Abstract:
BACKGROUND:The growing interest in the molecular and genetic alterations of craniopharyngiomas (CPs) is embodied in recent studies revealing insights into the CP tumorigenesis and identifying novel molecular pathways amenable of targeted therapies. The actual impact of this new information, however, remains inconclusive. METHODS:We present a comprehensive review of the accumulated knowledge on molecular biology of CPs and a critical analysis on the strengths and weaknesses of the studies focused on CP molecular/genetic alterations published to date. RESULTS:A thorough analysis of the alterations of β-catenin/CTNNB1 and BRAF genes investigated in 1123 CP cases included in 27 studies, showed that, on average, CTNNB1 mutations were present in two-thirds of adamantinomatous CPs and BRAF mutations in 90% of papillary CPs. Their role as oncogenic drivers has not been well established. Although rare, coexistence of both mutations may occur. The involvement of pituitary stem cells in human CP tumorigenesis is still uncertain. Expression of stem markers in human CP samples predominantly occurred along the CP border in contact with brain tissue. Finally, none of the various molecular alterations which have been proposed as markers for CP recurrence can be used today as reliable predictors of the CP behavior. CONCLUSIONS:The isolated evaluation of CPs' molecular or genetic profiles that do not take into consideration fundamental pathological and therapeutic factors, specifically the tumor topography and the degree of tumor removal, may actually generate confusion regarding the reliability of some biomarkers to predict the CP biological behavior.
journal_name
Pituitaryjournal_title
Pituitaryauthors
Prieto R,Pascual JMdoi
10.1007/s11102-018-0890-6subject
Has Abstractpub_date
2018-08-01 00:00:00pages
431-442issue
4eissn
1386-341Xissn
1573-7403pii
10.1007/s11102-018-0890-6journal_volume
21pub_type
杂志文章,评审相关文献
Pituitary文献大全abstract:PURPOSE:Hypophysitis develops in up to 19% of melanoma patients treated with ipilimumab, a cytotoxic T-lymphocyte antigen-4 antibody. Early detection may avert life-threatening hypopituitarism. We aimed to assess the incidence of ipilimumab-induced hypophysitis (IH) at a quaternary melanoma referral centre, and to dete...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-018-0866-6
更新日期:2018-06-01 00:00:00
abstract:PURPOSE:To determine the particle size, concentration, airborne duration and spread during endoscopic endonasal pituitary surgery in actual patients in a theatre setting. METHODS:This observational study recruited a convenience sample of three patients. Procedures were performed in a positive pressure operating room. ...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-021-01125-8
更新日期:2021-01-19 00:00:00
abstract:PURPOSE:Nelson's syndrome is a challenging condition that can develop following bilateral adrenalectomy for Cushing's disease, with high circulating ACTH levels, pigmentation and an invasive pituitary tumor. There is no established medical therapy. The aim of the study was to assess the effects of pasireotide on plasma...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-017-0853-3
更新日期:2018-06-01 00:00:00
abstract:PURPOSE:Patients treated for pituitary adenomas generally report a reduced quality of life (QoL). At present, the patient's perspective of QoL has not been fully addressed and this, and further insight in potential determinants of QoL in pituitary diseases is required to design strategies to improve QoL. We aimed to de...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-014-0561-1
更新日期:2015-02-01 00:00:00
abstract::In this report we emphasize the opportunity of considering the uncommon causes of chronic GH-excess in the initial diagnostic process, such as GHRH hypersecretion, especially in the presence of ambiguous pituitary neuroimaging. This topic may have an important clinical significance in order to plan the most cost-effec...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-008-0146-y
更新日期:2010-09-01 00:00:00
abstract::Published data on the effects of androgen deficiency and testosterone administration on body composition in men and women are reviewed. In experimental paradigms, androgen deprivation decreases lean body mass and increases fat mass in men, and physiologic replacement reverses these abnormalities. The anabolic effects ...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-008-0121-7
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:There has been growing interest on medical therapy for the management of Cushing's disease (CD), particularly in cases of persistent or recurrent hypercortisolism. Ketoconazole, an inhibitor of adrenal steroidogenesis, is the most widely used drug, whereas cabergoline and pasireotide are the most promising...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-015-0641-x
更新日期:2015-04-01 00:00:00
abstract::Ideal surgical treatment of craniopharyngiomas remains a major challenge for neurosurgeons. Craniopharyngiomas grow in the deep-seated hypothalamic area that is paramount for vegetative, emotional and endocrine function, and for maintaining worthwhile life. The benign histological nature of craniopharyngiomas belies t...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-008-0137-z
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:Tatton-Brown-Rahman syndrome (TBRS) is a newly defined genetic entity characterized by overgrowth and intellectual disability, resulting from germline mutations in the gene encoding DNA methyltransferase 3 alpha (DNMT3A). Affected individuals with benign and malignant tumors have been reported; to our knowledge...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-019-01019-w
更新日期:2020-04-01 00:00:00
abstract:CONTEXT:Outcome of acromegaly surgery is assessed by IGF-1 and glucose-suppressed GH, but whether the latter provides additional clinically relevant information when IGF-1 is normal is unclear. The role of GH suppression testing after surgery requires clarification. METHODS:We studied 97 acromegaly patients with norma...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-020-01094-4
更新日期:2020-10-30 00:00:00
abstract::The diagnosis of disorders of growth hormone (GH) is dependent upon accurate measurement of insulin-like growth factor-I (IGF-I) concentrations since serum IGF-I assays have been found to be useful as a screening tests for the presence of growth hormone deficiency (GHD) in children and in both children and adults they...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-007-0032-z
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:In this study, we set out to define our institutional criteria for patient eligibility for transsphenoidal resection of parasellar meningiomas, and to report our experience with extended transnasal approaches for these lesions. We aimed to discuss the important considerations of patient selection and risk strat...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-017-0818-6
更新日期:2017-10-01 00:00:00
abstract::The management of invasive giant prolactinomas (IGP) has been an area of some controversy. The relative roles of transsphenoidal surgery, craniotomy, radiation therapy and dopamine agonist based medical therapy are gradually becoming clarified. We report the results of management of 30 patients with IGP. Surgery was t...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-005-5087-0
更新日期:2005-01-01 00:00:00
abstract::Isolated familial somatotropinomas (IFS) rarely occurs in the absence of multiple endocrine neoplasia type I (MEN1) or the Carney complex. In the present study we report two Italian siblings affected by GH-secreting adenomas. There was no history of parental consanguinity. The sister presented at 18 years of age with ...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1023/a:1022193015993
更新日期:2002-01-01 00:00:00
abstract:PURPOSE:Doses of growth hormone in adults with growth hormone deficiency are now lower than previously. However, it is not clear they are as effective as higher doses. The objective of this meta-analysis was to assess efficacy of low to moderate dose (LD) GH replacement on standard endpoints of GH compared to higher do...
journal_title:Pituitary
pub_type: 杂志文章,meta分析,评审
doi:10.1007/s11102-014-0571-z
更新日期:2015-06-01 00:00:00
abstract:PURPOSE:Survivin is an apoptosis inhibitor, expressed in almost all types of human malignancies, but rarely in differentiated normal tissues. Recently, survivin gene splice variants with different anti-apoptotic activities have been reported. The current study was undertaken to examine the expression of survivin and it...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-014-0590-9
更新日期:2015-06-01 00:00:00
abstract::The morphology of the various pituitary cell types is highly dynamic and allows recognition of many cellular functions. Most pituitary cells show morphologic changes that reflect stimulation or inhibition by hormones. Drugs have also been shown to alter the morphology of several pituitary tumor types, allowing a measu...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1023/a:1022320732718
更新日期:2002-01-01 00:00:00
abstract::Adequate ADH secretion, adrenal and thyroid functions are vital during the acute and post-acute phases of TBI. Deficiencies of these functions as a result of TBI are increasingly recognized. During the acute phase of TBI the incidence of severe DI is 2.9%; the incidence of less severe forms of DI is 21.6-26%. The deve...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-006-6049-x
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Suprasellar pituitary adenomas (SPAs) are a special type of pituitary adenoma. Although dozens of SPA cases have been reported, the exact definition and the characteristics of SPA have not been exhaustively discussed before. METHODS:In a retrospective electronic medical records review, 13 patients with SPA ...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-020-01043-1
更新日期:2020-08-01 00:00:00
abstract:INTRODUCTION:Autoimmune lymphocytic hypophysitis associates predominantly with other autoimmune endocrinopathies and is most commonly treated with glucocorticoids and/or decompressive pituitary surgery. Here we report a new association and treatment modality for lymphocytic hypophysitis. METHODS:A 52-year-old woman pr...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-014-0592-7
更新日期:2015-08-01 00:00:00
abstract::The availability of various first-line treatment modalities for acromegaly and evolving surgical techniques emphasize the need for accurately defined predictors of surgical outcome. We retrospectively analysed the outcome of 30 patients with acromegaly after initial endoscopic transsphenoidal surgery in two university...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-012-0395-7
更新日期:2013-06-01 00:00:00
abstract:PURPOSE:The pituitary gland is an unusual site for metastatic spread, but as patients with metastatic malignancy are living longer, it may become more prevalent. Compression of important anatomy adjacent to the sella may produce disabling symptoms and endocrine derangement, leading to significant morbidity. METHODS:An...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-018-0899-x
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Xanthogranulomas are inflammatory masses most commonly found at peripheral sites such as the skin. Sellar and parasellar xanthogranulomas are rare and present a diagnostic challenge as they are difficult to differentiate from other sellar lesions such as craniopharyngiomas and Rathke's cleft cysts pre-operat...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-017-0859-x
更新日期:2018-06-01 00:00:00
abstract:PURPOSE:Long-acting somatostatin analogs are one of the main classes of medical therapy used for acromegaly and most patients require ongoing treatment. Few studies have evaluated the long-term efficacy and safety of lanreotide depot beyond 2 years. The goal of this study was to provide a long-term longitudinal assessm...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-016-0724-3
更新日期:2016-08-01 00:00:00
abstract::Clinically inapparent adrenal masses, or adrenal incidentalomas, are discovered inadvertently in the course of workup or treatment of unrelated disorders. Cortical adenoma is the most frequent type of adrenal incidentaloma accounting for approximately 50% of cases in surgical series and even greater shares in medical ...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-005-4024-6
更新日期:2004-01-01 00:00:00
abstract:PURPOSE:Granular cell tumors of the neurohypophysis are rare, solitary lesions, mostly presenting in the adult age. They rarely grow to a sufficient size to cause mass effect related symptoms and they may be found in most cases incidentally at autopsy. Because of their rarity as of now they have been described only as ...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-016-0704-7
更新日期:2016-06-01 00:00:00
abstract::The role of pituitary radiotherapy (RT) in the management of clinically non-functioning pituitary tumors (NFTs) remains controversial. Observational studies suggest that RT is effective in preventing the regrowth of NFT remnants following initial surgical debulking. However, not all tumor remnants will regrow in the a...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1023/b:pitu.0000004801.95086.e2
更新日期:2003-09-01 00:00:00
abstract::A high incidence of venous thromboembolic (VTE) complications has been reported in Cushing's syndrome (CS), mostly post-operatively and attributable to hypercoagulability. The prevalence of symptomatic VTE was investigated retrospectively in 58 consecutive CS patients in relation to acquired and genetic thrombotic ris...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-012-0398-4
更新日期:2013-06-01 00:00:00
abstract:PURPOSE:The SAGIT® instrument, designed to assist clinicians to stage acromegaly, assess treatment response and adapt patient management, was well received by endocrinologists in a pilot study. We report an interim analysis of baseline data from the validation phase. METHODS:The SAGIT® validation study (ClinicalTrials...
journal_title:Pituitary
pub_type: 杂志文章
doi:10.1007/s11102-019-00977-5
更新日期:2019-10-01 00:00:00
abstract::Cushing's disease, i.e., pituitary ACTH-secreting adenoma causing excess glucocorticoid secretion, is a rare disease with significant mortality and morbidity. Timely diagnosis and appropriate treatment can alter the course of the disease and are therefore mandatory. First step of the diagnostic work-up is the endogeno...
journal_title:Pituitary
pub_type: 杂志文章,评审
doi:10.1007/s11102-006-0407-6
更新日期:2006-01-01 00:00:00