Abstract:
:Cis-unsaturated free fatty acids (FFA) like oleic acid are strong blockers of both basal and stimulated GH secretion in vivo by acting directly on the somatotroph cell. Several lines of evidence suggest that this inhibitory action is the result of a perturbation of the function of several plasma membrane integral proteins. It has been reported recently that cis-FFA are able to block several steps in the inositolphosphates/phospholipase C/Ca2+ (InsPs/PLC/Ca2+) signal transduction pathway triggered by the activation of the TRH receptor. In this paper we present evidence showing that the inhibition of growth hormone (GH) and prolactin (PRL) secretion by cis-FFA in vitro is also exerted at several different levels on the cAMP-protein kinase A (cAMP/PKA) pathway triggered by the stimulation of the vasoactive intestinal peptide (VIP) receptor in pituitary clonal cells. By means of a sequential analysis of signal transduction events, we observed that cis-unsaturated FFA; (1) reduce the activity of adenylate cyclase; (2) perturb the activity of protein kinase A; (3) suppress the VIP-triggered Ca2+ influx, and (4) do not perturb VIP binding or the homologous desensitization of the VIP receptor.
journal_name
Pituitaryjournal_title
Pituitaryauthors
Pérez FR,Camiña JP,Menéndez C,Beiras A,Casabiell X,Casanueva FFdoi
10.1023/a:1009962624036subject
Has Abstractpub_date
1998-04-01 00:00:00pages
25-32issue
1eissn
1386-341Xissn
1573-7403journal_volume
1pub_type
杂志文章相关文献
Pituitary文献大全abstract:INTRODUCTION:Cystic prolactinoma is a variant of prolactin-secreting pituitary adenoma. The strategies for the management of cystic prolactinoma have not been addressed thoroughly in clinical guidelines. METHODS:A literature search was performed using Pubmed to review the current approaches to the treatment of cystic ...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-018-0888-0
更新日期:2018-08-01 00:00:00
abstract::Non-functioning pituitary carcinomas (NFPC) are defined as tumours of adenophyseal origin with craniospinal or systemic dissemination, with the absence of a hormonal hypersecretion syndrome. These are a histologically heterogenous group of tumours, comprising gonadotroph, null cell, "silent" tumours of corticotroph, s...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-017-0857-z
更新日期:2018-04-01 00:00:00
abstract::In this report we emphasize the opportunity of considering the uncommon causes of chronic GH-excess in the initial diagnostic process, such as GHRH hypersecretion, especially in the presence of ambiguous pituitary neuroimaging. This topic may have an important clinical significance in order to plan the most cost-effec...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-008-0146-y
更新日期:2010-09-01 00:00:00
abstract:INTRODUCTION:Cushing's syndrome is associated with a number of clinical manifestations and co-morbidities which may not resolve even after long-term remission leading to excessive mortality. MATERIALS AND METHODS:This review summarizes the main manifestations of Cushing's syndrome (active or in remission) with particu...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-014-0631-4
更新日期:2015-04-01 00:00:00
abstract:PURPOSE:To report the results of a consecutive series of patients who underwent an endoscopic endonasal approach (EEA) for resection of a pituitary adenoma and compare them to previous series of microscopic and endoscopic approaches. METHODS:A retrospective review of clinical and radiographic outcomes of a consecutive...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-013-0502-4
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:The growing interest in the molecular and genetic alterations of craniopharyngiomas (CPs) is embodied in recent studies revealing insights into the CP tumorigenesis and identifying novel molecular pathways amenable of targeted therapies. The actual impact of this new information, however, remains inconclusiv...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-018-0890-6
更新日期:2018-08-01 00:00:00
abstract::A 57-year-old woman presented with 2-year history of polyuria and polydipsia. Hormonal studies revealed almost normal anterior pituitary function and central diabetes insipidus. Magnetic resonance imaging showed thickening of the pituitary stalk and enlargement of the neurohypophysis without high intensity of the post...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1023/a:1009914711287
更新日期:1999-05-01 00:00:00
abstract::Double pituitary adenomas are rare in surgical specimens and the most common clinical feature in reported patients has been acromegaly. We report 3 cases of double pituitary lesions in patients who presented with Cushing's disease. In a 22-year-old man (case 1) with delayed puberty and low testosterone levels, mild hy...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1023/a:1011499609096
更新日期:2000-11-01 00:00:00
abstract:PURPOSE:Survivin is an apoptosis inhibitor, expressed in almost all types of human malignancies, but rarely in differentiated normal tissues. Recently, survivin gene splice variants with different anti-apoptotic activities have been reported. The current study was undertaken to examine the expression of survivin and it...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-014-0590-9
更新日期:2015-06-01 00:00:00
abstract::Acromegaly is associated with serious morbidity and mortality, if not well controlled. Approved somatostatin receptor ligands (SRLs) are a mainstay of medical therapy and exhibit preferential affinity for somatostatin receptor (SSTR) subtype 2. Our objective was to assess whether characteristic features of individual ...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-012-0445-1
更新日期:2013-12-01 00:00:00
abstract::Lymphoma involving the pituitary gland is very rare and usually results from metastatic spread of systemic lymphoma. We present a case of primary central nervous system (CNS) large B cell lymphoma that manifested as pituitary apoplexy. A 45-year-old woman presented with headache, and then rapidly developed a third ner...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-008-0084-8
更新日期:2009-01-01 00:00:00
abstract::Twenty years after the first description of combined hypopituitarism (CPHD) caused by PROP1 mutations, the phenotype of affected subjects is still challenging for clinicians. These patients suffer from pituitary hormone deficits ranging from IGHD to panhypopituitarism. ACTH deficiency usually develops later in life. P...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-020-01049-9
更新日期:2020-08-01 00:00:00
abstract:INTRODUCTION:In order to perform trans-sphenoidal endoscopic pituitary surgery safely and efficiently it is important to identify anatomical and pituitary disease features on the pre-operative CT and MRI scans; thereby minimising the risk to surrounding structures and optimising outcomes. We aim to create a checklist t...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-017-0787-9
更新日期:2017-08-01 00:00:00
abstract::The diagnosis of disorders of growth hormone (GH) is dependent upon accurate measurement of insulin-like growth factor-I (IGF-I) concentrations since serum IGF-I assays have been found to be useful as a screening tests for the presence of growth hormone deficiency (GHD) in children and in both children and adults they...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-007-0032-z
更新日期:2007-01-01 00:00:00
abstract::Growth hormone releasing hormone (GHRH) signals via G protein-coupled receptors (GHRH-R) to enhance intracellular Galphas/adenylyl cyclase/cAMP signaling, which in turn has positive effects on GH synthesis and release, as well as proliferation of the GH-producing cells of the anterior pituitary gland. Some GH-producin...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-005-5245-4
更新日期:2005-01-01 00:00:00
abstract:INTRODUCTION:Early disease onset, clinical manifestation, histomorphology, and increased tendency to relapse distinguish the adamantinomatous craniopharyngioma (adaCP) from the more favorable papillary variant (papCP). A molecular hallmark of adaCP is the activated Wnt signaling pathway indicated by nuclear β-catenin a...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-013-0543-8
更新日期:2014-12-01 00:00:00
abstract::Primary autoimmune hypophysitis (PAH) is considered an underdiagnosed disease, due to the difficulty in reaching a definitive diagnosis. PAH clinical diagnosis remains an exclusion diagnosis. We aimed to correlate PAH neuro-radiological signs to endocrine features and evaluate their prognostic role. 24 PAH cases were ...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-018-0892-4
更新日期:2018-08-01 00:00:00
abstract::The purpose of this study is to verify whether acute pre-treatment with alprazolam (ALP), a benzodiazepine that inhibits HPA secretion in normal subjects, could better characterize patients with subclinical Cushing's syndrome (SCS) than the 1-mg dexamethasone test (DST). In 22 patients with SCS, 10 with overt Cushing'...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-012-0433-5
更新日期:2013-09-01 00:00:00
abstract::Clinically inapparent adrenal masses, or adrenal incidentalomas, are discovered inadvertently in the course of workup or treatment of unrelated disorders. Cortical adenoma is the most frequent type of adrenal incidentaloma accounting for approximately 50% of cases in surgical series and even greater shares in medical ...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-005-4024-6
更新日期:2004-01-01 00:00:00
abstract::We report on a 74-year-old male patient who presented with progressive neuroophthalmologic symptoms soon after the administration of a long-acting gonadotropin-releasing hormone agonist for treatment of a prostate cancer. Imaging revealed a destructively growing and extensively calcified sellar mass inconsistent with ...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-009-0199-6
更新日期:2011-12-01 00:00:00
abstract::GH and IGF-1 play an important role in the regulation of metabolism and body composition. In patients with uncontrolled acromegaly, cardiovascular morbidity and mortality are increased but are supposed to be normalised after biochemical control is achieved. We aimed at comparing body composition and the cardiovascular...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-010-0218-7
更新日期:2010-09-01 00:00:00
abstract::Isolated familial somatotropinomas (IFS) rarely occurs in the absence of multiple endocrine neoplasia type I (MEN1) or the Carney complex. In the present study we report two Italian siblings affected by GH-secreting adenomas. There was no history of parental consanguinity. The sister presented at 18 years of age with ...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1023/a:1022193015993
更新日期:2002-01-01 00:00:00
abstract::Apart from the radiologic features regarding size and invasiveness, we had noticed some differences in morphology among types of pituitary adenomas. We conducted this study to verify the differences in radiologic morphology between growth hormone producing pituitary adenomas (GHoma) and nonfunctioning pituitary adenom...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-013-0479-z
更新日期:2014-04-01 00:00:00
abstract::Cushing's disease, i.e., pituitary ACTH-secreting adenoma causing excess glucocorticoid secretion, is a rare disease with significant mortality and morbidity. Timely diagnosis and appropriate treatment can alter the course of the disease and are therefore mandatory. First step of the diagnostic work-up is the endogeno...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-006-0407-6
更新日期:2006-01-01 00:00:00
abstract::Most patients with acromegaly have some degree of insulin resistance. The principal mediator of insulin resistance in acromegaly is hypersecretion of growth hormone. Growth hormone acts at several levels to block insulin actions including inhibiting phosphorylation of the insulin receptor and one of its principal sign...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1023/a:1023321421760
更新日期:2002-01-01 00:00:00
abstract::Cushing's Syndrome (CS) is associated with an increased mortality, where hypercoagulability seems to have a crucial role in both arterial and venous thrombosis. Parameters of in vitro thrombin generation (TG) such as lag time, peak thrombin and endogenous thrombin potential (ETP), that describe the time until thrombin...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-013-0467-3
更新日期:2014-02-01 00:00:00
abstract::In this report, an extremely rare case of pediatric thyrotropin-secreting pituitary macroadenoma (TSHoma) is described. An 8-year-old boy, complaining of unsteady gait, was suspected of endocrinopathy because of emaciation and muscle weakness of the legs. Endocrinological work-up established a diagnosis of hyperthyroi...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-010-0275-y
更新日期:2012-03-01 00:00:00
abstract::Craniopharyngiomas (CP) are partly cystic embryogenic malformations of the sellar and parasellar region. With an overall incidence of 0.5-2.0 new cases/million population/year, approximately 30-50 % of all cases represent childhood CP. Typical manifestations at diagnosis are headache, visual impairment, polyuria/polyd...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-012-0401-0
更新日期:2013-03-01 00:00:00
abstract::Nonfunctioning pituitary adenomas (NFPA) are typically benign neoplasms that can cause significant morbidity through local mass effects. MIB-1/Ki-67 and p53 immuno-reactivity are used to predict aggressive behavior but have known limitations. No marker to date is widely used to reliably predict tumor progression. Phos...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-011-0367-3
更新日期:2012-12-01 00:00:00
abstract::Symptomatic cerebral vasospasm (CVS) after transsphenoidal surgery (TSS) is very rare compared with vasospasm resulting from aneurysmal subarachnoid hemorrhage (SAH). Fewer than six cases documented by cerebral angiography have been reported. We evaluated the records of 15 patients in whom SAH developed after TSS. The...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-012-0415-7
更新日期:2013-06-01 00:00:00