after surgery and radiosurgery, received lanreotide i.m. with great clinical and biochemical improvement. He required NPH insulin (76 to 84 units/day) to control his diabetes mellitus. Thirty-six hours after changing to LAR-octreotide (20 mg i.m/month) he presented symptomatic hyp...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1023/a:1020710800842
更新日期:2001-09-01 00:00:00
abstract::Acromegaly is associated with serious morbidity and mortality, if not well controlled. Approved somatostatin receptor ligands (SRLs) are a mainstay of medical therapy and exhibit preferential affinity for somatostatin receptor (SSTR) subtype 2. Our objective was to assess whether characteristic features of individual ...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-012-0445-1
更新日期:2013-12-01 00:00:00
abstract:PURPOSE:Long-acting somatostatin analogs are one of the main classes of medical therapy used for acromegaly and most patients require ongoing treatment. Few studies have evaluated the long-term efficacy and safety of lanreotide depot beyond 2 years. The goal of this study was to provide a long-term longitudinal assessm...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-016-0724-3
更新日期:2016-08-01 00:00:00
abstract::The simultaneous occurrence of a hypothalamic and sellar gangliocytoma with a pituitary prolactinoma is very rare. The explanation for such an association is not known. We describe the case of a woman who had a coexisting adjacent pituitary prolactinoma and gangliocytoma within the same sellar mass. The tumor cells of...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-007-0022-1
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:Ectopic pituitary adenomas (EPA) are rare tumors thought to arise from embryological remnants along the route of normal pituitary migration. Clinically, these tumors vary in hormonal activity and can exert mass effect based on location and size. METHODS:We performed a single-center retrospective analysis of pa...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-019-00954-y
更新日期:2019-08-01 00:00:00
abstract:PURPOSE:Tatton-Brown-Rahman syndrome (TBRS) is a newly defined genetic entity characterized by overgrowth and intellectual disability, resulting from germline mutations in the gene encoding DNA methyltransferase 3 alpha (DNMT3A). Affected individuals with benign and malignant tumors have been reported; to our knowledge...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-019-01019-w
更新日期:2020-04-01 00:00:00
abstract::Pituitary radiotherapy (RT) is an effective second-line treatment for paediatric Cushing's disease (CD). We report long-term efficacy and anterior pituitary function in a cohort of paediatric CD patients treated with RT. Between 1988 and 2008, from our cohort of 48 paediatric CD patients, eight paediatric CD patients ...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-010-0231-x
更新日期:2010-12-01 00:00:00
abstract::Oral estrogens reduce GH-induced IGF-1 production and preliminary studies have shown that adjuvant estroprogestin (EP) therapy with octreotide LAR may control disease activity in some female patients who are partially responsive to octreotide LAR. Our aim was to verify if EP alone or in combination with octreotide LAR...
journal_title:Pituitary
pub_type: 临床试验,杂志文章
doi:10.1007/s11102-010-0236-5
更新日期:2010-12-01 00:00:00
abstract::We report a 59-year-old acromegalic woman, who presented with generalized bone pain, weakness, fatigue and foamy urine, who was found to have multiple myeloma (MM); and a 60-year-old acromegalic woman with dizziness, vomiting and abdominal pain, high blood pressure and splenomegaly that was posteriorly diagnosed as ha...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-009-0176-0
更新日期:2011-12-01 00:00:00
abstract:BACKGROUND:Survival rates among childhood cancer survivors (CCSs) have significantly risen in the last 40 years due to substantial improvements in treatment protocols. However, this improvement has brought with it serious late effects that frequently involve the endocrine system. Of the endocrine disorders, GH deficien...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-020-01052-0
更新日期:2020-08-01 00:00:00
abstract:PURPOSE:Doses of growth hormone in adults with growth hormone deficiency are now lower than previously. However, it is not clear they are as effective as higher doses. The objective of this meta-analysis was to assess efficacy of low to moderate dose (LD) GH replacement on standard endpoints of GH compared to higher do...
journal_title:Pituitary
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11102-014-0571-z
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Suprasellar pituitary adenomas (SPAs) are a special type of pituitary adenoma. Although dozens of SPA cases have been reported, the exact definition and the characteristics of SPA have not been exhaustively discussed before. METHODS:In a retrospective electronic medical records review, 13 patients with SPA ...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-020-01043-1
更新日期:2020-08-01 00:00:00
abstract:PURPOSE:Hypophysitis develops in up to 19% of melanoma patients treated with ipilimumab, a cytotoxic T-lymphocyte antigen-4 antibody. Early detection may avert life-threatening hypopituitarism. We aimed to assess the incidence of ipilimumab-induced hypophysitis (IH) at a quaternary melanoma referral centre, and to dete...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-018-0866-6
更新日期:2018-06-01 00:00:00
abstract::A 54-years-old woman diagnosed of myotonic dystrophy (MyD) with past medical history of massive postpartum haemorrhage at age 28 and panhypopituitarism was studied. BMI and body composition were determined and we determined baseline serum IGF-I, IGFBP3, insulin and leptin levels and after the IGF-I generation test per...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1023/a:1009984505312
更新日期:1999-01-01 00:00:00
abstract::The modern views on the anatomical and physiological interactions between the hypothalamus, pituitary and thyroid gland have emerged only in the last fifty years, although their historical roots may be found in a number of ancient and still not widely known ideas and observations. The regulation of energy body stores ...
journal_title:Pituitary
pub_type: 历史文章,杂志文章
doi:10.1023/a:1009953723963
更新日期:2000-10-01 00:00:00
abstract::The molecular pathogenesis of prolactinomas has resisted elucidation; with the exception of a RAS mutation in a single aggressive prolactinoma, no mutational changes have been identified. In prolactinomas, a further obstacle has been the paucity of surgical specimens suitable for molecular analysis since prolactionoma...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-007-0082-2
更新日期:2008-01-01 00:00:00
abstract:INTRODUCTION:Cushing's syndrome is associated with a number of clinical manifestations and co-morbidities which may not resolve even after long-term remission leading to excessive mortality. MATERIALS AND METHODS:This review summarizes the main manifestations of Cushing's syndrome (active or in remission) with particu...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-014-0631-4
更新日期:2015-04-01 00:00:00
abstract:PURPOSE:In a 10-week proof-of-concept study (LINC 1), the potent oral 11β-hydroxylase inhibitor osilodrostat (LCI699) normalized urinary free cortisol (UFC) in 11/12 patients with Cushing's disease. The current 22-week study (LINC 2; NCT01331239) further evaluated osilodrostat in patients with Cushing's disease. METHO...
journal_title:Pituitary
pub_type: 杂志文章,多中心研究
doi:10.1007/s11102-015-0692-z
更新日期:2016-04-01 00:00:00
abstract::Anemia and other hematological abnormalities are common in patients with Sheehan's syndrome. The response of these abnormalities to replacement of thyroxine and glucocorticoids is not clear. The aim of the present study was to document the profile of hematological abnormalities and response to treatment in patients wi...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-010-0255-2
更新日期:2011-03-01 00:00:00
abstract::Pituitary adenomas rarely originate outside the sella turcica. Ectopic locations include the suprasellar region, sphenoid sinus, cavernous sinus and clivus. We describe a 50-year-old female who presented with clinical signs and biochemical evidence of acromegaly. Pituitary MRI demonstrated a 2 mm hypointense lesion on...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-011-0345-9
更新日期:2012-12-01 00:00:00
abstract::Growth hormone excess has been associated with hypercalciuria and nephrolithiasis. Hypercalcemia in acromegaly is rare and usually due to coexistent primary hyperparathyroidism. To report two cases of 1,25-dihydroxyvitamin D (1,25 (OH)(2) D)-dependent hypercalcemia in cromegaly. A 50 year-old female with 2 years histo...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-010-0286-8
更新日期:2012-12-01 00:00:00
abstract::Acute lymphoblastic leukaemia (ALL) is the most common childhood malignancy. The survival rate in the Scandinavian countries is now around 85 %. ALL patients treated with cranial radiotherapy (CRT) are at risk for growth hormone deficiency (GHD), but little is known about other pituitary insufficiencies, e.g. ACTH. Ad...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-012-0459-8
更新日期:2014-02-01 00:00:00
abstract::We report a case of hepatolithiasis (intrahepatic stone) complicated by gram-negative sepsis in a 37 year old male with acromegaly being treated with octreotide. As a child, he had suffered a traumatic injury to his liver requiring the surgical repair of a laceration. This is the first reported case of hepatolithiasis...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1023/a:1012880113759
更新日期:2000-12-01 00:00:00
abstract::Silent growth hormone adenomas (SGHA) are a rare entity of non-functioning pituitary neuroendocrine tumors. Diagnosis is invariably made post-operatively of a tumor immunopositive for GH (and Pit-1 in selected cases) but without clinical acromegaly. Mainly young females are affected, and tumors are often uncovered by ...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-017-0858-y
更新日期:2018-04-01 00:00:00
abstract::Resistance to dopamine agonists can be defined with respect to failure to normalize PRL levels and failure to decrease tumor size by > or = 50%. Using these definitions, failure to normalize PRL levels is seen in 24% of those treated with bromocriptine, 13% of those treated with pergolide and 11% of those treated with...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1023/a:1026225625897
更新日期:2003-01-01 00:00:00
abstract::Cis-unsaturated free fatty acids (FFA) like oleic acid are strong blockers of both basal and stimulated GH secretion in vivo by acting directly on the somatotroph cell. Several lines of evidence suggest that this inhibitory action is the result of a perturbation of the function of several plasma membrane integral prot...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1023/a:1009962624036
更新日期:1998-04-01 00:00:00
abstract::An unusual case of tubercular granulomatous hypophysitis is reported. A sellar mass diagnosed as pituitary adenoma in MRI, showed non-caseating granulomas, glandular destruction and fibrosis in histology. Stain for acid-fast bacilli (AFB) were negative and the case was misdiagnosed as Idiopathic Granulomatous hypophys...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-007-0068-0
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:Survivin is an apoptosis inhibitor, expressed in almost all types of human malignancies, but rarely in differentiated normal tissues. Recently, survivin gene splice variants with different anti-apoptotic activities have been reported. The current study was undertaken to examine the expression of survivin and it...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-014-0590-9
更新日期:2015-06-01 00:00:00
abstract:PURPOSE:Granular cell tumors of the neurohypophysis are rare, solitary lesions, mostly presenting in the adult age. They rarely grow to a sufficient size to cause mass effect related symptoms and they may be found in most cases incidentally at autopsy. Because of their rarity as of now they have been described only as ...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-016-0704-7
更新日期:2016-06-01 00:00:00