Abstract:
:A 54-years-old woman diagnosed of myotonic dystrophy (MyD) with past medical history of massive postpartum haemorrhage at age 28 and panhypopituitarism was studied. BMI and body composition were determined and we determined baseline serum IGF-I, IGFBP3, insulin and leptin levels and after the IGF-I generation test performed after the GH administration of 0.1 U/kg/day s.c each evening for 4 days. As expected the patient had lower baseline IGF-I and IGFBP3 with high insulin and leptin levels. After IGF-I generation test, IGF-I, IGFBP3 and insulin levels increases without changes in body composition and leptin levels. In the current study, high leptin baseline levels may reflect the hyperinsulinism action over the adipose tissue in MyD and the effect of hypopituitarism over leptin regulation. After 4 days of GH administration, we demonstrated the lack of a modulatory role on leptin levels of GH and acute insulin increase, and a direct effect of GH on leptin can be excluded.
journal_name
Pituitaryjournal_title
Pituitaryauthors
Gómez JM,Martínez-Matos JAdoi
10.1023/a:1009984505312subject
Has Abstractpub_date
1999-01-01 00:00:00pages
121-3issue
2eissn
1386-341Xissn
1573-7403journal_volume
1pub_type
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