Primary (autoimmune) hypophysitis: a single centre experience.

abstract：:Cis-unsaturated free fatty acids (FFA) like oleic acid are strong blockers of both basal and stimulated GH secretion in vivo by acting directly on the somatotroph cell. Several lines of evidence suggest that this inhibitory action is the result of a perturbation of the function of several plasma membrane integral prot...

journal_title：Pituitary

authors： Pérez FR,Camiña JP,Menéndez C,Beiras A,Casabiell X,Casanueva FF

更新日期：1998-04-01 00:00:00

abstract：:Leptin is a key mediator in the maintenance of neuroendocrine homeostasis. The aim of this study was to determine the changes in serum leptin, tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), nitric oxide (NO) levels in patients with hyperprolactinemia. The study consists of 16 consecutive patients with ...

journal_title：Pituitary

authors： Balci H,Akgun-Dar K,Gazioglu N,Kapucu A,Bolayirli M,Oz B

更新日期：2009-01-01 00:00:00

abstract：:Primary autoimmune hypophysitis (PAH) is considered an underdiagnosed disease, due to the difficulty in reaching a definitive diagnosis. PAH clinical diagnosis remains an exclusion diagnosis. We aimed to correlate PAH neuro-radiological signs to endocrine features and evaluate their prognostic role. 24 PAH cases were ...

journal_title：Pituitary

authors： Tartaglione T,Chiloiro S,Laino ME,Giampietro A,Gaudino S,Zoli A,Bianchi A,Pontecorvi A,Colosimo C,De Marinis L

更新日期：2018-08-01 00:00:00

abstract：:Published data on the effects of androgen deficiency and testosterone administration on body composition in men and women are reviewed. In experimental paradigms, androgen deprivation decreases lean body mass and increases fat mass in men, and physiologic replacement reverses these abnormalities. The anabolic effects ...

journal_title：Pituitary

authors： Miller KK

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:Nelson's syndrome is a challenging condition that can develop following bilateral adrenalectomy for Cushing's disease, with high circulating ACTH levels, pigmentation and an invasive pituitary tumor. There is no established medical therapy. The aim of the study was to assess the effects of pasireotide on plasma...

journal_title：Pituitary

authors： Daniel E,Debono M,Caunt S,Girio-Fragkoulakis C,Walters SJ,Akker SA,Grossman AB,Trainer PJ,Newell-Price J

更新日期：2018-06-01 00:00:00

abstract：:Although leptin was originally viewed as an antiobesity hormone, it is now evident that it may have more pleiotropic actions. Experiments in rodents have shown that leptin activates the sympathetic nervous system, is involved in regulation of blood pressure, hematopoiesis, immune function, angiogenesis and brain, bone...

journal_title：Pituitary

authors： Popovic V,Damjanovic S,Dieguez C,Casanueva FF

更新日期：2001-01-01 00:00:00

abstract：:Oral estrogens reduce GH-induced IGF-1 production and preliminary studies have shown that adjuvant estroprogestin (EP) therapy with octreotide LAR may control disease activity in some female patients who are partially responsive to octreotide LAR. Our aim was to verify if EP alone or in combination with octreotide LAR...

journal_title：Pituitary

authors： Vallette S,Serri O

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:In a 10-week proof-of-concept study (LINC 1), the potent oral 11β-hydroxylase inhibitor osilodrostat (LCI699) normalized urinary free cortisol (UFC) in 11/12 patients with Cushing's disease. The current 22-week study (LINC 2; NCT01331239) further evaluated osilodrostat in patients with Cushing's disease. METHO...

journal_title：Pituitary

authors： Fleseriu M,Pivonello R,Young J,Hamrahian AH,Molitch ME,Shimizu C,Tanaka T,Shimatsu A,White T,Hilliard A,Tian C,Sauter N,Biller BM,Bertagna X

更新日期：2016-04-01 00:00:00

abstract：:Lactotroph adenomas, also called prolactinomas and prolactin-secreting adenomas, constitute nearly 80% of functioning pituitary tumors and about 30-50% of all adenomas in the clinical practice. Lactotroph adenomas occur in the general population at a prevalence of 45/100,000, are more common in women, but also involve...

journal_title：Pituitary

authors： Lopes MBS

更新日期：2020-02-01 00:00:00

abstract：PURPOSE:Long-acting somatostatin analogs are one of the main classes of medical therapy used for acromegaly and most patients require ongoing treatment. Few studies have evaluated the long-term efficacy and safety of lanreotide depot beyond 2 years. The goal of this study was to provide a long-term longitudinal assessm...

journal_title：Pituitary

authors： Sagvand BT,Khairi S,Haghshenas A,Swearingen B,Tritos NA,Miller KK,Klibanski A,Nachtigall LB

更新日期：2016-08-01 00:00:00

abstract：PURPOSE:The pituitary gland is an unusual site for metastatic spread, but as patients with metastatic malignancy are living longer, it may become more prevalent. Compression of important anatomy adjacent to the sella may produce disabling symptoms and endocrine derangement, leading to significant morbidity. METHODS:An...

journal_title：Pituitary

authors： Castle-Kirszbaum M,Goldschlager T,Ho B,Wang YY,King J

更新日期：2018-10-01 00:00:00

abstract：:Ideal surgical treatment of craniopharyngiomas remains a major challenge for neurosurgeons. Craniopharyngiomas grow in the deep-seated hypothalamic area that is paramount for vegetative, emotional and endocrine function, and for maintaining worthwhile life. The benign histological nature of craniopharyngiomas belies t...

journal_title：Pituitary

authors： Honegger J,Tatagiba M

更新日期：2008-01-01 00:00:00

abstract：INTRODUCTION:Cushing's syndrome is associated with a number of clinical manifestations and co-morbidities which may not resolve even after long-term remission leading to excessive mortality. MATERIALS AND METHODS:This review summarizes the main manifestations of Cushing's syndrome (active or in remission) with particu...

journal_title：Pituitary

authors： Ntali G,Grossman A,Karavitaki N

更新日期：2015-04-01 00:00:00

abstract：:The pituitary is the master endocrine gland of the body. It undergoes many changes after birth, and these changes may be mediated by the differentiation of pituitary stem cells. Stem cells in any tissue source must display (1) pluripotent capacity, (2) capacity for indefinite self-renewal, and (3) a lack of specializa...

journal_title：Pituitary

authors： Nassiri F,Cusimano M,Zuccato JA,Mohammed S,Rotondo F,Horvath E,Syro LV,Kovacs K,Lloyd RV

更新日期：2013-09-01 00:00:00

abstract：PURPOSE:Patients treated for pituitary adenomas generally report a reduced quality of life (QoL). At present, the patient's perspective of QoL has not been fully addressed and this, and further insight in potential determinants of QoL in pituitary diseases is required to design strategies to improve QoL. We aimed to de...

journal_title：Pituitary

authors： Andela CD,Niemeijer ND,Scharloo M,Tiemensma J,Kanagasabapathy S,Pereira AM,Kamminga NG,Kaptein AA,Biermasz NR

更新日期：2015-02-01 00:00:00

abstract：:A high incidence of venous thromboembolic (VTE) complications has been reported in Cushing's syndrome (CS), mostly post-operatively and attributable to hypercoagulability. The prevalence of symptomatic VTE was investigated retrospectively in 58 consecutive CS patients in relation to acquired and genetic thrombotic ris...

journal_title：Pituitary

authors： Koutroumpi S,Daidone V,Sartori MT,Cattini MG,Albiger NM,Occhi G,Ferasin S,Frigo A,Mantero F,Casonato A,Scaroni C

更新日期：2013-06-01 00:00:00

abstract：PURPOSE:Approximately 25 % of cases of clinically active acromegaly cases treated in our academic center between 1996 and 2000, were diagnosed in patients who had elevated plasma IGF-1 levels, but apparently "normal" 24-h mean plasma GH levels. The current study served to update the data for patients with acromegaly re...

journal_title：Pituitary

authors： Butz LB,Sullivan SE,Chandler WF,Barkan AL

更新日期：2016-12-01 00:00:00

abstract：:Hyperprolactinemia has been associated with impaired metabolism, including insulin resistance. However, the metabolic effects of elevated prolactin (PRL) levels are not completely clarified. The aim of this study was to obtain more insights of metabolic consequences in hyperprolactinemia patients. Fourteen consecutive...

journal_title：Pituitary

authors： Berinder K,Nyström T,Höybye C,Hall K,Hulting AL

更新日期：2011-09-01 00:00:00

abstract：:The molecular pathogenesis of prolactinomas has resisted elucidation; with the exception of a RAS mutation in a single aggressive prolactinoma, no mutational changes have been identified. In prolactinomas, a further obstacle has been the paucity of surgical specimens suitable for molecular analysis since prolactionoma...

journal_title：Pituitary

authors： Evans CO,Moreno CS,Zhan X,McCabe MT,Vertino PM,Desiderio DM,Oyesiku NM

更新日期：2008-01-01 00:00:00

abstract：:The availability of various first-line treatment modalities for acromegaly and evolving surgical techniques emphasize the need for accurately defined predictors of surgical outcome. We retrospectively analysed the outcome of 30 patients with acromegaly after initial endoscopic transsphenoidal surgery in two university...

journal_title：Pituitary

authors： van Bunderen CC,van Varsseveld NC,Baayen JC,van Furth WR,Aliaga ES,Hazewinkel MJ,Majoie CB,Freling NJ,Lips P,Fliers E,Bisschop PH,Drent ML

更新日期：2013-06-01 00:00:00

abstract：:Inferior petrosal sinus sampling (IPSS) of ACTH with CRH stimulation helps distinguish pituitary ACTH-dependent Cushing's syndrome from the ectopic ACTH syndrome (EAS). The usefulness of the paradoxical response of other pituitary hormones including prolactin to CRH remains controversial. Data from 33 IPSS procedures ...

journal_title：Pituitary

authors： Daousi C,Nixon T,Javadpour M,Hayden K,MacFarlane IA

更新日期：2010-06-01 00:00:00

abstract：:Silent growth hormone adenomas (SGHA) are a rare entity of non-functioning pituitary neuroendocrine tumors. Diagnosis is invariably made post-operatively of a tumor immunopositive for GH (and Pit-1 in selected cases) but without clinical acromegaly. Mainly young females are affected, and tumors are often uncovered by ...

journal_title：Pituitary

authors： Langlois F,Woltjer R,Cetas JS,Fleseriu M

更新日期：2018-04-01 00:00:00

abstract：:Growth hormone releasing hormone (GHRH) signals via G protein-coupled receptors (GHRH-R) to enhance intracellular Galphas/adenylyl cyclase/cAMP signaling, which in turn has positive effects on GH synthesis and release, as well as proliferation of the GH-producing cells of the anterior pituitary gland. Some GH-producin...

journal_title：Pituitary

authors： Kim E,Sohn S,Lee M,Park C,Jung J,Park S

更新日期：2005-01-01 00:00:00

abstract：PURPOSE:Secondary empty sella syndrome (SESS) following pituitary surgery remains a diagnostic and therapeutic challenge. The aim of this study was to specify the diagnostic criteria, surgical indications and results of chiasmapexy in the SESS. METHODS:Three cases from two experienced neurosurgical centers were collec...

journal_title：Pituitary

authors： Graillon T,Passeri T,Boucekine M,Meyer M,Abritti R,Bernat AL,Labidi M,Dufour H,Froelich S

更新日期：2020-11-02 00:00:00

abstract：:A 57-year-old woman presented with 2-year history of polyuria and polydipsia. Hormonal studies revealed almost normal anterior pituitary function and central diabetes insipidus. Magnetic resonance imaging showed thickening of the pituitary stalk and enlargement of the neurohypophysis without high intensity of the post...

journal_title：Pituitary

authors： Waki K,Yamada S,Ozawa Y,Seki K,Endo Y

更新日期：1999-05-01 00:00:00

abstract：:Pituitary cysts are usually craniopharyngiomas or remnants of Rathke's cleft. Histologically craniopharyngiomas are lined by stratified squamous epithelium whereas Rathke's cleft cysts are lined by cuboidal or columnar epithelium. The management of pituitary cysts remains difficult because of the risks associated with...

journal_title：Pituitary

authors： Dashora U,Mathias D,James A,Zammit-Maempel I,Perros P

更新日期：2002-01-01 00:00:00

abstract：:The management of invasive giant prolactinomas (IGP) has been an area of some controversy. The relative roles of transsphenoidal surgery, craniotomy, radiation therapy and dopamine agonist based medical therapy are gradually becoming clarified. We report the results of management of 30 patients with IGP. Surgery was t...

journal_title：Pituitary

authors： Yu C,Wu Z,Gong J

更新日期：2005-01-01 00:00:00

abstract：INTRODUCTION:Cystic prolactinoma is a variant of prolactin-secreting pituitary adenoma. The strategies for the management of cystic prolactinoma have not been addressed thoroughly in clinical guidelines. METHODS:A literature search was performed using Pubmed to review the current approaches to the treatment of cystic ...

journal_title：Pituitary

authors： Nakhleh A,Shehadeh N,Hochberg I,Zloczower M,Zolotov S,Taher R,Daoud Naccache D

更新日期：2018-08-01 00:00:00

abstract：:In western countries, the process of "ageing of the population" is increasingly forcing clinical medicine to find answers for pathologies affecting the elder segments of our community. In this respect, pituitary adenomas often raise difficult questions on surgical indications, since little is known about postoperative...

journal_title：Pituitary

authors： Locatelli M,Bertani G,Carrabba G,Rampini P,Zavanone M,Caroli M,Sala E,Ferrante E,Gaini SM,Spada A,Mantovani G,Lania A

更新日期：2013-06-01 00:00:00

abstract：:160 clinically non-secreting pituitary adenomas were examined in regard to their expression of the markers PCNA, bcl2, Ki 67 in the mib-1 modification and p53 which are still under investigation for their relevance to cell proliferation. The series contained 60 null cell adenomas, 60 oncocytomas and 40 gonadotroph ade...

journal_title：Pituitary

authors： Schreiber S,Saeger W,Lüdecke DK

更新日期：1999-05-01 00:00:00